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Neurological Disease

货号 产品名 CAS号 信息
CSN13790 (R)-2-(Methylamino)succinic acid 6384-92-5 NMDA is an amino acid derived specific agonist at the NMDA receptor.
CSN13896 DAPT 208255-80-5 DAPT is an inhibitor of γ-secretase and it can reduce the expression of Aβ40 and Aβ42 with IC50 values of 115 nM and 200 nM.
CSN13810 Piracetam 7491-74-9 Piracetam is a cyclic derivative of GABA which works as a positive allosteric modulator of the AMPA receptor.
CSN13865 N-(3-Oxo-3-(4-(pyridin-4-yl)piperazin-1-yl)propyl)benzo[c][1,2,5]thiadiazole-4-sulfonamide 1135243-19-4 VU 0255035 is a highly selective and brain penetrant M1 antagonist with Ki value of 14.87 nM, targeting the M1 orthosteric site.
CSN15692 Brexpiprazole 913611-97-9 Brexpiprazole is a partial agonist of the serotonin 5-HT1A receptor and the dopamine D2 and D3 receptors, used as an atypical antipsychotic for the treatment of schizophrenia and major depressive disorders.
CSN15719 Raxatrigine HCl 934240-31-0 CNV1014802 HCl is a blocker of Nav1.7 sodium channel with analgesic effects.
CSN15754 GSK2578215A 1285515-21-0 GSK2578215A is a brain-penetrant, potent and selective LRRK2 inhibitor with IC50 values of 8.9 and 10.1 nM for LRRK2[G2019S] mutant and wild-type LRRK2, respectively.
CSN15765 PF-06447475 1527473-33-1 PF-06447475 is a brain-penetrant, potent and selective LRRK2 inhibitor with IC50 values of 3 nM, possessing neuroprotective activity.
CSN15789 1-((2S,3S,5S,8R,9S,10S,13S,14S,16S,17R)-17-Acetoxy-3-hydroxy-10,13-dimethyl-2-morpholinohexadecahydro-1H-cyclopenta[a]phenanthren-16-yl)-1-allylpyrrolidin-1-ium bromide 119302-91-9 Rocuronium bromide is an aminosteroid non-depolarizing neuromuscular blocker.
CSN15983 Purmorphamine 483367-10-8 Purmorphamine is an activator of Smoothened, and blocks BODIPY-cyclopamine binding to Smo with IC50 of appr 1.5 μM and also is an inducer of osteoblast differentiation with EC50 of 1 μM.
CSN15984 AR-A014418 487021-52-3 AR-A014418 is a selective inhibitor of GSK3β with IC50 of 104 ± 27 nM.
CSN16030 Cariprazine 839712-12-8 Cariprazine exhibits high selectivity and affinity to dopamine D3 receptor (Ki=0.09 nM) and lower binding activity to dopamine D2 receptor and 5-HT(1A) with Ki of 0.5 nM and 2.6 nM repectively. It has been used as antipsychotics in the treatment of schizophrenia and bipolar disorder.
CSN13879 4-Amino-N-(2-(diethylamino)ethyl)benzamide hydrochloride 614-39-1 Procainamide HCl is a blocker of sodium channel and an inhibitor of DNA methyltransferase. It is an anti-arrhythmic agent.
CSN15935 Ciproxifan maleate 184025-19-2 Ciproxifan maleate is a highly potent and selective histamin H3-receptor antagonist with IC50 of 9.2 nM, with low apparent affinity at other receptor subtypes.
CSN15766 ML204 5465-86-1 ML204 is a selective antagonist of TRPC4 ion channel with IC50 of 0.96 μM and 2.6 μM in fluorescent and electrophysiological assays respectively.
CSN15882 VU0361737 1161205-04-4 VU 0361737 is a brain-penetrant and selective positive allosteric modulator of mGlu4 receptors with EC50 values of 240 nM.
CSN15920 DPN 1428-67-7 DPN is a non-steroidal estrogen receptor β (ER β) selective ligand.
CSN15752 ANA-12 219766-25-3 ANA-12 is antagonist of TrkB with Kd of 10 nM.
CSN16013 Doxapram HCl 7081-53-0 Doxapram HCl, a respiratory stimulant, exhibits inhibition of TASK-1 (EC50 = 410 nM), TASK-3 (EC50 = 37 nM) and TASK-1/TASK-3 heterodimeric (EC50 = 9 nM) channel function. It is widely used in central nervous system excitability and directly stimulate the medullary respiratory or vascular movement center.
CSN13883 Dizocilpine maleate 77086-22-7 (+)-MK 801 Maleate is a highly potent, selective and non-competitive NMDA receptor antagonist with Ki of 30.5 nM.
CSN15992 cis-(Z)-Flupentixol dihydrochloride 51529-01-2 Flupenthixol 2HCl, a typical antipsychotic drug, is non-selective antagonist of dopamine D1-5 receptors as well as 5-HT2A. It is also known as flupenthixol.
CSN15682 (R)-1-(2-Bromophenyl)-3-(1-(5-(trifluoromethyl)pyridin-2-yl)pyrrolidin-3-yl)urea 501951-42-4 SB-705498 is a selective antagonist of transient receptor potential vanilloid 1 (TRPV1) with pIC50 of 7.1.
CSN15912 GNE0877 1374828-69-9 GNE0877 is a highly potent, selective, and brain-penetrant aminopyrazole leucine-rich repeat kinase 2 (LRRK2) small molecule inhibitor with an IC50 of 3 nM.
CSN15979 (1S,2R)-Tranylcypromine HCl 4548-34-9 Tranylcypromine HCl, is a monoamine oxidase inhibitor (MAOI) that irreversibly inhibits MAO A and MAO B with the inhibition constant Ki values of 101.9 μM and 16 μM and the half maximal inhibition concentration IC50 values of 2.3 μM and 0.95 μM respectively.
CSN15698 L-838417 286456-42-6 L-838417 is a subtype-selective GABAA receptor partial agonist. L-838417 selectively binds to α1, α2, α3 and α5 subunits (Ki values are 0.79, 0.67, 0.67 and 2.25 nM respectively) but displays no efficacy at α1 (α1-sparing). L-838417 exhibits non-sedative anxiolytic, antinociceptive and anti-inflammatory activity.
CSN15761 URMC-099 1229582-33-5 URMC-099 is an orally bioavailable, brain penetrant inhibitor of Mixed Lineage Kinase 3 (MLK3) with IC50 of 14 nM. It inhibits LPS-induced TNFα release in microglial cells, HIV-1 Tat-induced release of cytokines in human monocytes, and up-regulation of phospho-JNK in Tat-injected brains of mice.
CSN13921 Edelinontrine 1082744-20-4 PF-04447943 is a potent, selective brain penetrant PDE9 inhibitor (Ki of 2.8, 4.5 and 18 nM) for human, rhesus and rat recombinant PDE9 respectively and high selectivity for PDE9 versus PDEs1-8 and 10-11.
CSN13781 JW 642 1416133-89-5 JW 642 is a potent inhibitor of monoacylglycerol lipase (MAGL) that displays IC50 values of 7.6, 14, and 3.7 nM for inhibition of MAGL in mouse, rat, and human brain membranes, respectively.
CSN13878 Raxatrigine 934240-30-9 CNV1014802 is a blocker of Nav1.7 sodium channel.
CSN13858 SB-269970 201038-74-6 SB-269970 is a 5-HT7 receptor antagonist with pKi of 8.3, and exhibits > 50-fold selectivity against other receptors.
CSN15940 MPEP HCl 219911-35-0 MPEP HCl is a potent and highly selective non-competitive antagonist at the mGlu5 receptor subtype with IC50 of 36 nM.
CSN16002 VU0364770 61350-00-3 VU 0364770 is a brain-penetrant and positive allosteric modulator of mGlu4 receptors with EC50 values of 290 nM. It also exhibits affinity for MAO-B and MAO-A with Ki values of 0.72 μM and 8.5 μM, respectively.
CSN15700 Basimglurant 802906-73-6 RG7090 is a potent, selective and orally available mGlu5 negative allosteric modulator with a Kd of 1.1 nM.
CSN15969 LM22A-4 37988-18-4 LM22A-4 is a specific agonist oftyrosine kinase receptor B.
CSN15876 VU0357017 HCl 1135242-13-5 VU 0357017 HCl is a positive allosteric modulator of muscarinic M1 receptors with EC50 value of 198 nM.
CSN15793 LY450108 376594-67-1 LY450108 is an alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptor potentiator.
CSN13932 PDE10-IN-1 1516896-09-5 PDE10-IN-1 is a potent PDE10 inhibitor for treating CNS and metabolic disorders.
CSN13820 MK-0752 471905-41-6 MK-0752 is a moderately potent γ-secretase inhibitor, which reduces Aβ40 production with IC50 of 5 nM.
CSN13859 GR 55562 hydrochloride 172854-55-6 GR55562 is a selective competitive 5-HT1B(5-HT1Dβ) silent antagonist with pKB values of 7.3 and 6.3 for human cloned 5-HT1B and 5-HT1D receptors respectively and only weak binding at a number of other 5-HT subtypes.
CSN13916 MDL 105519 161230-88-2 MDL 105519 is a potent and selective inhibitor of [3H]glycine binding to the NMDA receptor with Kd of 3.89 nM.
CSN15704 (+)-Tetrabenazine 1026016-83-0 Tetrabenazine (+)- is a potent, selective and reversible VMAT-2 (vesicular monoamine transporter-2) inhibitor with Ki value of 100 nM.
CSN15877 Telotristat etiprate 1137608-69-5 Telotristat Etiprate an orally bioavailable, small-molecule, tryptophan hydroxylase (TPH) inhibitor with potential antiserotonergic activity.
CSN15871 9-Methyl-3-((2-methyl-1H-imidazol-1-yl)methyl)-1,2,3,9-tetrahydro-4H-carbazol-4-one hydrochloride dihydrate 103639-04-9 Ondansetron HCl 2H2O is a competitive 5-HT3 receptor antagonist.
CSN15891 LRRK2-IN-1 1234480-84-2 LRRK2-IN-1 is a potent and selective LRRK2 inhibitor with IC50 values of 6 and 13 nM for G2019S mutant and wild-type LRRK2, respectively.
CSN13780 Almorexant HCl 913358-93-7 Almorexant HCl is a potent and competitive dual orexin 1 receptor (OX1)/orexin 2 receptor (OX2) antagonist with Ki values of 1.3 and 0.17 nM for OX1 and OX2, respectively.
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