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CFTR

CFTR

货号 产品名 CAS号 信息
CSN12300 VX-809 936727-05-8 VX-809 acts to correct CFTR mutations common in cystic fibrosis by increasing mutant CFTR (F508del-CFTR) maturation with an EC50 of 0.1 μM.
CSN15718 VX-661 1152311-62-0 VX-661 is a F508del CFTR corrector and is believed to help CFTR protein reach the cell surface.
CSN12266 PTC-124 775304-57-9 PTC-124 is nonsense allele inhibitor, used to treat Duchenne muscular dystrophy.
CSN16935 PPQ-102 931706-15-9 PPQ-102 is a potent and voltage-independent CFTR inhibitor, which completely inhibit CFTR chloride current with IC50 approximately 90 nM.
CSN11339 Lubiprostone 136790-76-6 Lubiprostone is an ClC-2 chloride channel activator used in the treatment of idiopathic chronic constipation.
CSN18426 KM11060 774549-97-2 KM11060 corrects the F508del-CFTR trafficking defect, also shows inhibition on PDE5 activity.
CSN13698 Ivacaftor 873054-44-5 Ivacaftor is a potentiator of CFTR targeting G551D-CFTR and F508del-CFTR with EC50 of 100 nM and 25 nM, respectively.
CSN17491 Ivacaftor Hydrate 1134822-07-3 Ivacaftor is a potentiator of CFTR targeting G551D-CFTR and F508del-CFTR with EC50 of 100 nM and 25 nM, respectively.
CSN17492 Ivacaftor Benzenesulfonate 1134822-09-5 Ivacaftor benzenesulfonate is a potentiator of CFTR targeting G551D-CFTR and F508del-CFTR with EC50 of 100 nM and 25 nM, respectively.
CSN13745 IOWH-032 1191252-49-9 IOWH-032 is a potent CFTR inhibitor (IC50=1.01 μM) in T84 and CHO-CFTR cell based assays.
CSN18214 GlyH-101 328541-79-3 GlyH-101, a glycinyl hydrazone compound, is a reversible and voltage-dependent CFTR chloride channel blocker with Ki of 4.3 μM.
CSN21065 GLPG1837 1654725-02-6 GLPG-1837 is a cystic fibrosis transmembrane conductance regulator (CFTR) potentiator1, shows enhanced efficacy on CFTR mutants harboring Class III mutations compared to Ivacaftor.
CSN22372 CFTR Corrector 1897384-89-2 CFTR corrector is a cystic fibrosis transmembrane conductance regulator (CFTR) modulator extracted from patent US9782408.
CSN19349 CFTR(inh)-172 307510-92-5 CFTR (inh)-172 is an reversibly inhibitor of CFTR short-circuit current in less than 2 minutes in a voltage-independent manner with Ki ~300 nM.
CSN23041 PG 01 853138-65-5
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