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Secretase

Secretase

货号 产品名 CAS号 信息
CSN22538 β-Secretase Inhibitor IV 797035-11-1 β-Secretase Inhibitor IV is a potent, cell-active BACE-1 inhibitor with IC50s of 15.6 and 16.3nM under BACE-1 concentrations of 2 nM and 100 pM, respectively.
CSN11079 Z-Ile-Leu-aldehyde 161710-10-7 Z-Ile-Leu-aldehyde is a potent gamma-secretase inhibitor and a Notch signaling inhibitor.
CSN18740 Verubecestat 1286770-55-5 Verubecestat is a BACE1 inhibitor. MK-8931 binds significantly to β-secretase.
CSN16909 Semagacestat 425386-60-3 Semagacestat is an inhibitor of γ-secretase. It inhibits Aβ42, Aβ38, Aβ40 and the Notch signaling with IC50 of 10 nM, 12 nM, 12.1 nM and 14.1 nM.
CSN16034 RO4929097 847925-91-1 RO4929097 is an inhibitor of γ secretase, the IC50s of Aβ40 and notch are 14 nM and 5 nM, respectively.
CSN17660 PF-3084014 1290543-63-3 PF-3084014 is a reversible inhibitor of γ-secretase with IC50 of 6.2 nM.
CSN21372 PF-06751979 1818339-66-0 PF-06751979 is a potent, brain penetrant, β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor with an IC50 of 7.3 nM in BACE1 binding assay.
CSN19274 LY411575 Isomer 3 2070009-28-6 LY411575 isomer 3 is an isomer of LY411575, which is a potent γ-secretase inhibitor with IC50 of 0.078 nM/0.082 nM (membrane/cell-based), also inhibits Notch clevage with withIC50 of 0.39 nM.
CSN19271 LY411575 Isomer 2 2070009-70-8 LY411575 isomer 2 is an isomer of LY411575, which is a potent γ-secretase inhibitor with IC50 of 0.078 nM/0.082 nM (membrane/cell-based), also inhibits Notch clevage with with IC50 of 0.39 nM.
CSN17132 LY411575 209984-57-6 LY411575 is an inhibitor of γ-secretase with IC50 of 0.078 nM and it can also inhibit Notch clevage (IC50 = 0.39 nM).
CSN17134 LY2886721 1262036-50-9 LY2886721 is an BACE inhibitor used for the treatment of Alzheimer's Disease.
CSN12810 LY2811376 1194044-20-6 LY2811376 is the first orally available non-peptidic β-secretase (BACE1) inhibitor with IC50 of 239 nM-249 nM, that acts to decrease Aβ secretion with EC50 of 300 nM, and demonstrates to have 10-fold selectivity towards BACE1 over BACE2, and more than 50-fold inhibition over other aspartic proteases including cathepsin D, pepsin, or renin.
CSN18101 LY411575 Isomer 1 209984-58-7 LY-411575 isomer 1 is an isomer of LY411575, which is a potent γ-secretase inhibitor with IC50 of 0.078 nM/0.082 nM (membrane/cell-based), also inhibits Notch clevage with with IC50 of 0.39 nM.
CSN17284 L-685,458 292632-98-5 L-685458 is an inhibitor of amyloid β-protein precursor gamma-secretase activity with Ki of 17 nM.
CSN18608 gamma-Secretase Modulators 937812-80-1 gamma-Secretase modulators is an Amyloid-β production inhibitor, useful for Alzheimer's disease.
CSN17843 gamma-Secretase Modulator 3 1431697-84-5 gamma-Secretase modulator 3 is a gamma-secretase modulator.
CSN17461 gamma-Secretase Modulator 2 1093978-89-2 gamma-Secretase modulator 2 is a potent and selective γ-secretase modulator for treatment of Alzheimer's disease.
CSN17513 gamma-Secretase Modulator 1 1172637-87-4 gamma-Secretase modulator 1 is a gamma-secretase modulator useful for Alzheimer's disease.
CSN19004 Epiberberine Chloride 889665-86-5 Epiberberine chloride, a natural alkaloid, is a BACE1 inhibitor, which also exhibits inhibition activity on CYP2D6 and aldose reductase, alpha-adrenoceptors, acetylcholinesterase (AChE), butyrylcholinesterase, and b-site amyloid precursor protein cleaving enzyme 1.
CSN17015 E-2012 870843-42-8 E 2012 is a potent γ-secretase modulator.
CSN13122 YO-01027 209984-56-5 Dibenzazepine is a dipeptidic γ-secretase inhibitor with IC50 of 2.6 nM and 2.9 nM in cell-free assays for APPL and Notch cleavage, respectively.
CSN13896 DAPT   208255-80-5 DAPT is an inhibitor of γ-secretase and it can reduce the expression of Aβ40 and Aβ42 with IC50 values of 115 nM and 200 nM.
CSN16335 CHF5074 749269-83-8 CHF5074 is a γ-secretase modulator, reduces Aβ42 and Aβ40 secretion, with an IC50 of 3.6 and 18.4 μM, respectively.
CSN19065 BMS-299897 290315-45-6 BMS 299897 is an orally active, potent γ-secretase inhibitor (IC50 = 12 nM).
CSN22229 BACE1-IN-1 1310347-50-2 BACE1-IN-1 is a potent and highly brain penetrant BACE1 inhibitor with IC50s of 32 and 47 nM for human BACE1 and BACE2, respectively.
CSN19061 AZD3839 1227163-84-9 AZD3839 is an inhibitor of BACE1 with IC50 of 23.6 uM.
CSN18659 AZD3293 1383982-64-6 AZD3293 is an oral beta-secretase 1 cleaving enzyme (BACE) inhibitor.
CSN12379 Avagacestat 1146699-66-2 Avagacestat is an inhibitor of γ-secretase Aβ40 and Aβ42 with IC50s of 0.3 nM and 0.27 nM, respectively.
CSN20327 27-Deoxyactein 264624-38-6 27-Deoxyactein, a natural product isolated and purified from Actaea racemosa, has shown stimulation of osteoblast function and inhibits bone resorbing mediators in the treatment of osteoporosis. It is a derivative of actein, a gamma secretase modulators derived from botanicals. It can also protect the pancreatic β-cells against MG-induced cell death.
CSN19237 Verubecestat Trifluoroacetate 2095432-65-6
CSN23769 LY900009 209984-68-9
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