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Potassium Channel

Potassium Channel

货号 产品名 CAS号 信息
CSN16050 VU 0240551 893990-34-6 VU 0240551 is a small molecule inhibitor of the neuronal K-Cl cotransporter, KCC2 (IC50 = 560 nM for K+ uptake assay in KCC2-overexpressing cells).
CSN12971 Vernakalant 794466-70-9 Vernakalant is an investigational mixed ion channel blocker that can terminate acute atrial fibrillation (AF) in humans at 2 to 5 mg/kg and may be more atrial-selective than available agents used in treatment of antiarrhythmic.
CSN12970 Vernakalant HCl 748810-28-8 Vernakalant HCl prolongs repolarization by blocking atrial potassium channels, it's a class III antiarrhythmics.
CSN12821 UK-78282 HCl 136647-02-4 UK-78282 is a blocker of the KV1.3 and KV1.4 voltage-gated potassium channels in T lymphocytes (IC50 values are 0.28 and 0.17 μM respectively) which suppresses T lymphocyte mitogenesis and leads to membrane depolarization and also blocks KV1.4 expressed in heart and brain.
CSN12701 TRAM-34 289905-88-0 TRAM-34 is a highly selective blocker of intermediate conductance Ca2+-activated K+ channels (KCa3.1) (Kd = 20 nM).
CSN12105 Tolbutamide 64-77-7 Tolbutamide is a potassium channel blocker, sulfonylurea oral hypoglycemic drug.
CSN12056 Terfenadine 50679-08-8 Terfenadine is a potent open-channel blocker of hERG with a mean IC50 of 204 nM.
CSN16112 TAK-438 1260141-27-2 TAK-438, a potassium proton pump inhibitor, can reversibly inhibit H+/K+ ATPase with IC50 of 17 nM and does not affect Na+/K+ ATPase. It also controls gastric acid secretion.
CSN16469 Sophocarpine 6483-15-4 Sophocarpine is a naturally-occuring HERG K+ channel blocker with IC50 ranging in 100-300 μM found from plant Sophora flavescens.
CSN12384 Senicapoc 289656-45-7 Senicapoc is a potent and selective Gardos channel blocker and blocks Ca(2+)-induced rubidium flux from human RBCs/ inhibited RBC dehydration with IC50s of 11 nM/30 nM, respectively.
CSN15798 RPR-260243 668463-35-2 RPR-260243 is an activator of HERG which modifies HERG currents inhibited by dofetilide (IC50 = 58 nM) and shows little effect on HERG current amplitude and no significant effects on steady-state activation parameters or on channel inactivation processes.
CSN11584 Repaglinide 135062-02-1 Repaglinide is a carbamoylmethyl benzoic acid (CMBA) derivative, which recently has become available for the treatment of type II diabetes.
CSN10033 PAP-1 870653-45-5 PAP-1 is a selective inhibitor of Kv1.3, voltage-gated K+ channel, it potently inhibits human T effector memory cell proliferation with EC50 of 2 nM and delayed hypersensitivity.
CSN18234 NS-6180 353262-04-1 NS-6180 is a channel blocker of KCa3.1 (IC50= 9 nM for rat and 14 nM for human). It can prevent T-cell activation and inflammation.
CSN13720 NS-309 18711-16-5 NS-309 is a positive modulator of small- and intermediate- conductance Ca2+-activated K+ channels (KCa2 and KCa3.1 channels). It increases Ca2+ sensitivity and displays no activity at BK channels.
CSN12824 NS-1643 448895-37-2 NS-1643 is a potent human ether-a-go-go related gene (hERG) KV11.1 channel activator with EC50 of 10.5 μM.
CSN12339 NS-1619 153587-01-0 NS-1619 is a selective large conductance Ca2+-activated K+-channel activator.
CSN11558 Nigericin Sodium 28643-80-3 Nigericin sodium is an antibiotic from Streptomyces hygroscopicus that works by acting as an H+, K+, and Pb2+ ionophore.
CSN17090 Nifekalant HCl 130656-51-8 Nifekalant hydrochloride is an antiarrhythmic shown to be effective against ventricular tachyarrhythmias by inhibiting HERG channels in a voltage- and frequency-dependent manner.
CSN12869 Nicorandil 65141-46-0 Nicorandil is a potassium channel activator, and stimulates guanylate cyclase to increase formation of cyclic GMP (cGMP).
CSN12478 Nateglinide 105816-04-4 Nateglinide is an insulin secretagog agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM).
CSN18626 ML365 947914-18-3 ML365 is a selective small molecule inhibitor of TASK1 (KCNK3) with IC50 of 4 nM (thallium influx fluorescent assay) and 16 nM (automated electrophysiology assay).
CSN17790 ML277 1401242-74-7 ML277 is a potent and selective K(v)7.1 (KCNQ1) potassium channel activator with EC50 of 270 nM.
CSN13712 ML133 HCl 1222781-70-5 ML133 hydrochloride selectively inhibit Kir2.1 with IC50 of 1.8 μM at pH7.4 and 290 nM at pH8.5 and has no effect on Kir1.1 and weak activity for Kir4.1 and Kir7.1.
CSN12556 Mitiglinide Calcium 145525-41-3 Mitiglinide calcium is a blood glucose-lowering drugs, stimulating insulin secretion by closing the ATP-sensitive K+ channels in pancreatic beta-cells.
CSN10129 Minoxidil Sulfate 83701-22-8 Minoxidil sulfate is a K+ channel agonist and a strong vascular smooth muscle relaxant. It has been shown to relax norepinephrine contraction, and is reported to be a vasodilator. Minoxidil sulfate has been used to better understand the blood-brain tumor barrier in syngeneic and allogeneic rat studies and has demonstrated to increase tumor permeability.
CSN11450 Minoxidil 38304-91-5 Minoxidil is an antihypertensive vasodilator medication.
CSN11197 Indapamide 26807-65-8 Indapamide is a thiazide sulphonamide diuretic compound, generally used in the treatment of hypertension, as well as decompensated cardiac failure.
CSN11163 Hydralazine HCl 304-20-1 Hydralazine hydrochloride is a direct-acting vasodilator that is used as an antihypertensive agent.
CSN24161 GSK369796 2HCl 1010411-21-8 GSK369796 is an anti-malaria drug candidate.
CSN11102 Gliquidone 33342-05-1 Gliquidone is an ATP-sensitive K+ channel antagonist with IC50 of 27.2 nM.
CSN11101 Glipizide 29094-61-9 Glipizide is used to treat high blood sugar levels caused by a type of diabetes mellitus called type 2 diabetes.
CSN16794 Glimepiride 93479-97-1 Glimepiride is a sulfonylurea which inhibit KATP with IC50 of 3.0 nM in pancreatic β-cells with fewer cardiac actions. It is used in the treatment of type 2 diabetes mellitus.
CSN16729 Gliclazide 21187-98-4 Gliclazide is a blocker of pancreatic β-cell ATP-sensitive potassium channels with IC50 of 184 nM in murine. It belongs to the sulfonylurea class of insulin secretagoguesIt. Gliclazide is an antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM).
CSN10055 Glibenclamide 10238-21-8 Glibenclamide is a sulfonylurea compound that modulates insulin production.
CSN24317 GI 530159 69563-88-8 GI 530159 is a selective and mechano-sensitive K2P channel opener, exhibits selectivity for TREK1/2 over TRAAK, TASK3 and a range of other potassium channels.
CSN18763 Flupirtine Maleate 75507-68-5 Flupirtine maleate is a non-opioid analgesic of KV7 potassium channels. Flupirtine also inderectly antagonizes NMDA receptor and GABAa receptors. It exhibits the relaxantion of muscles and neuroprotective.
CSN10543 Flupirtine 56995-20-1 Flupirtine is a selective neuronal potassium channel opener that also has NMDA receptor antagonist properties.
CSN13087 E-4031 2HCl 113559-13-0 E-4031 is a benzenesulfonamide antiarrhythmic agent which blocks the ATP-sensitive potassium channel.
CSN10860 Doxapram 309-29-5 Doxapram inhibits TASK-1, TASK-3, TASK-1/TASK-3 heterodimeric channel function with EC50 of 410 nM, 37 μM, 9 μM, respectively.
CSN16013 Doxapram HCl H2O 7081-53-0 Doxapram hydrochloride, a respiratory stimulant, exhibits inhibition of TASK-1 (EC50 = 410 nM), TASK-3 (EC50 = 37 nM) and TASK-1/TASK-3 heterodimeric (EC50 = 9 nM) channel function. It is widely used in central nervous system excitability and directly stimulate the medullary respiratory or vascular movement center.
CSN15735 Dofetilide 115256-11-6 Dofetilide is a potassium channel blocker that acts as a class III antiarrhythmic drug. It is used for the treatment of atrial fibrillation and flutter.
CSN12647 Diazoxide 364-98-7 Diazoxide is an ATP-sensitive potassium channel activator which causes local relaxation in smooth muscle by increasing membrane permeability to potassium ions. and can be used to treat hyperinsulinism.
CSN10772 Dequalinium Chloride 522-51-0 Dequalinium Chloride is a PKC inhibitor with IC50 of 7-18 μM, and also a selective blocker of apamin-sensitive K+ channels with IC50 of 1.1 μM.
CSN13101 Chlorzoxazone 95-25-0 Chlorzoxazone, a potassium channel activator, is a centrally acting muscle relaxant used to treat muscle spasm and the resulting pain or discomfort.
CSN10370 Azimilide 149908-53-2 Azimilide is a class III antiarrhythmic compound, inhibits I(Ks) and I(Kr) in guinea-pig cardiac myocytes and I(Ks) (minK) channels expressed in Xenopus oocytes.
CSN17898 Azimilide 2HCl 149888-94-8 Azimilide dihydrochloride, a class III antiarrhythmic compound, blocks the Kv7.1 and Kv11.1 patassium channels. It also inhibits Na+/Ca2+ exchanger in vitro.
CSN10287 Amiodarone 1951-25-3 Amiodarone is an antiarrhythmic drug for inhibition of ATP-sensitive potassium channel with IC50 of 19.1 μM.
CSN12596 Amiodarone HCl 19774-82-4 Amiodarone HCl is an antiarrhythmic drug for inhibition of ATP-sensitive potassium channel with IC50 of 19.1 μM.
CSN10068 Ajmaline 4360-12-7 Ajmaline, a natural alkaloid isolated and purified from the roots of Rauvolfia verticillata, is a class Ia antiarrhythmic agent.
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