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Potassium Channel

Potassium Channel

货号 产品名 CAS号 信息
CSN25578 VU590 2HCl 1783987-83-6 VU590 dihydrochloride has been reported to inhibit the renal, outer medullary potassium channel (KIR1.1) with IC50 of 294 nM, and also able to inhibit the inward rectifying potassium channel KIR7.1.
CSN25562 VU590 313505-85-0 VU590 dihydrochloride has been reported to inhibit the renal, outer medullary potassium channel (KIR1.1) with IC50 of 294 nM, and also able to inhibit the inward rectifying potassium channel KIR7.1.
CSN25285 VU0810464 2126040-21-7 VU0810464 is a potent and selective non-ureaG protein-gated inwardly-rectifying potassium channels (GIRK, Kir3) activator,with EC50 of 720 nM for GIRK1/4 channels.
CSN23185 VU 0463271 1391737-01-1 VU0463271 is a potent KCC2 antagonist, with an IC50 of 61 nM.
CSN16050 VU 0240551 893990-34-6 VU 0240551 is a small molecule inhibitor of the neuronal K-Cl cotransporter, KCC2 (IC50 = 560 nM for K+ uptake assay in KCC2-overexpressing cells).
CSN12105 Tolbutamide 64-77-7 Tolbutamide is a potassium channel blocker, sulfonylurea oral hypoglycemic drug.
CSN12056 Terfenadine 50679-08-8 Terfenadine is a potent open-channel blocker of hERG with a mean IC50 of 204 nM.
CSN23324 Tannic Acid 5424-20-4 Tannic acid is a novel hERG channel blocker with IC50 of 3.4 μM.
CSN16112 TAK-438 1260141-27-2 TAK-438, a potassium proton pump inhibitor, can reversibly inhibit H+/K+ ATPase with IC50 of 17 nM and does not affect Na+/K+ ATPase. It also controls gastric acid secretion.
CSN12384 Senicapoc 289656-45-7 Senicapoc is a potent and selective Gardos channel blocker and blocks Ca(2+)-induced rubidium flux from human RBCs/ inhibited RBC dehydration with IC50s of 11 nM/30 nM, respectively.
CSN15798 RPR-260243 668463-35-2 RPR-260243 is an activator of HERG which modifies HERG currents inhibited by dofetilide (IC50 = 58 nM) and shows little effect on HERG current amplitude and no significant effects on steady-state activation parameters or on channel inactivation processes.
CSN23838 Pinacidil H2O 85371-64-8 Pinacidil monohydrate, an antihypertensive drug, is a potassium channel activator.
CSN25559 NS 5806 426834-69-7 NS5806, a KV4.3 channel activator, increases peak current amplitude of the potassium channel Kv4.3 with EC50 of 5.3 uM. NS5806 also slows Kv4.3 and Kv4.2 current dacay in channel complexes containing KChIP2.
CSN25560 NS19504 327062-46-4 NS19504 is a selective activator of large-conductance Ca2+-activated potassium channels (BKCa, KCa1.1) with EC50 of 11 μM.
CSN18234 NS-6180 353262-04-1 NS-6180 is a channel blocker of KCa3.1 (IC50= 9 nM for rat and 14 nM for human). It can prevent T-cell activation and inflammation.
CSN13720 NS-309 18711-16-5 NS-309 is a positive modulator of small- and intermediate- conductance Ca2+-activated K+ channels (KCa2 and KCa3.1 channels). It increases Ca2+ sensitivity and displays no activity at BK channels.
CSN12339 NS-1619 153587-01-0 NS-1619 is a selective large conductance Ca2+-activated K+-channel activator.
CSN17090 Nifekalant HCl 130656-51-8 Nifekalant HCl is an antiarrhythmic shown to be effective against ventricular tachyarrhythmias by inhibiting HERG channels in a voltage- and frequency-dependent manner.
CSN12478 Nateglinide 105816-04-4 Nateglinide is an insulin secretagog agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM).
CSN17790 ML277 1401242-74-7 ML277 is a potent and selective K(v)7.1 (KCNQ1) potassium channel activator with EC50 of 270 nM.
CSN13712 ML133 HCl 1222781-70-5 ML133 HCl selectively inhibit Kir2.1 with IC50 of 1.8 μM at pH7.4 and 290 nM at pH8.5 and has no effect on Kir1.1 and weak activity for Kir4.1 and Kir7.1.
CSN25288 ML 297 1443246-62-5 ML 297 is a potent and selective GIRK1/2 activator, with an EC50 of 0.16 μM.
CSN18790 Mitiglinide Calcium Hydrate 207844-01-7 Mitiglinide calcium is a drug for the treatment of type 2 diabetes and it is a highly selective KATP channel antagonist.
CSN12556 Mitiglinide Calcium 145525-41-3 Mitiglinide calcium is a blood glucose-lowering drugs, stimulating insulin secretion by closing the ATP-sensitive K+ channels in pancreatic beta-cells.
CSN11450 Minoxidil 38304-91-5 Minoxidil is an antihypertensive vasodilator medication.
CSN24792 IK1 inhibitor PA-6 500715-03-7 IK1 inhibitor PA-6 (PA-6), a pentamidine analogue, is a selective and potent IK1 (KIR2.x ion-channel-carried inward rectifier current) inhibitor, with IC50 values of 12-15 nM for human and mouse KIR2.x currents. IK1 inhibitor PA-6 (PA-6) elevates KIR2.1 protein expression and induces intracellular KIR2.1 accumulation. IK1 inhibitor PA-6 (PA-6) has the potential to treat atrial fibrillation and arrhythmia[1][2][3].
CSN25242 ICA 110381 325457-99-6 ICA 110381 is a KV7.2/7.3 activator with EC50 of 0.38 μM.
CSN24161 GSK369796 2HCl 1010411-21-8 GSK369796 is an anti-malaria drug candidate.
CSN16794 Glimepiride 93479-97-1 Glimepiride is a sulfonylurea which inhibit KATP with IC50 of 3.0 nM in pancreatic β-cells with fewer cardiac actions. It is used in the treatment of type 2 diabetes mellitus.
CSN10055 Glibenclamide 10238-21-8 Glibenclamide is a sulfonylurea compound that modulates insulin production.
CSN10543 Flupirtine 56995-20-1 Flupirtine is a selective neuronal potassium channel opener that also has NMDA receptor antagonist properties.
CSN16013 Doxapram HCl H2O 7081-53-0 Doxapram HCl, a respiratory stimulant, exhibits inhibition of TASK-1 (EC50 = 410 nM), TASK-3 (EC50 = 37 nM) and TASK-1/TASK-3 heterodimeric (EC50 = 9 nM) channel function. It is widely used in central nervous system excitability and directly stimulate the medullary respiratory or vascular movement center.
CSN12647 Diazoxide 364-98-7 Diazoxide is an ATP-sensitive potassium channel activator which causes local relaxation in smooth muscle by increasing membrane permeability to potassium ions. and can be used to treat hyperinsulinism.
CSN10772 Dequalinium Chloride 522-51-0 Dequalinium Chloride is a PKC inhibitor with IC50 of 7-18 μM, and also a selective blocker of apamin-sensitive K+ channels with IC50 of 1.1 μM.
CSN15660 Daurisoline 70553-76-3 Daurisoline, a natural product isolated and purified from the roots of Menispermum dauricu with antiarrhythmic effects, exerts a blocking effect on hERG at concentrations below 30 uM, but does not affect the expression and function of the hERG channel.
CSN23809 Cloperastine Fendizoate 85187-37-7 Cloperastine fendizoate inhibits the hERG K+ currents in a concentration-dependent manner with an IC50 value of 27 nM.
CSN13101 Chlorzoxazone 95-25-0 Chlorzoxazone, a potassium channel activator, is a centrally acting muscle relaxant used to treat muscle spasm and the resulting pain or discomfort. It is also a CYP2E1 inhibitor with IC50 value of 1.03μM.
CSN10370 Azimilide 149908-53-2 Azimilide is a class III antiarrhythmic compound, inhibits I(Ks) and I(Kr) in guinea-pig cardiac myocytes and I(Ks) (minK) channels expressed in Xenopus oocytes.
CSN17898 Azimilide 2HCl 149888-94-8 Azimilide 2HCl, a class III antiarrhythmic compound, blocks the Kv7.1 and Kv11.1 patassium channels. It also inhibits Na+/Ca2+ exchanger in vitro.
CSN10287 Amiodarone 1951-25-3 Amiodarone is an antiarrhythmic drug for inhibition of ATP-sensitive potassium channel with IC50 of 19.1 μM.
CSN12596 Amiodarone HCl 19774-82-4 Amiodarone HCl is an antiarrhythmic drug for inhibition of ATP-sensitive potassium channel with IC50 of 19.1 μM.
CSN10068 Ajmaline 4360-12-7 Ajmaline, a natural alkaloid isolated and purified from the roots of Rauvolfia verticillata, is a class Ia antiarrhythmic agent.
CSN25278 A2793 88349-90-0 A2793 is an inhibitor of TRESK (IC50 value of 6.8 μM for mTRESK).
CSN25279 A2764 2HCl   861038-72-4 A2764 dihydrochloride is a selective inhibitor of TRESK (KCNK18) with an IC50 value of 11.8 μM. A2764 can inhibit TRESK in native cells, leading to cell depolarization and increased excitability.
CSN25420 ML335 825658-06-8
CSN25450 JNJ 303 878489-28-2
CSN25449 Tetraethylammonium bromide 71-91-0
CSN25452 1-EBIO 10045-45-1
CSN25451 Tetraethylammonium chloride 56-34-8
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