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Prostaglandin Receptor

Prostaglandin Receptor

货号 产品名 CAS号 信息
CSN23731 U-46619 56985-40-1 U 46619, PGH2 (TXA2) analog that is a potent and stable thromboxane A2 (TP) receptor agonist with EC50 of 0.035 μM.
CSN17319 2-(((1R,2R,3aS,9aS)-2-Hydroxy-1-((S)-3-hydroxyoctyl)-2,3,3a,4,9,9a-hexahydro-1H-cyclopenta[b]naphthalen-5-yl)oxy)acetic acid, sodium salt 289480-64-4 Treprostinil sodium is a potent DP1 and EP2 agonist with EC50 values of 0.6±0.1 and 6.2±1.2 nM, respectively.
CSN21858 Tiaprost 71116-82-0 Tiaprost is a prostaglandin F2 alpha analogue as an estrus-synchronizing agent.
CSN17247 TG6-10-1 1415716-58-3 TG6-10-1 is an antagonist of prostaglandin E2 receptor subtype EP2.
CSN24068 TG4-155 1164462-05-8 TG4-155 is a brain penetrant prostaglandin EP2 specific antagonist.
CSN17989 Terutroban 165538-40-9 Terutroban is a thromboxane/prostaglandin endoperoxide receptor antagonist.
CSN21854 Terbogrel 149979-74-8 Terbogrel is an orally available thromboxane A2 receptor antagonist and a thromboxane A2 synthase inhibitor with both IC50s of about 10 nM.
CSN22249 Taprenepag isopropyl 1005549-94-9 Taprenepag isopropyl is a highly selective EP2 receptor agonist.
CSN18419 Taprenepag 752187-80-7 Taprenepag is an agonist of prostaglandin E2 receptor with EC50 of 2.8 nM with hypotensive activity.
CSN12962 Tafluprost 209860-87-7 Tafluprost is an anti-glaucoma prostaglandin (PG) analog.
CSN25726 8-Chloro-N'-(3-(pyridin-4-yl)propanoyl)dibenzo[b,f][1,4]oxazepine-10(11H)-carbohydrazide hydrochloride 146033-02-5 SC-51089, also known as CID132748, is an antagonist of PGE2 and selective for the EP1 receptor subtype with antinociceptive activity.
CSN25725 SC-51322 146032-79-3 SC 51322 is an antagonist of EP1 prostanoid receptor with Ki of 13.8 nM.
CSN23716 Treprostinil 81846-19-7 Rumodolinl, a analog of prostacyclin, is an agonist of IP receptor that used clinically to treat pulmonary arterial hypertension. It is a vasodilator with antithrombotic and anti-inflammatory properties.
CSN21394 RO1138452 221529-58-4 RO1138452 is a selective antagonist of prostacyclin (IP) receptor with pKi of 9.3 ± 0.1 in human platelets.
CSN19825 Ralinepag 1187856-49-0 Ralinepag, is an orally available agonist of the prostacyclin (IP) receptor.
CSN20322 Prostaglandin D2 41598-07-6 Prostaglandin D2 is the major eicosanoid product of mast cells and is released in large quantities during allergic and asthmatic anaphylaxis.
CSN26238 PGD2-IN-1 885066-67-1 PGD2-IN-1 is a prostaglandin D2(PGD2) inhibitor.
CSN23451 p-Hydroxycinnamic acid 7400-08-0 p-Hydroxy-cinnamic acid is the isomer of cinnamic acid with anti-mutagenic and anti-tumor activities.
CSN18259 ONO-AE3-208 402473-54-5 ONO-AE3-208 is an antagonist of EP4 with Ki of 1.3 nM and exhibits suppression the invasion and metastasis of prostate cancer cells.
CSN25724 ONO-8130 459841-96-4 ONO 8130 is an antagonist of EP1 receptor.
CSN22473 Ebopiprant 2005486-31-5 OBE022 is an oral and selective prostaglandin F2α (PGF2α) receptor antagonist, with Kis of 1 nM, 26 nM for human and rat FP receptors, respectively.
CSN11531 Nedocromil 69049-73-6 Nedocromil is an inhaled anti-inflammatory agent for the preventive management of asthma.
CSN17385 MK-2894 Sodium 1006036-88-9 MK-2894 sodium is a highly potent and selective second generation EP4 antagonist.
CSN17384 MK-2894 1006036-87-8 MK-2894 is a highly potent and selective second generation EP4 antagonist.
CSN18339 Laropiprant 571170-77-9 Laropiprant is a potent, selective DP1 receptor antagonist with Ki value of 0.57 nM and exhibits > 1,000 fold selectivity over DP2 receptor (Ki=0.75 μM).
CSN20466 L-798106 244101-02-8 L-798106 is a potent and highly selective prostanoid EP3 receptor antagonist (Ki values are 0.3, 916, > 5000 and > 5000 nM at EP3, EP4, EP1 and EP2, respectively), and it can attenuate sulprostone-induced inhibition of EFS-evoked twitch and contractile responses in vivo.
CSN25731 L-161982 147776-06-5 L-161,982 is a potent EP4 receptor antagonist with Ki value of 0.024 μM.
CSN22113 Ifetroban 143443-90-7 Ifetroban is a long-acting thromboxane A2 receptor antagonist, with antiplatelet activity.
CSN18274 GW627368 439288-66-1 GW627368 is a potent and selective competitive antagonist of prostanoid EP4 receptor (Ki= 100 nM) with additional human TP receptor affinity (Ki= 150 nM).
CSN18265 Grapiprant 415903-37-6 Grapiprant is a selective EP4 receptor antagonist whose physiological ligand is prostaglandin E2 (PGE2).
CSN18130 Evatanepag 223488-57-1 Evatanepag is an EP2 receptor selective prostaglandin E2 (PGE2) agonist that induces local bone formation with EC50 of 0.3 nM.
CSN20029 Sodium 4-(2-Hydroxy-1-(3-hydroxy-4-methyloct-1-en-6-yn-1-yl)-2,3,3a,8b-tetrahydro-1H-cyclopenta[b]benzofuran-5-yl)butanoate 88475-69-8 Esuberaprost is a potential substance for treating pulmonary arterial hypertension (PAH).
CSN20026 Esuberaprost 94132-88-4 Esuberaprost is a potential substance for treating pulmonary arterial hypertension (PAH).
CSN25732 ER-819762 1155773-15-1 ER 819762 is an antagonist of EP4 receptor with IC50 of 59 nM.
CSN26370 Epoprostenol sodium 61849-14-7 Epoprostenol sodium, a potent agonist at IP prostanoid receptors, the synthetic form of the natural prostaglandin derivative prostacyclin (prostaglandin I2), is registered worldwide for the treatment of Pulmonary arterial hypertension (PAH)[1]. Epoprostenol sodium is used in pulmonary hypertension and transplantation as a potent inhibitor of platelet aggregation[2].
CSN25728 DG-041 861238-35-9 DG-041 is a potent and selective antagonist of prostanoid EP3 receptor with IC50 of 4.6 nM.
CSN21985 Decursinol angelate 130848-06-5 Decursinol angelate (DA) blocks PGE2-induced activation of the EP2 receptor signaling pathway, including the activation of PKA and the phosphorylation of CREB.
CSN26495 CRTh2 antagonist 2 780763-95-3 CRTh2 antagonist 2 is selective and potent CRTH2 antagonist extracted from patent US20140148470A1, compound Example 1, has an IC50 of ≤10 nM. CRTh2 antagonist 2 can be used in research of androgenic alopecia[1].
CSN25453 Cloprostenol sodium salt 55028-72-3 Cloprostenol sodium salt (ICI 80996 sodium salt) is a potent synthetic prostaglandin analogue, acts as a luteolytic agent, and is a PGF2α receptor agonist.
CSN26158 (+)-Cloprostenol sodium 62561-03-9 Cloprostenol is a PGF2 α analogue, working as an FP receptor agonist.
CSN22111 Carbacyclin 69552-46-1 Carbacyclin is a PGI2 analogue, acts as a prostacyclin (PGI2) receptor agonist and vasodilator, and potently inhibits platelet aggregation.
CSN21535 Bw245c 72814-32-5 BW 245C is a selective agonist for the DP1 receptor.
CSN25730 BGC-20-1531 hydrochloride 1962928-26-2 BGC 20-1531 hydrochloride is a selective antagonist of EP4 with Ki of 3 nM.
CSN25356 Asapiprant 932372-01-5 Asapiprant is a potent and selective DP1 receptor antagonist with a Ki of 0.44 nM.
CSN19378 Prostaglandin E1 745-65-3 Alprostadil is an analog of prostaglandin which is prostaglandin E1 agonist with vasodilatory properties and can be used to treat erectile dysfunction.
CSN21466 Aligeron 70713-45-0 Aligeron is a non-selective antagonist of prostaglandin (PG) with vasodilatory properties.  
CSN25755 (+)-Fluprostenol 54276-17-4 (+)-Fluprostenol is an agonist of prostaglandin F2α (FP) receptor with Ki of 49.9 nM and EC50 of 2.4 nM.
CSN42950 GSK-269984A 892664-04-9
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