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Lipoxygenase

Lipoxygenase

货号 产品名 CAS号 信息
CSN12237 Zileuton 111406-87-2 Zileuton is a reversible 5-lipoxygenase inhibitor with IC50 value of 0.5 µM in rat basophilic leukemia-1 (RBL-1) cells. It also potently inhibited leukotriene B4 production with an IC50 value of 0.6 µM in purified human peripheral blood polymorphonuclear leukocytes (PMNL).
CSN23549 Phenidone 92-43-3 Phenidone inhibited both the lipoxygenase and Cox pathways
CSN17912 ML355 1532593-30-8 ML355 is a selective 12-lipoxygenase inhibitor with an IC50 value of 0.34 µM, with much less potency against 15-LO-1, 15-LO-2, and 5-LO (IC50s = 9.7, >100, and >100 µM).
CSN11356 Malotilate 59937-28-9 Malotilate is hepatotrophic drug which can selectively inhibit the 5-lipoxygenase, whereas both the 12- and the 15-lipoxygenase pathways were stimulated, with antifibrotic and hepatoprotective properties.
CSN25325 FPL 62064 103141-09-9 FLP 62064 is a potent 5-lipoxygenase (5-LOX) and COX-2 dual inhibitor. FLP 62064 has potently anti-inflammatory activity.
CSN12630 Esculetin 305-01-1 Esculetin is a naturally occuring 5-lipoxygenase and 12-Lipoxygenase inhibitor with IC50 values of ID50 values of 4 and 2.5 µM, respectively.
CSN22648 2-TEDC 132465-10-2 2-TEDC is a potent inhibitor of 5-, 12-, and 15-lipoxygenase with IC50s of 0.09, 0.013 and 0.5 μM respectively.
CSN17071 2-(3,4-Dihydroxyphenyl)ethanol 10597-60-1 2-(3,4-Dihydroxyphenyl)ethanol is a potent and specific inhibitor of lipoxygenase activities, inhibits platelet 12-LO activity with IC50 of 4.2 mM and PMNL 5-LO activity with IC50 of 13 mM. It's a natural product isolated and purified from the herbs of Canarium album with antioxidant property.
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