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Neurological Disease

货号 产品名 CAS号 信息
CSN16226 AZD1080 612487-72-6 AZD1080 is a selective, orally active, brain permeable GSK3 inhibitor of GSK3α and GSK3β with Ki of 6.9 nM and 31 nM, respectively, shows > 14-fold selectivity against CDK2, CDK5, CDK1 and Erk2.
CSN16043 Tideglusib 865854-05-3 Tideglusib is an irreversible GSK-3 inhibitor with IC50 of 5 nM and 60 nM for GSK-3βWT (1 h preincubation) and GSK-3βC199A (1 h preincubation), respectively.
CSN16034 RO4929097 847925-91-1 RO4929097 is an inhibitor of γ secretase, the IC50s of Aβ40 and notch are 14 nM and 5 nM, respectively.
CSN16047 E-64d 88321-09-9 Aloxistatin is an irreversible and membrane-permeable cysteine protease inhibitor with blood platelet aggregation inhibiting activity.
CSN16125 Vanoxerine 2HCl 67469-78-7 Vanoxerine 2HCl is a selcetive and potent Dopamine reuptake inhibitor (DRI).
CSN16164 (S)-5-(1-(2,3-Dimethylphenyl)ethyl)-1H-imidazole hydrochloride 145108-58-3 Dexmedetomidine is a selectively activator of presynaptic alpha-2 adrenoceptors located in the brain. This leads to inhibition of postsynaptic activation of adrenoceptors through inhibiting the release of norepinephrine from synaptic vesicles, thereby leading to analgesia, sedation and anxiolysis.
CSN16275 Imepitoin 188116-07-6 AWD 131-138 is a partial agonist of benzodiazepine receptor with effective anticonvulsant and anxiolytic properties.
CSN16283 5H-Dibenzo[b,f]azepine-5-carboxamide 298-46-4 Carbamazepine is a blocker of sodium channel with IC50 of 131 μM in rat brain synaptosomes. It is an anticonvulsant drug.
CSN16300 (S)-4-Aminoisoxazolidin-3-one 339-72-0 L-cycloserine is an inhibitor of serine palmitoyltransferase and block sphingosine biosynthesis. It has antibiotic effective against mycobacterium tuberculosis.
CSN16301 4-Nitrophenyl 4-(bis(benzo[d][1,3]dioxol-5-yl)(hydroxy)methyl)piperidine-1-carboxylate 1101854-58-3 JZL 184 is a potent and selective inhibitor of MAGL with IC50 of 8 nM and 4 μM for inhibition of MAGL and FAAH in mouse brain membranes respectively.
CSN16342 3,5-Dimethyladamantan-1-amine hydrochloride 41100-52-1 Memantine HCl, an amantadine derivative with low to moderate-affinity for NMDA receptors, inhibit CYP2B6 and CYP2D6 with Ki of 0.51 nM and 94.9 μM, respectively, is used for the treatment of Alzheimer's disease.
CSN16436 (R)-2-Acetamido-3-mercaptopropanoic acid 616-91-1 Acetylcysteine is an inhibitor of ROS and the production of TNF. It is a pharmaceutical drug and nutritional supplement used as mucolytic agent.
CSN16498 4-(1-(2,3-Dimethylphenyl)ethyl)-1H-imidazole hydrochloride 86347-15-1 Medetomidine HCl is an α2 adrenergic agonist used as both a surgical anesthetic and analgesic.
CSN16120 Netupitant 290297-26-6 Netupitant a potent and highly selective NK1 receptor antagonist with Ki of 0.95 nM.
CSN16312 Sodium Channel inhibitor 1 1198117-23-5 Sodium Channel inhibitor1, one of 3-Oxoisoindoline-1-carboxamides, is a selective voltage-gated sodium channel for pain treatment.
CSN16521 SB-408124 288150-92-5 SB-408124 is a non-peptide antagonist for OX1 receptor with Ki of 57 nM and 27 nM in both whole cell and membrane, respectively, and exhibits 50-fold selectivity over OX2 receptor.
CSN16178 Sulpiride 15676-16-1 Sulpiride is a typical antipsychotic drug that binds to dopamine D2 receptor. Sulpiride is an effective treatment for schizophrenia and depressive disorder.
CSN16491 AK-7 420831-40-9 AK-7 is a selective and brain-permeable SIRT2 inhibitor and is neuroprotective in Huntington disease mouse models.
CSN16570 VU 0357121 433967-28-3 VU 0357121 is a positive allosteric mGlu5 receptors modulator with EC50 value of 33 nM.
CSN16213 N-(4-Hydroxy-3-methoxybenzyl)nonanamide 2444-46-4 Nonivamide, an analog of capsaicin, is agonist of transient receptor potential vanilloid type 1 (TRPV1). It can be extracted from the fruits of Capsicum annuum L..
CSN16263 Otilonium bromide 26095-59-0 Otilonium bromide is an mAchR antagonist used world-wide for the treatment of irritable bowel syndrome.
CSN16285 Tianeptine Sodium 30123-17-2 Tianeptine sodium salt is a selective facilitator of 5-HT uptake in vitro and in vivo.
CSN16066 A-803467 944261-79-4 A 803467 selectively block Nav1.8 sodium channel with IC50 of 8 nM.
CSN16180 Mepivacaine HCl 1722-62-9 Mepivacaine, a tertiary amine, is used as a local anesthetic.
CSN16115 CA-074 methyl ester 147859-80-1 CA-074 Methyl Ester is a membrane-permeable derivative of CA-074 and acts as an irreversible cathepsin B inhibitor.
CSN16339 ADX-47273 851881-60-2 ADX-47273 is a positive allosteric modulator of mGlu5 receptor with EC50 value of 0.23 μM in primary astrocyte culture.
CSN16587 LY2119620 886047-22-9 LY2119620 is a specific, and allosteric agonist of human M2 and M4 muscarinic acetylcholine receptors.
CSN16401 Modaline sulfate 2856-75-9 Modaline sulfate is a MAO inhibitor, used in the treatment of depression.
CSN16494 Encenicline HCl 550999-74-1 EVP-6124 HCl is a partial agonist of α7 neuronal nicotinic acetylcholine receptors (nAChRs).
CSN16070 Reboxetine mesylate 98769-84-7 Reboxetine Mesylate is a norepinephrine reuptake inhibitor (NRI) used in the treatment of unipolar depression.
CSN16486 Pimelic Diphenylamide 106 937039-45-7 Pimelic diphenylamide 106 is an inhibitor of class I HDAC with IC50 for HDAC1, HDAC2, and HDAC3 of 150 nM, 760nM, and 370 nM, respectively.
CSN16311 mAChR-IN-1 119391-56-9 mAChR-IN-1 is a potent muscarinic cholinergic receptor (mAChR) antagonist with IC50 of 17 nM.
CSN16537 AMG 517 659730-32-2 AMG-517 is a potent and selective TRPV1 antagonist, and antagonizes capsaicin, proton, and heat activation of TRPV1 with IC50 of 0.76 nM, 0.62 nM and 1.3 nM.
CSN16459 Ketanserin 74050-98-9 Ketanserin is a specific 5-HT2A serotonin receptor antagonist with Ki of 2.5 nM for rat and human 5-HT2A, used as an antihypertensive drug.
CSN16531 Desvenlafaxine succinate hydrate 386750-22-7 Desvenlafaxine succinate is a serotonin (5-HT) transporter and norepinephrine (NE) transporter reuptake inhibitor with Ki of 40.2 nM and 558.4 nM respectively.
CSN16335 Itanapraced 749269-83-8 CHF5074 is a γ-secretase modulator, reduces Aβ42 and Aβ40 secretion, with an IC50 of 3.6 and 18.4 μM, respectively.
CSN16309 CZC-54252 1191911-27-9 CZC-54252 is a potent LRRK2 inhibitor with IC50 values of 1.28 nM and 1.85 nM for wild-type and G2019S mutant LRRK2, respecitively, possessing neuroprotective effect.
CSN16202 Solifenacin Succinate 242478-38-2 Solifenacin succinate is a muscarinic receptor antagonist. Solifenacin succinate is a competitive and selective M3 receptor antagonist with elimination half-life‎ of 45 to 68 hours.
CSN16236 TCS 1102 916141-36-1 TCS 1102 is a potent, dual orexin receptor antagonist (Ki values are 0.2 and 3 nM for OX2 and OX1 receptors respectively).
CSN16245 Catharanthine 2468-21-5 Catharanthine showed muscarinic antagonism at 10 μM and fully inhibited nicotinic receptor mediated diaphragm contractions with an IC50 of 59.6 μM. As a precursor of the anti-tumor drugs vinblastine and vincristine, it also works as an inhibitor of tubulin self-assembly into microtubules.
CSN16568 SB 415286 264218-23-7 SB-415286 is an ATP-competitive inhibitor of GSK3α/GSK3β with IC50 of 78 nM and Ki of 31 nM.
CSN16149 (S)-2-(1-(2-(2,3-Dihydrobenzofuran-5-yl)ethyl)pyrrolidin-3-yl)-2,2-diphenylacetamide hydrobromide 133099-07-7 Darifenacin hydrobromide is a M3-selective antagonist with pKi of 8.9, an anticholinergic and antispasmotic agent used to treat urinary incontinence and overactive bladder syndrome.
CSN16167 Yohimbine 146-48-5 Yohimbine, a natural product isolated and purified from the peel of Corynante yohimbe, is a potent and relatively nonselective alpha 2-adrenergic receptor (AR) antagonist, with IC50 of 0.6 μM.
CSN16552 MK-3697 1224846-01-8 MK-3697 is an isonicotinamide small molecule, acting as a potent and selective Orexin 2 receptor antagonist with Ki = 0.95 nM.
CSN16267 BD-1047 2HBr 138356-21-5 BD-1047 dihydrobromide is a selective functional antagonist of sigma receptors, shows antipsychotic activity in animal models predictive of efficacy in schizophrenia.
CSN16296 Hydroxyamphetamine 103-86-6 Hydroxyamphetamine is a sympathomimetic drug. It can stimulate the sympathetic nervous system and is used medically in eye drops to dilate the pupil.
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