欢迎来到 CSNpharm! 产品仅用于科研!
首页 400-920-2911

GPCR

GPCR

货号 产品名 CAS号 信息
CSN13936 TUG-891 1374516-07-0 TUG-891 is a selective agonist of long chain free fatty acid (LCFA) receptor 4 (GPR120).
CSN17794 TUG-770 1402601-82-4 TUG-770 is a highly potent free fatty acid receptor 1 (FFA1/GPR40) agonist with EC50 of 6 nM for hFFA1.
CSN23913 TUG-1375   2247372-59-2 TUG-1375 is a free fatty acid receptor 2 (FFA2/GPR43) inhibitor with pKi of 6.69.
CSN13717 TGR5 Receptor Agonist 1197300-24-5 TGR5 receptor agonist, a potent TGR5 (GPCR19) agonist, showed improved potency in the U2-OS cell assay (pEC50 = 6.8) and in melanophore cells (pEC50 = 7.5).
CSN23156 TC-O 9311 444932-31-4 TC-O 9311 is a potent orphan G protein-coupled receptor 139 (GPR139) agonist with an EC50 of 39 nM[1].
CSN25253 TC-G 1005 1415407-60-1 TC-G 1005 is a TGR5 agonist with EC50 values of 0.72nM and 6.2nM for hTGR5 and mTGR5, respectively. It exhibited a significant dose-dependent glucagon-like peptide-1 (GLP-1) secretion effect.
CSN15825 TAK-875 Hemihydrate 1374598-80-7 TAK-875 is a selective GPR40 agonist with EC50 of 14 nM in human GPR40 expressing CHO cell line, 400-fold more potent than oleic acid.
CSN13586 TAK-875 1000413-72-8 TAK-875 is a potent, selective and orally bioavailable GPR40 agonist with EC50 of 0.072 μM.
CSN23214 ZQ 16 376616-73-8 Selective GPR84 agonist
CSN25229 SBI-115   882366-16-7 SBI-115 is a GPBAR1 (TGR5) antagonist.
CSN21268 SB-568849 395679-53-5 SB-568849 is a melanin-concentrating hormone receptor 1 (MCH R1) antagonist with a pKi of 7.7.
CSN16413 PSN632408 857652-30-3 PSN632408 is an optimized agonist of GPR119 receptors that shows similar potency to OEA at both recombinant mouse and human GPR119 receptors, exhibiting EC50 values of 5.6 and 7.9 μM, respectively.
CSN17281 NIBR189 1599432-08-2 NIBR189 is a potent and selective EBI2 (GPR183) receptor antagonist with IC50 value of 11nM.
CSN21271 NGD-4715 476322-70-0 NGD-4715 is a selective and orally active melanin-concentrating hormone receptor 1 (MCHR1) antagonist .
CSN20277 ML-290 1482500-76-4 ML290 is a biased allosteric agonist at the relaxin receptor RXFP1 possessing a signalling profile indicative of vasodilator and anti-fibrotic properties.
CSN18472 MK-0354 851776-28-8 MK-0354 is a partial agonist of GPR109a receptor, for hGPR109a/ mGPR109a with EC50 of 1.65/1.08 μM, showed no activation of GPR109b.
CSN23711 MCHr1 Antagonist 1 391610-37-0 MCHr1 antagonist 1 is a selective antagonist of MCH1 receptor with Kb of 1 nM and Ki of 4 nM at human MCHR1, may be used to reduce the body mass.
CSN21217 MCH-1 Antagonist 1 1039825-68-7 MCH-1 antagonist 1 is a potent melanin concentrating hormone (MCH-1) antagonist with a Ki of 2.6 nM. MCH-1 antagonist 1 also inhibits CYP3A4 with an IC50 of 10 μM.
CSN16084 MBX-2982 1037792-44-1 MBX-2982 is a selective, orally-available GPR119 agonist for the treatment of type 2 tiabetes.
CSN11273 Latanoprost 130209-82-4 Latanoprost is a prostaglandin F2alpha analogue and a prostanoid selective FP receptor agonist with an ocular hypertensive effect. Latanoprost increases uveoscleral outflow and thereby reduces intraocular pressure.
CSN18041 JNJ-63533054 1802326-66-4 JNJ-63533054 is a selective hGPR139 agonist with EC50 of 16 nM.
CSN18985 INT-777 R-Enantiomer 1198786-98-9 INT-777 R-enantiomer is the R-enantiomer of INT-777, with EC50 of 4.79 μM for TGR5, and less potent than INT-777.
CSN12659 GW9508 885101-89-3 GW9508 is selective FFA1 (GPR40) agonist with pEC50 of 7.32 and stimulates insulin secretion in a glucose-sensitive manner.
CSN16522 GW1100 306974-70-9 GW1100 is a selective antagonist of GPR40-mediated Ca2+ elevations in HEK293 cells stimulated by GW 9508 or linoleic acid with a pIC50 value equal to 5.99.
CSN16534 GSK137647A 349085-82-1 GSK137647A is an agonist of FFA4 with pEC50 of 6.3.
CSN13558 GSK1292263 1032823-75-8 GSK1292263 is an agonist of GPR119 receptor that is used to treat type 2 diabetes.
CSN24786 GPR40 agonist 4 2102196-57-4 GPR40 agonist 4 is a potent free fatty acid receptor 1 (FFA1/ GPR40) agonist with a pEC50 of 7.54.
CSN16256 GPR40 Activator 2 1312787-30-6 GPR40 activator 2 is a potent GPR40 activator.
CSN17674 GPR40 Activator 1 1309435-60-6 GPR40 activator 1 is a potent GPR40 activator for treatment of type 2 diabetes.
CSN20435 GPR4 Antagonist C39c 1197879-16-5 GPR4 antagonist C39c shows potent cellular activity and is efficacious in animal models of angiogenesis, inflammation and pain.
CSN17433 GPR120 Modulator 2 1050506-87-0 GPR120 modulator 2 is useful for modulating G protein-coupled receptor 120 (GPR120).
CSN17432 GPR120 Modulator 1 1050506-75-6 GPR120 modulator 1 is useful for modulating G protein-coupled receptor 120 (GPR120).
CSN20374 GPR119 Agonist C26 1353004-92-8 GPR119 agonist C26 shows potent GPR119 agonistic activity (EC50 = 42 nM, Emax = 117%) with improved liver microsome clearance than other GPR119 agonists in the series, and exerted 33% reduction in blood glucose AUC at a dose of 10 mg/kg in an oral glucose tolerance test in C57BL/6 N mice.
CSN20362 G-1 881639-98-1 G-1 is a nonsteroidal, high-affinity, selective agonist of GPR30 that binds with a Ki value of 11 nM.
CSN18981 Etrasimod 1206123-37-6 Etrasimod is a potent, selective and orally available antagonist of the sphingosine-1-phosphate-1 (S1P1) receptor with an IC50 value of 1.88 nM in CHO cells.
CSN20629 Diphenyleneiodonium Chloride 4673-26-1 Diphenyleneiodonium chloride is an agonist of GPR3 with EC50 of 1 μM. It can activate adenylate cyclase.
CSN20481 DC260126 346692-04-4 DC260126 is antagoniat of free fatty acid receptor 1 (FFA1/GPR40) and inhibits FFA-induced the increase of intracellular Ca2+ level.
CSN20443 CYM 5541 945128-26-7 CYM-5541 is an allosteric agonist of S1P3 with EC50 of 72 nM - 132 nM.
CSN20173 CP-154526 157286-86-7 CP-154526 is a selective, non-peptide CRF1 receptor antagonist (Ki values are 2.7 and > 10000 nM for CRF1 and CRF2 receptors respectively). CP-154526 blocks CRF-induced adenylate cyclase activation (Ki = 3.7 nM) and attenuates activation of the HPA axis by CRF.
CSN20202 BAR502 1612191-86-2 BAR502 is an agonist of FXR and GPBAR1 that promotes browning of white adipose tissue and reverses liver fibrosis and steatosis.
CSN20201 BAR501 1632118-69-4 BAR501 is an agonist of GPBAR1 with EC50 of 1 μM. It can effectively reduce hepatic perfusion pressure.
CSN13564 AR 231453 733750-99-7 AR 231453 is a potent and selective small molecule agonist of GPR119 that enhances glucose-dependent insulin secretion and glucagon-like peptide 1 (GLP-1) release, used as an antidiabetic agent.
CSN16029 APD668 832714-46-2 APD668 is a potent GPR119 agonist with EC50 of 2.7 nM and 33 nM for hGPR119 and ratGPR119 respectively..
CSN18543 APD597 897732-93-3 APD597 is an agonist of GPR119 with EC50 of 46 nM and is used for the treatment of type 2 diabetes.
CSN18497 AMG-837 Sodium 865231-45-4 AMG-837 sodium is a potent GPR40 agonist (EC50=13 nM) with a superior pharmacokinetic profile and robust glucose-dependent stimulation of insulin secretion in rodents.
CSN13002 AMG-837 865231-46-5 AMG-837 is a potent GPR40 agonist (EC50=13 nM) with a superior pharmacokinetic profile and robust glucose-dependent stimulation of insulin secretion in rodents.
CSN17634 AMG-837 Calcium Hydrate 1259389-38-2 AMG-837 Calcium is a potent GPR40 agonist (EC50=13 nM) with a superior pharmacokinetic profile and robust glucose-dependent stimulation of insulin secretion in rodents.
CSN21176 ALB-127158A 1173154-32-9 ALB-127158(a) is a potent and selective melanin concentrating hormone 1 (MCH1) receptor antagonist.
CSN20400 AEZS-108 139570-93-7 AEZS-108 is a peptide agonist of the gonadotropin releasing hormone-1 receptor (GnRH-1R).
CSN16337 6-OAU 83797-69-7 6-OAU is a surrogate agonist of GPR84 activating human GPR84 in the presence of Gqi5 chimera in HEK293 cells with an EC50 of 105 nM in the PI assay.
<< PREV 1 2 3 NEXT >>