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ROR

ROR

货号 产品名 CAS号 信息
CSN23199 XY 018 1873358-87-2 XY 018 is a RORγ antagonist that suppresses androgen receptor expression in prostate cancer cell lines and inhibits growth of tumors in androgen receptor-positive xenograft models.
CSN22520 TMP778 1422171-08-1 TMP778 is a potent and selevtive RORγt inverse agonist, with an IC50 of 7 nM in FRET assay.
CSN18188 SR-3335 293753-05-6 SR3335 can selectively bind to RORα and competitively inhibit the binding of 25-hydroxycholesterol to the ligand binding domain with Ki of 220 nM.
CSN23128 SR 2211 1359164-11-6 SR2211 is a potent, selective synthetic RORγ modulator and functions as an inverse agonist, with a Ki of 105 nM and an IC50 of ~320 nM.
CSN17703 SR-1001 1335106-03-0 SR1001 is a selective RORα and RORγ inverse agonist and inhibits TH17 cell differentiation and function.
CSN17619 SR-1078 1246525-60-9 SR-1078 is an agonist of RORα and RORγ and can increase transcriptional activity of RORα with 2 μM.
CSN23654 SR 0987 303126-97-8 SR 0987 is an agonist of T cell-specific RORγ (RORγt) with EC50 of 800 nM. It can induce IL-17 expression and decrease PD-1 expression in T cells.
CSN17833 RORgamma-t-IN-1 1426802-50-7 RORγt-IN-1 is a potent, orally bioavailable RORγt inhibitor with pIC50 of 8.4 and > 8.2 for RORγ FRET assay and Th17 assay.
CSN21433 L 601920-0 20231-57-6 L 601920-0 is a ROR gamma modulator extracted from patent US20110263046 A1, in figure 2.
CSN17892 GSK2981278 1474110-21-8 GSK2981278 is a retinoid-related orphan receptor gamma (RORy) modulator.
CSN22420 GNE-6468 1677668-27-7 GNE-6468 is a potent and selective RORγ(RORc) agonists with an EC50 value of 13 nM for HEK-293 cell.
CSN22418 GNE-0946 1677667-24-1 GNE-0946 is a potent and selective RORγ( RORc) agonist with an EC50 value of 4 nM for HEK-293 cell.
CSN22621 (±)-ML 209 1334526-14-5 (±)-ML 209 is a RORγt inverse agonist with IC50 of 460 nM.
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