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Sigma Receptor

Sigma Receptor

货号 产品名 CAS号 信息
CSN21074 Anavex 2-73 HCl 195615-84-0 σ1 agonist (IC50 = 860 nM); also displays affinity for muscarinic M1-M4 receptors (Ki values < 500 nM), but not for σ2 receptors. Exhibits neuroprotective effects, prevents tau hyperphosphorylation, and attenuates scopolamine- and (+)-MK 801-induced learning deficits in a mouse model of amyloid toxicity.
CSN16114 Siramesine 147817-50-3 Siramesine is a selective sigma-2 receptor agonist, which has been shown to trigger cell death of cancer cells and to exhibit a potent anticancer activity in vivo.
CSN16281 Siramesine HCl 224177-60-0 Siramesine hydrochloride is an agonist of sigma-2 receptor which can trigger cell death and exhibit anticancer activity.
CSN11878 SA4503 2HCl 165377-44-6 SA4503 is the dihydrochloride form of SA4503 which is an agonist of opioid sigma1 receptor (σ1R) with IC50 of 17.4 nM.
CSN17988 SA4503 165377-43-5 SA4503 is an agonist of opioid sigma1 receptor (σ1R) with IC50 of 17.4 nM.
CSN16936 S1RA 878141-96-9 S1RA is a potent and selective sigma-1 receptor (σ1R, Ki=17 nM) antagonist, showed good selectivity against σ2R (Ki > 1000 nM).
CSN17645 S1RA HCl 1265917-14-3 S1RA hydrochloride is a potent and selective sigma-1 receptor (σ1R, Ki=17 nM) antagonist, showed good selectivity against σ2R (Ki > 1000 nM).
CSN11834 Remoxipride 80125-14-0 Remoxipride is an atypical antipsychotic which was previously used in Europe for the treatment of schizophrenia and acute mania but was withdrawn due to toxicity concerns (incidence of aplastic anemia in 1/10,000 patients).
CSN21927 Pridopidine 346688-38-8 Pridopidine exhibits high affinity towards sigma 1 receptor (S1R) (Ki = 70-80 nM) which can counteract the effects of excessive or insufficient dopaminergic transmission and it can used as a dopamine (DA) stabilizer.
CSN18418 PRE-084 HCl 75136-54-8 PRE-084 hydrochloride is a high affinity, selective σ1 agonist, has an IC50 of 44 nM in the sigma receptor assay.
CSN16267 BD-1047 Dihydrobromide 138356-21-5 BD-1047 dihydrobromide is a selective functional antagonist of sigma receptors, shows antipsychotic activity in animal models predictive of efficacy in schizophrenia.
CSN17929 4-IBP 155798-08-6 4-IBP is selective σ1 agonist with Ki of 1.7 nM and 25.2 nM for σ2 receptor.
CSN23812 Dimemorfan Phosphate 36304-84-4
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