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Bcl-2

Bcl-2

货号 产品名 CAS号 信息
CSN13795 Gambogic Acid 2752-65-0 Gambogic acid activates caspases with EC50 of 0.78-1.64 μM and competitively inhibits Bcl-XL, Bcl-2, Bcl-W, Bcl-B, Bfl-1 and Mcl-1 with IC50 of 1.47, 1.21, 2.02, 0.66, 1.06 and 0.79 μM, respectively.
CSN20561 CID5721353 301356-95-6 CID5721353 is a B-Cell Lymphoma 6 inhibitor (BCL6 inhibitor).
CSN27381 BT2 34576-94-8 BT2 is a BCKDC kinase (BDK) inhibitor with an IC50 of 3.19 μM. BT2 binding to BDK triggers helix movements in the N-terminal domain, resulting in the dissociation of BDK from the branched-chain α-ketoacid dehydrogenase complex (BCKDC). BT2 (compound 4) is also a potent and selective Mcl-1 inhibitor with a Ki value of 59 μM.
CSN18341 Bax Inhibitor Peptide V5 579492-81-2 Bax inhibitor peptide V5 is a Bax-mediated apoptosis inhibitor, used for cancer treatment.
CSN16589 BAM7 331244-89-4 BAM 7 is a direct and selective activator of proapoptotic Bax with EC50 of 3.3 μM.
CSN23881 BAI1 335165-68-9 BAI1 is an inhibitor of Bax-mediated mitochondrial cytochrome c release (IC50 = 0.52 μM).
CSN12426 ABT-737 852808-04-9 ABT-737 is a BH3 mimetic inhibitor of Bcl-xL, Bcl-2 and Bcl-w with EC50 of 78.7 nM, 30.3 nM and 197.8 nM, respectively, showing no inhibition observed against Mcl-1, Bcl-B or Bfl-1.
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