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Bcl-2

Bcl-2

货号 产品名 CAS号 信息
CSN17851 WEHI-539 1431866-33-9 WEHI-539 is a selective inhibitor of Bcl-XL with IC50 of 1.1 nM.
CSN18898 WEHI-539 HCl 2070018-33-4 WEHI-539 hydrochloride is a selective inhibitor of Bcl-XL with IC50 of 1.1 nM.
CSN18313 UMI-77 518303-20-3 UMI-77 is a selective Mcl-1 SMI inhibitor, binding to the BH3 binding groove of Mcl-1 with Ki of 490 nM.
CSN16145 TW-37 877877-35-5 TW-37 is a nonpeptide inhibitor to recombinant Bcl-2, Bcl-xL and Mcl-1 with Ki of 0.29 μM, 1.11 μM and 0.26 μM, respectively.
CSN19228 Sabutoclax 1228108-65-3 Sabutoclax is a pan-Bcl-2 inhibitor, including Bcl-xL, Bcl-2, Mcl-1 and Bfl-1 with IC50 of 0.31 μM, 0.32 μM, 0.20 μM and 0.62 μM, respectively.
CSN19712 S63845   1799633-27-4 S63845 specifically binds with high affinity to the BH3-binding groove of MCL1. S63845 potently kills MCL1-dependent cancer cells, including multiple myeloma, leukaemia and lymphoma cells, by activating the BAX/BAK-dependent mitochondrial apoptotic pathway.
CSN18897 Pyridoclax 1651890-44-6 Pyridoclax is a potent Mcl-1 inhibitor with Kd value of 25 nM.
CSN11594 Obatoclax   803712-79-0 Obatoclax, a Bcl-2 homology domain-3 mimetic, antagonize all antiapoptotic Bcl-2 family proteins (average IC50, 3 μMol/L), including Mcl-1 (IC50, 2.9 μMol/L) and Bfl-1 (IC50, 5 μMol/L).
CSN18308 MIM1 509102-00-5 MIM1 is a selective small molecule inhibitor of Mcl-1(IC50= 4.8 uM) that overcomes Mcl-1-dependent leukemia cell survival.
CSN22462 Mcl1-IN-4 1580484-04-3 Mcl1-IN-4 is an inhibitor of Mcl1 with an IC50 of 0.2 μM.
CSN18186 Mcl1-IN-2 292057-76-2 Mcl1-IN-2 is a Mcl-1 inhibitor without reported IC50 value.
CSN18401 Mcl1-IN-1 713492-66-1 Mcl1-IN-1 is a potent Mcl-1-selective inhibitor relative to the related Bcl-2 family protein Bcl-xL and demonstrates good Mcl-1 inhibition (IC50 = 2.4 uM) with no appreciable inhibition of Bcl-xL at 100 uM.
CSN17591 Marinopyrrole A 1227962-62-0 Marinopyrrole A is a selective Mcl-1 inhibitor with IC50 of 10.1 μM and proapoptosis properties in some cancer cells.
CSN11133 HA14-1 65673-63-4 HA14-1 inhibits Bcl-2 with IC50 of ~9 μM by binding to the surface pocket and disturb the interaction of Bax/Bcl-2, it's cell-permeable.
CSN12617 Gossypol 303-45-7 Gossypol has been known to exert a potential for anti-cancer, anti-inflammatory and other important therapeutic activities, gossypol binds and antagonizes anti-apoptotic effect of Bcl-2 family proteins
CSN13795 Gambogic Acid 2752-65-0 Gambogic acid activates caspases with EC50 of 0.78-1.64 μM and competitively inhibits Bcl-XL, Bcl-2, Bcl-W, Bcl-B, Bfl-1 and Mcl-1 with IC50 of 1.47, 1.21, 2.02, 0.66, 1.06 and 0.79 μM, respectively.
CSN22317 FX1 1426138-42-2 FX1 is a BCL6 inhibitor that effectively blocks BCL6 N-terminal BTB domain-mediated corepressors chromosome recruitment (by 61-87%/SMRT and 67-82%/BCOR; 50 μM FX1 for 30 min) and selectively suppresses BCL6-depenent growth (GI50 16-54 μM; >125 μM against BCL6-independent cells) in diffuse large B cell lymphoma (DLBCL) cultures, exhibiting greater affinity than its structure analog 79-6 or BCL6 corepressor SMRT for BTB domain (KD = 7 μM/FX1, 30 μM/SMRT, 129 μM/79-6). FX1 shows greater efficacy than 79-6 in reversing BCL6/corepressors-mediated target genes repression in vitro (IC50 = 35 μM vs. 318 μM with 79-6 by HEK293T-based reporter assay) and in suppressing OCI-Ly7 DLBCL xenograft tumor growth mice in vivo (100% vs. 45% suppression with respective compound via 25 mg/kg/day i.p.).
CSN20561 CID5721353 301356-95-6 CID5721353 is a B-Cell Lymphoma 6 inhibitor (BCL6 inhibitor).
CSN23343 BTSA1 314761-14-3 BTSA1 is a BAX activator that binds to the N-terminal activation site with high affinity and specificity, induces conformational changes to BAX leading to BAX-mediated apoptosis.
CSN22193 BI-3812 2166387-64-8 BI-3812 is a BCL6 inhibitor, inhibiting the BTB domain of BCL6, with an IC50 of ≤3 nM.
CSN22358 BI-3802 2166387-65-9 BI-3802 is a highly potent BCL6 degrader, inhibiting the BTB domain of BCL6, with an IC50 of ≤3 nM; BI-3802 has antitumor activity.
CSN18193 BH3I-1 300817-68-9 BH3I-1 is an inhibitor of Bcl-xL with IC50 of 293.95 μM.
CSN18845 BDA-366 1909226-00-1 BDA-366 is a small-molecule Bcl2-BH4 domain antagonist and binds BH4 with high affinity and selectivity.
CSN18341 Bax Inhibitor Peptide V5 579492-81-2 Bax inhibitor peptide V5 is a Bax-mediated apoptosis inhibitor, used for cancer treatment.
CSN16589 BAM7 331244-89-4 BAM 7 is a direct and selective activator of proapoptotic Bax with EC50 of 3.3 μM.
CSN18551 AT-101 90141-22-3 AT101, the R-(-) enantiomer of Gossypol acetic acid, binds with Bcl-2, Bcl-xL and Mcl-1 with Ki of 0.32 μM, 0.48 μM and 0.18 μM.
CSN18501 AT-101 Acetic Acid 866541-93-7 AT101 acetic acid, the R-(-) enantiomer of gossypol acetic acid, binds with Bcl-2, Bcl-xL and Mcl-1 with Ki of 0.32 μM, 0.48 μM and 0.18 μM.
CSN13597 Apogossypolone 886578-07-0 Apogossypolone is an inhibitor of Bcl-2, Mcl-1 and Bcl-XL with Ki values of 35nM, 25nM and 660nM, respectively.
CSN12426 ABT-737   852808-04-9 ABT-737 is a BH3 mimetic inhibitor of Bcl-xL, Bcl-2 and Bcl-w with EC50 of 78.7 nM, 30.3 nM and 197.8 nM, respectively, showing no inhibition observed against Mcl-1, Bcl-B or Bfl-1.
CSN12932 ABT-263   923564-51-6 ABT-263 is a potent inhibitor of Bcl-xL, Bcl-2 and Bcl-w with Ki of ≤ 0.5 nM, ≤1 nM and ≤1 nM in cell-free assays, but binds more weakly to Mcl-1 and A1.
CSN13680 ABT-199   1257044-40-8 ABT-199 is a Bcl-2-selective inhibitor with Ki of < 0.01 nM, > 4800-fold selective versus Bcl-xL and Bcl-w, and showing no activity to Mcl-1.
CSN17604 A-1155463 1235034-55-5 A1155463 is a highly potent and selective BCL-XL inhibitor with an EC50 value of 70 nM in Molt-4 cell.
CSN16885 A-1210477   1668553-26-1 A-1210477 is a potent and selective inhibitor of MCL-1, and weakly binds to BCL-2 and BCL-XL, with Ki of 0.45 nM, 132 nM and > 660 nM, respectively.
CSN17536 (S)-Gossypol Acetic Acid 1189561-66-7 (S)-Gossypol acetic acid is an inhibitor of Bcl-2, potently induce cell death in Jurkat cells overexpressing Bcl-2 (IC50, 18.1μM) or Bcl-xL (IC50, 22.9μM).
CSN18376 (+)-Apogossypol 66389-74-0 (+)-Apogossypol is a potent inhibitor of Bcl-2 family proteins and competes with the BH3 peptide-binding sites on Bcl-2, Bcl-XL, Mcl-1, Bcl-W, and Bcl-B, but not Bfl-1, with IC50s of 0.5 to 2 μM.
CSN23122 SMBA 1 906440-37-7
CSN20524 AMG-176 1883727-34-1
CSN21100 MIK 665 1799631-75-6
CSN21099 AZD5991 2143061-81-6
CSN23881 BAI1 335165-68-9
CSN23786 Bax channel blocker 329349-20-4
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