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Topoisomerase

Topoisomerase

货号 产品名 CAS号 信息
CSN12283 β-Lapachone 4707-32-8 β-Lapachone is a naturally occurring quinone obtained from the bark of the lapacho tree (Tabebuia avellanedae) with cancer chemopreventive properties and a potent inhibitor of IDO1 (IC50=0.44 μM).
CSN10116 Valrubicin 56124-62-0 Valrubicin is a chemotherapy drug used to treat bladder cancer.
CSN12236 Topotecan HCl 119413-54-6 Topotecan HCl is the first topoisomerase I-directed cytotoxic agent to enter clinical trials in the United States.
CSN12049 Teniposide 29767-20-2 Teniposide, a derivative of podophyllotoxin, can interact with DNA topoisomerase II and is used in cancer medicine.
CSN12044 Temafloxacin 108319-06-8 Temafloxacin is a fluoroquinolone antibiotic drug which was withdrawn from sale in the United States shortly after its approval in 1992 because of serious adverse effects resulting in three deaths.
CSN11873 Rufloxacin 101363-10-4 Rufloxacin is a quinolone antibiotic.
CSN13079 Rubitecan 91421-42-0 Rubitecan is an oral topoisomerase inhibitor.
CSN14282 Podocarpusflavone A 22136-74-9 Podocarpusflavone A is a DNA topoisomerase I inhibitor isolated and purified from the barks of Podocarpus macrophyllus, and is the strongest noncytotoxic non-nucleotide molecule exhibiting a specific inhibitory activity against the RNA polymerase domain of DV-NS5 and thus is promising for chemotherapy development against dengue fever.
CSN13759 PNU-159682 202350-68-3 PNU-159682, a highly potent metabolite of the anthracycline nemorubicin with outstanding cytotoxicity, is a topoisomerase inhibitor and ADCs cytotoxin.
CSN12327 Pixantrone Dimaleate 144675-97-8 Pixantrone dimaleate is a topoisomerase II inhibitor and DNA intercalator, with anti-tumor activity. Pixantrone dimaleate is an experimental antineoplastic drug.
CSN11733 Pirarubicin 72496-41-4 Pirarubicin is an analogue of the anthracycline anti-neoplastic doxorubicin, which is an inhibitor of Topo II.
CSN12979 Ofloxacin 82419-36-1 Ofloxacin, a fluoroquinolone compound, can inhibit bacterial DNA gyrase.
CSN25281 NSC745887 54490-26-5 NSC745887 can effectively inhibit the proliferation of various cancers by trapping DNA-topoisomerase cleavage. NSC745887 reduced the cell survival rate and increased the sub-G1 population in dose- and time-dependent manners in GBM cells. Moreover, NSC745887 increased expression of γH2AX and caused DNA fragmentation leading to DNA damage.NSC745887 caused apoptosis by the caspase-8/9-caspase-3-poly(ADP-ribose) polymerase cascade.
CSN11583 Novobiocin Sodium 1476-53-5 Novobiocin sodium is an antibiotic that derived from Streptomyces niveus.
CSN11576 Norfloxacin 70458-96-7 Norfloxacin inhibits DNA gyrase and is used as a broad-spectrum antibiotic against both Gram-positive and Gram-negative bacteria.
CSN10393 Nitroxoline 4008-48-4 Nitroxoline is an antibiotic towards gram negative bacilli and can to treat the urinary tract infections.
CSN11514 Nalidixic Acid 389-08-2 Nalidixic acid, synthetic 1,8-naphthyridine, is a spectrum antimicrobial agent.
CSN16183 Moxifloxacin HCl 186826-86-8 Moxifloxacin HCl is a fluoroquinolone antibiotic agent.
CSN11452 Mitoxantrone 65271-80-9 Mitoxantrone is a type II topoisomerase inhibitor with IC50 of 2.0 μM, 0.42 mM for HepG2 and MCF-7/wt cells, respectively.
CSN11453 Mitoxantrone 2HCl 70476-82-3 Mitoxantrone 2HCl is an inhibitor of type II topoisomerase with antineoplastic activity.
CSN11362 Marbofloxacin 115550-35-1 Marbofloxacin can inhibit DNA-gyrase and it is an antibiotic.
CSN10001 Levofloxacin 100986-85-4 Levofloxacin is an inhibitor of type II topoisomerases. It can inhibit DNA gyrase and topoisomerase IV with IC50 of 8.06 µg/ml and 9.81 µg/ml. It is an antibacterial agent.
CSN12634 Irinotecan HCl 3H2O 136572-09-3 Irinotecan HCl inhibits topoisomerase 1 and prevent DNA from unwinding.
CSN12573 Gatifloxacin 112811-59-3 Gatifloxacin inhibits DNA gyrase and topoisomerase IV in bacterial. It is an antibiotic of the fourth-generation fluoroquinolone family.
CSN11026 Flumequine 42835-25-6 Flumequine is a topoisomerase II inhibitor with IC50 of 15 μM. It is a synthetic chemotherapeutic antibiotic.
CSN15938 Finafloxacin HCl 209342-41-6 Finafloxacin HCl, an 8-cyano subclass of fluoroquinolone, has demonstrated potent antibacterial activity in a range of in vitro and in vivo models against Gram-negative and Gram-positive bacterial isolates.
CSN16298 Etoposide 33419-42-0 Etoposide inhibits DNA synthesis by inhibiting topoisomerase II (IC50 = 60.3 μM).
CSN16402 Epirubicin HCl 56390-09-1 Epirubicin HCl, a L-arabino derivative of doxorubicin, can inhibit topoisomerase and used as antineoplastic agent.
CSN10908 Enoxacin 74011-58-8 Enoxacin is a broad-spectrum 6-fluoronaphthyridinone antibacterial agent.
CSN12607 Doxorubicin 23214-92-8 Doxorubicin is a topoisomerase II (Top2) catalytic inhibitor, also is a broad spectrum antibiotic used in the treatment of cancers, with IC50 of 374 nM for Hela cells.
CSN16255 Doxorubicin HCl   25316-40-9 Doxorubicin HCl is an antibiotic agent that inhibits DNA topoisomerase II and induces DNA damage and apoptosis in tumor cells.
CSN10807 Difluoxacin HCl 91296-86-5 Difluoxacin HCl is a quinolone antimicrobial antibiotic and an inhibitor of Topo II.
CSN10750 Daunorubicin 20830-81-3 Daunorubicin, a topoisomerase II inhibitor, inhibits both DNA and RNA synthesis and inhibits DNA synthesis with Ki of 0.02 μM.
CSN10163 Clinafloxacin 105956-97-6 Clinafloxacin is a fluoroquinolone that inhibits both DNA gyrase and topoisomerase IV dually in Streptococcus pneumoniae.
CSN13048 Ciprofloxacin 85721-33-1 Ciprofloxacin is a fluoroquinolone antibiotic, shows broad and potent antibacterial activity, with MIC90 of 0.024-6 μM.
CSN16042 Ciprofloxacin HCl H2O 86393-32-0 Ciprofloxacin HCl is an antibiotic agent and used to treat bacterial infections.
CSN16581 Campathecin 7689-03-4 Camptothecin is a potent DNA enzyme topoisomerase I (topo I) inhibitor with an IC50 and IC70 of 50 nM and 0.225 μM for breast cancer cell line MDA-MB-231.
CSN10463 Bisantrene 78186-34-2 Bisantrene is a highly effective antitumor drug, targets eukaryotic typeII topoisomerases.
CSN12520 Balofloxacin 127294-70-6 Balofloxacin, a quinolone antibiotic, can interfer with DNA gyrase and inhibit the synthesis of bacterial DNA.
CSN15926 Balofloxacin Dihydrate 151060-21-8 Balofloxacin is a fluorinated quinolone antibiotic agent and a topoisomerase ligase inhibitor.
CSN10306 Amsacrine HCl 54301-15-4 Amsacrine HCl is an antineoplastic agent which can intercalate into the DNA of tumor cells.
CSN10305 Amrubicin 110267-81-7 Amrubicin is an anthracycline derivative for treatment of bladder carcinoma.
CSN10293 Amonafide 69408-81-7 Amonafide produces protein-associated DNA-strand breaks through a topoisomerase II-mediated reaction, but does not produce topoisomerase I-mediated DNA cleavage.
CSN20400 AEZS-108 139570-93-7 AEZS-108 is a peptide agonist of the gonadotropin releasing hormone-1 receptor (GnRH-1R).
CSN20398 Aclarubicin 57576-44-0 Aclarubicin is an oligosaccharide anthracycline antineoplastic antibiotic isolated from the bacterium Streptomyces galilaeus.
CSN20399 Aclarubicin HCl 75443-99-1 Aclarubicin HCl is the HCl salt of aclarubicin, an oligosaccharide anthracycline antineoplastic antibiotic isolated from the bacterium Streptomyces galilaeus.
CSN10176 7-Ethylcamptothecin 78287-27-1 7-Ethylcamptothecin is derived from Camptothecin with anti-cancer activity against various murine tumors through inhibition of Topo I (topoisomerase).
CSN15244 3-O-trans-p-Coumaroyltormentic Acid 121064-78-6 3-O-trans-p-Coumaroyltormentic acid, a natural product isolated and purified from the leaves of Eriobotrya japonica calli, induces apoptotic cell death in human leukemia (HL60) via mainly mitochondrial pathway by, at least in part, Topo I inhibition, and may be promising lead compound for developing an effective drug for treatment of leukemia.
CSN10390 (S)-10-Hydroxycamptothecin 19685-09-7 (S)-10-hydroxycamptothecin is an inhibitor of DNA topoisomerase I with antitumor activity.
CSN25459 9-AC 723-62-6
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