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AChR

AChR

货号 产品名 CAS号 信息
CSN19999 VU0476406 1451993-12-6 VU0476406 is an important in vivo tool compound to enable translation of pharmacodynamics from rodent to non-human primates (NHP).
CSN21180 VU0467154 1451993-15-9 VU0467154 is a positive allosteric modulator of the M4 muscarinic acetylcholine receptor (mAChR), potentiating the response to ACh with pEC50s of 7.75, 6.2 and 6 for rat, human and cynomolgus monkey M4 receptor, respectively.
CSN27595 VU0238441 85511-68-8 VU0238441 is a potent agonist of muscarinic acetylcholine receptor M5 with EC50 of 2.1 μM.
CSN27586 VU0119498 79183-37-2 VU0119498 is a M1 muscarinic receptor agonist with EC50 of 3.1 μM, and pan mAChR M3, M5 positive allosteric modulator (PAM),and is a neuroprotective agent.
CSN23552 VU 0365114 1208222-39-2 VU 0365114 is a allosteric modulator of M5 with EC50 of 2.7 μM.
CSN23217 UB-165 Fumarate N/A UB-165 is a potent nAChR ligand, which displays functional selectivity between nAChR subtypes. It is a full agonist at α3β2- and very weak partial agonist at α4β2- containing nAChRs with Ki values of 0.27, 20 (IC50), 2790 and 990 nM for α4β2, α3, α7 and α1β1δε respectively.
CSN23174 UB 165 200432-86-6 UB 165 is a full nAChR α3β2 agonist and a very weak partial nAChR α4β2 agonist with Ki value of 0.27nM and IC50 value of 20nM, respectively.
CSN21941 Tacrine HCl H2O 206658-92-6 Tacirne is an active cholinesterase inhibitor that blocks the degradation of cholinergic nerves in the cerebral cortex and hippocampus to increase cholinergic transmission. Tacrine induces hepatic damages in vitro. It can also induce oxidative stress and mitochondrial dysfunction. Tacrine treatment in HepG2 cells markedly inhibits the phosphorylation of GSK3β.
CSN21835 Solifenacin 242478-37-1 Solifenacin is a competitive antagonist of muscarinic receptors that potently blocks signaling through M1, M2, and M3 with Kis of 25, 125, and 10 nM, respectively.
CSN23115 SIB 1553A HCl 191611-89-9 SIB-1553A is a nicotinic acetylcholine receptor agonist potentially for the treatment of Alzheimer’s disease (AD).
CSN24694 (R)-N-(Quinuclidin-3-yl)-2,3-dihydrobenzo[b][1,4]dioxine-6-carboxamide fumarate 527680-57-5 Selective α7 nAChR agonist
CSN23842 Scopolamine N-Oxide HydrobroMide Monohydrate N/A Scopolamine N-oxide hydrobromide is an antagonist of the muscarinic acetylcholine.
CSN19275 RJR-2403 Hemioxalate 2095433-95-5 RJR-2403 hemioxalate is a neuronal nicotinic receptor agonist, showing high selectivity for the α4β2 subtype (Ki=26 nM), and > 1,000 fold selectivity than α7 receptors (Ki= 36000 nM).
CSN25236 Pirmenol 68252-19-7 Pirmenol inhibited the muscarinic acetylcholine receptor-operated K+ current (I[K.ACh]) in atrial cells and on experimental atrial fibrillation in isolated guinea-pig hearts.
CSN19465 Pirmenol HCl 61477-94-9 Pirmenol HCl inhibits IK.ACh by blocking muscarinic receptors. The IC50 of Pirmenol for inhibition of Carbachol-induced IK.ACh is 0.1 μM.
CSN20198 PHA-543613 HCl 1586767-92-1 PHA-543613 HCl acts as a potent and selective agonist for the α7 subtype of neural nicotinic acetylcholine receptors, with a high level of brain penetration and good oral bioavailability.
CSN24691 (R)-N-(Furo[2,3-c]pyridin-5-ylmethyl)quinuclidin-3-amine 478149-53-0 PHA-543613 acts as a potent and selective agonist for the α7 subtype of neural nicotinic acetylcholine receptors, with a high level of brain penetration and good oral bioavailability. It is under development as a possible treatment for cognitive deficits in schizophrenia.
CSN20199 PHA-543613 2HCl 478148-58-2 PHA-543613 2HCl acts as a potent and selective agonist for the α7 subtype of neural nicotinic acetylcholine receptors, with a high level of brain penetration and good oral bioavailability.
CSN20484 PF-06827443 2115022-67-6 PF-06827443 is an otent, low clearance, orally bioavailable, and CNS penetrant muscarinic M1-selectivepositive allosteric modulator (PAM) with minimal agonist activity.
CSN24546 N,N,N-Trimethyl-4-(2-oxopyrrolidin-1-yl)but-2-yn-1-aminium iodide 3854-04-4 Oxotremorine M iodide is a potent and selective muscarinic acetylcholine receptor (mAChR) agonist. Oxotremorine M iodide potentiates NMDA receptors by muscarinic receptor dependent and independent mechanisms[1].
CSN24692 3-(3-Bromothiophen-2-yl)-8-methyl-8-azabicyclo[3.2.1]oct-2-ene fumarate 216853-60-0 NS3861 is an α3β2 full agonist and an α3β4 partial agonist.
CSN19962 N-Methylcytisine 486-86-2 N-Methylcytisine's nicotinic receptors have high affinity (KD = 50 nM)to nAChR from squid optical ganglia.
CSN19033 Monepantel 887148-69-8 Monepantel is organic anthelmintic, and acts as a positive allosteric modulator of a nematode-specific clade of nicotinic acetylcholine receptor (nAChR) subunits.
CSN23835 Mivacurium Chloride 106861-44-3 Mivacurium dichloride is a benzylisoquinoline derivative and is a short-acting non-depolarizing neuromuscular blocking agent and skeletal muscle relaxant. Mivacurium dichloride couples with the nAChR to reduce or inhibit the depolarizing effect of acetylcholine on the terminal disc of the muscle cell.
CSN21136 Methylbenactyzium Bromide 3166-62-9 Methylbenactyzium Bromide is a mAchR antagonist, used as a spasmolytic for the treatment of gastrointestinal ulcer and gastrointestinal spasms.
CSN24142 Mecamylamine HCl 826-39-1 Mecamylamine HCl is a non-competitive nicotinic acetylcholine receptor antagonist with antidepressant-like effects in mice.
CSN19428 Lobeline HCl 134-63-4 Lobeline HCl is a mixed agonist–antagonist of nAchR agonist and has multiple function such as VMAT2 ligand, inhibiting the reuptake of dopamine and serotonin, antagonist at μ-opioid receptors and P-glycoprotein inhibitor.
CSN19385 Isoimperatorin 482-45-1 Isoimperatorin is a natural occuring acetylcholinesterase inhibitor with IC50 value of 74.6μM, extracted from Angelica dahurica and Angelica koreana.
CSN24690 1,4-Diazabicyclo[3.2.2]nonan-4-yl(5-(3-(trifluoromethyl)phenyl)furan-2-yl)methanone hydrochloride 753499-14-8 High affinity α7 nAChR partial agonist; anti-inflammatory
CSN19398 Galanthamine Hydrobromide 1953-04-4 Galanthamine hydrobromide is a natural occuring AchE inhibitor with IC50 value of 410nM and allosteric potentiator at neuronal nAchRs, used for the treatment of cognitive decline in mild to moderate Alzheimer's disease and various other memory impairments.
CSN20647 Epibatidine 148152-66-3 Epibatidine is a high affinity nicotinic agonist (Ki values are 0.02 and 233 nM for α4β2 and α7 nicotinic receptors respectively).
CSN22786 Dianicline 292634-27-6 Dianicline is a selective α4β2 nAChR partial agonist with IC50 of 105 nM.
CSN25424 Cyclopentolate HCl 5870-29-1 Cyclopentolate (DL-Cyclopentolate) hydrochloride is an Atropine-like muscarinic receptors antagonist with a pKB value of 7.8 (on the circular ciliary muscle). Cyclopentolate hydrochloride is an anti-muscarinic agent commonly used in the ophthalmologic practice.
CSN19722 BMS-902483 1192810-88-0 BMS-902483 is a potent α7 nicotinic acetylcholine receptor partial agonist, which improved cognition in preclinical rodent models.
CSN22357 Beperidium Iodide 86434-57-3 Beperidium iodide shows a competitive antagonistic effect against acetylcholine receptor with a pA2 of 7.93.
CSN20796 Benactyzine HCl 57-37-4 Benactyzine HCl is a centrally acting mAchR antagonist, used in the treatment of depression and in research to investigate the role of cholinergic systems on behavior.
CSN20387 AZD1446 1025007-04-8 AZD1446 is a highly selective α4β2 nicotinic acetylcholine receptor agonist for the treatment of cognitive disorders.
CSN19803 AFDX384 118290-27-0 AFDX384 is a bioactive chemical interacting with muscarinic acetylcholine receptor.
CSN20263 ABT-126 1026134-63-3 ABT-126 is an alpha7 nicotinic acetylcholine receptor agonist and nicotinic acetylcholine receptor agonist. Nelonicline is potentially useful for the treatment of Alzheimer's diseases. ABT-126 may be useful to reduce dyskinesias in both early- and later-stage Parkinson's disease.
CSN25275 (S)-PNU-282987 HCl 128311-08-0 (S)-PNU-282987 is the an absolute stereochemistry form of PNU-282987.
CSN25570 (-)-(S)-B-973B 2244989-34-0 (-)-(S)-B-973B is positive allosteric modulator of α7 nAChRs with EC50 of ~0.3 μM.
CSN24754 CCMI   917837-54-8
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