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AChR

AChR

货号 产品名 CAS号 信息
CSN24514 α-Conotoxin PnIA 705300-84-1 α-Conotoxin PnIA is a selective antagonist of α3β2 nAChR receptors (IC50 = 9.56 nM) and α7 receptors (IC50 = 252 nM).
CSN24532 α-Conotoxin PIA 669050-68-4 α-Conotoxin PIA is a selective antagonist of α6-containing nAChRs with IC50 values of 0.95 and 74.2 nM for rat α6/α3β2β3 and α3β2 receptors respectively.
CSN24553 α-Conotoxin MII 175735-93-0 α-Conotoxin MII is a potent and selective α3β2 and β3 nAChR antagonist.
CSN24535 α-Conotoxin AuIB 216299-21-7 α-Conotoxin AuIB is a selective antagonist of α3β4 nicotinic acetylcholine receptors.
CSN24539 Zamifenacin fumarate 127308-98-9 Zamifenacin fumarate is a selective M3 muscarinic receptor antagonist with pKi value of 8.52.
CSN51368 VU0152099 612514-42-8 VU0152100 is a potent and selective allosteric potentiator of M4 mAChR.
CSN24545 VU10010 633283-39-3 VU 10010 is a selective allosteric potentiator of M4 acetylcholine receptor.
CSN24529 VU 0238429 1160247-92-6 VU 0238429 is a selective positive allosteric modulator of M5 receptors with EC50 values of 1.16, >30 and >30 μM at M5, M1 and M3 receptors respectively.
CSN21894 Vinconate 70704-03-9 Vinconate is an indolonaphthyridine derivative and can stimulate the muscariic acetylcholine receptor.
CSN21914 rel-(1R,2R,4S,5S,7s)-7-(2-Hydroxy-2,2-di(thiophen-2-yl)acetoxy)-9,9-dimethyl-3-oxa-9-azatricyclo[3.3.1.02,4]nonan-9-ium bromide hydrate 411207-31-3 Tiotropium Bromide is an considsered a long acting muscarinic receptor antagonist (LAMA) and is used clinically as an inhaled bronchodilator for COPD and asthma.
CSN21862 Timepidium bromide 35035-05-3 Timepidium bromide is an anticholinergic agent.
CSN21851 Tematropium 113932-41-5 Tematropium (CDDD3602) is a soft anticholinergics.
CSN24523 Telenzepine 2HCl 147416-96-4 Telenzepine 2HCl is a selective high affinity muscarinic M1 receptor antagonist with Ki of 0.94 nM.
CSN26510 Tebanicline 2HCl 209326-19-2 Tebanicline dihydrochloride (Ebanicline dihydrochloride) is a nAChR modulator with potent, orally effective analgesic activity. It inhibits the binding of cytisine to α4β2 neuronal nAChRs with a Ki of 37 pM[1].
CSN25667 TC-2559 fumarate 212332-35-9 TC 2559 difumarate is a selective partial agonist of α4β2 receptors. The EC50 values are 0.18, 12.5, 14.0μM for α4β2, α4β4, α2β4 receptor subtypes respectively.
CSN24554 SEN12333 874450-44-9 SEN 12333 is a selective agonist of α7 nicotinic acetylcholine receptor (nAChR) with EC50 and Ki of 1.6 μM, 260 nM in rat. It also displays functional antagonism at histamine H3 receptors (IC50 = 103 nM).
CSN21821 Rapacuronium bromide 156137-99-4 Rapacuronium is an allosteric modulator of muscarinic acetylcholine receptor (mAChR). It is an aminosteroidal nondepolarizing neuromuscular blocking agent and used as a anesthesia.
CSN26572 PQCA 1144504-35-7 PQCA is a muscarinic M1 receptor positive allosteric modulator. PQCA improves cognitive measures in rat, cynomolgus macaque, and rhesus macaque. PQCA demonstrates robust efficacy in rodent and nonhuman primate (NHP) cognition assays. PQCA Improves Performance on Translatable Tests of Memory and Attention in Rhesus Monkeys. PQCA attenuates learning and memory deficits in the Tg2576 Alzheimer's disease mouse model. PQCA may be potential useful in finding new drugs for patients with Alzheimer's diseases
CSN24541 Perlapine 1977-11-3 Perlapine is a potent muscarinic DREADD agonist.
CSN24528 PD 102807 23062-91-1 PD 102807 is a selective M4 muscarinic receptor antagonist with IC50 values of 91, 6559, 3441, 950 and 7412 nM for human M4, M1, M2, M3, and M5 receptors respectively.
CSN24547 Oxotremorine sesquifumarate 17360-35-9 Oxotremorine sesquifumarate is a muscarinic agonist.
CSN24548 Oxotremorine M 63939-65-1 Oxotremorine M is a muscarinic agonist.
CSN24538 McN-A-343 55-45-8 McN-A 343 is a selective muscarinic M1 receptor agonist.
CSN24909 (7R,7aR,14R,14aS)-Dodecahydro-2H,6H-7,14-methanodipyrido[1,2-a:1',2'-e][1,5]diazocine 492-08-0 Inhibition of human CYP2D6 expressed in Escherichia coli JM109
CSN26518 Fesoterodine L-mandelate 1206695-46-6 Fesoterodine L-mandelate is an orally active, nonsubtype selective, competitive muscarinic receptor (mAChR) antagonist with pKi values of 8.0, 7.7, 7.4, 7.3, 7.5 for M1, M2, M3, M4, M5 receptors, respectively. Fesoterodine L-mandelate is used for the overactive bladder (OAB)[1][2].
CSN26519 Fesoterodine 286930-02-7 Fesoterodine is an orally active, nonsubtype selective, competitive muscarinic receptor (mAChR) antagonist with pKi values of 8.0, 7.7, 7.4, 7.3, 7.5 for M1, M2, M3, M4, M5 receptors, respectively. Fesoterodine is used for the overactive bladder (OAB)[1][2].
CSN22004 ENS-163 phosphate 117707-51-4 ENS-163 phosphate is a selective muscarinic M1 receptor agonist.
CSN21625 Elucaine 25314-87-8 Elucaine is an antagonist of muscarinic acetylcholine receptor with anti-ulcerative activity.
CSN24537 DMP-543 160588-45-4 DMP 543 is a sitmulator of acetylcholine release. It can enhance K+-stimulated [3H]-ACh release from rat hippocampal slices (EC50 = 700 nM) and increase release of dopamine and glutamate (EC50 = 0.25 and 0.22 μM, respectively). 
CSN24518 Dihydro-β-erythroidine HBr 29734-68-7 Dihydro-β-erythroidine hydrobromide is a nicotinic acetylcholine receptor antagonist of neuronal α4 receptor subunit, the IC50 values against α4β4 and α4β2 receptors are 0.19 and 0.37 μM, espectively.
CSN24540 DAU 5884 hydrochloride 131780-48-8 DAU 5884 HCl is a selective muscarinic M3 receptor antagonist.
CSN21591 Darenzepine 84629-61-8 Darenzepine is an inhibitor of muscarinic receptor.
CSN24531 Chlorisondamine diiodide 96750-66-2 Chlorisondamine diiodide is an exceptionally long lasting nicotinic antagonist with IC50 of ~ 1.6 mM.
CSN24551 Benzoquinonium chloride 311-09-1 Benzoquinonium dibromide is a nicotinic antagonist.
CSN24542 Arecaidine propargyl ester tosylate 147202-94-6 Arecaidine propargyl ester tosylate is a potent muscarinic receptor agonist.
CSN24556 AR-R17779 HCl 178419-42-6 AR-R 17779 hydrochloride is a selective alpha7 nicotinic agonist with Ki value of 190 nM for rat.
CSN29468 VQW-765 669770-29-0 AQW-051 is a novel, potent and selective, orally bioavailable, brain-penetrant α7 nAChR partial agonist with pKd of 7.56.
CSN24525 AQ-RA 741 123548-16-3 AQ-RA 741 is a high affinity, selective muscarinic M2 receptor antagonist (pKi values are 8.3, 7.7 and 6.82 for M2, M1 and M3 receptors, respectively).
CSN22098 Ambutonium bromide 115-51-5 Ambutonium bromide is an acetylcholine antagonist.
CSN24526 AF-DX 384 118290-26-9 AF-DX 384 is a potent M2/M4 selective antagonist with pKi values of 8.22, 8.00, 7.51, 7.18 and 6.27 at human M2, M4, M1, M3 and M5 receptors respectively.
CSN24524 Otenzepad 102394-31-0 AF-DX 116 is a selective M2 muscarinic receptor antagonist with Ki values of 64, 417, 786, 211 and 5130 nM for human recombinant M2, M1, M3, M4 and M5 muscarinic receptors, respectively.
CSN24517 Pozanicline 2HCl 161416-61-1 ABT 089 dihydrochloride is the high affinity and selective partial agonist of α4β2 with Ki of 16 nM.
CSN24549 Methylfurmethide iodide 1197-60-0 5-Methylfurmethiodide is a potent muscarinic agonist.
CSN24543 4-DAMP 1952-15-4 4-DAMP is a muscarinic M3 antagonist.
CSN24533 4-Acetyl-1,1-dimethylpiperazinium iodide 75667-84-4 4-Acetyl-1,1-dimethylpiperazinium iodide is a nAChR agonist with Ki of 29.9 nM at α4β2.
CSN24521 3-Bromocytisine 207390-14-5 3-Bromocytisine is an agonist of α4β4, α4β2 and α7 nACh receptors with IC50s of 0.28, 0.30 and 31.6 nM respectively.
CSN24552 1-(4-Methylpiperazin-1-yl)ethanone hydrochloride 144205-68-5 1-Acetyl-4-methylpiperazine hydrochloride is a nAChR agonist.
CSN24530 (±)-Anatoxin A fumarate 1219922-30-1 (¡À)-Anatoxin A fumarat is a potent nicotinic agonist with Ki values of 1.25 and 1840 nM for α4β2 and α7 nicotinic receptors respectively.
CSN24562 (S)-(+)-Dimethindene maleate 136152-65-3 (S)-(+)-Dimethindene maleate is a subtype-selective M2 muscarinic receptor antagonist with pKi of 7.78 and is also a H1 histamine receptor antagonist with pKi of 7.48.
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