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HIV Integrase

HIV Integrase

货号 产品名 CAS号 信息
CSN12254 Raltegravir Potassium 871038-72-1 Raltegravir Potassium is an HIV integrase strand transfer inhibitor which acts as the first of the class of antiviral agents active against the human immunodeficiency virus (HIV).
CSN12253 Raltegravir 518048-05-0 Raltegravir is a potent integrase (IN) inhibitor for WT and S217Q PFV IN with IC50 of 90 nM and 40 nM in cell-free assays, respectively. It shows greater than 1000-fold selectivity for HIV-1 IN over several related Mg2+-dependent enzyme such as HCV polymerase, HIV reverse transcriptase, HIV RNaseH and human α-, β-, γ-polymerases.
CSN16815 MK-2048 869901-69-9 MK-2048 is a potent inhibitor of integrase and INR263K with IC50 of 2.6 nM and 1.5 nM, respectively.
CSN18639 HIV-1 Integrase Inhibitor 2 957890-42-5 HIV-1 integrase inhibitor, in the treatment of human immunodeficiency virus (HIV) infection.
CSN22210 HIV-1 Integrase Inhibitor 4 1638504-66-1 HIV-1 integrase inhibitor 4 is a HIV-1 integrase strand transfer (INST) inhibitor with an IC50 of 3.7 nM.
CSN22211 HIV-1 Integrase Inhibitor 3 1638504-56-9 HIV-1 integrase inhibitor 3 is a HIV-1 integrase strand transfer (INST) inhibitor with an IC50 of 2.7 nM.
CSN12955 Elvitegravir 697761-98-1 Elvitegravir is a quinolinemonocarboxylic-acid HIV-1 integrase strand transfer inhibitor used to treat HIV infection. It is also a cytochrome P450 2C9 inducer.
CSN15749 Dolutegravir Sodium 1051375-19-9 Dolutegravir sodium is an HIV integrase inhibitor (IC50= 2.7 nM) with modest activity against raltegravir-resistant signature mutants Y143R, Q148K, N155H, and G140S/Q148H.
CSN13497 Dolutegravir 1051375-16-6 Dolutegravir is an integrase inhibitor (IC50= 2.7 nM), modest activity against raltegravir-resistant signature mutants Y143R, Q148K, N155H, and G140S/Q148H.
CSN10610 Cichoric Acid   6537-80-0 Cichoric Acid is a naturally occuring phenylpropanoid found in a variety of plants, used as an HIV Integrase inhibitor.
CSN16297 Cabotegravir 1051375-10-0 Cabotegravir is a potent HIV integrase inhibitor as an oral lead-in tablet and long-acting injectable for the treatment and prevention of HIV infection. Cabotegravir is an inhibitor of OAT1 (IC50 0.81 μM) and OAT3 (IC50 0.41 μM).
CSN18409 BMS-707035 729607-74-3 BMS-707035 is a potent, specific, reversible HIV-I integrase inhibitor with IC50 value of 15 nM.
CSN16972 BMS-538203 543730-41-2 BMS-538203 is a highly efficient HIV integrase inhibitor and antiviral agent.
CSN20343 Bictegravir 1611493-60-7 Bictegravir is a potent, unboosted, once-Daily HIV-1 Integrase Strand Transfer inhibitor (INSTI) (IC50 - 1.6 nM) with improved pharmacokinetics and in vitro resistance profile.
CSN17501 BI-224436 1155419-89-8 BI-224436 is an HIV-1 noncatalytic site integrase inhibitor with EC50 values of less than 15 nM against different HIV-1 laboratory strains.
CSN17820 (±)-BI-D 1416258-16-6 (±)-BI-D is a potent ALLINI (An allosteric IN inhibitor) that binds integrase at the LEDGF/p75 binding site.
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