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The eukaryotic defective in cullin neddylation (DCN) protein family, may contribute to neddylation of cullin components of SCF-type E3 ubiquitin ligase complexes. These multi-protein complexes are required for polyubiquitination and subsequent degradation of target proteins by the 26S proteasome.

DCN

货号 产品名 CAS号 信息
CSN24059 NAcM-OPT 2089293-61-6 NAcM-OPT is an orally bioavailable cullin neddylation 1 (DCN1) inhibitor, which specific and reversible inhibits the interaction of N-Acetyl-UBE2M and DCN1 with IC50 of 79 nM in TR-FRET assays.
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