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Dopamine Receptor

Dopamine Receptor

货号 产品名 CAS号 信息
CSN12143 Trifluoperazine 117-89-5 Trifluoperazine is a typical antipsychotic of the phenothiazine chemical class.
CSN11417 Trifluoperazine 2HCl 440-17-5 Trifluoperazine 2HCl is a dopamine D2 receptor inhibitor with anti-dopaminergic and anti-adrenergic actions, which belongs to the phenothiazine compounds.
CSN12088 Tiapride HCl 51012-33-0 Tiapride HCl is a drug that selectively blocks D2 and D3 dopamine receptors in the brain.
CSN12068 Tetrahydroberberine 522-97-4 Tetrahydroberberine is an isoquinoline alkaloid isolated and purified from the barks of Phellodendron chinense Schneid. It has micromolar affinity for dopamine D(2) (pK (i) = 6.08) and 5-HT(1A) (pK (i) = 5.38) receptors but moderate to no affinity for other relevant serotonin receptors(5-HT(1B), 5-HT(1D), 5-HT(3), and 5-HT(4); pK (i) < 5.00).
CSN25548 Tavapadon 1643489-24-0 Tavapadon is an orally active and highly selective dopamine D1/D5 receptor partial agonist. It may be useful in the treatment of Parkinson's disease and Alzheimer's.
CSN12026 Talipexole 101626-70-4 Talipexole is a dopamine agonist that has been proposed as an antiparkinsonian agent.
CSN12723 Sumanirole Maleate 179386-44-8 Sumanirole maleate is a highly selective D2 receptor full agonist with an ED50 of about 46 nM.
CSN25662 SKF 77434 104422-04-0 SKF 77434 is Dopamine D1 receptor partial agonist. Chronic treatment with SKF 77434 produced dose-dependent effects on cocaine self-administration in Rhesus Monkeys.
CSN11868 Rotundine 483-14-7 Rotundine is antagonist for domapmine D1 receptor(Ki = 124 nM) and has a lower binding activity of domapmine D2 receptor and domapmine D3 receptor. It can also inhibit 5-HT1A (Ki = 340 nM).
CSN11867 Rotigotine 99755-59-6 Rotigotine is a full agonist of dopamine receptor, a partial agonist of the 5-HT1A receptor, and an antagonist of the α2B-adrenergic receptor, with Ki of 0.71 nM, 4-15 nM, and 83 nM for the dopamine D3 receptor and D2, D5, D4 receptors, and dopamine D1 receptor.
CSN11816 Quinagolide HCl 94424-50-7 Quinagolide HCl is a selective dopamine D2 receptor agonist, also is a prolactin inhibitor.
CSN11783 Promazine HCl 53-60-1 Promazine HCl is a D2 dopamine receptor antagonist, belongs to the phenothiazine class of antipsychotics, used to treat schizophrenia.
CSN12476 Pramipexole 104632-26-0 Pramipexole is an agonist of dopamine receptors D2, D3, and D4 (Ki = 3.9, 2.2, 0.5, and 5.1 nM respectively) and it is indicated for treating Parkinson's disease (PD) and restless legs syndrome (RLS).
CSN11760 Pramipexole 2HCl 104632-25-9 Pramipexole 2HCl is an dopamine agonist and can inhibit multiple dopamine receptors including dopamine D2S receptor, dopamine D2L receptor, dopamine D3 receptor, and dopamine D4 receptor with respectively Ki values of 3.9, 2.2, 0.5 and 5.1 nM.
CSN11685 Perphenazine 58-39-9 Perphenazine is an inhibitor of 5-HT2A receptor(5-HT2A), alpha-1A adrenergic receptor (α1A), dopamine D2 receptor/dopamine D3 receptor, D2L receptor, and Histamine H1 receptor ( Kis = 5.6, 10, 0.765/0.13, 3.4, and 8 nM respectively). It is commonly used as a typical antipsychotic drug.
CSN10895 Pergolide Mesylate 66104-23-2 Pergolide mesylate is an antiparkinsonian agent which functions as a dopaminergic agonist.
CSN11681 Pergolide 66104-22-1 Pergolide is an ergoline-based dopamine receptor agonist used in some countries for the treatment of Parkinson's disease.
CSN23235 PD-168077 190383-31-4 PD168,077 is a dopamine D4 receptor agonist which has a facilitatory effect on memory consolidation.
CSN10189 Paliperidone 144598-75-4 Paliperidone is a potent serotonin-2A and dopamine-2 receptor antagonist, it is the main active metabolite of risperidone and used in the treatment of schizophrenia.
CSN10154 Oxidopamine HCl 28094-15-7 Oxidopamine HCl is a neurotoxic synthetic organic compound, selectively destroys dopaminergic and noradrenergic neurons in the brain.
CSN11571 Nomifensine Maleate 32795-47-4 Nomifensine maleate is a selective inhibitor of dopamine uptake, used in adult attention deficit disorder.
CSN11570 Nomifensine 24526-64-5 Nomifensine is a norepinephrine-dopamine reuptake inhibitor, increases the amount of synaptic norepinephrine and dopamine available to receptors by blocking the dopamine and norepinephrine reuptake transporters.
CSN11546 Neuromedin N 92169-45-4 Neuromedin N is a potent modulator of dopamine D2 receptor agonist binding in rat neostriatal membranes.
CSN11472 Mosapramine 89419-40-9 Mosapramine is an atypical antipsychotic used in Japan. It is a potent dopamine antagonist with high affinity to the D2, D3, and D4 receptors, and with moderate affinity for the 5-HT2 receptors.
CSN11461 Molindone HCl 15622-65-8 Molindone HCl, the salt form of molindone which is a dopamine receptor antagonist, can be used in the treatment of schizophrenia and act as a therapeutic antipsychotic.
CSN11425 Metoclopramide 364-62-5 Metoclopramide is an antagonist of dopamine D2 and is commonly used as an antiemetic.
CSN11426 Metoclopramide HCl 7232-21-5 Metoclopramide HCl is a selective dopamine D2 receptor antagonist, used for the treatment of nausea and vomiting.
CSN11390 Metergoline 17692-51-2 Metergoline is a psychoactive drug of the ergoline chemical class which acts as a ligand for various serotonin and dopamine receptors.
CSN23832 Mesoridazine Besylate 32672-69-8 Mesoridazine besylate is a phenothiazine dopamine receptor anatagonist. Mesoridazine besylate is described to demonstrate inhibition for D2DR and D4DR. It has a high affinity for dopamine D4 receptor. Mesoridazine besylate is an antipsychotic agent.
CSN11293 Levosulpiride 23672-07-3 Levosulpiride, an atypical antipsychotic, can selectively inhibit D2 receptor and it is the (S)-enantiomer of sulpiride.
CSN25316 L-745870 158985-00-3 L-745870 is a high-affinity, selective and orally active human dopamine D4 receptor antagonist with a Ki of 0.43 nM and excellent brain penetration.
CSN11012 Fipexide 34161-24-5 Fipexide is a psychoactive drug of the piperazine chemical class, used as a nootropic drug, mainly for the treatment of senile dementia.
CSN11002 Fenoldopam Mesylate 67227-57-0 Fenoldopam mesylate is a partial specific agonist of D1 receptor, a synthetic benzoxipine derivative.
CSN10871 Droperidol 548-73-2 Droperidol is an antagonist of dopamine-2 receptor.
CSN12899 Dexpramipexole 104632-28-2 Dexpramipexole is a neuroprotective agent and weak non-ergoline dopamine agonist.
CSN10685 Clozapine 5786-21-0 Clozapine, an antipsychotic drug, is antagonist of dopamine and other receptors used to treat schizophrenia with a Ki value of 9.5 nM for M1 receptor.
CSN10678 trans-Clopenthixol 982-24-1 Clopenthixol is a thioxanthene with therapeutic actions similar to the phenothiazine antipsychotics. It is an antagonist at D1 and D2 dopamine receptors.
CSN10662 Clebopride Malate 57645-91-7 Clebopride malate, with antiemetic and prokinetic properties, is a dopamine antagonist drug used to treat gastrointestinal dysfunction.
CSN10490 Bromopride 4093-35-0 Bromopride is a dopamine antagonist with prokinetic properties, widely used as an antiemetic.
CSN10487 Bromocriptine Mesylate 22260-51-1 Bromocriptine mesylate is a potent dopamine D2/D3 receptoragonist, which binds D2 dopamine receptor with pKi of 8.05±0.2.
CSN10446 B-HT 920 36085-73-1 B-HT 920 is a dopamine D2 receptor agonist, α2-adrenoceptor agonist and 5-HT3 receptor antagonist, which displays antiParkinsonian activity.
CSN12577 Azaperone 1649-18-9 Azaperone functions as a dopamine antagonist that can bind to D1 and D2 receptors. It has the characteristics of antihistamines and anticholinergics.
CSN10288 Amisulpride 71675-85-9 Amisulpride is a selective dopamine antagonist wit Ki of 2.8 nM for D2 receptor and Ki of 3.2 nM D3 receptor, it's used as an antipsychotic drug.
CSN10242 Alizapride 59338-93-1 Alizapride is a dopamine antagonist with prokinetic and antiemetic effects used in the treatment of nausea and vomiting, including postoperative nausea and vomiting.
CSN10243 Alizapride HCl 59338-87-3 Alizapride HCl is a dopamine receptor antagonist used in the administration of nausea and vomiting.
CSN25294 ABT-724 70006-24-5 ABT-724 is a potent and highly selective dopamine D4 receptor agonist with EC50s of 12.4 nM, 14.3 nM and 23.2 nM for human dopamine D4 receptor, rat D4 receptor and ferret D4 receptor.
CSN25293 ABT-724 3HCl   587870-77-7 ABT-724 3HCl is a potent and highly selective dopamine D4 receptor agonist with EC50s of 12.4 nM, 14.3 nM and 23.2 nM for human dopamine D4 receptor, rat D4 receptor and ferret D4 receptor.
CSN24069 A-381393 726174-00-1 A-381393 is a potent, selective, brain penetrate dopamine D4 receptor antagonist, with Kis of 1.5, 1.9 and 1.6 nM for human dopamine D4.4, D4.2, and D4.7 receptor, respectively, >2700-fold selectivity over D1, D2, D3 and D5 dopamine receptors. A-381393 shows moderate affinity for 5-HT2A (Ki, 370 nM)[1].
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