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Dopamine Receptor

Dopamine Receptor

货号 产品名 CAS号 信息
CSN20169 Zicronapine 170381-16-5 Zicronapine is an atypical antipsychotic medication. Zicronapine exhibits monoaminergic activity and has a multi-receptorial profile. In vitro and in vivo it has shown potent antagonistic effects at dopamine D1, D2 and serotonin 5HT2A receptors.
CSN21891 Veralipride 66644-81-3 Veralipride is an antagonist of D2 receptor. It is used for the treatment of menopausal symptoms.
CSN23250 Trimethobenzamide HCl 554-92-7 Trimethobenzamide HCl is a dopamine D2 receptor antagonist and antiemetic drug.
CSN12086 Tiamenidine 31428-61-2 Thioridazine is an antipsychotic drug, used in the treatment of schizophrenia and psychosis, shows D4 selectivity or serotonin antagonism.
CSN25548 Tavapadon 1643489-24-0 Tavapadon is an orally active and highly selective dopamine D1/D5 receptor partial agonist. It may be useful in the treatment of Parkinson's disease and Alzheimer's.
CSN22118 Sultopride HCl 23694-17-9 Sultopride HCl is a selective antagonist of dopamine D2 receptor
CSN17500 ST-836 1148156-63-1 ST-836 is a dopamine receptor ligand and an antiparkinsonian agent.
CSN17819 ST-836 HCl 1415564-68-9 ST-836 HCl is a dopamine receptor ligand which act as an antiparkinsonian agent.
CSN27219 8-Bromo-3-methyl-5-phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-ol 99295-33-7 SKF-83566 is a potent, blood-brain permeable and orally active dopamine D1/D5 receptor antagonist . SKF-83566 is a competitive DAT (dopamine transporter) inhibitor with an IC50 of 5.7 μM and attenuates cocaine effects in vivo .
CSN18415 SKF-82958 Hydrobromide 74115-01-8 SKF-82958 hydrobromide is a D1/D5 receptor full agonist.
CSN20415 SKF 83959 Hydrobromide 67287-95-0 SKF 83959 hydrobromide is a dopamine D1-like receptor partial agonist (Ki values are 1.18, 7.56, 920 and 399 nM for rat D1, D5, D2 and D3 receptors respectively). It may act as an antagonist in vivo, producing anti-Parkinsonian effects and antagonizing the behavioral effects of cocaine.
CSN25662 SKF 77434 104422-04-0 SKF 77434 is Dopamine D1 receptor partial agonist. Chronic treatment with SKF 77434 produced dose-dependent effects on cocaine self-administration in Rhesus Monkeys.
CSN23554 SCH 23390 HCl 125941-87-9 SCH 23390 HCl is an antagonist of dopamine receptor D1 and D5 with Ki of 0.2 nM and 0.3 nM, respectively.
CSN18111 SB-277011 215803-78-4 SB-277011 is a potent and delective brain-penetrant dopamine D3 receptor antagonist (pKi values are 8.0, 6.0, 5.0 and < 5.2 for D3, D2, 5-HT1D and 5-HT1B respectively).
CSN18110 SB-269652 215802-15-6 SB-269652 is the first drug-like allosteric modulator of the dopamine D2 receptor (D2R) and a chemical probe that can differentiate D2R monomers from dimers or oligomers depending on the observed pharmacology.
CSN19852 SB 277011A 2HCl 1226917-67-4 SB 277011A 2HCl is a selective brain-penetrant dopamine D3 receptor antagonist (pKi values are 8.0, 6.0, 5.0 and < 5.2 for D3, D2, 5-HT1D and 5-HT1B respectively).
CSN23655 Ro 10-5824 2HCl 189744-94-3 Ro 10-5824 2HCl is an agonist of dopamine D4 receptor with Ki of 5.2 nM.
CSN25233 Raclopride 84225-95-6 Raclopride is a dopamine D2/D3 receptor antagonist, which binds to D2 and D3 receptors with dissociation constants (Kis) of 1.8 nM and 3.5 nM, respectively, but has a very low affinity for D1 and D4 receptors with Kis of 18000 nM and 2400 nM, respectively .
CSN17398 rac-Rotigotine HCl 102120-99-0 rac-Rotigotine HCl is a high potency and selectivity agonist for D-2 receptor with Ki of 0.69 nM.
CSN21076 SCH23390 87134-87-0 Potent dopamine receptor antagonist (Ki values are 0.2 nM and 0.3 nM at D1 and D5 receptor sub-types, respectively). Also an agonist at 5-HT1C and 5-HT2C receptors in vitro (Ki values are 6.3 nM and 9.3 nM respectively). Blocks quinpirole-induced Kir3 (GIRK) currents (EC50 = 268 nM) independently of receptors.
CSN23235 PD-168077 190383-31-4 PD168,077 is a dopamine D4 receptor agonist which has a facilitatory effect on memory consolidation.
CSN23271 PD 168077 Maleate 630117-19-0 PD 168077 maleate is an agonist of D4 dopamine receptor with Ki of 8.7 nM. It can induce synaptic translocation of CaMK II to postsynaptic sites in cultured prefrontal cortical neurons.
CSN18173 Pardoprunox HCl 269718-83-4 Pardoprunox HCl is a partial dopamine D2 and D3 receptor agonist and serotonin 5-HT1A receptor agonist, D2 (pKi = 8.1) and D3 receptor (pKi = 8.6) partial agonist and 5-HT1A receptor (pKi = 8.5) full agonist.
CSN27393 Paliperidone palmitate 199739-10-1 Paliperidone palmitate (9-Hydroxyrisperidone palmitate), an atypical long-acting antipsychotic agent, is an ester prodrug of Paliperidone. Paliperidone is a dopamine antagonist and 5-HT2A antagonist of the atypical antipsychotic class. Paliperidone palmitate shows efficacy against schizophrenia.
CSN19863 NGB 2904 HCl 189061-11-8 NGB 2904 is a potent and selective dopamine D3 receptor antagonist (Ki values are 1.4, 217, 223, 642, > 5000, > 10000 and > 10000 nM for D3, D2, 5-HT2, α1, D4, D1 and D5 receptors respectively).
CSN17271 MPTP HCl 23007-85-4 MPTP HCl is a neurotoxin that causes symptoms similar to parkinson's disease by destroying dopamine-producing nerve cells in the substantia nigra. It is widely used in the study of various animal models of Parkinson's disease.
CSN26125 ML417 1386162-69-1 ML417 is a novel and highly selective D3 dopamine receptor agonist with EC50 value of 38nM.
CSN19492 Metoclopramide HCl H2O 54143-57-6 Metoclopramide HCl is an antagonist of dopamine D2 receptor that is structurally related to procainamide. It has antiemetic and gastroprokinetic activities.
CSN23832 Mesoridazine Besylate 32672-69-8 Mesoridazine besylate is a phenothiazine dopamine receptor anatagonist. Mesoridazine besylate is described to demonstrate inhibition for D2DR and D4DR. It has a high affinity for dopamine D4 receptor. Mesoridazine besylate is an antipsychotic agent.
CSN23381 Melitracen HCl 10563-70-9 Melitracen HCl, a member of anthracenes, is an antagonist of dopamine D1 and D2 receptors. It is used as an antidepressant.
CSN21902 Lurasidone 367514-87-2 Lurasidone functions as an antagonist of the dopamine D2 and D3 receptors, the serotonin 5-HT2A and 5-HT7 receptors, the α2C-adrenergic receptor, and as a partial agonist of the serotonin 5-HT1A receptor.
CSN25316 L-745870 158985-00-3 L-745870 is a high-affinity, selective and orally active human dopamine D4 receptor antagonist with a Ki of 0.43 nM and excellent brain penetration.
CSN17665 Iloperidone HCl 1299470-39-5 Iloperidone HCl is a D(2)/5-HT(2) receptor antagonistis, which is an atypical antipsychotic for the treatment of schizophrenia symptoms.
CSN19476 Haloperidol 52-86-8 Haloperidol is an antagonist of dopamine D2-like receptors (D1-D5) and it is used as a typical antipsychotic.
CSN17905 Haloperidol HCl 1511-16-6 Haloperidol HCl blocks dopamine receptors in in the treatment of schizophrenia, acute psychosis, and delirium.
CSN20158 GSK598809 863680-45-9 GSK598809 is a selective D(3)R antagonist recently progressed in Phase I trials. GSK-598809 may decrease the rewarding effects of contextual cues associated with drug intake preclinically, which may reduce drug craving in humans.
CSN27239 Fluphenazine 69-23-8 Fluphenazine is a typical antipsychotic used for symptomatic management of psychosis in patients with schizophrenia.
CSN20161 FAUC 329 474432-48-9 FAUC 329 is a dopamine D3 receptor ligand showing protective effects against dopamine depletion in a MPTP mouse model of Parkinson's disease.
CSN18775 Chlorprothixene 113-59-7 Chlorprothixene is an antagonist of multiple receptors including 5-HT2 (Ki = 3.4 nM), D1 (Ki = 18 nM), D2 (Ki = 18 nM), D3 (Ki = 4.56 nM), H1 (Ki = 3.75 nM), muscarinic acetylcholine receptors, α1-Adrenergic.
CSN20529 BP897 314776-92-6 BP897 is a partially selective dopamine D3 receptor agonist (Ki = 0.92 nM) that developed for the study of cocaine addiction.
CSN18441 Amisulpride HCl 81342-13-4 Amisulpride HCl is an antipsychotic drug, which is a selective dopamine antagonist (Ki=2.8 nM D2 receptor; Ki=3.2 nM D3 receptor).
CSN18125 Adoprazine 222551-17-9 Adoprazine, a potential atypical antipsychotic bearing potent D2 receptor antagonist and 5-HT1A receptor agonist properties.
CSN25294 ABT-724 70006-24-5 ABT-724 is a potent and highly selective dopamine D4 receptor agonist with EC50s of 12.4 nM, 14.3 nM and 23.2 nM for human dopamine D4 receptor, rat D4 receptor and ferret D4 receptor.
CSN25293 ABT-724 3HCl   587870-77-7 ABT-724 3HCl is a potent and highly selective dopamine D4 receptor agonist with EC50s of 12.4 nM, 14.3 nM and 23.2 nM for human dopamine D4 receptor, rat D4 receptor and ferret D4 receptor.
CSN24069 A-381393 726174-00-1 A-381393 is a potent, selective, brain penetrate dopamine D4 receptor antagonist, with Kis of 1.5, 1.9 and 1.6 nM for human dopamine D4.4, D4.2, and D4.7 receptor, respectively, >2700-fold selectivity over D1, D2, D3 and D5 dopamine receptors. A-381393 shows moderate affinity for 5-HT2A (Ki, 370 nM)[1].
CSN22612 (+)-PD 128907 HCl 300576-59-4 (+)-PD 128,907 HCl is an agonist of D3 dopamine receptor with Ki of 2.3 nM.
CSN22323 (+)-Dihydrexidine HCl 158704-02-0 (+)-Dihydrexidine HCl is a dopamine D1 receptor agonist with an EC50 of 72± 21 nM.
CSN25685 (+)-AJ 76 HCl 85378-82-1 (+)-AJ 76 hydrochloride is an antagonist of dopamine receptor with preferential action at presynaptic receptors (pKi values are 6.95, 6.67, 6.37, 6.21 and 6.07 at hD3, D4, hD2S, hD2L and rD2 receptors respectively).
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