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Histamine Receptor

Histamine Receptor

货号 产品名 CAS号 信息
CSN19848 Thioperamide 106243-16-7 Thioperamide is a potent HRH4 antagonist and selective HRH3 antagonist capable of crossing the blood–brain barrier.
CSN17265 Setastine 64294-95-7 Setastine is an antihistamine used to treat allergies and rhinitis.
CSN21281 S 38093 862896-30-8 S 38093 is a brain-penetrant antagonist/inverse agonist of H3 receptors.
CSN26180 PU-02 313984-77-9 PU-02 is an antagonist of serotonin (5-HT) receptor subtype 5-HT3.
CSN18242 Pitolisant Oxalate 362665-57-4 Pitolisant oxalate is a potent, and selective nonimidazole inverse agonist at the recombinant human H3 receptor (Ki=0.16 nM).
CSN17352 Pitolisant 362665-56-3 Pitolisant is a potent, and selective nonimidazole inverse agonist at the recombinant human H3 receptor (Ki=0.16 nM).
CSN21315 Pirolate 55149-05-8 Pirolate (CP-32,387) is an antihistamine drug with a tricyclic chemical structure which was patented as an "antiallergen".
CSN18828 Osthole 484-12-8 Osthole, an O-methylated coumarin, is a histamine H1 receptor inhibitior. It exhibits immunomodulatory, antioxidative and anti-inflammatory activities.
CSN21105 N-omega-Acetylhistamine 673-49-4 N-acetylhistamine is a histamine metabolite. N-acetylhistamine can be used as a potential biomarker of histidine metabolism for anaphylactoid reactions.
CSN17435 Mizolastine 2HCl 1056596-82-7 Mizolastine 2HCl is a histamine H1-receptor antagonist with IC50 of 47 nM used in the treatment of hay fever (seasonal allergic rhinitis), hives and other allergic reactions.
CSN21134 Mebhydrolin 524-81-2 Mebhydrolin is a specific histamine H1 receptor antagonist.
CSN14575 Marmin 14957-38-1 Marmin, a natural product isolated and purified from the herbs of Citrus maxima with potent anti-ulcer, antibacterial, fungicidal, and algicidal properties, can inhibit contraction of the guinea-pig tracheal smooth muscle, especially by interfering histamine receptor, inhibiting the histamine release from mast, inhibiting intracellular Ca2+ release from the intracellular store and the Ca2+ influx through voltage-dependent Ca2+ channels, is potential to develop as antihistamine agents, especially as histamine H1 receptor antagonists by interacting with amino acid residues, Asp107, Lys179, Lys191, Asn198, and Trp428 of histamine H1 receptor, shows a cell-growth inhibitory effect against L1210 and K562 in vitro.
CSN25565 LML-134 1542135-76-1 LML134 is an orally active and high selective Histamine 3 receptor (H3R) inverse agonist with Kis of 0.3 nM and 12 nM for hH3R cAMP and hH3R bdg. LML134 penetrates the brain rapidly, leading to high H3R occupancy, and disengages its target with a fast kinetic profile. LML134 has the potential for excessive sleep disorders.
CSN19403 Ketotifen Fumarate 34580-14-8 Ketotifen fumarate is a noncompetitive H1 receptor antagonist and mast cell stabilizer that is used to treat asthma.
CSN20197 JNJ10181457 544707-19-9 JNJ10181457 is a histamine H3 receptor inverse agonist that regulates in vivo microglial functions and improves depression-like behaviours in mice.
CSN16759 JNJ-7777120 459168-41-3 JNJ-7777120 is a selective antagonist of histamine-4 receptor (H4R) with Ki of 4 ± 1 nM.
CSN25273 JNJ-5207852 398473-34-2 JNJ-5207852 is a novel, non-imidazole histamine H3 receptor antagonist, with high affinity at the rat (pKi=8.9) and human (pKi=9.24) H3 receptor.
CSN17063 Hydroxyzine 68-88-2 Hydroxyzine is a histamine H1-receptor antagonist.
CSN21410 H3R-IN-1 HCl N/A H3R-IN-1 HCl is a histamine receptor 3 (H3R) inverse agonist.
CSN18994 GSK189254A 720690-73-3 GSK189254A is a potent and selective histamine H3 receptor antagonist with pKi values of 9.59-9.90 and 8.51-9.17 for human and rat H3, respectively.
CSN19386 Epinastine 80012-43-7 Epinastine is mast cell stabilizer and antihistamine that is used to treat allergic conjunctivitis.
CSN19513 Diphenylpyraline HCl 132-18-3 Diphenylpyraline HCl is a first-generation antihistamine with anticholinergic effects, acts as a dopamine reuptake inhibitor, shows to be useful in the treatment of Parkinsonism.
CSN21346 Cyclizine 82-92-8 Cyclizine, a piperazine derivative, is an antihistaminic antiemetic that is useful in the prevention and treatment of nausea and vomiting associated with motion sickness.
CSN22573 Cyclizine 2HCl 5897-18-7 Cyclizine is a histamine H1 receptor antagonist of the piperazine class.
CSN21347 Cyclizine HCl 303-25-3 Cyclizine HCl is a piperazine derivative with anti-emetic activity that is useful in the prevention and treatment of nausea and vomiting associated with motion sickness.
CSN20584 Clobenpropit Dihydrobromide 145231-35-2 Clobenpropit hydrobromide is a selective histamine H3 receptor antagonist that crosses the blood-brain barrier, inhibiting histamine binding in rat brain.
CSN18049 Ciproxifan 184025-18-1 Ciproxifan is a highly potent and selective histamin H3-receptor antagonist with IC50 of 9.2 nM, with low apparent affinity at other receptor subtypes.
CSN22139 Cipralisant 213027-19-1 Cipralisant is a potent and selective histamine H3 receptor antagonist in vivo, and an agonist in vitro, with a pKi of 9.9 for histamine H3 receptor and a Ki of 0.47 nM for rat histamine H3 receptor; Cipralisant has entered in clinical trials for the treatment of attention-deficit hyperactivity disorder.
CSN23808 Chlorcyclizine HCl 14362-31-3 Chlorcyclizine hydrochloride is a histamine H1 antagonist.
CSN25269 Bromazine HCl 1808-12-4 Bromazine hydrochloride is an antagonist of histamine H1 receptor.
CSN22167 BMY-25271 78441-82-4 BMY-25271 is a histamine H2 receptor antagonist.
CSN25225 Betahistine 5638-76-6 Betahistine is a histamine analog and H1 receptor agonist.
CSN17080 Betahistine 2HCl 5579-84-0 Betahistine 2HCl is histamine H3 receptor inhibitor with IC50 of 1.9 μM. It is an antivertigo drug.
CSN24137 Bepotastine 125602-71-3 Bepotastine is a non-sedating and selective antagonist of the histamine 1 (H1) receptor.
CSN18594 Bavisant 929622-08-2 Bavisant is a highly selective, orally active antagonist of the human H3 receptor with a mechanism of action, involving wakefulness and cognition, with potential as a treatment for ADHD.
CSN18595 Bavisant 2HCl 929622-09-3 Bavisant HCl is a highly selective, orally active antagonist of the human H3 receptor with a mechanism of action, involving wakefulness and cognition, with potential as a treatment for ADHD.
CSN17467 Bavisant 2HCl H2O 1103522-80-0 Bavisant HCl is a highly selective, orally active antagonist of the human H3 receptor with a mechanism of action, involving wakefulness and cognition, with potential as a treatment for ADHD.
CSN16768 Azelastine 58581-89-8 Azelastine is a potent, second-generation, selective, histamine antagonist.
CSN22242 Antihistamine-1 1186430-60-3 Antihistamine-1 is a H1-antihistamine (Ki=6.9 nM) with acceptable blood-brain barrier penetration and also an inhibitor of CYP2D6 and hERG channel with IC50s of 5.4 and 0.8 μM, respectively.
CSN23462 5-Hydroxyindole-3-acetic acid 54-16-0 5-Hydroxyindole-3-acetic acid (5-HIAA), the major metabolite of serotonin, is a histamine H1 receptor antagonist and can be used to treat allergies.
CSN26178 4I 930478-88-9 5-HT3 antagonist-4i is a 5-HT3 receptor antagonist which modulates the serotonergic system.
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