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MEK

MEK

货号 产品名 CAS号 信息
CSN19200 Vacquinol-1 2HCl 1998099-96-9 Vacquinol-1 is an MKK4 activator, which rapidly and selectively induces glioma cell death.
CSN16379 U0126 109511-58-2 U0126 is a highly selective inhibitor of both MEK1 and MEK2, a type of MAPK/ERK kinase.
CSN12171 U0126 Ethanol   1173097-76-1 U0126 ethanol is a highly selective inhibitor of MEK1/2 with IC50 of 0.07 μM/0.06 μM.
CSN13667 Trametinib 871700-17-3 Trametinib is a highly specific and potent MEK1/2 inhibitor with IC50 of 0.92 nM/1.8 nM, no inhibition of the kinase activities of c-Raf, B-Raf, ERK1/2.
CSN16943 Trametinib DMSO Solvate 1187431-43-1 Trametinib DMSO Solvate is a specific MEK1/2 inhibitor with IC50 of 0.92 nM/1.8 nM.
CSN16108 TAK-733 1035555-63-5 TAK-733 is a potent and selective MEK allosteric site inhibitor for MEK1 with IC50 of 3.2 nM, inactive to Abl1, AKT3, c-RAF, CamK1, CDK2, c-Met, etc.
CSN11936 SL327 305350-87-2 SL327 is a cell-permeable vinylogous cyanamide that acts as a selective inhibitor of MEK-1 and MEK-2 (IC50 = 0.18 and 0.22 μM respectively).
CSN12386 Selumetinib   606143-52-6 Selumetinib is a potent, highly selective MEK1 inhibitor with IC50 of 14 nM, also inhibits ERK1/2 phosphorylation with IC50 of 10 nM, no inhibition to p38α, MKK6, EGFR, ErbB2, ERK2, B-Raf, etc.
CSN16380 RO4987655 874101-00-5 RO4987655 is an orally active small molecule, targeting mitogen-activated protein kinase kinase 1 (MAP2K1/MEK1 IC50=5.2 nM), with potential antineoplastic activity.
CSN18581 Refametinib R-Enantiomer 923032-38-6 Refametinib R-enantiomer is the only cyclopropane-1-sulfonamide derivative, and exhibits a highly selective allosteric inhibition of MEK 1/2.
CSN18580 Refametinib 923032-37-5 Refametinib is a specific and non-ATP-competitive MEK 1/2 inhibitor with IC50 values of 19 and 47 nM, respectively.
CSN15896 PF-3644022 1276121-88-0 PF-3644022 is a potent, ATP-competitive inhibitor of mitogen-activated protein kinase (MAPK)-activated protein kinase-2 (MK2) (IC50 = 5.2 nM and Ki = 3 nM). It inhibits tumor necrosis factor α (TNFα) production in U937 monocytic cells and peripheral blood mononuclear cells (PBMCs) (IC50 = 160 nM) and exhibits oral efficacy in acute and chronic inflammatory models.
CSN11663 PD98059   167869-21-8 PD98059 is a non-ATP competitive MEK inhibitor with IC50 of 2 μM, specifically inhibits MEK-1-mediated activation of MAPK and does not directly inhibit ERK1 or ERK2.
CSN16824 PD318088 391210-00-7 PD318088 is a non-ATP competitive allosteric MEK1/2 inhibitor, binds simultaneously with ATP in a region of the MEK1 active site that is adjacent to the ATP-binding site.
CSN20180 PD-184161 212631-67-9 PD184161 is an orally-active MEK inhibitor with antitumor effects in HCC in vitro and in vivo that appear to correlate with suppression of MEK activity.
CSN12886 PD0325901 391210-10-9 PD0325901 is selective and non ATP-competitive MEK inhibitor with IC50 of 0.33 nM.
CSN17709 OTS-964 1338545-07-5 OTS-964 is a TOPK (T-LAK cell originated protein kinase) inhibitor with IC50 value of 28 nM, which can specifically block cytokinesis, leading to apoptosis, in a broad range of cancer cells.
CSN18020 NQDI-1 175026-96-7 NQDI-1 is a selective inhibitor of apoptosis signal-regulating kinase 1 (ASK1) with IC50 of 3 μM and Ki of 500 nM.
CSN22161 MKI 833 863029-99-6 MKI 833 is a small molecule inhibitor of a target signaling molecule of the MEK/MAPK pathway.
CSN19736 MEK1 Inhibitor CL2 40784-65-4 MEK1 inhibitor CL2 exhibits MEK1 binding affinity with IC50 71 nM, which is so far the best result for metal complexes and more potent than U0126(7.02 μM) and AZD6244(2.20 μM).
CSN18222 MEK Inhibitor 334951-92-7 MEK inhibitor is a potent MEK inhibitor, antitumor agent.
CSN16307 GDC-0623 1168091-68-6 GDC-0623 is a selective and ATP-uncompetitive MEK1 inhibitor with Ki value of 0.13 nM.
CSN17263 DTP3 1809784-29-9 DTP3 is a selective GADD45β/MKK7 inhibitor, which inhibits cancer-selective NF-κB survival pathway.
CSN18600 Cobimetinib R-Enantiomer 934660-94-3 Cobimetinib R-enantiomer is the R-enantiomer of cobimetinib, which is a potent, highly selective inhibitor of mitogen-activated protein kinase kinase (MEK1/2).
CSN18601 Cobimetinib Racemate 934662-91-6 Cobimetinib is a potent, highly selective inhibitor of MEK1/2.
CSN15744 Cobimetinib   934660-93-2 Cobimetinib is a potent and highly selective MEK1 inhibitor with IC50 of 4.2 nM, showing more than 100-fold selectively for MEK1 over MEK2 and showed no significant inhibition when tested against a panel of more than 100 of serine-threonine and tyrosine kinases.
CSN13423 CI-1040 212631-79-3 CI-1040 is an ATP non-competitive MEK1/2 inhibitor with IC50 of 17 nM, being 100-fold selective for MEK1/2 than MEK5.
CSN17644 BIX-02189 1265916-41-3 BIX02189 is a selective MEK5/ERK5 inhibitor with an IC50 of 59 nM.
CSN18791 BIX-02189(Random Configuration) 1094614-85-3 BIX-02189(Random Configuration) is a selective and potent inhibitor of both MEK5 and ERK5 with IC50 values of 1.5 and 59 nM, respectively.
CSN18793 BIX-02188(Random Configuration) 1094614-84-2 BIX-02188(Random Configuration) is a potent and selective MEK5 inhibitor with IC50 value of 4.3 nM.
CSN12415 BIX-02188 334949-59-6 BIX-02188 is a selective inhibitor of MEK5 with IC50 of 4.3 nM, also inhibits ERK5 catalytic activity with IC50 of 810 nM, and does not inhibit closely related kinases MEK1, MEK2, ERK2, and JNK2.
CSN17122 AZD8330 869357-68-6 AZD8330 is a selective, non-ATP competitive MEK 1/2 inhibitor with IC50 of 7 nM.
CSN13700 AS-703026   1236699-92-5 AS7-03026 is a highly selective, potent, ATP non-competitive allosteric inhibitor of MEK1/2 with IC50 of 5 nM-2 μM in MM cell lines.
CSN16001 ARRY-162   606143-89-9 ARRY-162 is a potent inhibitor of MEK1/2 with IC50 of 12 nM in a cell-free assay.
CSN18997 APS-2-79 HCl 2002381-31-7 APS-2-79 HCl is a KSR (Kinase suppressor of Ras)-dependent MAPK modulator which can stabilize KSR inactive state with an IC50 value of 120 nM, resulting in inhibition of oncogenic Ras signaling, antagonizing the Ras–MAPK pathway.
CSN22850 HI TOPK 032 487020-03-1
CSN22992 MSC 2032964A 1124381-43-6
CSN23026 PD 334581 548756-68-9
CSN23144 TC ASK 10 1005775-56-3
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