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LPL Receptor

LPL Receptor

货号 产品名 CAS号 信息
CSN22133 W146 909725-61-7 W146 is a selective antagonist of sphingosine-1-phosphate receptor 1 (S1PR1) with an EC50 value of 398 nM.
CSN18599 TY-52156 934369-14-9 TY-52156 is a potent S1P3 receptor antagonist in a competitive manner, and the Ki value is estimated to be 110 nM for S1P3 receptor.
CSN17691 TC-G 1006 1324003-64-6 TC-G 1006 is a potent and orally active S1P1 agonist with EC50 of 18 nM, showing no activity on S1P3.
CSN23705 Sphingosine-1-phosphate 26993-30-6 Sphingosine 1-phosphate is the product of phosphorylation of sphingosine by sphingosine kinase and ligand for EDG-1 and EDG-3 and activator of GPR3, GPR6, and GPR12.
CSN16315 Siponimod 1230487-00-9 Siponimod is a selective S1P1 receptor modulator with EC50 of 0.4 nM, approved for treatment for secondary progressive multiple sclerosis.
CSN10124 SEW2871   256414-75-2 SEW2871 is a potent and selective sphingosine-1-phosphate 1 (S1P1) receptor agonist. Activates S1P1 receptor with an EC50 of 13 nM, but does not activate S1P2, S1P3, S1P4 or S1P5 receptors at concentrations up to 10 μM. Cell-permeable and active in vivo.
CSN19735 RP001 HCl 1781880-34-9 RP001 is a sphingosine-1-phosphate receptor 1 agonist which inhibits tertiary lymphoid tissue reactivation and hypersensitivity in the lung.
CSN12827 Ponesimod 854107-55-4 Ponesimod is a selective S1P1 receptor modulator with EC50 of 5.7 nM, used in the reserch of treatment of multiple sclerosis (MS) and psoriasis.
CSN16206 Ozanimod 1306760-87-1 Ozanimod is an oral, once daily, selective sphingosine 1-phosphate 1 and 5 receptor modulator in development for autoimmune indications including relapsing multiple sclerosis (RMS) and ulcerative colitis (UC).
CSN18971 ONO-7300243 638132-34-0 ONO-7300243 is a potent LPA1 (Lysophosphatidic Acid Receptor) antagonist with an IC50 of 160 nM.
CSN13421 KRP-203 509088-69-1 KRP-203 is a selective Sphingosine-1-phosphate receptor agonist that has been shown to reduce peripheral lymphocyte infiltration and to prolong survival in rat transplant models.
CSN23237 JTE 013 383150-41-2 JTE 013 is a potent, selective S1P2 receptor antagonist with IC50 value of 17.6 nM.
CSN21216 GSK-2018682 1034688-30-6 GSK-2018682 is a sphingosine 1 phosphate receptor (S1PR)-1 agonist potentially for the treatment of multiple sclerosis. GSK-2018682 induced acute, transient and non-symptomatic decreases in heart rate and blood pressure.
CSN12321 Fingolimod 162359-55-9 Fingolimod is a sphingosine 1-phosphate (S1P) antagonist with IC50 of 0.033 nM in K562 and NK cells.
CSN16720 Fingolimod HCl   162359-56-0 Fingolimod hydrochloride is a S1P antagonist with IC50 of 0.033 nM.
CSN20558 CYM-5442 1094042-01-9 CYM-5442 is a highly-selective S1P1 (Spingosine 1-Phosphate Receptor 1) agonist. CYM-5442 reduces the severity of acute GVHD by inhibiting macrophage recruitment.
CSN18842 BMS-986020 1257213-50-5 BMS-986020 is an LPA1 antagonist.
CSN18986 Amiselimod HCl 942398-84-7 Amiselimod hydrochloride is a sphingosine 1-phosphate receptor-1 (S1P1) modulator, designed to reduce the bradycardia effects associated with fingolimod and other S1P receptor modulators.
CSN17715 AM095 1345614-59-6 AM095 is a potent LPA1 receptor antagonist with IC50 values of 0.98 and 0.73 μM for recombinant human or mouse LPA1 respectively.
CSN17359 AM095 Free Acid   1228690-36-5 AM095 free acid is a potent LPA1 receptor antagonist with IC50 values of 0.98 and 0.73 μM for recombinant human or mouse LPA1 respectively.
CSN21223 AKP-11 1220973-37-4 AKP-11 is a S1P1 agonist with immunomodulatory activities.AKP-11 (1.3mg/kg) attenuates EAE disease.
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