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• PvdQ acylase

PvdQ acylase catalyzes the deacylation of acyl-homoserine lactone (AHL or acyl-HSL), releasing homoserine lactone (HSL) and the corresponding fatty acid. It possesses a specificity for the degradation of long-chain acyl-HSLs (side chains of 11 to 14 carbons in length). It degrades 3-oxo-C12-HSL, one of the two main AHL signal molecules of P.aeruginosa, and thereby functions as a quorum quencher, inhibiting the las quorum-sensing system. Therefore, PvdQ acylase may enable P.aeruginosa to modulate its own quorum-sensing-dependent pathogenic potential. Also appears to be required for pyoverdin biosynthesis.

PvdQ acylase

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