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CRM1

CRM1

货号 产品名 CAS号 信息
CSN17781 Verdinexor 1392136-43-4 Verdinexor is an orally bioavailable selective inhibitor of nuclear export (SINE), inhibits nuclear export protein Exportin 1 (XPO1/CRM1) against canine tumor cell lines and also reduce influenza virus replication in vitro and in vivo.
CSN20669 Leptomycin B 87081-35-4 Leptomycin B is an inhibitor of the nuclear export of proteins which acts by binding directly to and inhibiting CRM1/exportin-1. Leptomycin B inhibits the nuclear export of the HIV regulatory protein Rev and stabilizes p53, showing antiviral, antibiotic, antifunal and antitumor in vitro and in vivo.
CSN19083 KPT-8602 Z-Isomer 1642300-78-4 KPT-8602 Z-isomer is an isomer of KPT-8602, which is highly specific for XPO1 inhibition and demonstrates potent anti-leukemic activity.
CSN19082 KPT-8602 1642300-52-4 KPT-8602 is a second-generation and oral acitve exportin-1 (XPO1/CRM1) inhibitor with IC50 of 20−211 nM in 10 AML cell lines.
CSN16156 KPT-330 1393477-72-9 KPT-330, analog of KPT-185, is an orally bioavailable selective CRM1 inhibitor.
CSN17829 KPT-276 1421919-75-6 KPT-276, analog of KPT-185, is a CRM1 blocker and acts as an orally bioavailable selective inhibitor of nuclear export (SINE) by irreversibly binding to CRM1.
CSN17700 KPT-185 1333151-73-7 KPT-185 is a selective CRM1 inhibitor that induces growth inhibition and apoptosis in a panel of NHL cell lines with a median IC50 ~25 nM.
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