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c-Kit

c-Kit

货号 产品名 CAS号 信息
CSN17478 Sitravatinib 1123837-84-2 Sitravatinib is an inhibitor of receptor tyrosine kinase (RTK) involved in driving sarcoma cell growth, is developed for the treatment of cancer.
CSN18514 PLX647 873786-09-5 PLX647 is a highly specific dual FMS/KIT kinase inhibitor with IC50 of 28/16 nM respectively.
CSN17212 Pexidartinib     1029044-16-3 Pexidartinib is a small-molecule receptor tyrosine kinase (RTK) inhibitor of KIT, CSF1R and FLT3 with IC50s of 20, 10, and 160 nM in vitro, respectively.
CSN16409 OSI-930 728033-96-3 OSI-930 is a potent inhibitor of Kit, KDR and CSF-1R with IC50 of 80 nM, 9 nM and 15 nM, respectively and also potent to Flt-1, c-Raf and Lck and low activity against PDGFRα/β, Flt-3 and Abl.
CSN20497 ISCK03 945526-43-2 ISCK03 is a cell-permeable c-Kit inhibitor with IC50 < < 2.5 μM in cell-free kinase assays and blocks SCF-induced c-kit and Erk phosphorylation (1 μM causes > 90% inhibition) without any effect on HGF-induced Erk phosphorylation in 501mel melanoma cells, it's a phenyl-imidazolosulfonamide compound.
CSN16807 Imatinib Mesylate 220127-57-1 Imatinib is a multi-target inhibitor of v-Abl, c-Kit and PDGFR with IC50 of 0.6 μM, 0.1 μM and 0.1 μM, respectively.
CSN11190 Imatinib   152459-95-5 Imatinib is a multi-target inhibitor of v-Abl, c-Kit and PDGFR with IC50 of 0.6 μM, 0.1 μM and 0.1 μM in cell-free or cell-based assays, respectively.
CSN12885 Dovitinib Lactate Hydrate 915769-50-5 Dovitinib lactate is the Lactate of Dovitinib, which is a multitargeted RTK inhibitor, mostly for class III (FLT3/c-Kit) with IC50 of 1 nM/2 nM, also potent to class IV (FGFR1/3) and class V (VEGFR1-4) RTKs with IC50 of 8-13 nM, less potent to InsR, EGFR, c-Met, EphA2, Tie2, IGFR1 and HER2.
CSN12808 Dovitinib Lactate 692737-80-7 Dovitinib lactate is a potent inhibitor of fibroblast growth factor receptor 3 (FGFR3) with an IC50 of 5 nM.
CSN19493 Dovitinib 405169-16-6 Dovitinib is a multitargeted RTK inhibitor, mostly for class III (FLT3/c-Kit) with IC50 of 1 nM/2 nM, also potent to class IV (FGFR1/3) and class V (VEGFR1-4) RTKs with IC50 of 8-13 nM.
CSN19172 Dovitinib Dilactate 852433-84-2 Dovitinib dilactic acid is the dilactic acid of dovitinib, which is a multitargeted RTK inhibitor, mostly for class III (FLT3/c-Kit) with IC50 of 1 nM/2 nM, also potent to class IV (FGFR1/3) and class V (VEGFR1-4) RTKs with IC50 of 8-13 nM, less potent to InsR, EGFR, c-Met, EphA2, Tie2, IGFR1 and HER2.
CSN22109 Ripretinib 1442472-39-0 DCC-2618 is a pan-KIT and PDGFRA inhibitor, and has antitumor activity.
CSN17587 DCC-2618 1225278-16-9 DCC-2618 is a c-Kit and PDGFR inhibitor with IC50s of 6/30/13 nM for c-Kit/PDGFRα/PDGFRβ respectively.
CSN20264 c-KIT/PDGFRα Inhibitor C31 2101755-69-3 c-KIT/PDGFRα inhibitor C31 is a potent, selective stem cell factor receptor/platelet derived growth factor receptor alpha (c-KIT/PDGFRα) dual inhibitor for the treatment of imatinib-resistant gastrointestinal stromal tumors GISTs).
CSN22903 BLU-285 1703793-34-3 BLU-285 is a potent KIT receptor and PDGFRα dual inhibitor with IC50 of 0.27 and 0.24 nM for KIT (D816V) and PDGFRα (D842V) respectively, developed as a highly targeted therapy for SM.
CSN16127 Amuvatinib 850879-09-3 Amuvatinib is a potent and multi-targeted inhibitor that inhibits c-Kit, PDGFRα and Flt3 with IC50 of 10, 40 and 81 nM respectively.
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