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Ras

Ras

货号 产品名 CAS号 信息
CSN16326 ZCL278 587841-73-4 ZCL278 is a modulator of Cdc42 through directly binding to Cdc42 with Kd of 11.4 μM.
CSN15778 XRP44X 729605-21-4 XRP44X is an inhibitor of Ras-Net (Elk-3) pathway with IC50 of 10 nM - 20 nM and could inhibit the phosphorylation of ERK1/ERK2.
CSN17256 RBC8 361185-42-4 RBC8 is an inhibitor of GTPases RalA and RalB with IC50 of 3.5 μM in cell assay.
CSN19268 NSC 23766 733767-34-5 NSC 23766 is a specific inhibitor of the binding and activation of RAC GTPase with IC50 of ~50 μM and does not inhibit the closely related targets, Cdc42 or RhoA.
CSN24050 N-(2,6-Dioxopiperidin-3-yl)-2-phenylacetamide 77658-84-5 N-(2,6-Dioxopiperidin-3-yl)-2-phenylacetamide is the mixture of S- and R- form Antineoplaston A10, which is a Ras inhibitor potentially for the treatment of glioma, lymphoma, astrocytoma and breast cancer.
CSN16332 ML141 71203-35-5 ML141 is a reversible and selective inhibitor of Cdc42 GTPase with IC50 of 200 nM.
CSN18462 MDK-3017 84783-01-7 MDK-3017 is a K-Ras inhibitor, by binding to K-Ras in a hydrophobic pocket that is occupied by Tyr-71 in the apo-Ras crystal structure.
CSN19755 MBQ-167 2097938-73-1 MBQ-167 is a dual Rac and Cdc42 inhibitor, potential to be developed as an anticancer drug.
CSN15978 Kobe2602 454453-49-7 Kobe2602 is an effective small-molecule compound inhibiting Ras–Raf interaction by SBDD exhibiting potent activity to competitively inhibit the binding of H-Ras·GTP to c-Raf-1 RBD with a Ki value of 149 ± 55 μM.
CSN15977 Kobe0065 436133-68-5 Kobe0065 inhibits the binding of H-Ras·GTP to c-Raf-1 RBD with Ki of 46 ± 13 μM.
CSN17973 K-Ras G12C-IN-3 1629268-19-4 K-Ras G12C-IN-3 is an irreversible inhibitor of mutant K-ras G12C.
CSN17972 K-Ras G12C-IN-2 1629267-75-9 K-Ras G12C-IN-2 is an irreversible inhibitor of mutant K-ras G12C.
CSN17971 K-Ras G12C-IN-1 1629265-17-3 K-Ras G12C-IN-1 is an irreversible inhibitor of mutant K-ras G12C.
CSN16411 EHT 1864 754240-09-0 EHT 1864 dihydrochloride is an inhibitor of Rac1 (Kd = 40 nM), Rac1b (Kd = 50 nM), Rac2 (Kd = 60 nM) and Rac3 (Kd = 250 nM).
CSN17155 EHop-016 1380432-32-5 EHop-016 is an inhibitor of Rac1 with IC50 of 1.1 μM in MDA-MB-435 cells.
CSN16977 CASIN 425399-05-9 CASIN is an inhibitor of GTPase Cdc42 with IC50 of 2 μM that can generat a rejuvenated phenotype of HSCs.
CSN17244 BQU57 1637739-82-2 BQU57 shows selective inhibition for Ral relative to Ras or Rho and inhibit xenograft tumor growth similar to depletion of Ral by siRNA.
CSN10366 Azathioprine 446-86-6 Azathioprine can inhibit GTP-binding protein Rac1 activation and purine synthesis. Azathioprine is used to treat organ transplantation and autoimmune diseases.
CSN18987 ARS-853 1629268-00-3 ARS-853 is an inhibitor of KRAS G12C with IC50 of 2.5 μM.
CSN21239 ARS-1630 1698055-86-5 ARS-1630 is a novel inhibitor of mutant K-ras G12C extracted from patent WO 2015054572 A1.
CSN21101 ARS-1620 1698055-85-4 ARS-1620 is an atropisomeric selective KRASG12C inhibitor with desirable pharmacokinetics.
CSN21238 ARS-1323 1698024-73-5 ARS-1323 is a novel inhibitor of mutant K-ras G12C extracted from patent WO 2015054572 A1.
CSN24051 Antineoplaston A10 91531-30-5 Antineoplaston A10 is a Ras inhibitor potentially for the treatment of glioma, lymphoma, astrocytoma and breast cancer.
CSN24158 AMG 510 2296729-00-3 AMG-510 is a potent, orally bioavailable, and selective KRAS G12C covalent inhibitor, which locks KRAS G12C in an inactive GDP-bound state. AMG-510 selectively targets the KRAS p.G12C mutant and shows anti-tumor activity.
CSN18970 6H05 Trifluoroacetate 2061344-88-3 6H05 trifluoroacetate is a selective, and allosteric inhibitor of oncogenic mutant K-Ras (G12C).
CSN17885 6H05 1469338-01-9 6H05 is a selective, and allosteric inhibitor of oncogenic mutant K-Ras (G12C).
CSN24205 1A-116 1430208-73-3 1A-116 is a specific Rac1 inhibitor.
CSN13741 K-Ras(G12C) Inhibitor 12 1469337-95-8
CSN16515 NSC 23766 3HCl 1177865-17-6
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