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ERK

ERK

货号 产品名 CAS号 信息
CSN17855 XMD17-109 1435488-37-1 XMD17-109 is a specific ERK-5 inhibitor with an EC50 4.2 μM in HEK293 cells.
CSN18540 VX-11e 896720-20-0 VX-11e is a potent, selective, and orally bioavailable inhibitor of ERK (Extracellular Signal-Regulated Kinase) and is antitumor agent.
CSN23392 Ulixertinib HCl 1956366-10-1 Ulixertinib HCl, the salt of ulixertinib, is a reversible inhibitor of ERK1/ERK2. It can inhibit cell proliferation.
CSN12111 Tomatidine 77-59-8 Tomatidine, a natural product isolated and purified from the fruits of Lycopersicon esculentum Mill., shows antibiotic activity against small-colony variants of S. aureus, significantly suppresses the activity of ACAT and leads to reduction of atherogenesis. It also inhibits the phosphorylation of ERK, Akt, and the nuclear content of NF-κB.
CSN25710 TMCB 905105-89-7 TMCB is a dual-kinase inhibitor of both casein kinase 2 (CK2) and extracellular-signal-regulated kinase 8 (ERK8) with IC50s of 0.50 μM.
CSN13154 Tauroursodeoxycholate Sodium 35807-85-3 Tauroursodeoxycholate sodium can suppress ERK via PKCα-mediated MKP-1 induction, thus inhibiting neointimal hyperplasia of smooth muscle cells.
CSN17141 Pluripotin 839707-37-8 Pluripotin is a dual inhibitor of extracellular signal-regulated kinase 1 (ERK1, MAPK3) and RasGAP. It maintains embryonic stem cell (ESC) self-renewal.
CSN20623 LY3214996 1951483-29-6 LY3214996 can inhibit ERK1 and ERK2 with IC50s of 5 nM.
CSN22441 KO-947 1695533-89-1 KO-947 is a potent and selective inhibitor of ERK1/2 kinases with potential clinical utility in MAPK pathway dysregulated tumors.
CSN14412 Hirsutenone 41137-87-5 Hirsutenone, a natural product isolated and purified from the eaves of Alnus nepalensis, exhibits anti-cancer effect against prostate cancer through a direct physical inhibition of Akt1/2, attenuates adipogenesis by directly targeting PI3K and ERK during MCE in 3T3-L1 preadipocytes, underscoring the potential therapeutic application of Hirsutenone in preventing obesity, and may exert a preventive effect against microbial endotoxin lipopolysaccharide-induced inflammatory skin diseases through inhibition of ERK pathway-mediated NF-kappaB activation. Hirsutenone showed potent PL(pro) inhibitory activity with IC50 value of 4.1µM.
CSN16271 GDC-0994 1453848-26-4 GDC-0994 is highly selective for ERK1 and ERK2, with IC50 of 1.1 nM and 0.3 nM, respectively.
CSN19017 GDC-0994 HCl 2070009-58-2 GDC-0994 HCl is highly selective for ERK1 and ERK2, with biochemical potency of 1.1 nM and 0.3 nM, respectively.
CSN13064 FR 180204 865362-74-9 FR 180204 is a potent and selective ATP-competitive inhibitor of ERK1 and ERK2 with Ki value of 0.31 μM and 0.14 μM respectively and has IC50 values of 0.51 and 0.33 μM in enzymatic assays against ERK1 and ERK2, respectively.
CSN26645 SKI V 24418-86-8 for hPI3k. SKI V decreases formation of the mitogenic second messenger sphingosine-1-phosphate (S1P). SKI V induces apoptosis and has antitumor activity[1][2].
CSN17601 ERK5-IN-1 1234479-76-5 ERK5-IN-1 exhibits potent inhibition of ERK5 with cellular EC50 values of 0.19 μM and enzymatic IC50 values of 0.087 μM and of LRRK2[G2019S] with enzymatic IC50 values of 0.026μM.
CSN18045 DEL-22379 181223-80-3 DEL-22379 inhibits ERK dimerization with IC50 of 0.5 μM.
CSN13519 Corynoxeine 630-94-4 Corynoxeine is a potent ERK1/2 inhibitor of key PDGF-BB-induced VSMC proliferation, and is a useful and prospective compound in the prevention and treatment for vascular diseases.
CSN22365 CC-90003 1621999-82-3 CC-90003 is an irreversible inhibitor of ERK 1/2 with antitumor activity.
CSN24804 BCI-215   1245792-67-9 BCI-215 is a hyperactivator of fibroblast growth factor signaling that is devoid of developmental toxicity and restores defective MAPK activity caused by overexpression of DUSP1 and DUSP6 in mammalian cells. BCI-215 induced rapid and sustained phosphorylation of extracellular signal-regulated kinase (ERK), p38, and c-Jun N-terminal kinase (JNK) in the absence of reactive oxygen species, and its toxicity was partially rescued by inhibition of p38 but not JNK or ERK.
CSN27196 BAY-885   2307249-33-6 BAY-885 is a highly potent and selective ERK5 inhibitor with IC50 value of 35nM.
CSN21094 AZD0364 2097416-76-5 AZD0364 is an ERK1 and​/or ERK2 kinase for the treatment of cancer.
CSN22695 AX 15836 2035509-96-5 AX 15836 is a potent and selective ERK5 inhibitor with IC50 of 8 nM.
CSN19016 APS-2-79 2002381-25-9 APS-2-79 is an antagonist of MEK phosphorylation by RAF through direct binding of the KSR active site.
CSN21221 AG-126 118409-62-4 AG 126 selectively inhibits the phosphorylation of ERK1 and ERK2 at 25-50 μM.
CSN20372 ADA-07 N/A ADA-07, a T-LAK cell-originated protein kinase (TOPK) inhibitor, is a promising chemopreventive or potential therapeutic agent against SUV-induced skin carcinogenesis that acts by specifically targeting TOPK.
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