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p53

p53

货号 产品名 CAS号 信息
CSN17139 YH239-EE 1364488-67-4 YH239-EE, ethyl ester of the free carboxylic acid compound YH239, is a potent p53-MDM2 antagonizing and apoptosis-inducing agent.
CSN16937 Tenovin-3 1011301-27-1 Tenovin-3 is able to increase p53 levels, determined in MCF-7 cells treated for 6 hr at 10 μM.
CSN15970 Tenovin 1 380315-80-0 Tenovin-1 is an inhibitor of SIRT1 and SIRT2 and an activator of p21 and p53. It protects against MDM2-mediated p53 degradation, which involves ubiquitination, and acts through inhibition of protein-deacetylating activities of SirT1 and SirT2.
CSN13427 JNJ-26854165 881202-45-5 Serdemetan acts as a HDM2 ubiquitin ligase antagonist and also induces early apoptosis in p53 wild-type cells, and inhibits cellular proliferation followed by delayed apoptosis in the absence of functional p53.
CSN11769 PRIMA-1 5608-24-2 PRIMA-1 is a mutant p53 reactivator. It induces apoptosis and inhibits growth of human tumors with mutant p53.
CSN19860 Plumbagin 481-42-5 Plumbagin is an anticancer agent, induces G2/M cell cycle arrest and apoptosis in A549 cells through JNK-dependent p53 Ser15 phosphorylation and inhibits A549 and MDA-MD-231 tumour xenograft growth in nude mice.
CSN22900 PK11007 38275-34-2 PK11007 is a p53 targeting compond anti-tumor activities.
CSN11696 Pifithrin-μ 64984-31-2 Pifithrin-μ is a specific p53 inhibitor by reducing its affinity to Bcl-xL and Bcl-2, and also inhibits HSP70 function and autophagy.
CSN18356 Pifithrin-β 60477-34-1 Pifithrin-β is a potent p53 inhibitor with IC50 of 23 μM in an antiproliferative assay in the human ovarian carcinoma cell line, IGROV-1.
CSN16420 Pifithrin-β Hydrobromide 511296-88-1 Pifithrin-β hydrobromide is a potent p53 inhibitor with IC50 of 23 μM in an antiproliferative assay in the human ovarian carcinoma cell line, IGROV-1.
CSN16583 Pifithrin-α Hydrobromide 63208-82-2 Pifithrin-α hydrobromide is an inhibitor of p53, inhibiting p53-dependent transactivation of p53-responsive genes.
CSN13166 p53 and MDM2 Proteins-interaction-inhibitor Racemic 939983-14-9 p53 and MDM2 proteins-interaction-inhibitor racemate is an inhibitor of the interaction between p53 and MDM2 proteins.
CSN18899 p53 and MDM2 proteins-interaction-inhibitor 2HCl 2070009-27-5 p53 and MDM2 proteins-interaction-inhibitor dihydrochloride is an inhibitor of the interaction between p53 and MDM2 proteins.
CSN12393 p53 and MDM2 Proteins-interaction-inhibitor Chiral 939981-37-0 p53 and MDM2 proteins-interaction-inhibitor chiral is an inhibitor of the interaction between p53 and MDM2 proteins.
CSN16560 NSC 319726 71555-25-4 NSC319726 is a mutant p53R175 reactivator inhibiting growth of fibroblasts expressing the p53R175 mutation (IC50 = 8 nM) and showing no inhibition for p53 wild-type cells.
CSN15898 MI-773 1303607-07-9 MI-773 is an orally available spiro-oxindole HDM2 (human double minute 2) antagonist with potential antineoplastic activity.
CSN17245 Kevetrin HCl 66592-89-0 Kevetrin HCl is an activator of the tumor suppressor protein p53 with potential antineoplastic activity.
CSN20519 CP-31398 2HCl 1217195-61-3 CP-31398 dihydrochloride is a p53 stabilizing agent which stabilizes the active conformation of p53 and promotes p53 activity in cancer cell lines with mutant or wild-type p53.
CSN23315 COTI-2 1039455-84-9 COTI-2 is an orally available thiosemicarbazone and mutant p53 activator with potential antineoplastic activity.
CSN17044 APR-246 5291-32-7 APR-246, is a small organic molecule that has been shown to restore tumour-suppressor function primarily to mutant p53 and also to induce cell death in various cancer types.
CSN17736 AMG-232 1352066-68-2 AMG-232 is a highly potent, selective and orally bioavailable piperidinone inhibitor of the MDM2-p53 interaction ((SPR KD= 0.045 nM, SJSA-1 EdU IC50=9.1 nM).
CSN19769 10-Shogaol 36752-54-2 10-Shogaol, a natural product isolated and purified from the rhizomes of Zingber officinale Rosc., an antioxidant for human skin cell growth and a migration enhancer with potential to be a wound repair agent, has similar metabolic profiles to [6]-shogaol and exhibit similar toxicity toward human colon cancer cells.
CSN23065 RETRA HCl 1173023-52-3
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