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PGE synthesis (prostaglandin E synthase, PGES), which converts cyclooxygenase (COX)-derived prostaglandin (PG) H2 to PGE2, occurs in multiple forms with distinct enzymatic properties, modes of expression, cellular and subcellular localizations and intracellular functions. Cytosolic PGES (cPGES) is a cytosolic protein that is constitutively expressed in a wide variety of cells and tissues and is associated with heat shock protein 90 (Hsp90). Membrane-associated PGES (mPGES), the expression of which is stimulus-inducible and is downregulated by anti-inflammatory glucocorticoids, is a perinuclear protein belonging to the microsomal glutathione S-transferase (GST) family.

PG Synthase

货号 产品名 CAS号 信息
CSN12019 Suprofen 40828-46-4 Suprofen is a COX1/2 inhibitor and a non-steroidal anti-inflammatory drug (NSAID).
CSN16384 Pranoprofen 52549-17-4 Pranoprofen is a non-steroidal COX inhibitor with anti-inflammatory effects, used in treatment of ophthalmology.
CSN12831 HPGDS Inhibitor 1 1033836-12-2 HPGDS inhibitor 1 is a selective Hematopoietic Prostaglandin D Synthase (HPGDS) inhibitor with an IC50 Value of 0.7 nM.
CSN11044 Flurbiprofen 5104-49-4 Flurbiprofen is a nonsteroidal anti-inflammatory agent (NSAIA) with antipyretic and analgesic activity.
CSN10466 Bismuth Subsalicylate 14882-18-9 Bismuth subsalicylate is the active ingredient in Pepto-Bismol and inhibits prostaglandin G/H Synthase 1/2.
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