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E1/E2/E3 Enzyme

E1/E2/E3 Enzyme

货号 产品名 CAS号 信息
CSN20606 VH-298 2097381-85-4 VH-298 is a highly affinity inhibitor of E3 ubiquitin ligase VHL inhibitor (Kd = 80-90 nM) which can block the interaction of VHL and HIF-α, thus initiating hypoxic response.
CSN20441 UbcH5c Inhibitor C6d N/A UbcH5c inhibitor C6d exhibits potent anti-inflammatory activity against complete Freund's adjuvant-induced adjuvant arthritis in vivo and is a promising lead compound for the development of anti-rheumatoid arthritis (RA) agent.
CSN17382 TZ9 1002789-86-7 TZ9 is an inhibitor of Rad6 ubiquitin conjugating enzyme (E2 enzyme) and inhibits MDA-MB-231 cell proliferation with IC50 of ~6 μM.
CSN22266 E3 Ligand-Linker Conjugate 10 1957236-22-4 Thalidomide-O-amido-PEG4-C2-Amine is a PROTAC block consist of Thalidomide and a linker with Amine functional group for conjugation reactions.
CSN22269 E3 Ligand-Linker Conjugate 9 1957236-20-2 Thalidomide-O-amido-PEG3-C2-Amine is a PROTAC block consist of Thalidomide and a linker with an Amine functional group for conjugation reactions.
CSN22270 E3 Ligand-Linker Conjugate 8 1957235-74-3 Thalidomide-O-amido-PEG2-C2-Amine is a PROTAC block consist of Thalidomide and a linker with Amine functional group for conjugation reactions.
CSN22271 E3 Ligand-Linker Conjugate 7 2022182-59-6 Thalidomide-O-amido-PEG-C2-Amine is a PROTAC block consist of Thalidomide and a linker with Amine functional group for conjugation reactions.
CSN22274 E3 Ligand-Linker Conjugate 3 1799711-24-2 Thalidomide-O-amido-C4-Amine is a PROTAC block consist of Thalidomide linked to alkyl with Amine functional group for conjugation reactions.
CSN22272 E3 Ligand-Linker Conjugate 6 2022182-57-4 Thalidomide-O-amido-C3-Amine is a PROTAC block consist of Thalidomide linked to alkyl with Amine functional group for conjugation reactions.
CSN22519 Teslexivir 1075798-37-6 Teslexivir is a topical antiviral agent that is a potent and selective inhibitor of the interaction between two essential viral proteins, E1 and E2, an interaction that is a necessary step for Human Papilloma Virus (HPV) 6 and 11 DNA replication and thus viral production.
CSN21424 E3 ligase Ligand 3 1061605-21-7 TC E3 5031 is a thalidomide derivate for conjugation reactions of PROTAC, which can hijack cereblon as the E3 ubiquitin ligase component.
CSN24144 TAK-981 1858276-04-6 TAK-981 is a first in class and selective inhibitor of the SUMOylation enzymatic cascade, with potential immune-activating and antineoplastic activities.
CSN17260 SZL P1-41 222716-34-9 SZL P1-41 is Skp2 inhibitor, selectively suppresses Skp2 E3 ligase activity, but not activity of other SCF complexes.
CSN16569 PYZD-4409 423148-78-1 PYZD-4409 is a small molecule inhibitor of Ubiquitin-activating enzyme UBA1/E1 enzyme with an IC50 of 20 μM (cell-free enzymatic assay).
CSN18199 PRT4165 31083-55-3 PRT4165, an inhibitor of bim1 and ring1A, could block PRC1 (Polycomb-repressive complex 1)-mediated H2A ubiquitylation.
CSN22492 PROTAC Linker 1 1835705-53-7 PROTAC Linker 1 is a linker used to link the warhead and the E3 ligase ligand.
CSN17303 NSC 697923 343351-67-7 NSC 697923 is a cell-permeable and selective inhibitor of the Ub-conjugating enzyme (E2) complex Ubc13-Uev1A.
CSN20617 ML-792 1644342-14-2 ML-792 is a mechanism-based SUMO-activating enzyme (SAE) inhibitor with nanomolar potency in cellular assays, which selectively blocks SAE enzyme activity and total SUMOylation, thus decreasing cancer cell proliferation.
CSN20357 MDK7526 1448297-52-6 MDK7526 is a ligand of Von Hippel–Lindau protein, that can be used for making proteolysis targeting chimeras (PROTACs).
CSN22273 E3 Ligand-Linker Conjugate 4 2093388-45-3 Lenalidomide-C5-Amine is a PROTAC block consist of Lenalidomide linked to alkyl with Amine functional group for conjugation reactions.
CSN22267 E3 Ligand-Linker Conjugate 5 2093388-69-1 Lenalidomide-C4-Amine is a PROTAC block consist of Lenalidomide linked to alkyl with Amine functional group for conjugation reactions.
CSN22427 HaloPROTAC 1 1799506-06-1 HaloPROTAC 2 is a PROTAC block consist of VH032 and a linker with chlorine functional group for conjugation reactions.
CSN21237 E3 Ligase Ligand 6 1631137-51-3 E3 Ligase Ligand 6 is used for conjugation reactions of PROTAC, which can hijack VHL as the E3 ubiquitin ligase component.
CSN21420 E3 ligase Ligand 2 5054-59-1 E3 ligase Ligand 2 is a thalidomide derivate for conjugation reactions of PROTAC, which can hijack cereblon as the E3 ubiquitin ligase component.
CSN21252 E3 Ligase Ligand 1A 1948273-02-6 E3 ligase Ligand 1A is a VH032 derivate for conjugation reactions of PROTAC, which can hijack VHL as the E3 ubiquitin ligase component.
CSN17689 CC0651 1319207-44-7 CC0651 is an allosteric inhibitor of the human cdc34 ubiquitin-conjugating enzyme that potently (IC50 = 1.72 μM) inhibited the ubiquitination of p27 Kip1.
CSN22248 CC-885 1010100-07-8 CC-885 is a cereblon (CRBN) modulator with potent anti-tumour activity.
CSN19693 CC-220 1323403-33-3 CC-220 is a modulator of cereblon that is potential to treat systemic lupus erythematosis and multiple myeloma.
CSN15860 CC-122 1015474-32-4 CC-122, also known as avadomide, binds to CRBN and induces degradation of aiolos and ikaros that result in cell apoptosis. It is a antitumor and immunomodulatory agent used to treat DLBCL.
CSN15975 PYR-41 418805-02-4
CSN21083 TAK-243 1450833-55-2
CSN23792 VL285 1448188-57-5
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