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Sirtuin

Sirtuin

货号 产品名 CAS号 信息
CSN25238 UBCS039   358721-70-7 UBCS039 is a specific Sirtuin 6 activator which showed robust activating effects on Sirt6-dependent H3K18ac deacetylation of both full-length histone proteins and complete HeLa nucleosomes.
CSN15867 Tenovin-6 1011557-82-6 Tenovin-6 is the water soluble analog of Tenovin-1 and acts as a potent SIRT1 (IC50=21 μM) and SIRT2 (IC50= 10 μM) inhibitor as well as p53 activator.
CSN18940 SRT3025 HCl 2070015-26-6 SRT3025 HCl is an orally available sirtuin modulator.
CSN24314 SRT1720 2HCl 1001645-58-4 SRT1720 2HCl is a selective SIRT1 activator.
CSN25631 SRT1460 925432-73-1 SRT1460 is a SIRT1 activator with EC50 value of 2.9μM in an in vitro fluorescence polarization assay.
CSN25457 OSS_128167 887686-02-4 OSS_128167 is a potent selective sirtuin 6 (SIRT6) inhibitor with IC50s of 89 μM, 1578 μM and 751 μM for SIRT6, SIRT1 and SIRT2, respectively. OSS_128167 has anti-HBV activity that inhibits HBV transcription and replication. OSS_128167 has anti-cancer, anti-inflammation and anti-viral effects.
CSN16796 Nicotinamide 98-92-0 Nicotinamide can act as an inhibitor of sirtuins and it is the active component of NAD and NADP.
CSN18677 Fisetin 528-48-3 Fisetin is an active flavonol that can be used in the synthesis of pharmaceutical with anti-inflammatory and antiproliferative activities.
CSN16491 AK-7 420831-40-9 AK-7 is a selective and brain-permeable SIRT2 inhibitor and is neuroprotective in Huntington disease mouse models.
CSN13831 AGK2 304896-28-4 AGK2 is a potent, and selective SIRT2 inhibitor with IC50 of 3.5 μM that minimally affects either SIRT1 or SIRT3 at 10-fold higher levels.
CSN20654 3-TYP 120241-79-4 3-TYP is a selective inhibitor of SIRT3.
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