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Sirtuin

Sirtuin

货号 产品名 CAS号 信息
CSN20494 Thiomyristoyl 1429749-41-6 Thiomyristoyl is an inhibitor of Sirt2 and Sirt1 with IC50 of 28 nM, 98 μM.
CSN15867 Tenovin-6 1011557-82-6 Tenovin-6 is the water soluble analog of Tenovin-1 and acts as a potent SIRT1 (IC50=21 μM) and SIRT2 (IC50= 10 μM) inhibitor as well as p53 activator.
CSN17390 Tenovin 6 HCl 1011301-29-3 Tenovin 6 hydrochloride is the water soluble analog of Tenovin-1 and acts as a potent SIRT1 (IC50=21 μM) and SIRT2 (IC50= 10 μM) inhibitor as well as p53 activator.
CSN18940 SRT3025 HCl 2070015-26-6 SRT3025 hydrochloride is an orally available sirtuin modulator.
CSN19241 SRT2183 1001908-89-9 SRT2183 is a small-molecule activator of the sirtuin subtype SIRT1.
CSN17459 SRT2104 1093403-33-8 SRT2104 is an activator of SIRT1 which is involved in the regulation of energy homeostasis.
CSN12823 SRT1720 925434-55-5 SRT1720 is a selective activator of human SIRT1 (EC1.5 = 0.16 μM) versus the closest sirtuin homologues, SIRT2 and SIRT3 (SIRT2: EC1.5 = 37 μM;SIRT3: EC1.5 > 300 μM).
CSN24314 SRT1720 2HCl N/A SRT1720 2HCl is a selective SIRT1 activator.
CSN12889 Splitomicin 5690-03-9 Splitomicin is a selective NAD(+)-dependent histone deacetylase Sir2p inhibitor with IC50 of 60 μM, showing a higher activity in a cell-based assay.
CSN20027 Sirtuin Inhibitor C18 1392810-44-4 Sirtuin inhibitor C18 is a histone deacetylase class III inhibitor of sirtuin 1 and 2 exerting antiproliferative activity against cancer cell lines.
CSN12523 Sirtinol 410536-97-9 Sirtinol is a specific SIRT1 and SIRT2 inhibitor with IC50 of 131 μM and 38 μM in cell-free assays, respectively.
CSN19216 SirReal2 709002-46-0 SirReal2 is a potent and selective Sirt2 inhibitor with IC50 of 140 nM.
CSN18937 Salermide 1105698-15-4 Salermide, a reverse amide, can act as an inhibitor of sirt, especially of sirt2, with the property of inducing apoptosis of tumor cells.
CSN22311 Sirt2-PROTAC-1 2098487-75-1 PROTAC Sirt2 Degrader-12 is a PROTAC selectively targeting on Sirt2, consist an isotype-selective Sirt2 inhibitor SirReal as a warhead linked to cereblon ligand thalidomide.
CSN16796 Nicotinamide 98-92-0 Nicotinamide can act as an inhibitor of sirtuins and it is the active component of NAD and NADP.
CSN15959 Inauhzin 309271-94-1 Inauhzin is a small molecule that effectively reactivates p53 by inhibiting SIRT1 activity, and promotes p53-dependent apoptosis of human cancer cells without causing apparently genotoxic stress (IC50=3 μM, in A549 cell).
CSN18677 Fisetin 528-48-3 Fisetin is an active flavonol that can be used in the synthesis of pharmaceutical with anti-inflammatory and antiproliferative activities.
CSN15833 EX-527 S-Enantiomer 848193-68-0 EX-527 S-enantiomer is a potent and selective SIRT1 inhibitor with IC50 of 123 nM, showing no inhibition on SIRT3 and SIRT3.
CSN15817 EX-527 R-Enantiomer 848193-69-1 EX-527 R-enantiomer is the R-enantiomer of EX-527. EX-527 is a potent and selective SIRT1 inhibitor with IC50 of 38 nM. EX-527 has much lower potency against SIRT2 (IC50, 19.6 μM) or SIRT3 (IC50, 48.7 μM).
CSN10146 EX-527 49843-98-3 EX-527 is a potent and selective SIRT1 inhibitor with IC50 of 38 nM, exhibits > 200-fold selectivity against SIRT2 and SIRT3.
CSN23882 MDL-800   2275619-53-7 DL-800 is an allosteric and selective SIRT6 activator with EC50 of 10.3μM.
CSN16491 AK-7 420831-40-9 AK-7 is a selective and brain-permeable SIRT2 inhibitor and is neuroprotective in Huntington disease mouse models.
CSN21121 AK-1 330461-64-8 AK-1 is a cell permeable, benzylsulfonamide that inhibits SIRT2 activity (IC50= 12.5 µM through enzymatic assay) by targeting the SIRT2 nicotinamide binding site, but may also target SIRT1 and SIRT3 (IC50 >40 µM) with much less potency.
CSN13831 AGK2 304896-28-4 AGK2 is a potent, and selective SIRT2 inhibitor with IC50 of 3.5 μM that minimally affects either SIRT1 or SIRT3 at 10-fold higher levels.
CSN20654 3-TYP 120241-79-4 3-TYP is a selective inhibitor of SIRT3.
CSN15828 SRT1720 HCl 1001645-58-4
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