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货号 产品名 CAS号 信息
CSN25739 ZK 164015 177583-70-9 ZK 164015 is an antagonist of estrogen receptor. It inhibits 17β-estradiol stimulation of luciferase activity with IC50 of 0.025 μM.
CSN22522 TR antagonist 1 500794-88-7 TR antagonist 1 is a high-affinity thyroid hormone receptor (TR) antagonist with IC50s of 36 and 22 nM for TRα and TRβ, respectively.
CSN22304 SNIPER(ER)-110 2241690-03-7 SNIPER(ER)-110 is a nongenetic IAP-dependent protein eraser (SNIPER) targeting estrogen receptor α (ERα), induces ERα degradation and induces apoptosis in MCF-7 human breast cancer cells; inhibits the growth of MCF-7 tumor xenografts in mice more potently than the previously characterized SNIPER(ER)-87, preferentially recruits XIAP, rather than cIAP1, to degrade ERα.
CSN21407 MPP 2HCl 911295-24-4 Selective, high affinity silent antagonist at ERα receptors. Displays > 200-fold selectivity for ERα over ERβ. Ki values are 2.7 and 1800 nM at ERα and ERβ receptors respectively.
CSN23201 Y134 849662-80-2 Selective estrogen receptor modulator (SERM), selective for ERα
CSN17566 Protirelin acetate 120876-23-5 Protirelin is used to test the response of the anterior pituitary gland.
CSN28462 PROTAC ERα Degrader-2 1351169-29-3 PROTAC ERα Degrader-2 comprises a cIAP1 ligand binding group, a linker and an estrogen receptor α (ERα) binding group. PROTAC ERα Degrader-2 is an ERα degrader. Maximal ERα degradation at 30 μM concentration in human mammary tumor MCF7 cells. Degradation inducers based on cIAP1 are called specific and non-genetic IAP-dependent protein erasers (SNIPERs).
CSN24005 PROTAC ERα Degrader-1 N/A PROTAC ERα Degrader-1 is a PROTAC targeting ERα.
CSN28481 PROTAC ERRα Degrader-2 2306388-85-0 PROTAC ERRα Degrader-2 comprises a MDM2 ligand binding group, a linker and an estrogen-related receptor alpha (ERRa) binding group. PROTAC ERRα Degrader-2 is an estrogen-related receptor alpha (ERRa) degrader.
CSN28500 PROTAC ERRα Degrader-1 2306388-84-9 PROTAC ERRα Degrader-1 comprises a MDM2 ligand binding group, a linker and an estrogen-related receptor alpha (ERRa) binding group. PROTAC ERRα Degrader-1 is an PROTAC estrogen-related receptor alpha (ERRa) degrader.
CSN28497 PROTAC ER Degrader-4 2361114-15-8 PROTAC ER Degrader-4 is a PROATC estrogen receptor (ER) degrader, binding to ER with an IC50 of 0.8 nM. PROTAC ER Degrader-4 induces ER degradation in MCF-7 cells with an IC50 of 0.3 nM.
CSN26190 Propyl pyrazole triol 263717-53-9 Propyl pyrazole triol (PPT) is a selective estrogen receptor alpha (ERα) agonist. The relative binding affinity of Propyl pyrazole triol for ERα (ERα: 49%) around 410 times higher compared with estrogen receptor beta (ERβ: 0.12%). PPT also exerts anti-diabetic effects in mouse models.
CSN22305 PAC 2158322-33-7 PAC1 (Compound PAC1) is a PROTAC antibody conjugate, more potent estrogen receptor-alpha (ERα) degrader compared to PROTAC without antibody conjugation.
CSN19099 2-(3,5-Dichloro-4-((5-isopropyl-6-oxo-1,6-dihydropyridazin-3-yl)oxy)phenyl)-3,5-dioxo-2,3,4,5-tetrahydro-1,2,4-triazine-6-carbonitrile 920509-32-6 MGL-3196 is a selective thyroid hormone receptor β agonist with EC50s of 0.21 and 3.74 µM for TRβ and TRα respectively.
CSN23280 Lynestrenol 52-76-6 Lynestrenol is a progesterone receptor agonist. It is synthetic progestational hormone.
CSN33124 Lasofoxifene 180916-16-9 Lasofoxifene is a non-steroidal selective estrogen receptor modulator (SERM).
CSN19318 L-Thyroxine sodium salt pentahydrate 6106-07-6 L-Thyroxine sodium is an iodine containing hormone produced from thyroglobulin in the thyroid follicular cells and reduces total cholesterol level, low-density lipoprotein cholesterol as well as waist to hip ratio in subclinical hypothyroidism pateints.
CSN12271 (S)-2-Amino-3-(4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl)propanoic acid 51-48-9 L-Thyroxine is an iodine-containing hormone produced from thyroglobulin in the thyroid follicular cells.
CSN26546 GSK5182 877387-37-6 GSK5182 is a specific inverse agonist for estrogen-related receptor γ.
CSN22842 GSK-4716 101574-65-6 GSK4716 is an agonist of ERRβ/γ with IC50 of 2 µM with similar potency as the protein ligand PGC-1α.
CSN26648 Giredestrant tartrate 2407529-33-1 Giredestrant tartrate (GDC-9545 tartrate), a non-steroidal ER ligand, is an orally active and selective estrogen receptor (ER) antagonist. Giredestrant tartrate potently competes with estradiol for binding and induces a conformational change within the ER ligand binding domain. Anti-tumor activity[1].
CSN26647 Giredestrant 1953133-47-5 Giredestrant (GDC-9545), a non-steroidal ER ligand, is an orally active and selective estrogen receptor (ER) antagonist. Giredestrant potently competes with estradiol for binding and induces a conformational change within the ER ligand binding domain. Giredestrant has anti-tumor activity[1].
CSN21091 GDC-0927 1642297-01-5 GDC-0927, also known as SRN-927, is a next-generation oral SERD, appears to have greater potential than GDC-0810 to be a best-in-class SERD molecule.
CSN22408 GC 14 447415-34-1 GC 14 is a selective agonist of thyroid hormone β1 activation (TRβ1) with an EC50 of 680 nM.
CSN22817 FERb 033 1111084-78-6 FERb 033 is a potent and selective ERβ receptor agonist with Ki of 7.1 nM and EC50 of 4.8 nM.
CSN25302 Estrogen receptor modulator 1 63676-22-2 Estrogen receptor modulator 1 is an orally active and selective estrogen receptor modulator (SERM), with a pIC50 of 0.46. It has been found to be both estrogenic and antiproliferative in ER-positive endocrine-resistant breast cancer cell lines that overexpress protein kinase C alpha (PKCα).
CSN24698 PROTAC ERRα ligand 2 2306388-57-6 ERRα degrader ligand 4a block the protein-protein interaction of ERRα with PGC-1α coactivator with IC50 value of 5.67nM in a TR-FRET assay.
CSN27511 ERRα antagonist-1 1072145-33-5 ERRα antagonist-1 (Compound A) is a selective and high affinity estrogen-related receptor α (ERRα) antagonist. ERRα antagonist-1 inhibits interaction of ERRα with Proliferator-activated Receptor γ Coactivator-1α (PGC-1α) and PGC-1β, the IC50 values are 170 nM and 180 nM, respectively. ERRα antagonist-1 does not inhibit the interaction of either ERRβ or ERRγ with PGC-1α and PGC-1β coactivator, and also does not inhibit interaction of ERα or ERβ with PGC-1α or SRC-1.
CSN22143 ERB-196 550997-55-2 ERB-196 is a nonsteroidal selective estrogen receptor-β (ERβ) agonist.
CSN22801 Eeyarestatin I 412960-54-4 Eeyarestatin I is a potent inhibitor of endoplasmic reticulum associated protein degradation (ERAD).
CSN27510 Dihydroresveratrol 58436-28-5 Dihydroresveratrol, a potent phytoestrogen, is a hormone receptor modulator. Dihydroresveratrol exhibits proliferative effects in androgen-independent prostate and breast cancer cells at picomolar and nanomolar concentrations.
CSN21522 Bifluranol 34633-34-6 Bifluranol is a synthetic nonsteroidal estrogen of the stilbestrol group related to diethylstilbestrol that has been used as an antiandrogen in the United Kingdom in the treatment of benign prostatic hyperplasia.
CSN27628 Camizestrant 2222844-89-3 AZD-9833 is a potent and orally active estrogen receptor (ER) antagonist. AZD-9833 is used for the study of ER+ HER2-advanced breast cancer[1].
CSN22351 Arzoxifene HCl 182133-27-3 Arzoxifene hydrocloride is a selective estrogen receptor modulator that is a potent estrogen antagonist in mammary and uterine tissue while acting as an estrogen agonist to maintain bone density and lower serum cholesterol.
CSN28406 ARV-471 2614417-52-4 ARV-471 is the first-clinical-entered ERα PROTAC degrader with DC50 of ~1nM. It degrades clinically-relevant ESR1 variants (Y537S and D538G) and inhibits growth of cell lines expressing those variants.
CSN32897 Amcenestrant 2114339-57-8 Amcenestrant is an orally active, nonsteroidal and selective estrogen receptor degrader (SERD).
CSN26189 4-(1-(4-(2-(Dimethylamino)ethoxy)phenyl)-2-phenylbut-1-en-1-yl)phenol   68392-35-8 Afimoxifene is the active metabolite of tamoxifen and a selective estrogen receptor (ER) modulator that is widely used in the therapeutic and chemopreventive treatment of breast cancer. Afimoxifene is a potent activator of ER and has been shown to have a higher affinity for estrogen receptors compared to tamoxifen. It has significant dose and time-dependent direct effects to alter the contractile function of isolated adult rat cardiac myocytes. This product has no specified isomer.
CSN22335 Acolbifene 182167-02-8 Acolbifene (EM652) is a fourth-generation selective estrogen receptor antagonist with a LC50 value of 22±3 nM.
CSN22663 AC-186 1421854-16-1 AC 186 is a potent and selective ERβ agonist with EC50 of 6 nM.
CSN22105 (Z)-4-(1-(4-(2-(Dimethylamino)ethoxy)phenyl)-2-phenylbut-1-en-1-yl)phenol 68047-06-3 4-Hydroxytamoxifen is the active metabolite of tamoxifen and a selective estrogen receptor (ER) modulator that is widely used in the therapeutic and chemopreventive treatment of breast cancer.
CSN22102 p,p'-DDE 72-55-9 4,4-DDE is an organochlorine pesticide and may behave as a potent androgen receptor antagonist.
CSN22628 (R,R)-THC 138090-06-9 (R,R)-THC is a selective estrogen receptor ligand that agonist at ERα receptor (Ki = 9.0 nM) and antagonist at ERβ receptor (Ki = 3.6 nM).
CSN21921 (R)-Equol 221054-79-1 (R)-Equol is an agonist of both ERα and ERβ with Kis of 27.4 and 15.4 nM, respectively.
CSN38973 (E)-3-(4-((E)-1-(4-Hydroxyphenyl)-2-phenylbut-1-en-1-yl)phenyl)acrylic acid 195611-82-6
CSN37248 17,17-(Ethylenedioxy)androst-4-en-3-one 1044-89-9
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