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NF-κB

NF-κB

货号 产品名 CAS号 信息
CSN10425 Wogonoside 51059-44-0 Wogonoside is a natural product isolated and purified from the herbs of Scutellaria baicalensis Georgi.
CSN14055 Velutin 25739-41-7 Velutin, a natural product isolated and purified from the leaves of Vernonia flexuosa with anti-inflammatory property, exhibits the greatest potency among all flavones in reducing TNF-α and IL-6 production and shows the strongest inhibitory effect in nuclear factor (NF)-κB activation and exhibits the greatest effects in blocking the degradation of inhibitor of NF-κB as well as in inhibiting mitogen-activated protein kinase p38 and JNK phosphorylation.
CSN12111 Tomatidine 77-59-8 Tomatidine, a natural product isolated and purified from the fruits of Lycopersicon esculentum Mill., shows antibiotic activity against small-colony variants of S. aureus, significantly suppresses the activity of ACAT and leads to reduction of atherogenesis. It also inhibits the phosphorylation of ERK, Akt, and the nuclear content of NF-κB.
CSN12011 Sulfasalazine 599-79-1 Sulfasalazine is a potent and specific NF-κB inhibitor and also inhibits system Xc and induces ferroptosis.
CSN23322 (S)-1,1-Dimethylpyrrolidin-1-ium-2-carboxylate 471-87-4 Stachydrine is a major constituent of Chinese herb leonurus heterophyllus sweet used to promote blood circulation and dispel blood stasis. Stachydrine can inhibit the NF-κB signal pathway.
CSN16392 Sodium Salicylate 54-21-7 Sodium Salicylate is anti-inflammatory drugs which can inhibit the activation of NF-kappa B.
CSN19187 SC75741 913822-46-5 SC75741 is a novel NF-kappaB inhibitor.
CSN16105 Sarsasapogenin 126-19-2 Sarsasapogenin, a natural product isolated and purified from the rhizomes of Anemarrhena asphodeloides Bunge with anti-inflammatory, anti-diabetes,antidepressant, antitumor and protective effects, against glutamate-induced neurotoxicity in the cultured cortical neurons in rats, can improve memory by elevating the low muscarinic acetylcholine receptor density in brains of memory-deficit rat models, and effectively promote the proliferation, differentiation and mineralization of osteoblasts cultured in vitro, also inhibit the generation of osteoclasts from marrow cells.
CSN27534 Quinoclamine 2797-51-5 Quinoclamine, a naphthoquinone derivative, is a NF-κB inhibitor. Quinoclamine exhibits anti-cancer activity.
CSN12289 QNZ 545380-34-5 QNZ can inhibit the activation of NF-κB and the production of TNF-α with IC50 of 11 nM and 7 nM, respectively.
CSN18699 Parthenolide 20554-84-1 Parthenolide is a sesquiterpene lactone from the plant feverfew (T. parthenium) with multiple biological functions. Parthenolide inhibits the growth of the promastigote form of L. amazonensis with IC50 of 3.6 μg/mL, induces apoptosis in cancer cells and blocks inflammation by inhibiting signaling through NF-κB.
CSN20622 NIK Inhibitor C33 1451079-18-7 NIK inhibitor C33 is a high-selective inhibitor of tricyclic NF-κB inducing kinase (NIK) over PI3K.
CSN20621 NIK Inhibitor C32 1555655-78-1 NIK inhibitor C32 is a high-selective inhibitor of tricyclic NF-κB inducing kinase (NIK) over PI3K.
CSN11532 Neferine 2292-16-2 Neferine, is a major alkaloid present in the green embryos of Nelumbo nucifera Gaertn with anti-arrhythmia, anti-hypertensive and vaso-relaxant properties , and is also a NF-κB inhibitor.
CSN12446 Magnolol 528-43-8 Magnolol is a multifunctional compound isolated from the Chinese medicinal plant Magnolia officinalis, with antifungal, antibacterial and antioxidant effects, as well as anti-inflammatory activity by interferring with NF-κB signaling and inhibiting IL-6-induced STAT3 activation.
CSN12507 Lipoic Acid 1200-22-2 Lipoic Acid can inhibit TNF-alpha-induced NF-kappaB activation.
CSN16019 JSH-23 749886-87-1 JSH-23 is an inhibitor of NF-κB transcriptional activity with IC50 of 7.1 μM in RAW 264.7 cell line.
CSN14611 Isochamaejasmine 93859-63-3 Isochamaejasmine, a natural product isolated and purified from the roots of Stellera chamaejasme Linn., has inhibition of NF-kappaB activation reversed the anti-apoptotic effect, shows antiplasmodial activity, with an IC(50) of 7.3+/-3.8 mM, but the selectivity was rather limited, and induces apoptosis in leukemia cells by inhibiting the activity of Bcl-2 family proteins, providing evidence for further studying the underlying anti-cancer mechanism of S.
CSN23067 Ro 106-9920 62645-28-7 Inhibitor of NF-κB activation
CSN21426 GSK-963 2049868-46-2 GSK'963 inhibits RIP1-dependent cell death with an IC50 of between 1 and 4 nM in human and murine cells.
CSN23601 Ethyl caffeate 102-37-4 Ethyl caffeate shows suppressesion of NF-κB activation and its downstream inflammatory mediators. It can be found in bidens pilosa.
CSN14581 Eriocalyxin B 84745-95-9 Eriocalyxin B, a natural product isolated and purified from the herbs of Isodon eriocalyx, is a potent NF-kappaB inhibitor, can inhibit the NF-kappaB transcriptional activity but not that of cAMP response element-binding protein.
CSN15678 Epifriedelanol 16844-71-6 Epifriedelanol, a natural product isolated and purified from the herbs of Vitis trifolia with antitumor activity, exhibits significant inhibition of NF-kappa B, it may be used to treat asthma, and suppresses adriamycin-induced cellular senescence as well as replicative senescence in human fibroblasts (HDFs) and human umbilical vein endothelial cells (HUVECs), suggesting that it can reduce cellular senescence in human primary cells and may be used to develop dietary supplements or cosmetics that modulate tissue aging or aging-associated diseases.
CSN21353 Edasalonexent 1204317-86-1 Edasalonexent is an orally bioavailable NF-κB inhibitor.
CSN10802 Diethyl Maleate 141-05-9 Diethylmaleate is the diethyl ester of maleic acid and a glutathione-depleting compound that inhibits NFkB.
CSN18398 Didox 69839-83-4 Didox can prevent LPS-induced NF-KB activation and translocation of NF-kappa beta p65 subunits.
CSN19920 Dehydrodiisoeugenol 2680-81-1 Dehydrodiisoeugenol, a natural product isolated and purified from the seeds of Myristica fragrans Houtt.
CSN10751 Dauricine 524-17-4 Dauricine is a plant metabolite, chemically classified as a phenol, an aromatic ether, and an isoquinoline alkaloid.
CSN23316 Curcumenol 19431-84-6 Curcumenol inhibits NF-κB activation by suppressing the nuclear translocation of the NF-κB p65 subunit and blocking IκBα phosphorylation and degradation.
CSN14238 Coronarin D 119188-37-3 Coronarin D, a natural product isolated and purified from the rhizomes of Hedychium coronarium, inhibits NF-κB activation pathway, which leads to inhibition of inflammation, invasion, and osteoclastogenesis, as well as potentiation of apoptosis.
CSN15792 CID-2858522 758679-97-9 CID-2858522 selectively inhibits the NF-κB pathway (IC50 < 0.1 μM for PMA-stimulated IL-8 production) induced by PKC, operating downstream of PKC but upstream of IKKbeta, without inhibiting other NF-kappaB activation pathways.
CSN22315 CBL0137 HCl 1197397-89-9 CBL0137 HCl is a metabolically stable curaxin that activates p53 with an EC50 value of 0.37 µM and inhibits NF-κB with an EC50 of 0.47 µM.
CSN10538 Caffeic Acid Phenethyl Ester 104594-70-9 Caffeic acid phenethyl ester, a natural product isolated and purified from the barks of Cinnamomum cassia Presl, is a potent and specific inhibitor of NF-κB activation, and also displays antioxidant, immunomodulatory and antiinflammatory activities.
CSN22711 Bengamide B 104947-69-5 Bengamide B is a potent inhibitor of NF-κB activation with IC50 of 85 nM.
CSN19420 Andrographolide 5508-58-7 Andrographolide is a naturally occuring NF-κB inhibitor.
CSN17286 Ammonium Pyrrolidine-1-Carbodithioate 5108-96-3 Ammonium pyrrolidine-1-carbodithioate is a selective NF-κB inhibitor, inhibits translation of nitric oxide synthase mRNA to prevent induction.
CSN18157 Adjudin 252025-52-8 Adjudin exhibits anti-inflammatory properties by suppression of NF-κB p65 nuclear translocation and DNA binding activity as well as ERK MAPK phosphorylation.
CSN17995 Adelmidrol 1675-66-7 Adelmidrol is an ethanolamide derivative of azelaic acid with anti-inflammatory properties partly dependent on PPARγ, it also markedly reduce pro-inflammatory NF-κB pathway.
CSN23620 4-Aminosalicylic acid 65-49-6 4-Aminosalicylic acid, known as PAS, is an antibacterial agent used to treat tuberculosis. It works by suppressing NF-κB and scavenging free radicals.
CSN23578 4'-Hydroxychalcone 2657-25-2 4'-Hydroxychalcone has diverse biological activities including inhibiting TNFα-induced NF-κB pathway activation and activating BMP signaling. It is found in herbs and spices and tea, is a member of the class of compounds known as retrochalcones.
CSN14101 14-Deoxy-11,12-Didehydroandrographolide 42895-58-9 14-Deoxy-11,12-didehydroandrographolide, herbs of Andrographis paniculata (Burm.
CSN14830 11-Hydroxytephrosin 72458-85-6 11-Hydroxytephrosin, a natural product isolated and purified from the herbs of Derris robusta, inhibits NF-kappaB activity.
CSN13425 (-)-DHMEQ 287194-40-5 (-)-DHMEQ, the eutomer of DHMEQ , is a developed NF-kB inhibitor with stronger activity than (+)-DHMEQ., inhibits nuclear factor kB activation with IC50 value of 20 ug/mL.
CSN19066 (+)-DHMEQ 287194-41-6 (+)-DHMEQ, the distomer of DHMEQ, is an inhibitor of NF-κB.
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