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OX Receptor

OX Receptor

货号 产品名 CAS号 信息
CSN27292 YNT-185 1804978-81-1 YNT 185 is potent and selective orexin OX2 receptor agonist with EC50 of 28 nM at human OX2 expressed in CHO cells. YNT 185 displays approximately 100-fold selectivity for OX2 over OX1 (EC50 = 2.75 μM at human OX1 expressed in CHO cells).
CSN18978 TCS-OX2-29 372523-75-6 TCS-OX2-29 is a potent and selective orexin 2 (OX2) receptor antagonist with IC50 of 40 nM.
CSN16236 TCS 1102 916141-36-1 TCS 1102 is a potent, dual orexin receptor antagonist (Ki values are 0.2 and 3 nM for OX2 and OX1 receptors respectively).
CSN20432 Seltorexant 1293281-49-8 Seltorexant is a selective orexin-2 receptor antagonist that has been shown to promote sleep in various species.
CSN16826 SB-674042 483313-22-0 SB-674042 is a potent and selective non-peptide orexin OX1 receptor antagonist (Kd = 3.76 nM) exhibiting 100-fold selectivity for OX1 over OX2 receptors.
CSN20633 SB-649868 380899-24-1 SB-649868 is a potent and selective orally active orexin (OX) 1 and OX2 receptor antagonist (pKi =9.4 and 9.5 at the OX1 and OX2 receptor, respectively).
CSN16521 SB-408124 288150-92-5 SB-408124 is a non-peptide antagonist for OX1 receptor with Ki of 57 nM and 27 nM in both whole cell and membrane, respectively, and exhibits 50-fold selectivity over OX2 receptor.
CSN17847 SB-408124 HCl 1431697-90-3 SB-408124 HCl is a non-peptide antagonist for OX1 receptor with Ki of 57 nM and 27 nM in both whole cell and membrane, respectively and exhibits 50-fold selectivity over OX2 receptor.
CSN11490 1-(2-Methylbenzo[d]oxazol-6-yl)-3-(1,5-naphthyridin-4-yl)urea hydrochloride 249889-64-3 SB-334867 is a selective non-peptide orexin OX1 receptor antagonist with a pKb value of 7.2.
CSN11489 1-(2-Methylbenzo[d]oxazol-6-yl)-3-(1,5-naphthyridin-4-yl)urea 792173-99-0 SB-334867 free base is a selective non-peptide orexin OX1 receptor antagonist with pKb of 7.2.
CSN50652 (S)-(2-((3-(5-FLuoropyridin-2-yl)-1H-pyrazol-1-yl)methyl)-1,3-oxazinan-3-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone hydrate(4:1) 1793073-93-4 ORN-0829 is a potent dual orexin 1/2 receptor antagonist.
CSN18036 Orexin 2 Receptor Agonist 1796565-52-0 Orexin 2 receptor agonist is a potent and selective OX2R agonist with EC50 of 23 nM.
CSN13779 Filorexant 1088991-73-4 MK-6096 is an orally bioavailable potent and selective reversible antagonist of OX1 and OX2 receptor (< 3 nM in binding).
CSN16552 MK-3697 1224846-01-8 MK-3697 is an isonicotinamide small molecule, acting as a potent and selective Orexin 2 receptor antagonist with Ki = 0.95 nM.
CSN18852 MK-1064 1207253-08-4 MK-1064 is a selective orexin 2 receptor antagonist(2-SORA) for the research of insomnia.
CSN26720 YNT-185 2HCl 1804978-82-2 for OX2R and OX1R, respectively. YNT-185 dihydrochloride ameliorates narcolepsy-cataplexy symptoms in mouse models[1][2].
CSN26371 EMPA 680590-49-2 EMPA is highly potent, selective OX2 receptor antagonist with IC50 values of 2.3 nM and 1900 nM for OX2 and OX1 respectively.
CSN17023 Almorexant 871224-64-5 Almorexant is a potent and competitive dual orexin 1 receptor (OX1)/orexin 2 receptor (OX2) antagonist with Ki values of 1.3 and 0.17 nM for OX1 and OX2, respectively.
CSN13780 Almorexant HCl 913358-93-7 Almorexant HCl is a potent and competitive dual orexin 1 receptor (OX1)/orexin 2 receptor (OX2) antagonist with Ki values of 1.3 and 0.17 nM for OX1 and OX2, respectively.
CSN20430 ACT-462206 1361321-96-1 ACT-462206 is a potent and brain-penetrant dual orexin receptor antagonist (IC50 values are 11 and 60 nM for OX2 and OX1 receptors respectively), and it exhibits anxiolytic-like properties in vivo.
CSN33694 GSK1059865 1191044-58-2
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