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Inflammation/Immunology

货号 产品名 CAS号 信息
CSN22353 AZ3451 2100284-59-9 AZ3451 is a protease-activated receptor-2 (PAR2) antagonist.
CSN22493 Pumaprazole 158364-59-1 Pumaprazole is a reversible proton pump antagonist.
CSN22537 α-2,3-sialyltransferase-IN-1 881179-06-2 α-2,3-sialyltransferase-IN-1 is a noncompetitive α-2,3-sialyltransferase inhibitor with an IC50 of 6 μM.
CSN22357 Beperidium Iodide 86434-57-3 Beperidium iodide shows a competitive antagonistic effect against acetylcholine receptor with a pA2 of 7.93.
CSN22336 ACP-105 899821-23-9 ACP-105 is a potent nonsteroidal selective androgen receptor modulator (SARM) with partial agonist activity relative to the natural androgen testosterone.
CSN22337 Adavivint 1467093-03-3 Adavivint is a potent and selective inhibitor of canonical Wnt signaling, with an EC50 of 19.5 nM via a high-throughput TCF/LEF-reporter assay in SW480 colon cancer cells.
CSN22322 (-)-Ketoconazole 142128-57-2 (-)-Ketoconazole is one of the enantiomer of Ketoconazole. Ketoconazole is a racemic mixture of two enantiomers, levoketoconazole ((2S,4R)-(−)-ketoconazole) and dextroketoconazole ((2R,4S)-(+)-ketoconazole).
CSN22483 PBI-4050 1254472-97-3 PBI-4050 acts as an agonist for GPR40 and as an antagonist or inverse agonist for GPR84.
CSN22471 Nedocromil Sodium 69049-74-7 Nedocromil Sodium is a potent TNF-α inhibitor with an IC50 value of 1.67 μM for Blood eosinophils.
CSN22442 KRN2 248260-75-5 KRN2 is a selective inhibitor of nuclear factor of activated T cells (NFAT5), with an IC50 of 0.1 μM.
CSN22508 SM 16 614749-78-9 SM 16 is an an ATP-competitive ALK5/ALK4 inhibitor with IC50 value between 160 and 620 nM for inhibition of TGF-β1-induced Smad2/3 phosphorylation in cell study.
CSN22402 Fodipir 118248-91-2 Fodipir is an active metabolite of mangafodipir, involved in mangafodipir-mediated cytoprotection against 7β-hydroxycholesterol-induced cell death.
CSN22454 Lymecycline 992-21-2 Lymecycline is a tetracycline derivative, with broad-spectrum antibacterial activity and also has anti-inflammatory property.
CSN22371 Cephalosporin C Zinc Salt 59143-60-1 Cephalosporin C zinc salt is a potent inhibitor of SAMHD1 with an IC50 of 1.1 μM.
CSN22191 MK-0429 227963-15-7 MK-0429 is a potent integrin antagonist with IC50s of 12.2 nM (α5β1 integrin) and 2.8 nM (αvβ3 integrin), respectively.
CSN22201 CI-1044 197894-84-1 CI-1044 is an orally active PDE4 inhibitor with IC50s of 0.29, 0.08, 0.56, 0.09 μM for PDE4A5, PDE4B2, PDE4C2 and PDE4D3, respectively.
CSN22186 GW 766994 408303-43-5 GW 766994 is a specific and oral chemokine receptor-3 (CCR3) antagonist, which has entered clinical trial for asthma and eosinophilic bronchitis.
CSN22204 Bimosiamose 187269-40-5 Bimosiamose is a pan-selectin antagonist, inhibits E-, P-, and L-selectin with IC50s of 88 μM, 20 μM, and 86 μM, respectively, and can be used in the research of inflammatory disease.
CSN22225 NecroX-5 1383718-29-3 NecroX-5 is a derivative of the NecroX, reduces intracellular calcium concentration, and possesses anti-inflammatory and anti-cancer activity.
CSN22206 Parimifasor 1796641-10-5 Parimifasor is an immunomodulator, with anti-inflammatory activity.
CSN22249 Taprenepag Isopropyl 1005549-94-9 Taprenepag isopropyl is a highly selective EP2 receptor agonist.
CSN22338 AE-3763 291778-77-3 AE-3763 is a peptide-based human neutrophil elastase inhibitor with an IC50 of 29 nM.
CSN22386 Dihydromunduletone 674786-20-0
CSN22375 Cl-amidine 913723-61-2 Cl-amidine is a peptidylarginine deminase (PAD) inhibitor, with an IC50 5.9±0.3 μM for PAD4.
CSN22388 E-6123 131614-02-3 E-​6123 is a platelet-activating factor (PAF) receptor antagonist.
CSN22390 E6130 1427058-33-0 E6130 is an orally available and highly selective CX3CR1 modulator, that may be effective for treatment of inflammatory bowel disease.
CSN22333 A-69412 123606-23-5 A-69412 is a reversible, specific inhibitor of the hydrophilic 5-lipoxygenase (5-LO).
CSN22367 CDK8-IN-3 1884500-15-5 CDK8-IN-3 is an inhibitor of CDK8 extracted from patent WO2016041618A1, compound example 1.7.
CSN22434 JAK Inhibitor 1 2096999-92-5 JAK inhibitor 1 is an inhibitor of JAK extracted from patent US20170121327A1, compound example 283.
CSN22347 AN-3485 1213827-99-6 AN-3485 is a benzoxaborole analog, Toll-Like Receptor(TLR) inhibitor with IC50 values ranging from 18 to 580 nM.
CSN22435 JAK-IN-1 1334673-53-8 JAK-IN-1 is a JAK1/2/3 inhibitor with IC50s of 0.26, 0.8 and 3.2 nM, respectively. JAK-IN-1 shows improved selectivity for JAK3 over JAK1.
CSN22372 CFTR Corrector 1897384-89-2 CFTR corrector is a cystic fibrosis transmembrane conductance regulator (CFTR) modulator extracted from patent US9782408.
CSN22418 GNE-0946 1677667-24-1 GNE-0946 is a potent and selective RORγ( RORc) agonist with an EC50 value of 4 nM for HEK-293 cell.
CSN22433 Iralukast 151581-24-7 Iralukast is a cysteinyl-leukotriene antagonist (CysLT) with a pKi of 7.8 for CysLT1.
CSN22383 Dagrocorat 1044535-52-5 Dagrocorat is a novel and dissociated Glucocorticoid Receptor Agonist.
CSN22419 GNE-4997 1705602-02-3 GNE-4997 is a potent and selective ITK/TSK inhibitor.
CSN22420 GNE-6468 1677668-27-7 GNE-6468 is a potent and selective RORγ(RORc) agonists with an EC50 value of 13 nM for HEK-293 cell.
CSN22521 TNF-α-IN-1 444287-49-4 TNF-α-IN-1 is a TNF-α inhibitor extracted from patent US20030096841A1, compound example I-7.
CSN22409 Gefapixant 1015787-98-0 Gefapixant is an orally active P2X3 receptor (P2X3R) antagonist with IC50s of ~30 nM versus recombinant hP2X3 homotrimers and 100-250 nM at hP2X2/3 heterotrimeric receptors.
CSN22498 ROCK2-IN-2 1995065-79-6 ROCK2-IN-2 is a selective ROCK2 inhibitor extracted from patent US20180093978A1, Compound A-30, has an IC50 of <1 μM.
CSN22421 GPR84 Antagonist 8 1445846-30-9 GPR84 antagonist 8 is a selective GPR84 antagonist.
CSN22523 Trehalose 6-behenate 66755-19-9 Trehalose 6-behenate is a Th1/Th17 skewing vaccine adjuvant.
CSN22422 GSK 4027 2079896-25-4 GSK 4027 is a chemical probe for the PCAF/GCN5 bromodomain with an pIC50 of 7.4±0.11 for PCAF in a time-resolved fluorescence resonance energy transfer (TR-FRET) assay.
CSN22512 SPL-707 2195361-33-0 SPL-707 is a potent, selective and orally available signal peptide peptidase-like 2a (SPPL2a) inhibitor with an IC50 of 80 nM.
CSN22527 TY-51469 603987-59-3 TY-51469 is a chymase inhibitor with IC50s for simian and human chymases of 0.4 and 7.0 nM, respectively.
CSN22535 YM-264 131888-54-5 YM-264 is a selective, potent and orally active platelet-activating factor (PAF) antagonist with a pKi value of 8.85 for rabbit platelet membranes.
CSN22482 PAT-505 1782070-22-7 PAT-505 is a potent, selective, noncompetitive and orally available autotaxin inhibitor, with an IC50 of 2 nM in Hep3B cells, 9.7 nM in human blood and 62 nM in mouse plasma.
CSN22495 RGX-104 610318-03-1 RGX-104 is a small-molecule LXR agonist that modulates innate immunity via transcriptional activation of the ApoE gene.
CSN23767 JAK3-IN-6 1443235-95-7
CSN24268 Mitoquinone Mesylate 845959-50-4 Mitoquinone Mesylate is a ubiquinone derivative, TPP-based and mitochondrially targeted antioxidant, preventing lipid peroxidation-induced apoptosis and protecting mitochondria from oxidative damage.
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