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Abbreviations

Routes of drug administration

RouteIntracerebroventricularIntra-arterial IntracerebralIntradermalntramuscularIntragastricIntraperitonealIntravenousOralSubcutaneous
Abbreviationi.c.v.i.a.i.c.i.d.i.m.i.g.i.t.i.v.p.o.s.c.q.d.b.i.d.t.i.d.
DescriptionInto the ventricles of the brainInto the lumen of an arteryInto the brainInto the dermal layer of the skinInto a skeletal muscleInto the stomachInto the spinal canalInto a veinBy mouthUnder the skinonce a daytwice a daythree times a day

Targets

Abbreviation
Description
Abl
V-abl Abelson murine leukemia viral oncogene homolog 1
ALK
anaplastic lymphoma kinase
ATM
Ataxia telangiectasia mutated
B-Raf
B-Raf proto-oncogene serine/threonine-protein kinase (B-RAF), also known as V-raf murine sarcoma viral oncogene homolog B1
Bcl-2
B-cell lymphoma 2
bcr
breakpoint cluster region
Caspase
cysteine-aspartic proteases or cysteine-dependent aspartate-directed proteases
CCR5
co-receptors chemokine receptor 5
CDK
Cyclin-dependent kinase
CFTR potentiator
Cystic fibrosis transmembrane conductance regulator
CTSK
Cathepsin K, abbreviated CTSK
C-kit
CD117, also called KIT or C-kit receptor
c-Met
mesenchymal-epithelial transition factor
DNA-PK
DNA-dependent protein kinase
DPP-4
Dipeptidyl peptidase-4
EGFR
Epidermal growth factor receptor
Factor Xa
also known by the eponym Stuart-Prower factor or as prothrombin
FGFR
Fibroblast growth factor receptor
FLT-3
fms-like tyrosine kinase receptor-3
FTS
farnesyl thiosalicylic
GSK-3
Glycogen synthase kinase 3
HER2
Human Epidermal growth factor Receptor 2
Hedgehog
an intercellular signaling molecule called Hedgehog (Hh)
HDAC
Histone deacetylase
HIF
Hypoxia-inducible factor
HSP-70
heat-shock protein-70
HSP-90
heat-shock protein-90
IGF-1R
Insulin-like growth factor 1 receptor
Abbreviation
Description
JAK
Janus kinase
JNK
c-Jun N-terminal kinases
Ksp
Kinesin spindle protein
MAPK
Mitogen-activated Protein Kinase
MEK
MAPK/ERK kinase
mGlu2/3 receptors
metabotropic glutamate receptors
mTOR
Mammalian target of rapamycin
NF-kB
Nuclear factor κ B
p38 MAPK
p38 Mitogen-activated Protein Kinase
p53
protein 53 or tumor protein 53
PARP
Poly (ADP-ribose) polymerase
PDGFR
platelet-derived growth factor receptor
PDK-1
phosphoinositide-dependent kinase-1
Rho
ρ factor
PI3K
Phosphatidylinositol 3-kinases
PKC
protein kinase C
PLK
Polo-like kinase
Ras
renin-angiotensin system
RNA Polymerase I
RNAP or RNApol
S1PR1
sphingosine-1-phosphate receptor 1,also known as S1P1 or EDG1
(endothelial differentiation gene 1)
sPLA2
Secreted phospholipases A2
Src
Rous sarcoma oncogene cellular homolog
Stat
Signal Transducers and Activator of Transcription
Survivin
also called baculoviral inhibitor of apoptosis repeat-containin 5 orBIRC5
TGF-beta
Transforming growth factor
TNF-alpha
Tumor necrosis factors
VEGFR-PDGFR
Vascular Endothelial Growth Factor Receptor -platelet derived growth factor receptor
Wee1
Small cell protein, a mitotic inhibitor kinase
Wnt
a combination of Wg (wingless) and Int