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Sesquiterpenoids

Sesquiterpenoids

货号 产品名 CAS号 信息
CSN11893 β-Santalol 11031-45-1 β-Santalol is a compound of sandalwood oil showing antiinflammatory property by suppressing of lipopolysaccharide-stimulated cytokine/chemokine production in skin cells and anti-viral effect against influenza viral replication in vitro.
CSN14076 Zederone 7727-79-9 Zederone, a natural product isolated and purified from the rhizomes of Curcuma zedoaria, inhibits Gram-positive bacteria activity and induces hepatotoxicity implicated the induction of Cyps, which leads to the formation of biological reactive metabolites and that cause the oxidative stress and liver cell injuries.
CSN13998 Xanthatin 26791-73-1 Xanthatin, a natural product isolated and purified from the fruits of Xanthium sibiricum with cytotoxic, antibacterial and antifungal activities, can inhibit murine melanoma B16-F10 cell proliferation possibly associated with activation of Wnt/β-catenin pathway and its activity against melanoma tumor might also be relevant to inhibition of angiogenesis.
CSN14458 Vomifoliol 23526-45-6 Vomifoliol, a natural product isolated and purified from the herbs of Vitis vinifera, can cause as much stomatal closure in epidermal strips of Eichhornia crassipes (Mart.) Solms as ABA at identical concentrations.
CSN14464 Voleneol 70389-88-7 Voleneol, a natural product isolated and purified from the herbs of Curcuma wenyujin, can attenuate the lipopolysaccharide (LPS)-induced inflammation in BV2 microglial cells. it also can dose-dependently suppress the protein expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2), suggest thats DE may be a good candidate to regulate LPS-induced inflammatory response.
CSN13958 Tussilagone 104012-37-5 Tussilagone, a natural product isolated and purified from the flower of Tussilago farfara, has potential treatment of neuro-inflammatory diseases through the inhibition of overproduction of nitric oxide and prostaglandin E(2) .
CSN14470 Torilolone 13018-09-2 Torilolone, a natural product isolated and purified from the herbs of Cnidium monnieri, show hepatoprotective effects on tacrine-induced cytotoxicity in human liver-derived Hep G2 cells,the EC50 value is 20.6 +/- 1.86.
CSN14469 Torilin 13018-10-5 Torilin, a natural product isolated and purified from the fruits of Torilis japonica with anti-inflammatory, antimicrobial, anti-angiogenic, antitumor and hepatoprotective properties.
CSN13977 Spathulenol 6750-60-3 Spathulenol, a natural product isolated and purified from the herbs of Salvia sclarea, has immunoinhibitory effect and shows the capacity to inhibit proliferation in the lymphocytes and to induce apoptosis in these cells possibly through a caspase-3 independent pathway.
CSN14075 Shyobunone 21698-44-2 Shyobunone, a natural product isolated and purified from the rhizomes of Acorus calamus L. with insecticidal and repellant activity, exhibits strong contact toxicity against Lasioderma serricorne (LS adults with LD50 values of 20.24 and 24.19 ug/adult, respectively and they are strongly repellent against Tribolium castaneum (TC) at 78.63 nL/cm2.
CSN15498 Shizukaol D 142279-42-3 Shizukaol D, a natural product isolated and purified from the herbs of Chloranthus japonicus, exerts a growth inhibition effect on liver cancer cells in a dose- and time-dependent manner by modulating wnt signalling pathway, and induces mitochondrial dysfunction by depolarizing the mitochondrial membrane and suppressing energy production, which may result in AMPK activation, suggests that shizukaol D may be used to treat metabolic syndrome.
CSN14472 Pterosin C 35938-43-3 Pterosin C is a natural product isolated and purified from the rhizome Pteridium aquilinum (L.) Kuhn.
CSN14948 Pterosin B 34175-96-7 Pterosin B is a natural product isolated and purified from the aerial parts of Pteris semipinnata, is a salt-inducible kinase 3 (Sik3) pathway inhibitor, preventing chondrocyte hypertrophy and osteoarthritis in mice by inhibiting Sik3.
CSN14948 Pterosin B 34175-96-7 Pterosin B is a natural product isolated and purified from the aerial parts of Pteris semipinnata, is a salt-inducible kinase 3 (Sik3) pathway inhibitor, preventing chondrocyte hypertrophy and osteoarthritis in mice by inhibiting Sik3.
CSN13095 Pterodondiol 60132-35-6 Pterodondiol has moderate activity against bacteria including Staphylococcus aureus, Pseudomonas aeruginosa, Bacillus subtilis, Mycobacteium phlei and Bacillus circulans.
CSN11658 Patchouli Alcohol 5986-55-0 Patchouli Alcohol is a naturally occuring sesquiterpene alcohol found in patchouli oil with antibacterial, antifungal, and antiviral properties.
CSN14460 Oplodiol 13902-62-0 Oplodiol is a natural product isolated and purified from the branch of Platycladus orientalis, exhibits noteworthy anti-plasmodial activity against Plasmodium falciparum strains, has a stimulative effect on significantly proliferation and differentiation of culture osteoblasts, and shows moderate cytotoxic effects on the human lung adenocarcinoma A549 with IC50 values at 25.5 ug/mL.
CSN11611 Onitin 53823-02-2 Onitin, a natural product isolated and purified from the herbs of Onychium japonicum, exhibits hepatoprotective activity on tacrine-induced cytotoxicity in human liver-derived Hep G2 cells.
CSN13549 Linderene 26146-27-0 Linderene is a natural product isolated and purified from the roots of Lindera aggregata (Sims) Kosterm.
CSN13180 Linderalactone 728-61-0 Linderalactone, a natural product isolated and purified from the roots of Lindera aggregata, shows significant inhibitory effects on superoxide anion generation by human neutrophils in response to fMLP/CB, values of IC50 is 8.48 µg/mL.
CSN14473 Leucomisine 17946-87-1 Leucomisine is a natural product isolated and purified from Artemisia leucodes.
CSN14465 Kobusone 24173-71-5 Kobusone is a natural product isolated and purified from the roots of Cyperus rotundus L..
CSN14461 Isofuranodiene 57566-47-9 Isofuranodiene, a natural product isolated and purified from the herbs of Chloranthus spicatus, has anticancer activity, by inhibiting the proliferation and inducing apoptosis in cancer cells, protects GalN/LPS-induced liver injury in SD rats, it may be a potential functional food ingredient for the prevention and treatment of liver diseases and can induce apoptosis in colon cancer cells in a time and concentration-dependent manner suggesting a potential role as models for the development of chemopreventive agents.
CSN14457 Isocostic Acid 69978-82-1 Isocostic acid is a natural product isolated and purified from the roots of Aucklandia lappa Decne..
CSN14073 Ilicic Acid 4586-68-9 Ilicic acid is a natural product isolated and purified from the bark of Laggera pterodonta with anti-hyperglycemic and anti-inflammatory activities.
CSN13571 Humulene Epoxide II 19888-34-7 Humulene epoxide II, a natural product isolated and purified from the rhizomes of Zingiber officinale Roscoe, has mildly phytotoxic and antifungal activities.
CSN16838 Guaiol 489-86-1 Guaiol, a natural product isolated and purified from the roots of Ferula ferulaeoides with insecticidal activity, shows significant inhibition of aphids at a concentration of 70 mg/L and good contact activities against the 4th instar larvae of Mythimna separate and 3rd instar larvae of Plutella xylostella, with LD50 values of 0.07 and 8.9 mg/larva, as well as fumigation activity against the 4th instar larvae of M.
CSN16452 Germacrone 6902-91-6 Germacrone, a natural product isolated and purified from the rhizoma of Curcuma wenyujin with anti-tumor activity, can inhibit the proliferation of breast cancer cell lines by inducing cell cycle arrest and apoptosis through mitochondria-mediated caspase pathway, and may be a potent chemopreventive drug candidate for liver cancer via regulating the expression of proteins related to G2/M cell cycle and apoptosis, and p53 and oxidative damage may play important roles in the inhibition of human hepatoma cells growth by germacrone.
CSN13554 Eupalinolide B 877822-41-8 Eupalinolide A is a natural product isolated and purified from the herbs of Eupatorium lindleyanum DC.
CSN13554 Eupalinolide B 877822-41-8 Eupalinolide A is a natural product isolated and purified from the herbs of Eupatorium lindleyanum DC.
CSN13999 Epiglobulol 88728-58-9 Epiglobulol is a natural product isolated and purified from the leaves of Callicarpa japonica Thunb..
CSN14468 Deoxyelephantopin 29307-03-7 Deoxyelephantopin is a natural product isolated and purified from the herbs of Elephantopus scaber Linn. with hepatoprotective and antitumor activity, by inhibiting metastatic, inducing apoptosis, modulating oxidative stress , STAT3/p53/p21 signaling, MAPK pathway, PI3k/Akt/mTOR pathway, caspase cascades, and ROS .
CSN14136 Cryptomeridiol 4666-84-6 Cryptomeridiol, a natural product isolated and purified from the herbs of Blumea balsamifera DC, exhibits a significant and concentration-dependent inhibitory effect on platelet-activating factor receptor binding, and has low activity against A.
CSN14466 Corchoionoside C 185414-25-9 Corchoionoside C, a natural product isolated and purified from the herbs of Polygonum hydropiper with antifungal, anti-allergic and anti-histaminic effects, inhibits the histamine release from rat peritoneal exudate cells induced by antigen-antibody reaction.
CSN14467 Corchoionol C 189351-15-3 Corchoionol C is a natural product isolated and purified from Peperomia obtusifolia.
CSN14463 Clovanediol 2649-64-1 Clovanediol is a natural product isolated and purified from the herbs of Psidium guajava.
CSN14698 Brevilin A 16503-32-5 Brevilin A, a natural product isolated and purified from the herbs of Centipeda minima, is a strong impetus for the development of selective JAK-STAT inhibitors and therapeutic drugs in order to improve survival of patients with hyperactivated JAKs and STATs, and has antigiardial activity (IC50 = 16.1 μM) and was similarly active in vitro against Entamoeba histolytica (IC50 between 4.5 and 9 μM) and against Plasmodium falciparum (IC50 = 9.42 μM).
CSN14074 beta-Costic Acid 3650-43-9 beta-Costic acid, a natural product isolated and purified from the herb of Dittrichia graveolens, is used against the acari Varroa destructor as parasite of the honey bee.
CSN13607 Atractylone 6989-21-5 Atractylone, a natural product isolated and purified from the roots of Atractylodes macrocephala, has inhibitory effects on mast cell-mediated allergic reactions, it regulates the degranulation of mast cell, proves its potential in the treatment of mast cell-mediated allergic reactions.
CSN16456 Atractylenolide III 73030-71-4 Atractylenolide III, a natural product isolated and purified from the rhizome of Atractylodes macrocephala Koidz., may have therapeutic potential in treating homocysteine-mediated cognitive impairment and neuronal injury, and is a potential candidate for treatment of human lung carcinoma by inducing the release of cytochrome c, upregulating the expression of bax and translocating apoptosis-inducing factor.
CSN13071 Artesunate 88495-63-0 Artesunate is a part of the artemisinin group of agents with an IC50 of < 5 μM for small cell lung carcinoma cell line H69. It is a potential inhibitor of STAT-3 and EXP1 and exhibits selective cytotoxicity of cancer cells over normal cells in vitro.
CSN14459 Alismol 87827-55-2 Alismol, a natural product isolated and purified from the tubers of Alisma plantago-aquatica Linn., acts primarily on nerve terminals and inhibits their responses to electrical stimulation by interfering with NAd release, inhibits mainly Ca2+ influx through a voltage-dependent Ca2+ channel, holds great promise for use in chemopreventive and chemotherapeutic strategies.
CSN12310 Abscisic Acid 21293-29-8 Abscisic Acid is a plant hormone with functions in many plant developmental processes, including seed and bud dormancy, the control of organ size and stomatal closure.
CSN15189 9-Oxo-10,11-Dehydroageraphorone 79491-71-7 9-Oxo-10,11-dehydroageraphorone, a natural product isolated and purified from the herbs of Eupatorium adenophorum with acaricidal activity, induces hepatotoxicity and cholestasis in rats, effectively inhibits the proliferation of HeLa cells by arresting the cell cycle transition from S to G2/M phase, did not continue to complete the cell cycle activity and induces apoptosis by improving the gene expression level of apoptotic proteases such as caspase-10 in HeLa cells.
CSN13034 6,8-Cyclo-1,4-Eudesmanediol 213769-80-3 6,8-Cyclo-1,4-eudesmanediol is a natural product isolated and purified from the branchs of Eucalyptus robusta Smith.
CSN13389 4(15),5,10(14)-Germacratrien-1-Ol 81968-62-9 4(15),5,10(14)-Germacratrien-1-ol is a natural product isolated and purified from the roots of Acorus calamus L..
CSN14462 3,6-Caryolanediol 155485-76-0 3,6-Caryolanediol is a natural product isolated and purified from the herbs of Sindora sumatrana..
CSN13027 3,4-Dihydro-2,2-Dimethyl-2H-Naphtho[1,2-B]pyran 16274-33-2 3,4-Dihydro-2,2-dimethyl-2H-naphtho[1,2-b]pyran is a natural product isolated and purified from the herbs of Catalpa ovata.
CSN14135 11(13)-Dehydroivaxillin 87441-73-4 11(13)-Dehydroivaxillin possesses a promising antiplasmodial activity, which can be exploited in malaria therapy.
CSN14471 (+)-Germacrone-4,5-Epoxide 92691-35-5 (+)-Germacrone-4,5-epoxide, a natural product isolated and purified from the herbs of Curcuma phaeocaulis, inhibits certain subtypes of cytochrome P450 (CYP).
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