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3C-like proteinase is a family of enzymes found in the Coronavirus polyprotein. It cleaves the polyprotein at two self-cleavage sites. It is a cysteine protease under clan PA, MEROPS classification C30. In coronaviruses, it is nonstructural protein number 5 (nsp5).

3CLpro

货号 产品名 CAS号 信息
CSN12229 (2R,3R,4S)-3-Acetamido-4-guanidino-2-((1R,2R)-1,2,3-trihydroxypropyl)-3,4-dihydro-2H-pyran-6-carboxylic acid 139110-80-8 Zanamivir is the first of two registered neuraminidase inhibitors for the treatment and prophylaxis of influenza. Zanamivir could inhibit SARS-CoV-2 3CLpro main protease.
CSN25593 Theaflavin 3,3'-digallate 30462-35-2 Theaflavin-3,3'-digallate is a tea extract. Theaflavin-3,3'-digallate inhibited 3CLpro with IC50 value of 9.5μM in a fluorogenic substrate peptide assay.
CSN12034 Tanshinone IIB 17397-93-2 Tanshinone IIB (TSB), a natural product isolated and purified from the roots of Salvia miltiorrhiza, can significantly inhibit the DNA laddering, cytotoxicity and apoptosis of rat cortical neurons induced by staurosporine in a concentration-dependent manner. Tanshinone IIB showed inhibitory effect on PL(pro) with IC50 value of 10.7μM and less inhibitory effect on 3CLpro with IC50 value of 24.8μM.
CSN13608 Sodium 1,6,6-trimethyl-10,11-dioxo-6,7,8,9,10,11-hexahydrophenanthro[1,2-b]furan-2-sulfonate 69659-80-9 Tanshinone IIA sulfonate sodium is a water-soluble derivative of tanshinone IIA, which acts as an inhibitor of store-operated Ca2+entry (SOCE), and is used to treat cardiovascular disorders.
CSN19410 1,6,6-Trimethyl-6,7,8,9-tetrahydrophenanthro[1,2-b]furan-10,11-dione 568-72-9 Tanshinone IIA is a naturally occuring cardioprotective agent which can inhibit NF-κB and AP-1 DNA binding and display antioxidant and anti-inflammatory properties. Tanshinone IIA showed inhibitory effect on PL(pro) with IC50 value of 1.6μM and less inhibitory effect on 3CLpro with IC50 value of 89.1μM.
CSN12435 1,6-Dimethylphenanthro[1,2-b]furan-10,11-dione 568-73-0 Tanshinone I, an active principle isolated from the roots of Salvia miltiorrhiza (Danshen), is an inhibitor of type IIA human recombinant sPLA2 and rabbit recombinant cPLA2 with IC50s of 11 μM and 82 μM, respectively, is structurally similar to tanshinone IIA and may possess similar cytotoxic effects on tumor cells. Tanshinone I showed inhibitory effect on PL(pro) with IC50 value of 8.8μM and less inhibitory effect on 3CLpro with IC50 value of 38.7μM.
CSN25589 Miltirone 27210-57-7 Rosmariquinone showed inhibitory effect on PL(pro) and 3CLpro with IC50 values of 30μM and 21.1μM, respectively.
CSN12572 Rhoifolin 17306-46-6 Rhoifolin, a natural product isolated and purified from the leaves of Turpinia arguya Seem, hows monolithic proliferation inhibitory activities against Hela, A549 and MCF-7 cell lines, and may be beneficial for diabetic complications through their enhanced adiponectin secretion, tyrosine phosphorylation of insulin receptor-β and GLUT4. It was found to efficiently block the enzymatic activity of SARS-CoV 3CLpro.
CSN19703 2-Ethylbutyl ((S)-(((2R,3S,4R,5R)-5-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)-L-alaninate 1809249-37-3 Remdesivir is an nucleotide-analog antiviral prodrug. Remdesivir could inhibit SARS-CoV-2 3CLpro main protease.
CSN28746 (1R,2S,5S)-N-((S)-1-Cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-3-((S)-3,3-dimethyl-2-(2,2,2-trifluoroacetamido)butanoyl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide 2628280-40-8 PF-07321332 is an orally active 3CL protease inhibitor, binding covalently and directly to the catalytic cysteine (Cys145) residue of the enzyme. It works as an anti-SARS-CoV-2 drug.
CSN25590 Methyl tanshinonate 18887-19-9 Methyl tanshinonate showed inhibitory effect on PL(pro) with IC50 value of 9.2μM and less inhibitory effect on 3CLpro with IC50 value of 21.1μM.
CSN16383 (S)-5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one 520-33-2 Hesperetin is a flavanone extracted from the peel of citrus that exhibits inhibition of PDE4 and UGT. Hesperetin has antioxidative and anti-inflammatory effects as well. Hesperetin dose-dependently inhibited cleavage activity of the 3CLpro with IC50 value of 8.3μM in the cell-based assay.
CSN19988 Herbacetin 527-95-7 Herbacetin, a natural product isolated and purified from the herbs of Equisetum hyemale L. It was found to efficiently block the enzymatic activity of SARS-CoV 3CLpro.
CSN25342 Sodium (2S)-2-((S)-2-(((benzyloxy)carbonyl)amino)-4-methylpentanamido)-1-hydroxy-3-(2-oxopyrrolidin-3-yl)propane-1-sulfonate 1416992-39-6 GC376 is a 3CLpro (3C-like protease) inhibitor that shows promise in treating cats with certain presentations of FIP and has opened the door to targeted antiviral drug therapy.
CSN16500 Dihydrotanshinone I 87205-99-0 Dihydrotanshinone I, a natural product isolated and purified from the roots of Salvia miltiorrhiza Bge., exhibits dose-dependent inhibition towards HLM-catalyzed propofol glucuronidation. Dihydrotanshinone I showed inhibitory effect on PL(pro) with IC50 value of 4.9μM and less inhibitory effect on 3CLpro with IC50 value of 14.4μM.
CSN16361 (R)-1,2,6,7,8,9-Hexahydro-1,6,6-trimethyl-phenanthro(1,2-b)furan-10,11-dione 35825-57-1 Cryptotanshinone is a potent STAT3 inhibitor (IC50 =4.6 μM) and inhibits STAT3 Tyr705 phosphorylation in DU145 prostate cancer cells. Cryptotanshinone showed inhibitory effect on PL(pro) with IC50 value of 0.8μM and slight inhibitory effect on 3CLpro with IC50 value of 226.7μM.
CSN50790 CCF0058981 2708934-53-4 CCF0058981 is a ML300-derived, non-covalent SARS-CoV‑2 3CLpro inhibitor.
CSN17350 1,8-Dihydroxy-3-(hydroxymethyl)anthracene-9,10-dione 481-72-1 Aloe-emodin, a natural product isolated and purified from the root of Rheum palmatum L. with a specific in vitro and in vivo anti-neuroectodermal tumor activity, reduces the toxicity and ROS induced by both monomeric and oligomeric Aβ species, appears to have some protective effect not only against hepatocyte death but also on the inflammatory response subsequent to lipid peroxidation and has a strong non-carcinogenic stimulant-laxative action when applied to the skin, although it may increase the carcinogenicity of some kind of radiation. Aloe-Emodine dose-dependently inhibited cleavage activity of the 3CLpro with IC50 value of 366μM in the cell-based assay.
CSN25594 (2R,3R)-5,7-Dihydroxy-2-(3,4,6-trihydroxy-5-oxo-8-((2R,3S)-3,5,7-trihydroxychroman-2-yl)-5H-benzo[7]annulen-1-yl)chroman-3-yl 3,4,5-trihydroxybenzoate 220473-67-6 3-isotheaflavin-3-gallate is a tea extract. It inhibited 3CLpro with IC50 value of 7μM in a fluorogenic substrate peptide assay.
CSN27868 (S)-N-(4-(tert-Butyl)phenyl)-N-(2-(tert-butylamino)-2-oxo-1-(pyridin-3-yl)ethyl)furan-2-carboxamide   1417700-12-9 16-(S)-ML188 is a non-covalent SARS-CoV 3CLpro inhibitor with good enzyme and antiviral inhibitory activity.
CSN35888 (±)-Alliin 17795-26-5
CSN50497 Lufotrelvir 2468015-78-1
CSN61906 Ledipasvir-d6 2050041-12-6
CSN62232 Niazinin 147821-57-6
CSN62389 (Rac)-X77 2144491-78-9
CSN62313 Ritonavir-d6 1616968-73-0
CSN62375 SARS-CoV-2-IN-10 2722634-95-7
CSN51374 (E)-6-((6-Chloro-2-methyl-2H-indazol-5-yl)imino)-3-((1-methyl-1H-1,2,4-triazol-3-yl)methyl)-1-(2,4,5-trifluorobenzyl)-1,3,5-triazinane-2,4-dione 2647530-73-0
CSN51375 Ensitrelvir fumarate 2757470-18-9
CSN64922 YH-53 1471484-62-4
CSN65007 Silymarin 65666-07-1
CSN67369 X77 2455518-33-7
CSN67707 SARS-CoV MPro-IN-1 2413716-71-7
CSN68344 Lopinavir-d8 1224729-35-4
CSN68548 SDZ 224-015 161511-45-1
CSN68949 SARS-CoV-2-IN-11 2722635-28-9
CSN73846 INSCoV-614(1B) 2735704-33-1
CSN73852 INSCoV-601I(1) 2735704-19-3
CSN73851 INSCoV-600K(1) 2735704-15-9
CSN77866 Hydroxyethylamine 1418733-36-4
CSN77859 SARS-CoV-2 Mpro-IN-1 2758359-91-8
CSN78437 SARS-CoV MPro-IN-2 81418-42-0
CSN78233 Mpro/PLpro-IN-1 2766185-78-6
CSN78989 Antiviral agent 5 2698336-82-0
CSN79117 3CPLro-IN-2 2758278-51-0
CSN79168 3CPLro-IN-1 2432956-06-2
CSN80638 SARS-CoV-2 3CLpro-IN-3 2505241-13-2
CSN90043 SARS-CoV-2 3CLpro-IN-2 2765088-93-3
CSN95895 SH-5 701976-54-7
CSN107754 Mpro inhibitor N3 884650-98-0
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