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CAS No.: 481-72-1
Synonyms: NSC 38628;Rhabarberone;3-Hydroxymethylchrysazine
Aloe-emodin, a natural product isolated and purified from the root of Rheum palmatum L. with a specific in vitro and in vivo anti-neuroectodermal tumor activity, reduces the toxicity and ROS induced by both monomeric and oligomeric Aβ species, appears to have some protective effect not only against hepatocyte death but also on the inflammatory response subsequent to lipid peroxidation and has a strong non-carcinogenic stimulant-laxative action when applied to the skin, although it may increase the carcinogenicity of some kind of radiation. Aloe-Emodine dose-dependently inhibited cleavage activity of the 3CLpro with IC50 value of 366μM in the cell-based assay.
生物活性
实验方案
技术信息
CAS号 | 481-72-1 | 储存条件 |
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分子式 | C15H10O5 | 运输 | 蓝冰 | |||||
分子量 | 270.24 | 别名 | NSC 38628;Rhabarberone;3-Hydroxymethylchrysazine;芦荟大黄素 | |||||
溶解度 |
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动物实验配方 |
Cell Lines | Concentration | Assay Type | Time | Activity Description | Data Sources |
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A2780 cells | - | Cytotoxicity assay | - | Cytotoxicity against human A2780 cells, IC50=26 μM | 24326280 |
HCT116 cells | - | Cytotoxicity assay | 24 h | Cytotoxicity against MDR1 Pgp under-expressing human HCT116 cells after 24 hrs by MTT assay, IC50=8.7 μM | 17949858 |
HepG2 cells | - | Cytotoxicity assay | 24 h | Cytotoxicity against MDR1 Pgp overexpressing human HepG2 cells after 24 hrs by MTT assay, IC50=10 μM | 17949858 |
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