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FGFR

FGFR

货号 产品名 CAS号 信息
CSN18656 Sulfatinib 1308672-74-3 Sulfatinib is an inhbitor of KDR and FGFR1 with IC50 values of 0.021 μM and 0.053 μM respectively. It also shows inhibition of hERG (IC50 = 6.8 μM).
CSN15810 SSR128129E 848318-25-2 SSR128129E is an allosteric modulator of FGFR by binding to the extracellular FGFR domain.
CSN18466 SSR128129E Free Acid 848463-13-8 SSR128129E free acid is a multi-FGFR blocker with allosteric properties and inhibits FGFR signaling by binding to the extracellular FGFR domain without affecting orthosteric FGF binding.
CSN20388 PRN1371 1802929-43-6 PRN1371 is an irreversible covalent FGFR inhibitor used for the treatment of solid tumor.
CSN12916 PD173074 219580-11-7 PD173074 is a potent FGFR1 inhibitor with IC50 of ~25 nM and also inhibits VEGFR2 with IC50 of 100-200 nM, ~1000-fold selective for FGFR1 than PDGFR and c-Src.
CSN13927 PD166866 192705-79-6 PD 166866 is a selective FGFR tyrosine kinase inhibitor with an IC50 of 52.4 nM.
CSN19223 NSC 12 102586-30-1 NSC 12 is an orally available pan-FGF trap able to inhibit FGF2/FGFR interaction and endowed with promising antitumor activity.
CSN16111 LY2874455 1254473-64-7 LY2874455 is a pan-FGFR inhibitor with IC50 of 2.8 nM, 2.6 nM, 6.4 nM, and 6 nM for FGFR1, FGFR2, FGFR3, and FGFR4, respectively, and also inhibits VEGFR2 activity with IC50 of 7 nM.
CSN18841 H3B-6527 1702259-66-2 H3B-6527 acts as a selective FGFR4 inhibitor (IC50 <1.2 nM) over FGFR1-3.
CSN13938 FIIN-3 1637735-84-2 FIIN-3 is an irreversible inhibitor of FGFR1-4 with IC50s of 13, 21, 31, and 35 nM, respectively.
CSN13937 FIIN-2 1633044-56-0 FIIN-2 is an irreversible inhibitor of FGFR1-4 with IC50 values of 3.1, 4.3, 27, and 45 nM, respectively.
CSN18853 FGFR4-IN-1 1708971-72-5 FGFR4-IN-1 is a potent inhibiotr of FGFR4 with IC50 of 0.7 nM.
CSN20012 FGFR4 Inhibitor C(-)-11 2020395-38-2 FGFR4 inhibitor C(-)-11 is a highly potent FGFR4 inhibitor with selectivity over FGFR1 with good stability and CYP inhibition.
CSN19155 FGFR-IN-1 1448169-71-8 FGFR-IN-1 is a potent and highly selective FGFR inhibitor, used for antitumor treatment.
CSN19757 FGF401 1708971-55-4 FGF401, an inhibitor of human fibroblast growth factor receptor 4 (FGFR4, IC50 = 1.1 nM), has potential antineoplastic activity.
CSN17720 Erdafitinib 1346242-81-6 Erdafitinib inhibits FGFR1 (pIC50 = 9), FGFR2 (pIC50 = 8.5), FGFR3 (pIC50 = 8.5) and FGFR4 (pIC50 = 8.25) and it is a quinoxaline derivative compound.
CSN20555 Derazantinib 1234356-69-4 Derazantinib is a fibroblast growth factor receptor (FGFR) inhibitor that has antitumor activity.
CSN21245 ARQ-087 2HCl 1821329-75-2 Derazantinib (ARQ-087) is an ATP competitive tyrosine kinase inhibitor; exhibits potent activity against FGFR1-3 chondrocytes with IC50s of 4.5, 1.8, and 4.5 nM, respectively.
CSN17224 CH5183284   1265229-25-1 CH5183284 is a selective and orally available FGFR inhibitor with IC50 of 9.3 nM, 7.6 nM, 22 nM, and 290 nM for FGFR1, FGFR2, FGFR3, and FGFR4, respectively.
CSN13925 BLU9931 1538604-68-0 BLU9931 is an inhibitor of FGFR4 with IC50 of 3 nM and is less potent for FGFR1/2/3 (IC50 > 150 nM).
CSN18780 BLU-554 1707289-21-1 BLU-554 is a selective inhibitor of FGFR4 with the IC50 of 5 nM.
CSN17679 NVP-BGJ398 Phosphate 1310746-10-1 BGJ398 Phosphate is a selective and potent inhibitor of FGFRs with IC50 values of 1nM for FGFR11-3 and 60nM for FGFR4, as well as 4.9nM for FGFR3-K650E mutant.
CSN16144 BGJ398   872511-34-7 BGJ-398 is a selective, pan-specific FGFR inhibitor with IC50 of 0.9, 1.4, and 1 nM for FGFR1, FGFR2, and FGFR3, respectively and > 40-fold selective for FGFR versus FGFR4 and VEGFR2, and little activity to Abl, Fyn, Kit, Lck, Lyn and Yes.
CSN12890 AZD4547 1035270-39-3 AZD4547 is a selective FGFR inhibitor targeting FGFR1/2/3 with IC50 of 0.2 nM/2.5 nM/1.8 nM with weaker activity against FGFR4, VEGFR2 (KDR), and little activity observed against IGFR, CDK2, and p38.
CSN19705 ASP5878 1453208-66-6 ASP5878 is a selective FGFR inhibitor, to treat FGFR3-dependent urothelial cancer with or without chemoresistance.
CSN22608 Alofanib 1612888-66-0 Alofanib is a selective and allosteric inhibitor of FGFR2 with potential antitumor activity.
CSN18610 ACTB-1003 939805-30-8 ACTB-1003 is a potent inhibitor of FGFR1 with IC50 < 10 nM in FGFR-1 biochemical assay.
CSN22818 FIIN 1 HCl 1256152-35-8
CSN23024 PD 161570 192705-80-9
CSN23858 PF-05231023 1037589-69-7
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