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Microtubule/Tubulin

Microtubule/Tubulin

货号 产品名 CAS号 信息
CSN17551 Vinflunine Tartrate 1201898-17-0 Vinflunine tartrat is a vinca alkaloid uniquely fluorinated with the properties of mitotic-arresting and tubulin-interacting activity.
CSN12201 Vinflunine 162652-95-1 Vinflunine is a vinca alkaloid uniquely fluorinated with the properties of mitotic-arresting and tubulin-interacting activity.
CSN16163 Vinblastine Sulfate 143-67-9 Vinblastine Sulfate is a natural product targeting on microtubule formation, and also inhibits nAChR with IC50 value of 8.9 μM.
CSN16499 Vinblastine 865-21-4 Vinblastine can inhibit the formation of microtubule, it also inhibit nAChR (IC50=8.9 μM).
CSN17793 Vc-MMAD 1401963-17-4 Vc-MMAD consists the ADCs linker (Val-Cit) and potent tubulin inhibitor (MMAD), Vc-MMAD is an antibody drug conjugate.
CSN13504 Tubulysin A 205304-86-5 Tubulysin A is a myxobacterial product that can function as an antiangiogenic agent in many in vitro assays with anti-microtubule, anti-mitotic, apoptosis inducing, anticancer, anti-angiogenic, and antiproliferative activities.
CSN16451 Triclabendazole 68786-66-3 Triclabendazole is a benzimidazole carbamate anthelmintic which can bind to beta-tublin and inhibits protein synthesis.
CSN18138 Taltobulin Trifluoroacetate 228266-41-9 Taltobulin trifluoroacetat is an analogue of hemiasterlin. It is a potent tubulin inhibitor and an ADCs cytotoxin.
CSN18137 Taltobulin 228266-40-8 Taltobulin is an analogue of hemiasterlin. It is a potent tubulin inhibitor and an ADCs cytotoxin.
CSN16748 Podophyllotoxin 518-28-5 Podophyllotoxin is a competitive microtubule assembly inhibitor.
CSN13791 Plinabulin 714272-27-2 Plinabulin is a vascular disrupting agent (VDA) against tubulin-depolymerizing with IC50 of 9.8~18 nM in tumor cells.
CSN17857 PF-06380101 1436391-86-4 PF-06380101 is a cytotoxic Dolastatin 10 analogue and with excellent potencies in tumor cell proliferation assays and differential ADME properties when compared to other synthetic auristatin analogues that are used in the preparation of ADCs.
CSN11569 Nocodazole 31430-18-9 Nocodazole is a rapidly-reversible inhibitor of microtubule polymerization, also inhibits Abl, Abl (E255K) and Abl (T315I) with IC50 of 0.21 μM, 0.53 μM and 0.64 μM, respectively.
CSN11537 Nemorubicin 108852-90-0 Nemorubicin is a 3'-deamino-3'[2-(S)-methoxy-4-morpholinyl]derivative of doxorubicin with anticancer activity on human hepatocellular carcinoma with an IC50 of 80 nM.
CSN17814 MMAF HCl 1415246-68-2 MMAF hydrochloride is an antitubulin agent that inhibit cell division. It inhibits H3397 cell growth with an IC50 of 105 nM.
CSN13727 MMAF 745017-94-1 MMAF can inhibit tubulin polymerization used in ADCs, with lower cytotoxic activity than MMAE.
CSN13588 MMAE 474645-27-7 MMAE can inhibit tubulin polymerization used in ADCs.
CSN13588 MMAE 474645-27-7 MMAE can inhibit tubulin polymerization used in ADCs.
CSN18091 MMAD 203849-91-6 MMAD, a potent tubulin inhibitor, is a toxin payload in antibody drug conjugate.
CSN18012 MMAD HCl 173441-26-4 MMAD hydrochloride, a potent tubulin inhibitor, is a toxin payload in antibody drug conjugate.
CSN12992 Maytansinol 57103-68-1 Maytansinol inhibits microtubule assembly and induces microtubule disassembly in vitro.
CSN17189 Lexibulin 917111-44-5 Lexibulin can potently inhibit microtubule polymerization with vascular-disrupting, and potential antineoplastic activities.
CSN17257 Leucomethylene Blue Mesylate 1236208-20-0 Leucomethylene blue mesylate, a common reduced form of methylene blue, is a second-generation tau protein aggregation inhibitor for the treatment of Alzheimer's disease (AD) and frontotemporal dementia.
CSN18117 Ixabepilone 219989-84-1 Ixabepilone is a microtubule inhibitor working by binding to tubulin and promoting tubulin polymerization and microtubule stabilization.
CSN16575 INH1 313553-47-8 INH1 is a Hec1 inhibitor which can cause arrest of mitosis.
CSN12790 Fosbretabulin Disodium 168555-66-6 Fosbretabulin disodium is the water-soluble prodrug of Combretastatin A4 (CA4), which is a microtubule-targeting agent that binds β-tubulin with Kd of 0.4 μM in a cell-free assay. Fosbretabulin disodium inhibits the polymerization of tubulin with IC50 of 2.4 μM, and also disrupts tumor vasculature.
CSN16859 Estramustine Phosphate Sodium 52205-73-9 Estramustine phosphate sodium is an antimicrotubule chemotherapy agent and arrests prostate cancer cells in the G2/M phase of the cell cycle.
CSN15734 Epothilone D 189453-10-9 Epothilone D is a potent microtubule stabilizer.
CSN12965 Epothilone B 152044-54-7 Epothilone B is a microtubule stablizer which can promote tubulin polymerization.
CSN23677 Entasobulin 501921-61-5 Entasobulin is an inhibitor of β-tubulin polymerization with antineoplastic activity.
CSN16317 ELR510444 1233948-35-0 ELR510444 is an inhibitor of tubulin polymerization with IC50 value of 10 μM.
CSN17468 Dolastatin 10 110417-88-4 Dolastatin 10 is a potent antimitotic peptide from a marine animal, strongly inhibits microtubule assembly. Dolastatin and Dolastatin's analogs are the cytotoxic components in Antibody-drug conjugates design (eg. cAC10-vcMMAE)
CSN12495 Docetaxel     114977-28-5 Docetaxel, an analog of taxol, is an inhibitor of depolymerisation of microtubules through binding to stabilized microtubules.
CSN16704 Docetaxel Trihydrate 148408-66-6 Docetaxel Trihydrate can promote the assembly of microtublules.
CSN14353 Deoxypodophyllotoxin 19186-35-7 Deoxypodophyllotoxin, a natural microtube inhibitor isolated and purified from the roots of Dysosma versipellis (Hance) M.Cheng ex Ying, is cytotoxic agent, antineoplastic agent and potent antitumor agent and may be beneficial in regulating the immediate-type allergic reaction.
CSN10733 Cytochalasin D 22144-77-0 Cytochalasin D, a metabolite of the fungus Drechslera dematoidea, which is about 10-fold more effective than cytochalasin B, inhibits CT26 tumor growth potentially through inhibition of cell proliferation, induction of cell apoptosis and suppression of tumor angiogenesis.
CSN10732 Cytochalasin B 14930-96-2 Cytochalasin B, a metabolite of the fungus Drechslera dematoidea, is an cell-permeable inhibitor of actin polymerization which inhibits cell division, migration and glucose transport and causes G2/M cell cycle arrest and apoptosis in HCT-116 colorectal carcinoma cells.
CSN10711 Cucurbitacin B 6199-67-3 Cucurbitacin B belongs to a class of highly oxidized tetracyclic triterpenoids and could repress cancer cell progression.
CSN12500 Combretastatin A4 117048-59-6 Combretastatin A4 is a tubulin polymerization inhibitor with Kd value of 0.4 μM for binding to β-tubulin.
CSN16597 Colchicine 64-86-8 Colchicine, a natural product isolated and purified from the bulb of Colchicum autumnale L., is a tubulin inhibitor, it blocks polymerization of microtubules by binding to tubulin (IC50 = 3.2 μM).
CSN12964 Cabazitaxel   183133-96-2 Cabazitaxel is a semi-synthetic derivative of the natural taxoid 10-deacetylbaccatin III with potential antineoplastic activity. Cabazitaxel exerts its effects by inhibiting microtubule growth and assembly, processes that are essential for cells to divide and grow.
CSN17976 Auristatin F 163768-50-1 Auristatin F is a cytotoxic tubulin modifier with potent and selective antitumor activity, and it is MMAF analog and cytotoxin in antibody-drug conjugates.
CSN17946 Auristatin E 160800-57-7 Auristatin E is a cytotoxic tubulin modifier with potent and selective antitumor activity and it is an MMAE analog and cytotoxin in Antibody-drug conjugates.
CSN11486 Albendazole Oxide 54029-12-8 Albendazole Oxide can selectively inhibit beta-tubulin polymerization, used as an anthelmintic medicine.
CSN16395 Albendazole 54965-21-8 Albendazole is a microtubule depolymerizing agent which can affect tubulin dynamics.
CSN16987 ABT-751 141430-65-1 ABT-751 can inhibit microtubule polymerization through binding to β-tubulin on the colchine site.
CSN17000 7-Xylosyltaxol 90332-66-4 7-Xylosyltaxol, a natural product isolated and purified from the barks of Taxus baccata, is a taxol (paclitaxel) derivative.
CSN13479 7-Xylosyl-10-Deacetyltaxol 90332-63-1 7-Xylosyl-10-deacetyltaxol is a paclitaxel derivative with improved pharmacological features and higher water solubility.
CSN16777 4'-Demethylepipodophyllotoxin 6559-91-7 4'-Demethylepipodophyllotoxin is a potent microtubule assembly inhibitor, acting as an antimitotic agent.
CSN11119 (+)-Griseofulvin 126-07-8 (+)-Griseofulvin is a naturally occuring centrosomal clustering inhibitor and induces keratin cytoskeleton alterations. It is also an antifungal drug.
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