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Microtubule/Tubulin

Microtubule/Tubulin

货号 产品名 CAS号 信息
CSN19766 Zampanolide 179730-36-0 Zampanolide, discovered in a sponge extract, is a microtubule-stabilizing agent in 2009, is a covalent binding secondary metabolite with potent, low nanomolar activity in mammalian cells. Zampanolide was not susceptible to single amino acid mutations at the taxoid site of β-tubulin in human ovarian cancer 1A9 cells, despite evidence that it selectively binds to the taxoid site.
CSN20215 WX-132-18B 1415262-07-5 WX-132-18B is a microtubule inhibitor, exhibits promising anti-tumor effects.
CSN18754 Leurocristine Sulfate 2068-78-2 Vincristine sulfate is an inhibitor of polymerization of microtubules by binding to tubulin with IC50 of 32 μM.
CSN23847 Vincristine 57-22-7 Vincristine (Leurocristine) is a microtubule-destabilizing agent (MDA). Vincristine (Leurocristine) binds to tubulin and inhibits the formation of microtubules, thereby inhibiting mitosis of the cancer cell. Vincristine (Leurocristine) is used to treat hematologic cancers, such as leukemia and lymphoma, and childhood sarcomas[1][2].
CSN20039 Tubulysin M 936691-46-2 Tubulysin M is a myxobacterial product that can function as an antiangiogenic agent in many in vitro assays with anti-microtubule, anti-mitotic, an apoptosis inducer, anticancer, anti-angiogenic, and antiproliferative activity.
CSN20035 Tubulysin B 205304-87-6 Tubulysin B is a myxobacterial product that can function as an antiangiogenic agent in many in vitro assays with anti-microtubule, anti-mitotic, an apoptosis inducer, anticancer, anti-angiogenic, and antiproliferative activity.
CSN18138 Taltobulin Trifluoroacetate 228266-41-9 Taltobulin trifluoroacetat is an analogue of hemiasterlin. It is a potent tubulin inhibitor and an ADCs cytotoxin.
CSN18137 Taltobulin 228266-40-8 Taltobulin is an analogue of hemiasterlin. It is a potent tubulin inhibitor and an ADCs cytotoxin.
CSN18881 Taltobulin HCl N/A Taltobulin HCl is an cytotoxin, an analogue of hemiasterlin, and a potent tubulin inhibitor.
CSN19199 TAI-1 1334921-03-7 TAI-1 is a potent and specific Hec1 inhibitor, which disrupts Hec1-Nek2 protein interaction.
CSN25544 T-1101 tosylate 2250404-95-4 T-1101 tosylate is a Hec1/Nek2 (Highly expressed in cancer 1 / NIMA-related kinase 2) inhibitor with antitumor activity. T-1101 tosylate is inactive toward normal cells, kinases and hERG.
CSN26117 SSE15206 1370046-40-4 SSE15206 is a microtubule depolymerizing agent which inhibits microtubule polymerization both in biochemical and cellular assays by binding to colchicine site in tubulin. It causes aberrant mitosis resulting in G2/M arrest due to incomplete spindle formation.
CSN20223 SP-6-27 1384170-58-4 SP-6-27, a microtubule inhibitor, inhibits angiogenesis and induces apoptosis in ovarian cancer cells.
CSN17857 PF-06380101 1436391-86-4 PF-06380101 is a cytotoxic Dolastatin 10 analogue and with excellent potencies in tumor cell proliferation assays and differential ADME properties when compared to other synthetic auristatin analogues that are used in the preparation of ADCs.
CSN25428 Parbendazole 14255-87-9 Parbendazole is a potent inhibitor of microtubule assembly, destabilizes tubulin, with an EC50 of 8.79 nM, and exhibits a broad-spectrum anthelmintic activity.
CSN19486 Paclitaxel 33069-62-4 Paclitaxel is a microtubule polymer stabilizer with IC50 of 0.1 pM in human endothelial cells.
CSN18091 MMAD 203849-91-6 MMAD, a potent tubulin inhibitor, is a toxin payload in antibody drug conjugate.
CSN18012 MMAD HCl 173441-26-4 MMAD HCl, a potent tubulin inhibitor, is a toxin payload in antibody drug conjugate.
CSN18492 Mc-MMAE 863971-24-8 Mc-MMAE is a protective group (maleimidocaproyl)-conjugated MMAE.
CSN20042 Maytansinoid DM4 796073-69-3 Maytansinoid DM4 is a tubulin inhibitor, inhibits the assemblyof microtubules by binding to tubulin, with a linker structure can create an antibody-drug conjugate (ADC).
CSN19821 Maitansine 35846-53-8 Maitansine is a cytotoxic agent. It inhibits the assembly of microtubules by binding to tubulin at the rhizoxin binding site.
CSN18573 Lexibulin 2HCl 917111-49-0 Lexibulin 2HCl is a potent tubulin polymerisation inhibitor with IC50 of 10-100 nM in cancer cell lines and with potent cytotoxic and vascular disrupting activity in vitro and in vivo.
CSN25678 Latrunculin B 76343-94-7 Latrunculin B is a toxic inhibitor of actin polymerization. It interacts with G-actin in 1:1 ratio to inhibit polymerization into F-actin in vitro (IC50 values are ~60 and ~900 nM in absence and presence of calf serum, respectively).
CSN25679 Latrunculin A 76343-93-6 Latrunculin A is a reversible and selective inhibitor of actin assembly. It can block actin adenine nucleotide exchange.
CSN25215 Estramustine 2998-57-4 Estramustine is an antimicrotubule chemotherapy agent and arrests prostate cancer cells in the G2/M phase of the cell cycle.
CSN18160 Eribulin 253128-41-5 Eribulin, a synthetic analogue of halichondrin B used for breast cancer, binds to tubulin and microtubules.
CSN18275 Eribulin Mesylate 441045-17-6 Eribulin mesylate, a synthetic analogue of halichondrin B used for breast cancer, binds to tubulin and microtubules.
CSN18805 Epothilone A 152044-53-6 Epothilone A is a paclitaxel-like microtubule-stabilizing agent with EC0.01 of 2 μM.
CSN23677 Entasobulin 501921-61-5 Entasobulin is an inhibitor of β-tubulin polymerization with antineoplastic activity.
CSN20044 DM4-SMe 796073-68-2 DM4-Me is a tubulin inhibitor, inhibits the assemblyof microtubules by binding to tubulin, with a linker structure can create an antibody-drug conjugate (ADC).
CSN20043 DM3-SMe 796073-70-6 DM3-SMe is a tubulin inhibitor, inhibits the assemblyof microtubules by binding to tubulin, with a linker structure can create an antibody-drug conjugate (ADC).
CSN20041 DM3 796073-54-6 DM3 is a tubulin inhibitor, inhibits the assemblyof microtubules by binding to tubulin, with a linker structure can create an antibody-drug conjugate (ADC).
CSN20054 DM1-SMe 138148-68-2 DM1-SMe is a tubulin inhibitor, inhibits the assemblyof microtubules by binding to tubulin, with a linker structure can create an antibody-drug conjugate (ADC).
CSN18416 D-64131 74588-78-6 D-64131 is a novel tubulin polymerization inhibitor working by competitively binding with colchicine to αβ-tubulin.
CSN18882 Cys-mcMMAD N/A Cys-mcMMAD, a potent tubulin inhibitor, is a toxin payload in antibody drug conjugate.
CSN25687 CHM 1 154554-41-3 CHM-1 induces apoptosis, and it binds tubulin and inhibits tubulin polymerization. CHM-1 possess antimitotic antitumor activity. It is a potent and selective antitumor agent.
CSN18469 Cevipabulin 849550-05-6 Cevipabulin is a potent, synthetic small molecule, inhibits binding of vinblastine at the Vinca alkaloid site of the αβ-tubulin heterodimer.
CSN20459 BTB1 86030-08-2 BTB1 an ATP-competitive and selective inhibitor of the mitotic motor protein Kif18A with IC50 value of 1.7 μM.
CSN20542 BRD70326 N/A BRD70326 potentiates IL-10 production by suppressing microtubule polmerization.
CSN18622 BNC105 945771-74-4 BNC105 is a tubulin polymerization inhibitor with potent antiproliferative and tumor vascular disrupting properties.
CSN27280 Batabulin sodium 195533-98-3 Batabulin sodium can bind covalently and selectively to a subset of the β-tubulin isotypes, thereby disrupting microtubule polymerization. It affects cell morphology and leads to cell-cycle arrest.
CSN18933 Auristatin PE 149606-27-9 Auristatin PE is a synthetic Dolastatin 10 derivative and inhibitor oftubulinpolymerization.
CSN17976 Auristatin F 163768-50-1 Auristatin F is a cytotoxic tubulin modifier with potent and selective antitumor activity, and it is MMAF analog and cytotoxin in antibody-drug conjugates.
CSN17946 Auristatin E 160800-57-7 Auristatin E is a cytotoxic tubulin modifier with potent and selective antitumor activity and it is an MMAE analog and cytotoxin in Antibody-drug conjugates.
CSN18377 Ansamitocin P-3 66584-72-3 Ansamitocin P-3, which is used as an antibody drug conjugate cytotoxin is a maytansine analog which displays potent cytotoxicity against the human solid tumor cell lines A-549 and HT-29.
CSN22155 Amphethinile 91531-98-5 Amphethinile is an anti-tubulin agent and a novel anti-mitotic agent. The affinity constant for the association (Ka) of Amphethinile with tubulin is 1.3 μM.
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