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FAK

FAK

货号 产品名 CAS号 信息
CSN17077 Y15 4506-66-5 Y15 is a small molecule FAK phosphorylation inhibitor which specifically block phosphorylation of Y397-FAK and total phosphorylation of FAK.
CSN20842 Solanesol 13190-97-1 Solanesol is a C45 isoprenoid alcohol, it is the most abundant lipid in tobacco leaves and may be an important precursor of the tumorigenic polynuclear aromatic hydrocarbons of smoke.
CSN16593 PND-1186   1061353-68-1 PND-1186 is a potent FAK inhibitor with IC50 of 1.5 nM.
CSN16483 PF-573228   869288-64-2 PF-573228 is a potent and selective FAK inhibitor with IC50 of 4 nM for inhibiton of purified recombinant catalytic fragment of FAK and inhibits FAK phosphorylation on Tyr(397) with an IC(50) of 30-100 nM.
CSN16016 PF-562271 717907-75-0 PF-562271 is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM, ~10-fold less potent for Pyk2 than FAK and > 100-fold selectivity against other protein kinases, except for some CDKs.
CSN19192 PF-562271 HCl 939791-41-0 PF-562271 hydrochloride is the hydrochloride salt of PF-562271, which is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM, ~10-fold less potent for Pyk2 than FAK and > 100-fold selectivity against other protein kinases, except for some CDKs.
CSN13737 PF-562271 Besylate   939791-38-5 PF-562271 besylate is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM, ~10-fold less potent for Pyk2 than FAK and > 100-fold selectivity against other protein kinases, except for some CDKs.
CSN13426 PF-431396 717906-29-1 PF-431396 is dual focal adhesion kinase (FAK) and proline-rich tyrosine kinase 2 (PYK2) inhibitor (IC50 values are 2 and 11 nM respectively), PF-431396 has a Kd value of 445 nM for BRD4.
CSN13117 NVP-TAE 226 761437-28-9 NVP-TAE 226 is a potent FAK inhibitor with IC50 of 5.5 nM, modestly potent to Pyk2 (IC50=3.5 nM) and 10- to 100-fold less potent against InsR, IGF-1R, ALK, and c-Met.
CSN18810 GSK2256098 1224887-10-8 GSK2256098, is a focal adhesion kinase-1 (FAK) inhibitor with potential antiangiogenic and antineoplastic activities.
CSN17445 Defactinib   1073154-85-4 Defactinib is a potent FAK phosphorylation inhibitor and overcomes YB-1–mediated paclitaxel resistance by an AKT-dependent pathway.
CSN17446 Defactinib HCl 1073160-26-5 Defactinib hydrochloride is a potent FAK phosphorylation inhibitor and overcomes YB-1–mediated paclitaxel resistance by an AKT-dependent pathway.
CSN16907 CEP-37440 1391712-60-9 CEP-37440 is a potent and selective Dual FAK/ALK inhibitor with IC50 s of 2.3 nM (FAK) and 120 nM (ALK cellular IC50 in 75% human plasma).
CSN23200 Y 11 1086639-59-9
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