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EGFR

EGFR

货号 产品名 CAS号 信息
CSN16032 Varlitinib 845272-21-1 Varlitinib is a selective and potent ErbB1 (EGFR) and ErbB2 (HER2) inhibitor with IC50 of 7 nM and 2 nM, respectively.
CSN20619 Tyrphostin RG14620 136831-49-7 Tyrphostin RG14620 is an EGFR inhibitor of tyrphostin family, which selectively reverses ABCG2-mediated multidrug resistance in cancer cell lines.
CSN21355 AG 528 133550-49-9 Tyrphostin is a potent inhibitor of EGFR protein tyrosine kinase.
CSN25719 Tyrphostin B44, (+) enantiomer 133550-37-5 Tyrphostin B44, (+) enantiomer is an inhibitor of EGFR with IC50 of 0.86 μM. It is slightly less active than the (-) enantiomer.
CSN26110 TQB3804 2267329-76-8 TQB3804 is the forth-generation EGFR inhibitor with IC50 values of 7.92nM,0.218nM and 0.16nM for EGFR(WT), EGFR (C797S/T790M/del19) and EGFR (L858R/T790M/C797S), respectively.
CSN20011 Theliatinib 1353644-70-8 Theliatinib, is a small molecule, epidermal growth factor receptor tyrosine kinase inhibitor with potential antineoplastic and anti-angiogenesis activities.
CSN20156 Pyrotinib Maleate 1397922-61-0 Pyrotinib maleate is an irreversible pan-ErbB receptor tyrosine kinase inhibitor, in patients with HER2-Positive metastatic breast cancer.
CSN20157 Pyrotinib 1269662-73-8 Pyrotinib is an irreversible pan-ErbB receptor tyrosine kinase inhibitor, in patients with HER2-Positive metastatic breast cancer.
CSN22485 PF-06459988 1428774-45-1 PF-06459988 is an irreversible inhibitor of T790M-Containing EGFR Mutants.
CSN23039 PF 6274484 1035638-91-5 PF 6274484 is a high affinity and potent covalent EGFR kinase inhibitor with Ki of 0.14 nM.
CSN22616 NSC-228155 113104-25-9 NSC228155 can enhance the tyrosine phosphorylation of EGFR via binding to the dimerization domain II. It blocks KIX-KID interaction as well (IC50 = 0.36 μM).
CSN27281 Mobocertinib succinate 2389149-74-8 Mobocertinib succinate is an inhibitor of EGFR and HER2 oncogenic mutants, including exon 20 insertions, with selectivity over WT EGFR.
CSN25720 Methyl 2,5-dihydroxycinnamate 63177-57-1 Methyl 2,5-dihydroxycinnamate, the erbstatin analog, is an inhibitor of EGF receptor-associated tyrosine kinases.
CSN22878 Lavendustin A 125697-92-9 Lavendustin A is a potent, cell-permeable inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase with IC50 of 11 nM.
CSN25434 Khellin 82-02-0 Khellin, a naturally occurring furochromone, is an EGFR inhibitor with an IC50 of 0.15 µM. Khelline has anti-proliferative activity in vitro. Khellin has antispasmodic and coronary vasodilator effects.
CSN26106 JCN037   2305154-31-6 JCN037 is a potent EGFR inhibitor with IC50 values of 2.49 nM, 3.95 nM and 4.48 nM for EGFR, p-wtEGFR and pEGFRvⅢ, respectively. It displayed potent activity against EGFR amplified/mutant patient-derived cell cultures, significant BBB penetration (2:1 brain-to-plasma ratio), and superior efficacy in an EGFR-driven orthotopic glioblastoma xenograft model.
CSN26167 JBJ-04-125-02 2140807-05-0 JBJ-04-125-02 is a mutant-selective EGFR allosteric inhibitor with IC50 of 0.26 nM for EGFRL858R/T790M. As a single agent, it can inhibit cell proliferation and EGFRL858R/T790M/C797S signaling in vitro and in vivo.
CSN25621 HS-10296 1899921-05-1 HS-10296 is the third-generation EGFR TKIs which exhibited inhibitory effect on both EGFR-activating mutations and T790M-resistant mutation.
CSN25718 GW 583340 dihydrochloride 1173023-85-2 GW 583340 dihydrochloride is an effective inhibitor of dual EGFR/ErbB2 tyrosine kinase with IC50 values of 0.01 and 0.014 μM respectively.
CSN22156 Epertinib 908305-13-5 Epertinib is a potent, oral, reversible, and selective tyrosine kinase inhibitor of EGFR, HER2 and HER4, with IC50s of 1.48 nM, 7.15 nM and 2.49 nM, respectively; Epertinib shows potent antitumor activity.
CSN22392 EGFR-IN-2 1643497-70-4 EGFR-IN-2 is a a noncovalent, irreversible, mutant-selective second generation EGFR inhibitor.
CSN19954 Cyasterone 17086-76-9 Cyasterone is an inhibitor of EGFR that maybe a promising anti-cancer agent espcially in skin carcinoma.
CSN25283 CGP 52411 145915-58-8 CGP 52411 inhibited the EGF-R protein-tyrosine kinase in vitro with high selectivity. In cells, CGP52411 selectively inhibited both ligand-induced EGF-R and p185c-erbB2 autophosphorylation and c-fos mRNA induction.
CSN15701 BMS-690514 859853-30-8 BMS-690514 is a potent and selective inhibitor of epidermal growth factor receptor (EGFR), HER2, and HER4, as well as the VEGF receptor kinases.
CSN25721 BIBU 1361 dihydrochloride 793726-84-8 BIBU 1361 dihydrochloride is a selective inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase with IC50 of 3 nM.
CSN25556 BI-4020 N/A BI-4020 is a noncovalent, new-generation, wild-type EGFR sparing, macrocyclic tyrosine kinase inhibitor.
CSN18835 AST-1306 p-Toluenesulfonic Acid 1050500-29-2 AST-1306 p-toluenesulfonic acid is an irreversible inhibitor of EGFR and ErbB2 with IC50 of 0.5 nM and 3 nM, also effective in mutation EGFR T790M/L858R, more potent to ErbB2-overexpressing cells, 3000-fold selective for ErbB family than other kinases.
CSN16578 AST-1306 897383-62-9 AST-1306 is an irreversible inhibitor of EGFR and ErbB2 with IC50 of 0.5 nM and 3 nM, also effective in mutation EGFR T790M/L858R, more potent to ErbB2-overexpressing cells, 3000-fold selective for ErbB family than other kinases.
CSN21119 AG-494 133550-35-3 AG-494 is an inhibitor of EGFR with an IC50 value of 0.7 µM and it is inactive toward ErbB2, PDGFR and insulin receptor kinase.
CSN23735 AG 99 122520-85-8 AG 99 is an EGF receptor kinase inhibitor with IC50 of 10 µM in the human epidermoid carcinoma cell line A431.
CSN21882 AG 555 133550-34-2 AG 555 is an inhibitor of epidermal growth factor receptor (EGFR) with IC50 of 0.7 μM.
CSN12809 AC480 714971-09-2 AC480 is a selective and efficacious inhibitor of HER1 and HER2 with IC50 of 20 nM and 30 nM, ~8-fold less potent to HER4, > 100-fold to VEGFR2, c-Kit, Lck, MET etc.
CSN24709 AG-1557 189290-58-2
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