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EGFR

EGFR

货号 产品名 CAS号 信息
CSN16336 XL647 781613-23-8 XL647 or tesevatinib inhibits EGFR, HER2, VEGFR and EphB4 with potential antineoplastic activity.
CSN16551 WZ8040 1214265-57-2 WZ8040 is a mutant-selective irreversible EGFRT790M inhibitor, does not inhibit ERBB2 phosphorylation (T798I).
CSN16109 WZ4002 1213269-23-8 WZ4002 is an irreversible inhibitor of mutant EGFR (L858R) and EGFR (T790M) with IC50 of 2 nM and 8 nM respectively.
CSN16032 Varlitinib 845272-21-1 Varlitinib is a selective and potent ErbB1 (EGFR) and ErbB2 (HER2) inhibitor with IC50 of 7 nM and 2 nM, respectively.
CSN16204 Poziotinib 1092364-38-9 Poziotinib is an irreversible Pan-HER inhibitor with IC50s of 3/5/23 nM for HER1/HER2/HER4 respectively.
CSN11666 Pelitinib 257933-82-7 Pelitinib irreversiblly inhibits EGFR with IC50 of 38.5 nM.
CSN16908 PD168393 194423-15-9 PD168393 is an inhibitor that targets EGFR with IC50 of 0.70 nM irreversibly. It is not active against insulin, PDGFR, FGFR and PKC.
CSN13798 PD158780 171179-06-9 PD158780, a pyridopyrimidine derivative, is reversible inhibitor of ErbB receptor family (IC50s for EGFR, ErbB2 and ErbB2/ErbB4 are 0.008 nM, 49 nM and 52 nM respectively).
CSN12357 PD153035 153436-54-5 PD153035 is EGFR inhibitor with Ki and IC50 of 5.2 pM and 29 pM and could rapidly suppress autophosphorylation of EGFR.
CSN13923 Osimertinib Mesylate 1421373-66-1 Osimertinib Mesylate is a selective inhibitor of mutant EGFR with IC50s of 12 nM and 1 nM for L858R and L858R/T790M in enzyme assay respectively.
CSN15680 OSI-420 183320-51-6 OSI-420 is the active metabolite of Erlotinib (EGFR inhibitor with IC50 of 2 nM).
CSN17738 Olmutinib 1353550-13-6 Olmutinib inhibits EGFR with IC50 values of 9.2 nM and 10 nM in HCC827 (expressing EGFR-del 19) and H1975 (expressing EGFR-L858R/T790M) cell respectively. It is a new targeted drug for the treatment of mutation-positive NSCLC.
CSN20576 Neratinib Maleate 915942-22-2 Neratinib maleate is an orally available, irreversible tyrosine kinase inhibitor with IC50 of 59 nM and 92 nM for HER2 and EGFR, respectively.
CSN17827 Mutant EGFR Inhibitor 1421373-62-7 Mutant EGFR inhibitor is a selective and potent Mutated EGFR inhibitor (L858R activating mutant, the Exonl9 deletion activating mutant and the T790M resistance mutant).
CSN11268 Lapatinib 231277-92-2 Lapatinib is a potent EGFR and ErbB2 inhibitor with IC50 of 10.8 and 9.2 nM, respectively.
CSN26106 JCN037   2305154-31-6 JCN037 is a potent EGFR inhibitor with IC50 values of 2.49 nM, 3.95 nM and 4.48 nM for EGFR, p-wtEGFR and pEGFRvⅢ, respectively. It displayed potent activity against EGFR amplified/mutant patient-derived cell cultures, significant BBB penetration (2:1 brain-to-plasma ratio), and superior efficacy in an EGFR-driven orthotopic glioblastoma xenograft model.
CSN25621 HS-10296 1899921-05-1 HS-10296 is the third-generation EGFR TKIs which exhibited inhibitory effect on both EGFR-activating mutations and T790M-resistant mutation.
CSN25641 HS-10296 HCl 2134096-03-8 HS-10296 is the third-generation EGFR TKIs which exhibited inhibitory effect on both EGFR-activating mutations and T790M-resistant mutation.
CSN11084 Gefitinib   184475-35-2 Gefitinibis an EGFR inhibitor for Tyr1173, Tyr992, Tyr1173 and Tyr992 in the NR6wtEGFR and NR6W cells with IC50 of 37 nM, 37nM, 26 nM and 57 nM, respectively, and interrupts signaling through the epidermal growth factor receptor (EGFR) in target cells.
CSN10931 Erlotinib 183321-74-6 Erlotinib is an EGFR inhibitor with IC50 of 2 nM, > 1000-fold more sensitive for EGFR than human c-Src or v-Abl.
CSN16725 Erlotinib HCl 183319-69-9 Erlotinib HCl is a directly acting inhibitor of human EGFR tyrosine kinase with an IC50 of 2 nM.
CSN22156 Epertinib 908305-13-5 Epertinib is a potent, oral, reversible, and selective tyrosine kinase inhibitor of EGFR, HER2 and HER4, with IC50s of 1.48 nM, 7.15 nM and 2.49 nM, respectively; Epertinib shows potent antitumor activity.
CSN25629 EGFR Inhibitor 879127-07-8 EGFR Inhibitor is a potent, ATP-competitive and highly selective EGFR inhibitor with IC50 values of 21nM, 63nM and 4nM for EGFR, EGFR (L858R) and EGFR (L861Q), respectively. It blocked EGF-induced EGFR autophosphorylation in U-2OS cells at 10µM.
CSN17903 EGF816 Mesylate 1508250-72-3 EGF816 mesylate is a covalent mutant-selective EGFR inhibitor, with Ki and Kinact of 31 nM and 0.222 min−1 on EGFR(L858R/790M) mutant, respectively.
CSN10745 Daphnetin 486-35-1 Daphnetin is an inhibitor of EGFR, PKA and PKC with IC50 of 7.67 μM, 9.33 μM and 25.01 μM respectively. It derives from plants of the genus Daphne.
CSN13899 Dacomitinib 1110813-31-4 Dacomitinib is a potent, orally available, irreversible tyrosine kinase HER 1 (EGFR), HER2 and HER4 inhibitor with IC50 of 6, 45.7 and 73.7 nM for EGFR, ERBB2 and ERBB4, respectively.
CSN15847 CUDC-101 1012054-59-9 CUDC-101 inhibits HDAC, EGFR and HER2 with IC50 of 4.4 nM, 2.4 nM and 15.7 nM, respectively.
CSN17871 CO-1686 Hydrobromide 1446700-26-0 CO-1686 hydrobromide is an irreversible and orally delivered kinase inhibitor that specifically targets the mutant forms of EGFR including T790M (IC50=21 nM).
CSN13912 CO-1686 1374640-70-6 CO-1686 functions as an irreversible and mutant-selective inhibitor of EGFRL858R/T790M and EGFRWT with Ki of 21.5 nM and 303.3 nM respectively.
CSN17167 CNX-2006 1375465-09-0 CNX-2006 is an irreversible mutant-selective EGFR inhibitor with IC50 of < 20 nM, with very weak inhibition at wild-type EGFR.
CSN25283 CGP 52411 145915-58-8 CGP 52411 inhibited the EGF-R protein-tyrosine kinase in vitro with high selectivity. In cells, CGP52411 selectively inhibited both ligand-induced EGF-R and p185c-erbB2 autophosphorylation and c-fos mRNA induction.
CSN12261 Canertinib 267243-28-7 Canertinib is a pan-ErbB inhibitor for EGFR and ErbB2 with IC50 of 1.5 nM and 9.0 nM, no activity to PDGFR, FGFR, InsR, PKC, or CDK1/2/4.
CSN10535 Canertinib 2HCl 289499-45-2 Canertinib 2HCl, an irreversible quinazoline-based HER family tyrosine kinase inhibitor, inhibits EGFR and ErbB2 with IC50 of 1.5 nM and 9.0 nM respectively. Phase II.
CSN15701 BMS-690514 859853-30-8 BMS-690514 is a potent and selective inhibitor of epidermal growth factor receptor (EGFR), HER2, and HER4, as well as the VEGF receptor kinases.
CSN18515 BMS-599626 HCl 873837-23-1 BMS-599626 is an inhibitor of HER1 (IC50 = 20 nM) and HER2 (IC50 = 30 nM).
CSN25556 BI-4020 N/A BI-4020 is a noncovalent, new-generation, wild-type EGFR sparing, macrocyclic tyrosine kinase inhibitor.
CSN15755 AZ5104 1421373-98-9 AZ5104 is an irreversible inhibitor of EGFR-L858R/T790M, EGFR-L858R, EGFR-L861Q, and EGFR (IC50s of < 1 nM, 6 nM, 1 nM, and 25 nM respectively). AZ5104 is the demethylated metabolite of AZD-9291.
CSN16948 AV-412 Tosylate 451493-31-5 AV-412 is a potent dual inhibitor of EGFR and ErbB2(IC50=19 nM) tyrosine kinases, including the mutant EGFR(L858R IC50=0.51 nM, T790M IC50=0.79 nM). It inhibits autophosphorylation of EGFR and ErbB2 with IC(50) of 43 and 282 nM.
CSN24797 AST2818 mesylate   2130958-55-1 AST2818 mesylate is an EGFR inhibitor.
CSN18835 AST-1306 p-Toluenesulfonic Acid 1050500-29-2 AST-1306 p-toluenesulfonic acid is an irreversible inhibitor of EGFR and ErbB2 with IC50 of 0.5 nM and 3 nM, also effective in mutation EGFR T790M/L858R, more potent to ErbB2-overexpressing cells, 3000-fold selective for ErbB family than other kinases.
CSN16578 AST-1306 897383-62-9 AST-1306 is an irreversible inhibitor of EGFR and ErbB2 with IC50 of 0.5 nM and 3 nM, also effective in mutation EGFR T790M/L858R, more potent to ErbB2-overexpressing cells, 3000-fold selective for ErbB family than other kinases.
CSN17439 Anlotinib 1058156-90-3 Anlotinib is an EGFR inhibitor which can be used to treat non-small cell lung cancer.
CSN12358 AG-1478 153436-53-4 AG-1478 selectively inhibits EGFR with IC50 of 3 nM in cell-free assay.
CSN12371 Afatinib 439081-18-2 Afatinib is an irreversible inhibitor of pan-ErbB inhibitor with IC50 values of 0.4nM, 0.5nM, 10nM, 14nM and 1nM for EGFR (L858R), EGFR (wt), EGFR (L858R/T790M), HER2 and ErbB4, respectively.
CSN12703 Afatinib 850140-72-6 Afatinib E-isomer is an irreversible inhibitor of dual EGFR and HER2 that shows obvious activitives of EGFR wt, EGFR L858R, EGFR L858R/T790M and HER2 with IC50 of 0.5 nM, 0.4 nM, 10 nM and 14 nM respectively.
CSN16035 Afatinib Dimaleate 850140-73-7 Afatinib dimaleate is an irreversible inhibitor of EGFR and HER2, the IC50s for EGFR (wt), EGFR (L858R), EGFR (L858R/T790M) and HER2 are 0.5 nM, 0.4 nM, 10 nM and 14 nM respectively.
CSN12385 AEE788 497839-62-0 AEE788 is an inhibitor of both EGFR and VEGFR, the IC50s for EGFR and ErbB2 is 2 nM, 6 nM respectively.
CSN12809 AC480 714971-09-2 AC480 is a selective and efficacious inhibitor of HER1 and HER2 with IC50 of 20 nM and 30 nM, ~8-fold less potent to HER4, > 100-fold to VEGFR2, c-Kit, Lck, MET etc.
CSN24709 AG-1557 189290-58-2
CSN25386 AG 1478 hydrochloride 170449-18-0
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