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HDAC

HDAC

货号 产品名 CAS号 信息
CSN11991 Vorinostat     149647-78-9 Vorinostat is an HDAC1/3 inhibitor with IC50 of ~10 nM.
CSN16689 Valproic Acid Sodium 1069-66-5 Valproic acid sodium is a histone deacetylase (HDAC) inhibitor (IC50=10 μM in Hela cell, 24h) has an anticancer effect.
CSN13138 Valproic Acid 99-66-1 Valproic acid is a histone deacetylase (HDAC) inhibitor with IC50 of 10 μM in Hela cell with anticancer effect. It can be used in the treatment of epilepsy and bipolar disorder.
CSN17250 UF010 537672-41-6 UF010 is a selective inhibitor of HDAC3, 2, 1 and 8 with IC50s of 0.06 μM, 0.1 μM, 0.5 μM and 1.5 μM, respectively.
CSN17162 Tubastatin A 1252003-15-8 Tubastatin A is a potent and selective HDAC6 inhibitor with IC50 of 15 nM and is selective(1000-fold more) against all other isozymes except HDAC8(57-fold more).
CSN13649 Tubastatin A HCl 1310693-92-5 Tubastatin A hydrochloride is a potent and selective HDAC6 inhibitor with IC50 of 15 nM and is selective(1000-fold more) against all other isozymes except HDAC8(57-fold more).
CSN16346 Tubacin 537049-40-4 Tubacin is a highly potent and selective, reversible, cell-permeable HDAC6 inhibitor with an IC50 of 4 nM in a cell-free assay, approximately 350-fold selectivity over HDAC1.
CSN12139 Trichostatin A 58880-19-6 Trichostatin A is a selective and potent HDAC inhibitor with IC50 of ~1.8 nM and HDAC8 is the only known member of the HDAC-family that is not affected by TSA.
CSN15899 TMP269 1314890-29-3 TMP269 is an inhibitor of class IIa HDAC with IC50 of 157 nM, 97 nM, 43 nM and 23 nM for HDAC4, HDAC5, HDAC7 and HDAC9, respectively.
CSN15949 Tasquinimod 254964-60-8 Tasquinimod allosterically inhibits HDAC4 signalling with antiangiogenic and antineoplastic activities. It is a quinoline-3-carboxamide linomide analogue.
CSN11945 Sodium Butyrate 156-54-7 Sodium butyrate is a histone deacetylase (HDAC) inhibitor with IC50s are 0.3 mM, 0.4 mM, 0.3 mM for HDAC1, 2 and 7 respectively.
CSN11942 Sodium 4-Phenylbutanoate 1716-12-7 Sodium 4-phenylbutyrate is an inhibitor of histone deacetylase that has been used to treat urea cycle disorders.
CSN24467 SIS17 2374313-54-7 SIS17 is a specific HDAC11 inhibitor with IC50 value of 0.83μM for inhibition of the demyristoylation HDAC11 substrate, serine hydroxymethyl transferase 2.
CSN13123 Scriptaid 287383-59-9 Scriptaid is an inhibitor of HDAC with greater effect on acetylated H4.
CSN13835 Santacruzamate A 1477949-42-0 Santacruzamate A is an inhibitor of HDAC2 with IC50 of 119 pM.
CSN13496 Romidepsin     128517-07-7 Romidepsin is a potent HDAC1 and HDAC2 inhibitor with IC50 of 36 nM and 47 nM, respectively.
CSN17367 RG2833 1215493-56-3 RG2833 is a brain-penetrant HDAC inhibitor with IC50 of 60 nM and 50 nM for HDAC1 and HDAC3, respectively.
CSN13881 Remodelin 949912-58-7 Remodelin is a potent and selective inhibitor of the acetyl-transferase protein NAT10.
CSN13126 Quisinostat 875320-29-9 Quisinostat is an orally available, potent HDAC inhibitor with IC50 values of 0.11 nM for HDAC1.
CSN15971 Pyroxamide 382180-17-8 Pyroxamide is an inhibitor of histone deacetylase (HDAC) which potently inhibits affinity purified HDAC1. Also inhibits the growth of tumor cells in vitro and in vivo. Induces p21/WAF1 expression in tumor cells.
CSN13125 PTACH 848354-66-5 PTACH is a SAHA-based inhibitor of human HDAC. PTACH exerts potent growth inhibition against various human cancer cells, with EC50 values ranging from 1 to 10 μM.
CSN16063 Pracinostat   929016-96-6 Pracinostat is a potent pan-HDAC inhibitor with IC50 of 40-140 nM with exception for HDAC6 and has no activity against the class III isoenzyme SIRT I.
CSN16486 Pimelic Diphenylamide 106 937039-45-7 Pimelic diphenylamide 106 is an inhibitor of class I HDAC with IC50 for HDAC1, HDAC2, and HDAC3 of 150 nM, 760nM, and 370 nM, respectively.
CSN16819 PCI-34051 950762-95-5 PCI-34051 is a potent and specific HDAC8 inhibitor with IC50 of 10 nM in a cell-free assay. It has greater than 200-fold selectivity over HDAC1 and 6, more than 1000-fold selectivity over HDAC2, 3, and 10.
CSN15819 PCI-24781 783355-60-2 PCI-24781 is a pan-HDAC inhibitor mostly targeting HDAC1 with Ki of 7 nM, modest potent to HDACs 2, 3, 6, and 10 and greater than 40-fold selectivity against HDAC8.
CSN12908 Panobinostat   404950-80-7 Panobinostat is a broad-spectrum HDAC inhibitor with IC50 of 5 nM in a cell-free assay.
CSN17253 NKL 22 537034-15-4 NKL 22 is a HDAC inhibitor. The value of IC 50 is 78 uM.
CSN15915 Nexturastat A 1403783-31-2 Nexturastat A is a selective inhibitor of HDAC6 with IC50 of 5 nM.
CSN16017 Mocetinostat 726169-73-9 Mocetinostat is an inhibitor of HDAC1 (IC50 = 0.15 μM), HDAC2 (IC50 = 0.29 μM) and HDAC3 (IC50 = 1.66 μM).
CSN16038 MC1568 852475-26-4 MC1568 is a selective inhibitor of class II (IIa) histone deacetylas (HDAC II) with IC50 of 220 nM.
CSN12888 M344 251456-60-7 M344 is HDAC inhibitor with IC50 of 100 nM and can induce cell differentiation.
CSN10407 ITSA-1 200626-61-5 ITSA-1 is activator of HDAC by suppressing TSA.
CSN16577 ITF2357 HCl H2O 732302-99-7 ITF2357 HCl is a potent HDAC inhibitor for Maize HD2, HD1-B and HD1-A with IC50 of 10 nM, 7.5 nM and 16 nM, respectively.
CSN17395 HDAC-IN-3 1018673-42-1 HDAC-IN-3 is a histone deacetylase (HDAC) inhibitor.
CSN12566 Gallic Acid 149-91-7 Gallic acid is an organic acid that found in a variety of foods and herbs with effective antioxidant activity.
CSN15774 Dacinostat 404951-53-7 Dacinostat is a HDAC inhibitor with IC50 of 32 nM which can activate the p21 promoter.
CSN16258 CUDC-907 1339928-25-4 CUDC-907 is a dual PI3K and HDAC inhibitor for PI3Kα and HDAC1/2/3/10 with IC50 of 19 nM and 1.7 nM/5 nM/1.8 nM/2.8 nM, respectively.
CSN13794 Citarinostat 1316215-12-9 Citarinostat selectively inhibits HDAC6 with IC50 of 4 nM. It can also inhibit HDAC3 (IC50 = 76 nM).
CSN12488 CI-994 112522-64-2 CI-994 is an inhibitor of HDAC1 with IC50 of 0.57 μM with anti-tumor effect. It can cause G1 cell cycle arrest.
CSN16989 Chidamide 743420-02-2 Chidamide is a class I HDAC inhibitor with IC50s of 95/160/67/733 nM for HDAC1/2/3/8, also inhibiting HDAC10/11 (IC50=78/432 nM) and showing no inhibition on HDAC4/5/7/9/6 (IC50> 30 μM).
CSN13836 CAY10603 1045792-66-2 CAY10603 is a selective inhibitor of HDAC6 with IC50 of 2 pM.
CSN17366 BRD73954 1440209-96-0 BRD73954 is a selective inhibitor of HDAC6 and HDAC8 with IC50 of 36 nM and 120 nM, respectively.
CSN24145 BRD 4354 Ditrifluoroacetate N/A BRD 4354 Ditrifluoroacetate is an inhibitor of HDAC5 and HDAC9 with IC50s of 0.85 and 1.88 μM respectively.
CSN17249 BML-210 537034-17-6 BML-210 is the HDAC inhibitor, and its mechanism of action has not been characterized.
CSN17264 BG45 926259-99-6 BG45 is a selective inhibitor for HDAC3 with IC50 of 289 nM.
CSN11550 Belinostat(Random Configuration) 414864-00-9 Belinostat is a HDAC inhibitor with IC50 of 27 nM in a cell-free assay, with activity demonstrated in cisplatin-resistant tumors.
CSN13429 AR-42 935881-37-1 AR-42 is an inhibitor of HDAC with IC50 30 nM.
CSN17328 ACY-738 1375465-91-0 ACY-738 inhibits HDAC6 with IC50 value of 1.7 nM.
CSN13744 ACY-1215   1316214-52-4 ACY-1215 is a selective HDAC6 inhibitor with IC50 of 5 nM, being > 10-fold selective for HDAC6 than HDAC1/2/3 (IC50 = 58, 48, and 51 nM) with slight activity against HDAC8, minimal activity against HDAC4/5/7/9/11, Sirtuin1, and Sirtuin2.
CSN24175 JAK/HDAC-IN-1 2284621-75-4
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