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HDAC

HDAC

货号 产品名 CAS号 信息
CSN11991 Vorinostat   149647-78-9 Vorinostat is an HDAC1/3 inhibitor with IC50 of ~10 nM.
CSN16689 Valproic Acid Sodium 1069-66-5 Valproic acid sodium is a histone deacetylase (HDAC) inhibitor (IC50=10 μM in Hela cell, 24h) has an anticancer effect.
CSN13138 Valproic Acid 99-66-1 Valproic acid is a histone deacetylase (HDAC) inhibitor with IC50 of 10 μM in Hela cell with anticancer effect. It can be used in the treatment of epilepsy and bipolar disorder.
CSN17250 UF010 537672-41-6 UF010 is a selective inhibitor of HDAC3, 2, 1 and 8 with IC50s of 0.06 μM, 0.1 μM, 0.5 μM and 1.5 μM, respectively.
CSN17162 Tubastatin A 1252003-15-8 Tubastatin A is a potent and selective HDAC6 inhibitor with IC50 of 15 nM and is selective(1000-fold more) against all other isozymes except HDAC8(57-fold more).
CSN16346 Tubacin 537049-40-4 Tubacin is a highly potent and selective, reversible, cell-permeable HDAC6 inhibitor with an IC50 of 4 nM in a cell-free assay, approximately 350-fold selectivity over HDAC1.
CSN12139 Trichostatin A 58880-19-6 Trichostatin A is a selective and potent HDAC inhibitor with IC50 of ~1.8 nM and HDAC8 is the only known member of the HDAC-family that is not affected by TSA.
CSN15899 TMP269 1314890-29-3 TMP269 is an inhibitor of class IIa HDAC with IC50 of 157 nM, 97 nM, 43 nM and 23 nM for HDAC4, HDAC5, HDAC7 and HDAC9, respectively.
CSN24808 Tinostamustine HCl 1793059-58-1 Tinostamustine is an alkylatlng histone-deacetylase inhibitor (HDACi) fusion molecule. It is a functional pan-histone-deacetylase inhibitor and is assumed to potentiate the alkylating activity of the compound and/or may help to overcome resistance to other therapeutic agents.
CSN15949 Tasquinimod 254964-60-8 Tasquinimod allosterically inhibits HDAC4 signalling with antiangiogenic and antineoplastic activities. It is a quinoline-3-carboxamide linomide analogue.
CSN11945 Sodium Butyrate 156-54-7 Sodium butyrate is a histone deacetylase (HDAC) inhibitor with IC50s are 0.3 mM, 0.4 mM, 0.3 mM for HDAC1, 2 and 7 respectively.
CSN11942 Sodium 4-Phenylbutanoate 1716-12-7 Sodium 4-phenylbutyrate is an inhibitor of histone deacetylase that has been used to treat urea cycle disorders.
CSN24467 SIS17 2374313-54-7 SIS17 is a specific HDAC11 inhibitor with IC50 value of 0.83μM for inhibition of the demyristoylation HDAC11 substrate, serine hydroxymethyl transferase 2.
CSN13123 Scriptaid 287383-59-9 Scriptaid is an inhibitor of HDAC with greater effect on acetylated H4.
CSN13835 Santacruzamate A 1477949-42-0 Santacruzamate A is an inhibitor of HDAC2 with IC50 of 119 pM.
CSN13496 Romidepsin 128517-07-7 Romidepsin is a potent HDAC1 and HDAC2 inhibitor with IC50 of 36 nM and 47 nM, respectively.
CSN17367 RG2833 1215493-56-3 RG2833 is a brain-penetrant HDAC inhibitor with IC50 of 60 nM and 50 nM for HDAC1 and HDAC3, respectively.
CSN13881 Remodelin 949912-58-7 Remodelin is a potent and selective inhibitor of the acetyl-transferase protein NAT10.
CSN13126 Quisinostat 875320-29-9 Quisinostat is an orally available, potent HDAC inhibitor with IC50 values of 0.11 nM for HDAC1.
CSN15971 Pyroxamide 382180-17-8 Pyroxamide is an inhibitor of histone deacetylase (HDAC) which potently inhibits affinity purified HDAC1. Also inhibits the growth of tumor cells in vitro and in vivo. Induces p21/WAF1 expression in tumor cells.
CSN13125 PTACH 848354-66-5 PTACH is a SAHA-based inhibitor of human HDAC. PTACH exerts potent growth inhibition against various human cancer cells, with EC50 values ranging from 1 to 10 μM.
CSN16063 Pracinostat 929016-96-6 Pracinostat is a potent pan-HDAC inhibitor with IC50 of 40-140 nM with exception for HDAC6 and has no activity against the class III isoenzyme SIRT I.
CSN16486 Pimelic Diphenylamide 106 937039-45-7 Pimelic diphenylamide 106 is an inhibitor of class I HDAC with IC50 for HDAC1, HDAC2, and HDAC3 of 150 nM, 760nM, and 370 nM, respectively.
CSN16819 PCI-34051 950762-95-5 PCI-34051 is a potent and specific HDAC8 inhibitor with IC50 of 10 nM in a cell-free assay. It has greater than 200-fold selectivity over HDAC1 and 6, more than 1000-fold selectivity over HDAC2, 3, and 10.
CSN15819 PCI-24781 783355-60-2 PCI-24781 is a pan-HDAC inhibitor mostly targeting HDAC1 with Ki of 7 nM, modest potent to HDACs 2, 3, 6, and 10 and greater than 40-fold selectivity against HDAC8.
CSN12908 Panobinostat 404950-80-7 Panobinostat is a broad-spectrum HDAC inhibitor with IC50 of 5 nM in a cell-free assay.
CSN17253 NKL 22 537034-15-4 NKL 22 is a HDAC inhibitor. The value of IC 50 is 78 uM.
CSN15915 Nexturastat A 1403783-31-2 Nexturastat A is a selective inhibitor of HDAC6 with IC50 of 5 nM.
CSN23161 TCS HDAC6 20b 956154-63-5 NCT-14b is a selective HDAC6 inhibitor. It inhibits cell growth of α-positive MCF-7 breast cancer cells treated with estrogen but not untreated cells.
CSN16017 Mocetinostat 726169-73-9 Mocetinostat is an inhibitor of HDAC1 (IC50 = 0.15 μM), HDAC2 (IC50 = 0.29 μM) and HDAC3 (IC50 = 1.66 μM).
CSN16038 MC1568 852475-26-4 MC1568 is a selective inhibitor of class II (IIa) histone deacetylas (HDAC II) with IC50 of 220 nM.
CSN12888 M344 251456-60-7 M344 is HDAC inhibitor with IC50 of 100 nM and can induce cell differentiation.
CSN24175 JAK/HDAC-IN-1   2284621-75-4 JAK/HDAC-IN-1 is a potent JAK2/HDAC dual inhibitor with improved antiproliferative and proapoptotic activities over SAHA and ruxolitinib in several hematological cell lines.
CSN10407 ITSA-1 200626-61-5 ITSA-1 is activator of HDAC by suppressing TSA.
CSN16577 ITF2357 HCl H2O 732302-99-7 ITF2357 HCl H2O is a potent HDAC inhibitor for Maize HD2, HD1-B and HD1-A with IC50 of 10 nM, 7.5 nM and 16 nM, respectively.
CSN17395 HDAC-IN-3 1018673-42-1 HDAC-IN-3 is a histone deacetylase (HDAC) inhibitor.
CSN12566 Gallic Acid 149-91-7 Gallic acid is an organic acid that found in a variety of foods and herbs with effective antioxidant activity.
CSN15774 Dacinostat 404951-53-7 Dacinostat is a HDAC inhibitor with IC50 of 32 nM which can activate the p21 promoter.
CSN13794 Citarinostat 1316215-12-9 Citarinostat selectively inhibits HDAC6 with IC50 of 4 nM. It can also inhibit HDAC3 (IC50 = 76 nM).
CSN12488 CI-994 112522-64-2 CI-994 is an inhibitor of HDAC1 with IC50 of 0.57 μM with anti-tumor effect. It can cause G1 cell cycle arrest.
CSN16989 Chidamide 743420-02-2 Chidamide is a class I HDAC inhibitor with IC50s of 95/160/67/733 nM for HDAC1/2/3/8, also inhibiting HDAC10/11 (IC50=78/432 nM) and showing no inhibition on HDAC4/5/7/9/6 (IC50> 30 μM).
CSN13836 CAY10603 1045792-66-2 CAY10603 is a selective inhibitor of HDAC6 with IC50 of 2 pM.
CSN17366 BRD73954 1440209-96-0 BRD73954 is a selective inhibitor of HDAC6 and HDAC8 with IC50 of 36 nM and 120 nM, respectively.
CSN20569 BRD3308 1550053-02-5 BRD3308 is a highly selective inhibitor of histone deacetylase 3 (HDAC3) with an IC50 value of 65 nM for HDAC3 vs.
CSN24145 BRD 4354 Ditrifluoroacetate N/A BRD 4354 Ditrifluoroacetate is an inhibitor of HDAC5 and HDAC9 with IC50s of 0.85 and 1.88 μM respectively.
CSN17249 BML-210 537034-17-6 BML-210 is the HDAC inhibitor, and its mechanism of action has not been characterized.
CSN17264 BG45 926259-99-6 BG45 is a selective inhibitor for HDAC3 with IC50 of 289 nM.
CSN13429 AR-42 935881-37-1 AR-42 is an inhibitor of HDAC with IC50 30 nM.
CSN17328 ACY-738 1375465-91-0 ACY-738 inhibits HDAC6 with IC50 value of 1.7 nM.
CSN13744 ACY-1215 1316214-52-4 ACY-1215 is a selective HDAC6 inhibitor with IC50 of 5 nM, being > 10-fold selective for HDAC6 than HDAC1/2/3 (IC50 = 58, 48, and 51 nM) with slight activity against HDAC8, minimal activity against HDAC4/5/7/9/11, Sirtuin1, and Sirtuin2.
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