欢迎来到 CSNpharm! 产品仅用于科研!
首页 400-920-2911

PI3K

PI3K

货号 产品名 CAS号 信息
CSN12308 ZSTK474 475110-96-4 ZSTK474 inhibits class I PI3K isoforms with IC50s of of 16/44/4.6 and 49 nM for PΙ3Κα/β/δ and γ respectively.
CSN15908 XL765 Analogue 1349796-36-6 XL765 analogue is a dual inhibitor of mTOR/PI3K, mostly for p110γ with IC50 of 9 nM, and also inhibits DNA-PK and mTOR.
CSN16985 XL147 934526-89-3 XL147 is a potent, orally bioavailable inhibitor of the class I PI3K family of lipid kinases with IC50 values of 39 nM/383 nM/36 nM/23 nM for PI3Kα/β/δ/γ, respectively and less potent to PI3Kβ.
CSN12670 XL147 Analogue 956958-53-5 XL147 analogue is a selective and reversible class I PI3K inhibitor for PI3Kα/δ/γ with IC50 of 39 nM/36 nM/23 nM in cell-free assays, less potent to PI3Kβ.
CSN13854 VS-5584 1246560-33-7 VS-5584 is a potent and selective dual PI3K/mTOR inhibitor for mTOR, PI3Kα/β/δ/γ with IC50 of 3.4 nM and 2.6-21 nM.
CSN16944 Voxtalisib 934493-76-2 Voxtalisib is a potent and highly selective inhibitor of class I PI3Ks with IC50 of 39/110/9/43 nM for PI3Kα/β/γ/δ, also inhibits mTOR with IC50 of 160-910 nM.
CSN12315 TGX-221 663619-89-4 TGX-221 is a p110β-specific inhibitor with IC50 of 5 nM in a cell-free assay, and is 1000-fold selective for p110β than p110α.
CSN16414 TG 100713 925705-73-3 TG100713 is a pan-PI3K inhibitor against PI3Kγ, PI3Kδ, PI3Kα and PI3Kβ with IC50 of 50 nM, 24 nM, 165 nM and 215 nM.
CSN16010 TG 100115 677297-51-7 TG100-115 is a PI3Kγ/δ inhibitor with IC50 of 83 nM/235 nM, with little effect on PI3Kα/β.
CSN15739 SAR405   1523406-39-4 SAR405 is highly potent and selective inhibitor of PIK3C3 with an IC50 of 27 nM.
CSN15741 RP-5264 1532533-67-7 RP-5264 is an orally available, next generation PI3Kdelta inhibitor, inhibits PI3Kδ activity in enzyme and cell based assays with IC50 and EC50 values of 22.2 and 24.3 nM respectively.
CSN16214 PKI-587 1197160-78-3 PKI-587 is a highly potent dual PI3K/mTOR kinase inhibitor with IC50 of 0.4 nM, 5.4 nM and 1.6 nM for PI3Kα, PI3Kγ and mTOR, respectively.
CSN16550 PKI-402 1173204-81-3 PKI-402 is a potent dual pan-PI3K/mTOR inhibitor targeting PI3Kα/β/γ/δ and mTOR with IC50 of 2 nM/7 nM/16 nM/14 nM and 3 nM.
CSN16011 PIK-90 677338-12-4 PIK-90 is a PI3Kα/γ/δ inhibitor with IC50 of 11 nM/18 nM/58 nM, respectively, less potent to PI3Kβ (IC50= 350 nM).
CSN13561 PI3Kγ Inhibitor 1 1172118-03-4 PI3Kγ inhibitor 1 is a potent PI3Kγ inhibitor.
CSN13877 PI-3065 955977-50-1 PI-3065 is a selective p110δ inhibitor with IC50 of 15 nM, > 70-fold selectivity over other PI3K family members.
CSN12265 PI-103 371935-74-9 PI-103 is a potent inhibitor with low IC50 values against recombinant PI3K isoforms p110alpha (IC50= 2 nM), p110beta (IC50= 3 nM), p110delta (IC50= 3 nM), and p110gamma (IC50= 15 nM), less potent to mTOR/DNA-PK with IC50 of 30 nM/23 nM.
CSN13906 PI-103 HCl 371935-79-4 PI-103 HCl is a potent PI3K/Akt and mTOR inhibitor with IC50 values of 2 nM for recombinant PI3K isoform p110α and 30 nM for mTOR.
CSN16085 PF-04691502 1013101-36-4 PF-04691502 is an ATP-competitive PI3K (α/β/δ/γ)/mTOR dual inhibitor with Ki of 1.8 nM/2.1 nM/1.6 nM/1.9 nM and 16 nM, little activity against either Vps34, AKT, PDK1, p70S6K, MEK, ERK, p38, or JNK.
CSN13693 NVP-BKM120 HCl 1312445-63-8 NVP-BKM120 Hcl(BKM120) is a selective PI3K inhibitor of p110α/β/δ/γ with IC50 of 52 nM/166 nM/116 nM/262 nM, respectively. Reduced potency against VPS34, mTOR, DNAPK, with little activity to PI4Kβ.
CSN15893 NVP-BGT226 1245537-68-1 NVP-BGT226 is a class I PI3K/mTOR inhibitor for PI3Kα/β/γ with IC50 of 4 nM/63 nM/38 nM.
CSN16039 NVP-BAG956 853910-02-8 NVP-BAG956 is a potent, ATP-competitive and selective dual PI3K and PDK1 inhibitor in vitro and in vivo,with IC50 values to be 56, 444, 34, 117 and 240 nM for PI3K p110 alpha, beta, delta and gamma and PDK1 kinases.
CSN11484 Myricetin 529-44-2 Myricetin, a natural flavonoid isolated and purified from the root bark of Myrica cerifera L. with antioxidant and anti tumor properties, is an inhibitor of MEK1 activity and transformation of JB6 P+ mouse epidermal cells. It also inhibits PI3Kγ with Kd of 0.17 μM.
CSN11346 LY294002   154447-36-6 LY294002 is the first synthetic molecule known to inhibit PI3Kα/δ/β with IC50 of 0.5 μM/0.57 μM/0.97 μM in cell-free assays.
CSN12216 Wortmannin 19545-26-7 KY 12420 is the first described PI3K inhibitor with IC50 of 3 nM in a cell-free assay, with little selectivity within the PI3K family. It also blocks autophagosome formation and potently inhibits DNA-PK/ATM with IC50 of 16 nM and 150 nM in cell-free assays.
CSN16586 KU-0060648 881375-00-4 KU-0060648 is a dual inhibitor of DNA-PK and PI3Kα, PI3Kβ, PI3Kδ with IC50 of 8.6 nM and 4 nM, 0.5 nM, 0.1 nM respectively, and with less inhibition of PI3Kγ with IC50 of 0.59 μM.
CSN15967 IC-87114 371242-69-2 IC-87114 is a selective PI3Kδ inhibitor with IC50 of 0.5 μM in a cell-free assay.
CSN12474 GSK2126458   1086062-66-9 GSK2126458 is a highly selective and potent inhibitor of PI3K with Ki of 0.019 nM/0.13 nM/0.024 nM/0.06 nM and 0.18 nM/0.3 nM for p110α/β/δ/γ, mTORC1/2 , respectively.
CSN16235 GSK1059615 958852-01-2 GSK1059615 is a dual inhibitor of PI3Kα/β/δ/γ (reversible) and mTOR with IC50 of 0.4 nM/0.6 nM/2 nM/5 nM and 12 nM
CSN17123 GNE-477 1032754-81-6 GNE-477 is a potent and efficacious dual PI3K/mTOR inhibitor with IC50 of 4 nM for PI3Kα, Ki of 21 nM for mTOR.
CSN15869 GDC-0980 1032754-93-0 GDC-0980 is a potent, class I PI3K inhibitor for PI3Kα/β/δ/γ with IC50 of 5 nM/27 nM/7 nM/14 nM in cell-free assays
CSN12429 GDC-0941 957054-30-7 GDC-0941 is a potent inhibitor of PI3Kα/δ with IC50 of 3 nM, with modest selectivity against p110β(11-fold) and p110γ(25-fold).
CSN16999 GDC-0032 1282512-48-4 GDC-0032 is a potent, next-generation β isoform-sparing PI3K inhibitor targeting PI3Kα/δ/γ with IC50 of 0.29 nM/0.12 nM/0.97nM, > 10 fold selective over PI3Kβ.
CSN13707 Duvelisib 1201438-56-3 Duvelisib is a selective PI3K δ/γ inhibitor with Ki and IC50 of 23 pM/243 pM and 1 nM/50 nM, highly selective for PI3K δ/γ than other protein kinases.
CSN15117 Dehydroglyasperin C 199331-35-6 Dehydroglyasperin C, a natural product isolated and purified from the roots of Glycyrrhiza uralensis Fisch, suppresses TPA-induced cell transformation through direct inhibition of MKK4 and PI3K.
CSN15881 CZC-24832 1159824-67-5 CZC-24832 is the first selective PI3Kγ inhibitor with IC50 of 27 nM, with 10-fold selectivity over PI3Kβ and > 100-fold selectivity over PI3Kα and PI3Kδ.
CSN15713 Copanlisib   1032568-63-0 Copanlisib is a potent and highly selective reversible PI3K inhibitor for PI3Kα/β with IC50 of 0.469 nM/3.72 nM.
CSN15797 CH5132799 1007207-67-1 CH5132799 inhibits class I PI3Ks, particularly PI3Kα with IC50 of 14 nM, and is less potent to PI3Kβδγ, while sensitive in PIK3CA mutations cell lines.
CSN12930 CAL-101 870281-82-6 CAL-101 is a selective p110δ inhibitor with IC50 of 2.5 nM, shown to have 40- to 300-fold greater selectivity for p110δ than p110α/β/γ, and 400- to 4000-fold selectivity to p110δ than C2β, hVPS34, DNA-PK and mTOR.
CSN13168 BKM-120 944396-07-0 BKM120 is a selective PI3K inhibitor of p110α/β/δ/γ with IC50 of 52 nM/166 nM/116 nM/262 nM in cell-free assays, respectively.
CSN12260 BEZ235 915019-65-7 BEZ235 is a dual ATP-competitive PI3K and mTOR inhibitor for p110α/γ/δ/β and mTOR(p70S6K) with IC50 of 4 nM /5 nM /7 nM /75 nM /6 nM in cell-free assays, respectively. Inhibits ATR with IC50 of 21 nM in 3T3TopBP1-ER cell.
CSN16946 AZD8835 1620576-64-8 AZD8835 ia a mixed inhibitor of PI3Kα and PI3Kδ with IC50 of 6.2 nM and 5.7 nM, respectively, also with selectivity against PI3Kβ (IC50=431 nM) and PI3Kγ (IC50=90 nM).
CSN15821 AZD8186 1627494-13-6 AZD8186 is an isoform-specific small-molecule PI3K inhibitor, potently inhibits PI3Kβ (IC50=4 nM) and PI3Kδ (IC50=12 nM) with selectivity over PI3Kα (IC50=35 nM) and PI3Kγ (IC50=675 nM).
CSN12381 AZD6482 1173900-33-8 AZD6482 is a PI3Kβ inhibitor with IC50 of 10 nM, 8-, 87- and 109-fold selective to PI3Kβ than PI3Kδ, PI3Kα and PI3Kγ.
CSN13098 AS-605240 648450-29-7 AS-605240 selectively inhibits PI3Kγ with IC50 of 8 nM, over 30-fold and 7.5-fold selective for PI3Kγ than PI3Kδ/β and PI3Kα in cell-free assays, respectively.
CSN16052 AS-252424 900515-16-4 AS-252424 is a potent PI3Kγ inhibitor with IC50 of 30 nM in a cell-free assay with 30-fold selectivity for PI3Kγ than PI3Kα, and low inhibitory activity towards PI3Kδ/β.
CSN15834 AMG-319 1608125-21-8 AMG-319 is a potent and selective PI3Kδ inhibitor with IC50 of 18 nM, > 47-fold selectivity over other PI3Ks.
CSN13709 Alpelisib   1217486-61-7 Alpelisib is a potent and selective PI3Kα inhibitor with IC50 of 5 nM, liitle or no effect on PI3Kβ/γ/δ.
CSN16673 A66 1166227-08-2 A66 is a potent and specific p110α inhibitor with IC50 of 32 nM, > 100 fold selectivity for p110α over other class-I PI3K isoforms.
CSN24176 ME-401 1595129-71-7
<< PREV 1 2 3 4 NEXT >>