欢迎来到 CSNpharm! 产品仅用于科研!
首页
400-920-2911 sales@csnpharm.cn    

Epigenetic Reader Domain

Epigenetic Reader Domain

货号 产品名 CAS号 信息
CSN23787 YF-2 1311423-89-8 YF-2 is a highly selective and blood-brain-barrier permeable histone acetyltransferase activator, it acetylates H3 in the hippocampus.
CSN20473 UNC 926 1184136-10-4 UNC 926 HCl binds to MBT domain of L3MBTL protein (Kd = 3.9 µM) and block the interaction with methylated lysine on histone 4, H4K20.
CSN16356 SGC-CBP30   1613695-14-9 SGC-CBP30 is a potent CREBBP/EP300 bromodomain inhibitor with IC50 of 21-69 and 38 nM for CREBBP and EP300 bromodomains, respectively.
CSN13057 RVX-208 1044870-39-4 RVX-208 is an inhibitor of BET bromodomain BD2 with IC50 of 0.510 μM.
CSN21389 BETd-260 2093388-62-4 PROTAC BET Degrader 23 is a highly potent and efficacious PROTAC targeting on BET with DC50 value of 30pM for degradation of BRD4 in RS4;11 leukemia cell line.
CSN21058 PLX51107 1627929-55-8 PLX51107 is a potent and selective BRD4 inhibitor or BET inhibitor with novel in vitro and in vivo pharmacologic properties that emulates or exceeds the efficacy of BCR signaling agents in preclinical models of CLL.
CSN13852 PFI-4 900305-37-5 PFI-4 selectively inhibits BRPF1 bromodomain with IC50 of 80 nM.
CSN17164 PFI-1   1403764-72-6 PFI-1 is a highly selective BET (bromodomain-containing protein) inhibitor for BRD4 with IC50 of 0.22 μM and for BRD2 with IC50 of 98 nM in a cell-free assay.
CSN13739 OTX-015 202590-98-5 OTX-015 is a potent BET bromodomain inhibitor with EC50 ranging from 10 to 19 nM for BRD2, BRD3, and BRD4 in cell-free assays.
CSN16354 OF-1 919973-83-4 OF-1 is an inhibitor of the proteins BRPF1B (Kd = 100 nM) and BRPF2 (Kd = 500 nM) bromodomain.
CSN21379 MZP-55 2010159-48-3 MZP-55 is a VHL-based PROTAC targeting on BET with pDC50/Dmax (%) values of 8.1/95, 7.5/93, 7.7/92, −/26 for Brd4 short, Brd4 long, Brd3 and Brd2 in HeLa cells, consist of I-BET726 as a warhead ligand linked to VHL ligand VH032.
CSN17242 MS436 1395084-25-9 MS436, a diazobenzene-based small compound, is an inhibitor of BRD4 bromodomains with Ki values of 30-50 nM.
CSN18822 Mivebresib 1445993-26-9 Mivebresib, also known as ABBV-075, is an inhibitor of bormodomain and extra terminal domain (BET). The Ki values of BRD2, BRD4, BRDT are 1 nM - 2.2 nM.
CSN21386 L-45 2079885-05-3 L-45 is the first potent, selective, and cell-active p300/CBP-associated factor (PCAF) bromodomain (Brd) inhibitor with a Kd of 126±15 nM.
CSN22252 KG-501 18228-17-6 KG-501 is histochemical substrate of alkaline phosphatases and can inhibit CREB-CBP interaction.
CSN17207 I-BRD9 1714146-59-4 I-BRD9 is a BRD9 bromodomain inhibitor with pIC50 value of 7.3 and pKd of 8.7. BRD9 fuctions as part of the SWI/SNF complex in chromatin remolding .
CSN13060 I-BET-151 1300031-49-5 I-BET-151 is a selective BET inhibitor for BRD2, BRD3 and BRD4 with IC50 of 0.5 μM, 0.25 μM, and 0.79 μM in cell-free assays, respectively.
CSN13061 I-BET-762 1260907-17-2 I-BET 762 is an inhibitor for BET proteins with IC50 of ~35 nM.
CSN18953 GSK6853 1910124-24-1 GSK6853 selectively inhibits the BRPF1 bromodomain with the pKd value of 9.5.
CSN16355 GSK5959 901245-65-6 GSK5959 is a potent, selective and cell permeable BRPF1 bromodomain inhibitor with IC50 ~ 80 nM.
CSN17637 GSK525768A 1260530-25-3 GSK525768A is the enantiomer compound of GSK 525762A, which is a potent small molecule inhibitor that disrupt the function of the BET family of bromodomains (Brd2, Brd3, and Brd4) and has NO activity towards BET.
CSN13657 GSK2801 1619994-68-1 GSK2801 inhibits BAZ2 family of bromodomain-containing proteins BAZ2A (Kd = 260 nM) and BAZ2B (Kd= 140 nM, IC50 = 9-350 nM).
CSN16910 GSK1324726A   1300031-52-0 GSK1324726A is an inhibitor of BET proteins BRD2, BRD3, BRD4 with IC50 of 41 nM, 31 nM, and 22 nM respectively.
CSN19674 GNE-272 1936428-93-1 GNE-272 is a potent and selective in Vivo Probe for the Bromodomains of CBP/EP300 (CBP IC50 = 0.02 μM, EP300 IC50 = 0.03 μM, BRET IC50 = 0.41 μM, BRD4(1) C50 = 13 μM).
CSN21184 FL-411 2118944-88-8 FL-411 selectively inhibits BRD4 with an IC50 of 0.43 ± 0.09 μM.
CSN20172 EML631 2101206-36-2 EML631 interacts with the Tudor-domain-containing protein Spindlin1 (SPIN1), blocking its ability to 'read' H3K4me3 marks and inhibit its transcriptional-coactivator activity.
CSN18854 EED226 2083627-02-3 EED226 is a potent and selective PRC2 inhibitor that directly binds to the H3K27me3 binding pocket of EED.
CSN19072 CPI-637 1884712-47-3 CPI-637 is an efficient inhibitor of CBP/EP300 bromodomain with IC50 of 0.03 ± 0.01μM.
CSN24814 CPI-268456 1380087-86-4 CPI-268456 is a ligand of BRD4.
CSN17768 CPI-0610   1380087-89-7 CPI-0610 is an inhibitor of BET bromodomains BRD2, BRD3, BRD4, and BRDT via binding to the acetylated lysine recognition motifs.
CSN16219 CPI-203 1446144-04-2 CPI 203 is a potent, selective and cell permeable inhibitor of the bromodomain and extra terminal (BET) family protein BRD4 with an IC50 of ~37 nM (BRD4 α-screen assay).
CSN19752 CD161 1627716-22-6 CD161 is a potent, selective, and orally active BET inhibitor.
CSN15855 Bromosporine 1619994-69-2 Bromosporine inhibits various bromodomains including BRD2, BRD4, BRD9 and CECR2 with IC50s of 0.41 μM, 0.29 μM, 0.122 μM and 0.017 μM respectively.
CSN18952 BI-9564 1883429-22-8 BI-9564 is an inhibitor of BRD9 (IC50 = 75 nM) and BRD7 (IC50 = 3.4 µM).
CSN18673 BI-7273 1883429-21-7 BI-7273 is a potent, selective, and cell-permeable BRD9 BD Inhibitor.
CSN22309 BETd-246 2140289-17-2 BETd-246 is a second-generation BET bromodomain inhibitor. It causes a dose-dependent depletion of BRD2, BRD3 and BRD4 in representative TNBC cell lines with 30-100 nM for 1 h or with 10-30 nM for 3 h incubation.
CSN17831 BET-IN-1 1422554-34-4 BET-IN-1 is a bromodomain inhibitor with a plC50 in the range 6.0 - 7.0.
CSN18957 BET-BAY 002 S-Enantiomer 2070009-49-1 BET-BAY 002 S-enantiomer is the S-enantiomer of BET-BAY 002.
CSN17940 BET-BAY 002 1588521-78-1 BET-BAY 002 is a potent BET inhibitor and shows efficacy in a multiple myeloma model.
CSN20265 BET Inhibitor C3 874594-37-3 BET inhibitor C3 is a BET bromodomain inhibitor of epigenetic regulatory proteins BrdT and Brd4.
CSN20607 AZD5153 6-Hydroxy-2-Naphthoic Acid 1869912-40-2 AZD5153 is an inhibitor of BET/BRD4 bromodomain, the IC50 for BRD4 is 1.7 nM.
CSN19702 AZD5153 1869912-39-9 AZD5153 exhibits excellent pharmacokinetic profile and high potency in vitro and in vivo effecting c-Myc downregulation and tumor growth inhibition in xenograft studies.
CSN21392 AT6 2098836-50-9 AT6 is a PROTAC targeting on Brd4.
CSN21391 AT 1 2098836-45-2 AT1 is a highly selective Brd4 degrader with a modified VHL ligand retained binding to VHL (Kd = 330 nM).
CSN21253 EED inhibitor-1 1951408-58-4 An inhibitor of embryonic ectoderm development protein (EED) and allosteric inhibitor of polycomb repressive complex 2 (PRC2), with potential antineoplastic activity.
CSN21197 ABBV-744 2138861-99-9 ABBV-744 is an inhibitor of BDII-selective BET bromodomain that is being investigated to treat AML and metastic castration-resistant prostate cancer.
CSN24157 666-15 1433286-70-4 666-15 is a potent and cell-permeable inhibitor of cAMP-response element binding protein (CREB) with efficacious anti-cancer activity both in vitro and in vivo.
CSN13913 (-)-JQ-1 1268524-71-5 (R)-(-)-JQ1 enantiomer, the stereoisomer(+)-JQ1, showed no significant interaction with any bromodomain. (+)-JQ1 is an inhibitor for the BET which targets the BET bromodomain. The (R)-(-)-JQ1 enantiomer stereoisomer has no appreciable affinity to BET bromodomains, whereas S-enantiomer pure (+)-JQ1 binds to BRD4 bromodomains 1 and 2 with Kd values of ~ 50 and 90 nM, respectively.
CSN13058 (+)-JQ-1 1268524-70-4 (+)-JQ1 is a BET bromodomain inhibitor, with IC50 of 77 nM/33 nM for BRD4(1/2) in cell-free assays, binding to all bromodomains of the BET family, but not to bromodomains outside the BET family.
CSN18086 JQ-1 Carboxylic Acid 202592-23-2 (+)-JQ1 carboxylic acid is a warhead ligand with a carboxylic acid functional group for conjugation reactions of PROTAC targeting on BET.
<< PREV 1 2 3 NEXT >>