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STAT

STAT

货号 产品名 CAS号 信息
CSN27573 STAT3-IN-7 1313019-65-6 STAT3-IN-7 is a Sorafenib analogue and potently inhibits the phosphorylation of STAT3. STAT3-IN-7 induces cell apoptosis through SHP-1 dependent STAT3 inactivation. STAT3-IN-7 does not inhibit kinase activity and has anticancer effects.
CSN27227 STAT3-IN-1   2059952-75-7 STAT3-IN-1 (compound 7d) is an excellent, selective and orally active STAT3 inhibitor, with IC50 values of 1.82 μM and 2.14 μM in HT29 and MDA-MB 231 cells, respectively. STAT3-IN-1 (compound 7d) induces tumor apoptosis .
CSN11557 Nifuroxazide 965-52-6 Nifuroxazide suppresses the transcription activity of STAT1, STAT3 (IC50 = 3 μM in cells) and STAT5. It is a nitrofuran-based antidiarrheal agent that can prevent urinary tract infections.
CSN12693 Niclosamide 50-65-7 Niclosamide can inhibit DNA replication and inhibit STAT3 with IC50 of 0.7 μM in a cell-free assay. Niclosamide selectively inhibits the phosphorylation of STAT3 and has no obvious inhibition against the activation of other homologues (e.g., STAT1 and STAT5).
CSN20515 inS3-54-A18 328998-53-4 inS3-54-A18 is an inhibitor of STAT3 that suppresses tumor growth, metastasis and the expression of STAT3 target genes.
CSN19012 HO-3867 1172133-28-6 HO-3867 selectively inhibits the phosphorylation and transcription of STAT3. It is an analog of curcumin.
CSN27216 Colivelin TFA N/A Colivelin TFA is a brain penetrant neuroprotective peptide and a potent activator of STAT3, suppresses neuronal death by activating STAT3 in vitro . Colivelin TFA exhibits long-term beneficial effects against neurotoxicity, Aβ deposition, neuronal apoptosis, and synaptic plasticity deficits in neurodegenerative disease . Colivelin TFA has the potential for the treatment of alzheimer's disease and ischemic brain injury .
CSN17200 BP-1-102 1334493-07-0 BP-1-102 is an orally available, small-molecule inhibitor of transcription factor STAT3.
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