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P2X Receptor

P2X Receptor

货号 产品名 CAS号 信息
CSN19854 Ro 51 1050670-85-3 Ro 51 is a potent, dual P2X3 and P2X2/3 antagonist (IC50 values are 2 and 5 nM for rP2X3 and hP2X2/3 respectively).
CSN21352 BzATP Triethylammonium Salt 112898-15-4 Prototypic P2X7 receptor agonist that exhibits 5 - 10 fold greater potency than ATP (EC50 = 0.7 μM in HEK 293 cells; EC50 values are 3.6 and 285 μM for rat and mouse receptors respectively). Exhibits partial agonist activity at P2X1 (pEC50 = 8.7) and P2Y1 receptors and can be used as a photoaffinity label for ATPase.
CSN21404 BzATP 81790-82-1 Prototypic P2X7 receptor agonist that exhibits 5 - 10 fold greater potency than ATP (EC50 = 0.7 μM in HEK 293 cells; EC50 values are 3.6 and 285 μM for rat and mouse receptors respectively). Exhibits partial agonist activity at P2X1 (pEC50 = 8.7) and P2Y1 receptors and can be used as a photoaffinity label for ATPase.
CSN16004 NF449 627034-85-9 NF449 is a potent purinergic receptor antagonist that displays high selectivity for P2X1 (IC50 values are 0.28, 0.69, 120, 1820, 47000 and > 300000 nM for rP2X1, rP2X1+5, rP2X2+3, rP2X3, rP2X2 and P2X4 receptors respectively). Provides antithrombotic protection in vivo. Also acts as a Gsα-selective antagonist.
CSN20323 NF023 104869-31-0 NF023, a subtype-selective, competitive and reversible P2X1 receptor antagonist, displays IC50 values of 0.21, 28.9, > 50 and > 100 μM for human P2X1, P2X3, P2X2, and P2X4-mediated responses respectively.
CSN11254 KN-62 127191-97-3 KN-62 is a selective and potent inhibitor of calmodulin-dependent protein kinase II (CaMK-II) with IC50 of 0.9 μM, KN-62 also displays noncompetitive antagonism at P2X7 receptors in HEK293 cells, with an IC50 value of approximately 15 nM..
CSN20216 JNJ-54175446 1627902-21-9 JNJ-54175446 is a potent and selective P2X7 Receptor Antagonist.
CSN19839 JNJ 47965567 1428327-31-4 JNJ 47965567 is a potent and selective P2X7 antagonist (pIC50 values are 8.3, 7.5 and 7.2 for human, mouse and rat receptors respectively).
CSN18197 GW791343 3HCl 309712-55-8 GW791343 trihydrochloride is a P2X7 allosteric modulator and exhibits species-specific activity and acts as a negative allosteric modulator of human P2X7 (pIC50 = 6.9 - 7.2).
CSN16798 GW791343 2HCl 1019779-04-4 GW791343 dihydrochloride is a P2X7 allosteric modulator exhibiting species-specific activity and acts as a negative allosteric modulator of human P2X7 (pIC50 = 6.9 - 7.2).
CSN22409 Gefapixant 1015787-98-0 Gefapixant is an orally active P2X3 receptor (P2X3R) antagonist with IC50s of ~30 nM versus recombinant hP2X3 homotrimers and 100-250 nM at hP2X2/3 heterotrimeric receptors.
CSN10731 CTP Disodium Dihydrate 81012-87-5 CTP Disodium Dihydrate is a P2X4 purinergic receptor agonist.
CSN22173 CE-224535 724424-43-5 CE-224535 is a selective P2X7 receptor antagonist.
CSN19027 AZD9056 HCl 345303-91-5 AZD9056 hydrochloride is a selective orally active inhibitor of P2X7 which plays a significant role in inflammation and pain-causing diseases.
CSN16154 AF-353 865305-30-2 AF-353 is a potent and orally bioavailable P2X3/P2X2/3 receptor antagonist, inhibits human and rat P2X3 (pIC50= 8.0).
CSN18509 A 839977 870061-27-1 A-839977 is a selective P2X7 antagonist and blocks BzATP-evoked calcium influx at recombinant human, rat and mouse P2X7 receptors (IC50 values are 20, 42 and 150 nM respectively).
CSN19020 A-804598 1125758-85-1 A-804598 is a competitive, and selective P2X7 receptor antagonist with IC50 of 10 nM, 9 nM and 11 nM in rat, mouse and human P2X7 receptors respectively.
CSN13107 A-740003 861393-28-4 A-740003 is potent, selective and competitive P2X7 receptor antagonist (IC50 values are 18 and 40 nM for rat and human receptors respectively).
CSN19024 A-317491 Sodium Hydrate N/A A-317491 sodium is a non-nucleotide P2X3 and P2X2/3 receptor antagonist, which inhibits calcium flux mediated by the receptors.
CSN18291 A-317491 475205-49-3 A-317491 is a potent and selective non-nucleotide antagonist of P2X3 and P2X2/3 receptors with Ki values of 22 nM and 9 nM for human P2X3 and P2X2/3 receptors.
CSN18547 A 438079 899507-36-9 A 438079 is a competitive P2X7 receptor antagonist (pIC50 = 6.9 for the inhibition of Ca2+ influx in the human recombinant P2X7 cell line).
CSN18546 A 438079 HCl 899431-18-6 A 438079 HCl is a competitive P2X7 receptor antagonist (pIC50 = 6.9 for the inhibition of Ca2+ influx in the human recombinant P2X7 cell line).
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