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TRP Channel

货号 产品名 CAS号 信息
CSN19515 Vanillyl Alcohol 498-00-0 Vanillyl alcohol is a free radical scavenger with anticonvulsive and bile secretion promoting effect. It can be extracted from the herbs of Gastrodia elata Bl..
CSN16412 SN 2 823218-99-1 SN 2 is a potent activator of TRPML3 ion channel with EC50 of 1.8±0.13 μM.
CSN15682 SB-705498 501951-42-4 SB-705498 is a selective antagonist of transient receptor potential vanilloid 1 (TRPV1) with pIC50 of 7.1.
CSN19507 SB-366791 472981-92-3 SB-366791 is an antagonist of vanilloid receptor VR1 or TRPV1 with IC50 of 5.7±1.2 nM.
CSN18783 SAR7334 1333210-07-3 SAR7334 is a potent TRPC6 (Transient receptor potential cation channel, subfamily C, member 6) inhibitor.
CSN12436 SAR7334 2HCl 1333207-63-8 SAR7334 dihydrochloride is a potent and specific TRPC6 inhibitor, inhibiting TRPC6 currents with IC50 of 7.9 nM.
CSN17628 RQ-00203078 1254205-52-1 RQ-00203078 is a selective antagonist of TRPM8 with IC50 of 8.3 nM.
CSN18624 RN-1734 946387-07-1 RN-1734 is selective antagonist of the TRPV4 channel, completely antagonizes 4αPDD-mediated activation of TRPV4 with comparable, low micromolar IC50 values for all three species (hTRPV4: IC50 = 2.3 μM, mTRPV4: IC50 = 5.9 μM, rTRPV4: IC50 = 3.2 μM).
CSN18152 Pyr6 245747-08-4 Pyr6 is a selective inhibitor of TRPC3 with IC50 of 0.49 μM (Ca2+ influx inhibition in thapsigargin depleted native RBL-2H3 cells).
CSN17688 Pyr10 1315323-00-2 Pyr 10 is a TRPC3-selective inhibitor. IC50 of Ca2+ influx inhibition by Pyr10 in carbachol-stimulated YFP-TRPC3-transfected HEK293 cells for ROCE and thapsigargin-depleted native RBL-2H3 cells for SOCE is 0.72 uM and 13.08 uM.
CSN11772 Probenecid 57-66-9 Probenecid inhibits TRP channels such as TRPV2, TRPM8 and TRPA1. It is an inhibitor of the renal excretion of organic anions.
CSN21376 AM-0902   1883711-97-4 Potent and selective TRPA1 antagonist (IC50 = 0.02 μM for human TRPA1). Exhibits no siginificant activity against human TRPV1 or TRPV4, and rat TRPV1, TRPV3 or TRPM8. Exhibits efficacy in a rat pain model. Orally bioavailable.
CSN19028 Podocarpic Acid 5947-49-9 Podocarpic acid is a natural product, which has the best all-round positive effect and acts as a TRPA1 activator.
CSN13939 PF-4840154 1332708-14-1 PF-4840154 is a potent, selective agonist of the rat and human TrpA1 channel and elicited TrpA1-mediated nocifensive behaviour in mouse, with EC50 of 97 nM and 23 nM for rTrpA1 and hTrpA1, respectively.
CSN20615 PF-05105679 1398583-31-7 PF-05105679 is an orally-bioavailable and selective TRPM8 blocker (IC50 = 103 nM) which exhibits > 100-fold selectivity for TRPM8 over a panel of receptors, ion channels and enzymes, including TRPV1 and TRPA1 ion channels.
CSN17365 Optovin 348575-88-2 Optovin is a reversible and photoactive activator of TRPA1 with EC50 of 2 μM in wild-type zebrafish.
CSN16213 N-Vanillylnonanamide 2444-46-4 Nonivamide, an analog of capsaicin, is agonist of transient receptor potential vanilloid type 1 (TRPV1). It can be extracted from the fruits of Capsicum annuum L..
CSN20361 MRS1477 212200-21-0 MRS1477 is a positive allosteric modulator of TRPV1 channels targeting breast cancer cells.
CSN15766 ML204 5465-86-1 ML204 is a selective antagonist of TRPC4 ion channel with IC50 of 0.96 μM and 2.6 μM in fluorescent and electrophysiological assays respectively.
CSN19023 ML204 HCl 2070015-10-8 ML204 hydrochloride is a potent, selective TRPC4 channel inhibitor with IC50 of 0.96 μM.
CSN18632 Mavatrep 956274-94-5 Mavatrep is an orally bioavailable TRPV1 antagonist (Ki=6.5 nM), exhibits minimal effect on the enzymatic activity (IC50 > 25 μM) of CYP isoforms 3A4, 1A2, and 2D6.
CSN22440 JYL 1421 401907-26-4 JYL 1421 is a TRPV1 receptor antagonist, with an IC50 of 8 nM.
CSN18446 JNJ-17203212   821768-06-3 JNJ-17203212 is a selective TRPV1 antagonist, with IC50 of 65 nM and 102 nM for human TRPV1 and rat TRPV1.
CSN16140 Icilin 36945-98-9 Icilin is an agonist of TRPM8 ion channel with EC50 of 0.36 μM in HEK 293 cells.
CSN18524 HC-067047 883031-03-6 HC-067047 is a TRPV4 antagonist with IC50 value of 48 ± 6 nM in human.
CSN16823 HC-030031 349085-38-7 HC-030031 is a blocker of TRPA1 channel that exhibits antagonistic effect on AITC- and formalin-evoked calcium influx with IC50 of 6.2 μM and 5.3 μM respectively.
CSN19708 GSK2193874 1336960-13-4 GSK2193874 is a selective transient receptor potential vanilloid 4 (TRPV4) blocker with IC50 value of 0.04 μM.
CSN18613 GSK1016790A 942206-85-1 GSK1016790A is a potent activator of TRPV4 (transient receptor potential vanilloid 4) with EC50 of 34nM in choroid plexus epithelial cells.
CSN19025 D-3263 HCl 1008763-54-9 D-3263 hydrochloride is an orally bioavailable (transient receptor potential melastatin member 8) TRPM8 agonist.
CSN18220 Chembridge-5861528 332117-28-9 Chembridge-5861528 is a TRPA1 channel blocker that antagonizes AITC- and 4-HNE-evoked calcium influx (IC50 values are 14.3 and 18.7μM respectively).
CSN10542 Capsazepine 138977-28-3 Capsazepine is an antagonist of TRPV1 receptor with IC50 of 562 nM. It is synthetic analogue of sensory neurone excitotoxin.
CSN20616 Cannabidivarin 24274-48-4 Cannabidivarin is a non-psychoactive cannabinoid found in Cannabis that activates CB2 cannabinoid receptors as well as the transient receptor potential channels TRPA1, TRPV1, and TRPV2 (EC50s = 0.42, 3.6, and 7.3 µM, respectively). It is also reported to antagonize TRPM8 (IC50 = 0.9 µM) and to inhibit diacylglycerol lipase (IC50 = 16.6 µM).
CSN15352 Bisandrographolide A 160498-00-0 Bisandrographolide A, a natural product, activates TRPV4 channels, could play a role in some of the effects of Andrographis extract described in traditional medicine.
CSN16141 BCTC 393514-24-4 BCTC is a potent and specific inhibitor of transient receptor potential cation channel subfamily M member 8 (TRPM8) in prostate cancer (PCa) DU145 cells.
CSN20581 ASP 7663 1190217-35-6 ASP 7663 is an orally-bioavailabe, selective TRPA1 activator (EC50 values are ~0.5 μM in human, mouse and rat), which displays little or no affinity at more than 60 other related receptors, channels and enzymes. It stimulates 5-HT release from QGP-1 cells and exhibits an abdominal analgesic effect in vivo.
CSN21956 AMG9810 545395-94-6 AMG9810 is an antagonist of TRPV1 receptor with IC50 of 17 nM and exhibits antihyperalgesic properties in rat model.
CSN16537 AMG-517 659730-32-2 AMG-517 is a potent and selective TRPV1 antagonist, and antagonizes capsaicin, proton, and heat activation of TRPV1 with IC50 of 0.76 nM, 0.62 nM and 1.3 nM.
CSN24182 AMG 333 1416799-28-4 AMG 333 is a potent and selective TRPM8 antagonist with IC50 value of 13nM.
CSN10343 α-Spinasterol 481-18-5 alpha-Spinasterol is an efficacious and safe antagonist of the TRPV1 receptor with antinociceptive effect.
CSN24195 AC1903 831234-13-0 AC1903 is an inhibitor of transient receptor potential canonical channel 5 (TRPC5) with IC50 of 14.7 µM.
CSN19859 A 967079 1170613-55-4 A 967079 is a selective TRPA1 channel blocker (IC50 values are 67 and 289 nM at human and rat TRPA1 receptors respectively).
CSN12433 6-Gingerol 23513-14-6 6-Gingerol is activator transient receptor potential vanilloid receptor TRPV1 and TRP ankyrin receptor TRPA1 with EC50 of 3.3 µM and 10.4 µM. It's a natural chemical found in the rhizomes of ginger (Z. officinale).
CSN23287 2-Aminoethyl diphenylborinate 524-95-8 2-Aminoethyl diphenylborinate is an antagonist of membrane permeable IP3 receptor and a blocker of broad TRP channels including TRPC5 and TRPM2.
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