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TRP Channel

货号 产品名 CAS号 信息
CSN25461 WS 3 39711-79-0 WS 3 is an agonist of TRPM8 with an EC50 of 3.7 μM.
CSN19515 Vanillyl Alcohol 498-00-0 Vanillyl alcohol is a free radical scavenger with anticonvulsive and bile secretion promoting effect. It can be extracted from the herbs of Gastrodia elata Bl..
CSN27198 TRPM8 antagonist 14 259674-19-6 TRPM8 antagonist 14 is a tryptophan-derived selective TRPM8 antagonist with IC50 value of 0.2nM. It showed significant target coverage in both an icilin-induced WDS (at 1-30 mg/kg s.c.) and oxaliplatin-induced cold allodynia (at 0.1-1 μg s.c.) mice models.
CSN16412 SN 2 823218-99-1 SN 2 is a potent activator of TRPML3 ion channel with EC50 of 1.8±0.13 μM.
CSN25460 9-Phenanthrol 484-17-3 Selective TRPM4 blocker (IC50 = 20 μM in HEK293 cells). Exhibits no effect on CFTR or TRPM5 (at 0.25 and 1 mM respectively). Abolishes arrhythmias induced by hypoxia in a mouse heart model.
CSN15682 SB-705498 501951-42-4 SB-705498 is a selective antagonist of transient receptor potential vanilloid 1 (TRPV1) with pIC50 of 7.1.
CSN17628 RQ-00203078 1254205-52-1 RQ-00203078 is a selective antagonist of TRPM8 with IC50 of 8.3 nM.
CSN18624 RN-1734 946387-07-1 RN-1734 is selective antagonist of the TRPV4 channel, completely antagonizes 4αPDD-mediated activation of TRPV4 with comparable, low micromolar IC50 values for all three species (hTRPV4: IC50 = 2.3 μM, mTRPV4: IC50 = 5.9 μM, rTRPV4: IC50 = 3.2 μM).
CSN18152 Pyr6 245747-08-4 Pyr6 is a selective inhibitor of TRPC3 with IC50 of 0.49 μM (Ca2+ influx inhibition in thapsigargin depleted native RBL-2H3 cells).
CSN17688 Pyr10 1315323-00-2 Pyr 10 is a TRPC3-selective inhibitor. IC50 of Ca2+ influx inhibition by Pyr10 in carbachol-stimulated YFP-TRPC3-transfected HEK293 cells for ROCE and thapsigargin-depleted native RBL-2H3 cells for SOCE is 0.72 uM and 13.08 uM.
CSN21376 AM-0902 1883711-97-4 Potent and selective TRPA1 antagonist (IC50 = 0.02 μM for human TRPA1). Exhibits no siginificant activity against human TRPV1 or TRPV4, and rat TRPV1, TRPV3 or TRPM8. Exhibits efficacy in a rat pain model. Orally bioavailable.
CSN19028 Podocarpic Acid 5947-49-9 Podocarpic acid is a natural product, which has the best all-round positive effect and acts as a TRPA1 activator.
CSN13939 PF-4840154 1332708-14-1 PF-4840154 is a potent, selective agonist of the rat and human TrpA1 channel and elicited TrpA1-mediated nocifensive behaviour in mouse, with EC50 of 97 nM and 23 nM for rTrpA1 and hTrpA1, respectively.
CSN20615 PF-05105679 1398583-31-7 PF-05105679 is an orally-bioavailable and selective TRPM8 blocker (IC50 = 103 nM) which exhibits > 100-fold selectivity for TRPM8 over a panel of receptors, ion channels and enzymes, including TRPV1 and TRPA1 ion channels.
CSN17365 Optovin 348575-88-2 Optovin is a reversible and photoactive activator of TRPA1 with EC50 of 2 μM in wild-type zebrafish.
CSN25722 OLDA 105955-11-1 OLDA is an agonist of endogenous vanilloid TRPV1 (VR1) receptor with EC50 of 36 nM and low affinity for rCB1 receptors (Ki = 1.6 μM).
CSN16213 Nonivamide 2444-46-4 Nonivamide, an analog of capsaicin, is agonist of transient receptor potential vanilloid type 1 (TRPV1). It can be extracted from the fruits of Capsicum annuum L..
CSN20361 MRS1477 212200-21-0 MRS1477 is a positive allosteric modulator of TRPV1 channels targeting breast cancer cells.
CSN15766 ML204 5465-86-1 ML204 is a selective antagonist of TRPC4 ion channel with IC50 of 0.96 μM and 2.6 μM in fluorescent and electrophysiological assays respectively.
CSN19023 ML204 HCl 2070015-10-8 ML204 HCl is a potent, selective TRPC4 channel inhibitor with IC50 of 0.96 μM.
CSN26127 MDR-652 1933528-96-1 MDR-652 is a high-affinity TRPV1 agonist with Ki value of 11.4nM.
CSN18632 Mavatrep 956274-94-5 Mavatrep is an orally bioavailable TRPV1 antagonist (Ki=6.5 nM), exhibits minimal effect on the enzymatic activity (IC50 > 25 μM) of CYP isoforms 3A4, 1A2, and 2D6.
CSN26181 Linoleylethanolamide 68171-52-8 Linoleylethanolamide is an endocannabinoid agent. It acts by binding to TRPV1, increasing ERK phosphorylation and AP-1 dependent transcription in CB-receptor in an independent manner.
CSN22440 JYL 1421 401907-26-4 JYL 1421 is a TRPV1 receptor antagonist, with an IC50 of 8 nM.
CSN16140 Icilin 36945-98-9 Icilin is an agonist of TRPM8 ion channel with EC50 of 0.36 μM in HEK 293 cells.
CSN19708 GSK2193874 1336960-13-4 GSK2193874 is a selective transient receptor potential vanilloid 4 (TRPV4) blocker with IC50 value of 0.04 μM.
CSN18613 GSK1016790A 942206-85-1 GSK1016790A is a potent activator of TRPV4 (transient receptor potential vanilloid 4) with EC50 of 34nM in choroid plexus epithelial cells.
CSN25311 GFB-8438 2304549-73-1 GFB-8438 is a potent and subtype selective TRPC5 inhibitor, with IC50s of 0.18 and 0.29 μM of hTRPC5 and hTRPC4, respectively.
CSN25462 EIPA 1154-25-2 EIPA (L593754) is a TRPP3 channel inhibitor with an IC50 of 10.5 μM. EIPA also inhibits Na+/H+-exchanger (NHE) and macropinocytosis.
CSN25671 Eact 461000-66-8 Eact is an activator of TMEM16A calcium-activated chloride channel (CaCC) with EC50 of 3 μM. It is also transient receptor potential vanilloid 1 (TRPV1) channel activator (EC50 = 11.6 μM).
CSN19025 D-3263 HCl 1008763-54-9 D-3263 HCl is an orally bioavailable (transient receptor potential melastatin member 8) TRPM8 agonist.
CSN18220 Chembridge-5861528 332117-28-9 Chembridge-5861528 is a TRPA1 channel blocker that antagonizes AITC- and 4-HNE-evoked calcium influx (IC50 values are 14.3 and 18.7μM respectively).
CSN15352 Bisandrographolide A 160498-00-0 Bisandrographolide A, a natural product, activates TRPV4 channels, could play a role in some of the effects of Andrographis extract described in traditional medicine.
CSN24060 β-Eudesmol 473-15-4 Beta-Eudesmol is a natural oxygenated sesquiterpene, activates hTRPA1, with an EC50 of 32.5 μM. Beta-Eudesmol increases appetite through TRPA1[1].
CSN20581 ASP 7663 1190217-35-6 ASP 7663 is an orally-bioavailabe, selective TRPA1 activator (EC50 values are ~0.5 μM in human, mouse and rat), which displays little or no affinity at more than 60 other related receptors, channels and enzymes. It stimulates 5-HT release from QGP-1 cells and exhibits an abdominal analgesic effect in vivo.
CSN25672 Arvanil 128007-31-8 Arvanil is an antagonist of cannabinoid CB1 and vanilloid TRPV1 (VR1) with Ki values are 0.5 and 0.3 μM respectively.
CSN16537 AMG-517 659730-32-2 AMG-517 is a potent and selective TRPV1 antagonist, and antagonizes capsaicin, proton, and heat activation of TRPV1 with IC50 of 0.76 nM, 0.62 nM and 1.3 nM.
CSN24195 AC1903 831234-13-0 AC1903 is an inhibitor of transient receptor potential canonical channel 5 (TRPC5) with IC50 of 14.7 µM.
CSN19859 A 967079 1170613-55-4 A 967079 is a selective TRPA1 channel blocker (IC50 values are 67 and 289 nM at human and rat TRPA1 receptors respectively).
CSN23287 2-Aminoethyl diphenylborinate 524-95-8 2-Aminoethyl diphenylborinate is an antagonist of membrane permeable IP3 receptor and a blocker of broad TRP channels including TRPC5 and TRPM2.
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