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PDE

PDE

货号 产品名 CAS号 信息
CSN12231 Zardaverine 101975-10-4 Zardaverine is a dual-selective PDE3/4 inhibitor with IC50 values of 0.5 μM and 0.8 μM respectively.
CSN23206 YM 976 191219-80-4 YM976 is an orally active PDE4 inhibitor (IC50 = 2.2 nM). YM976 has low emetogenic activity, suggested to be due to poor brain penetration.
CSN12204 Vinpocetine 42971-09-5 Vinpocetine is a selective inhibitor for PDE1 with IC50 of 21 μM, it also blocks voltage-gated Na+ channels. It's a natural product isolated and purified from the herbs of Catharanthus roseus (L.) G. Don.
CSN12196 Vesnarinone 81840-15-5 Vesnarinone is a PDE3 inhibitor with IC50 value of 1.1μM for inhibiton of HERG current.
CSN13690 Vardenafil 224785-90-4 Vardenafil is a PDE5 inhibitor used for treating erectile dysfunction.
CSN12189 Vardenafil HCl 3H2O 330808-88-3 Vardenafil HCl is a type PDE inhibitor with IC50 of 0.7 and 180 nM for PDE5 and PDE1, respectively.
CSN12994 Udenafil 268203-93-6 Udenafil is a PDE5 inhibitor used in urology to treat erectile dysfunction.
CSN23151 TC-E 5005 959705-64-7 TC-E 5005 is a selective PDE10A inhibitor.
CSN16723 Tadalafil 171596-29-5 Tadalafil is a PDE5 inhibitor with an IC50 value of 1.8 nM.
CSN23137 T 0156 HCl 324572-93-2 T 0156 hydrochloride is a potent and selective inhibitor of phosphodiesterase type 5 (PDE5). It is more selective than sildenafil (IC50 values are 0.23, 56 and > 63000 nM for T 0156 and 3.6, 29 and > 270 nM for sildenafil at PDE5, PDE6 and PDEs 1 - 4 respectively). T 0156 hydrochloride is selective over 30 other enzymes and receptors (IC50 > 10 mM) and potentiates electrical field stimulation-induced relaxation of isolated rabbit corpus cavernosum.
CSN11923 Sildenafil 139755-83-2 Sildenafil, one of the selective phosphodiesterase-5 (PDE5) inhibitors (IC50= 5.22 nM), is considered the best treatment for erectile dysfunction.
CSN11924 Sildenafil Citrate 171599-83-0 Sildenafil citrate, one of the selective phosphodiesterase-5 (PDE5) inhibitors (IC50= 5.22 nM), is considered the best treatment for erectile dysfunction.
CSN23118 Siguazodan 115344-47-3 Siguazodan is a selective phosphodiesterase inhibitor with anti-platelet action properties.
CSN11859 Rolipram 61413-54-5 Rolipram is a selective inhibitor of phosphodiesterases PDE 4, especially the PDE 4B with IC50 of 130 nM while IC50 for PDE4D is 240 nM, it's an anti-inflammatory agent.
CSN23068 Ro 20-1724 29925-17-5 Ro20-1724 is a widely used inhibitor of cyclic nucleotide phosphodiesterase, selective for PDE4 (IC50 = 2.0 μM)
CSN23075 RS 25344 HCl 152815-28-6 Potent PDE4 inhibitor
CSN11723 Pimobendan 74150-27-9 Pimobendan is a selective inhibitor of PDE3 with IC50 of 0.32 μM.
CSN13560 PF-8380 1144035-53-9 PF-8380 is a potent and specific autotaxin inhibitor with IC50 of 2.8 nM.
CSN12802 PF-2545920 898562-94-2 PF-2545920 is a potent and selective PDE10A inhibitor with IC50 of 0.37 nM, with > 1000-fold selectivity over the other PDEs.
CSN13921 PF-04447943 1082744-20-4 PF-04447943 is a potent, selective brain penetrant PDE9 inhibitor (Ki of 2.8, 4.5 and 18 nM) for human, rhesus and rat recombinant PDE9 respectively and high selectivity for PDE9 versus PDEs1-8 and 10-11.
CSN10102 Pentoxifylline 6493-05-6 Pentoxifylline is a competitive nonselective phosphodiesterase inhibitor.
CSN13932 PDE10-IN-1 1516896-09-5 PDE10-IN-1 is a potent PDE10 inhibitor for treating CNS and metabolic disorders.
CSN17450 PDE-9 Inhibitor 1082743-70-1 PDE-9 inhibitor is useful for neurodegenerative diseases.
CSN10027 Olprinone 106730-54-5 Olprinone is a selective phosphodiesterase 3 (PDE3) inhibitor.
CSN11605 Olprinone HCl 119615-63-3 Olprinone HCl is a selective phosphodiesterase 3 (PDE3) inhibitor.
CSN13420 Oglemilast 778576-62-8 Oglemilast is a potent PDE4 inhibitor, under clinical studies in the treatment of allergen-induced asthma.
CSN15931 Nortadalafil 171596-36-4 Nortadalafil is demethyl tadalafil, which is a PDE5 inhibitor, currently marketed in pill form for treating erectile dysfunction (ED) and pulmonary arterial hypertension.
CSN14435 Moracin M 56317-21-6 Moracin M is a phytoalexin and inhibits PDE4D2, PDE4B2, PDE5A1, and PDE9A2 with the IC(50) values of 2.9, 4.5, > 40, and > 100 μM, respectively.
CSN12406 Mirodenafil 862189-95-5 Mirodenafil is a phosphodiesterase type 5 (PDE-5) inhibitor developed for the treatment of erectile dysfunction.
CSN12286 Milrinone Lactate 100286-97-3 Milrinone lactate is a phosphodiesterase 3 (PDE3) inhibitor and a medication used in patients who have heart failure.
CSN11549 Milrinone 78415-72-2 Milrinone is a phosphodiesterase 3 (PDE3) inhibitor with IC50 of 56 nM, it increases intracellular cyclic adenosine monophosphate resulting in improved ventricular function and vasodilation.
CSN24782 Lotamilast   947620-48-6 Lotamilast (RVT-501; E6005) is a selective phosphodiesterase 4 (PDE4) inhibitor with an IC50 of 2.8 nM.
CSN16764 Irsogladine 57381-26-7 Irsogladine is a PDE4 inhibitor and muscarinic acetylcholine receptor binder.
CSN13001 Irsogladine Maleate 84504-69-8 Irsogladine is a PDE4 inhibitor and muscarinic acetylcholine receptor binder.
CSN16998 HA130 1229652-21-4 HA130 is a selective ATX (autotaxin) inhibitor with IC50 of 28 nM.
CSN16026 GSK256066 801312-28-7 GSK256066 is a selective PDE4B (equal affinity to isoforms A-D) inhibitor with IC50 of 3.2 pM, showing > 380,000-fold selectivity versus PDE1/2/3/5/6 and > 2500-fold selectivity against PDE4B versus PDE7.
CSN10162 Diphylline 479-18-5 Dyphylline, a xanthine derivative, acts as an adenosine receptor antagonist and phosphodiesterase inhibitor, which is used in the treatment of respiratory disorders.
CSN10863 Doxofylline 69975-86-6 Doxofylline is a methylxanthine bronchodilator used to treat asthma, COPD and bronchospasm, whiel the anti-asthmatic effects are mediated primarily through inhibiting the activities of the phosphodiesterase (PDE) enzyme.
CSN16408 Dipyridamole 58-32-2 Dipyridamole is a phosphodiesterase inhibitor that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells.
CSN23886 D 159687 1155877-97-6 D 159687 is selective inhibitor of PDE4B and PDE4D with brain permeability.
CSN14045 Citreorosein 481-73-2 Citreorosein, a cAMP phosphodiesterase inhibitor isolated and purified from the root and rhizome of Rheum palmatum L., has anti-inflammatory effect, inhibits proinflammatory cytokines production through the inhibition of both MAPKs and AKT-mediated IκB kinase (IKK) phosphorylation and subsequent inhibition of transcription factor NF-κB activation.
CSN12923 Cilostazol 73963-72-1 Cilostazol is a potent cyclic nucleotide phosphodiesterase type 3 (PDE3) inhibitor with IC50 of 0.2 μM and inhibitor of adenosine uptake.
CSN10640 Cilomilast 153259-65-5 Cilomilast is a potent PDE4 inhibitor with IC50 of about 110 nM, has anti-inflammatory activity and low central nervous system activity.
CSN24065 BAY 73-6691 794568-92-6 BAY 73-6691 is a potent, selective brain penetrant PDE9A inhibitor.
CSN10307 Anagrelide 68475-42-3 Anagrelide is a drug used for the treatment of essential thrombocytosis (ET; essential thrombocythemia), or overproduction of blood platelets, and also has been used in the treatment of chronic myeloid leukemia. It inhibits cyclic AMP phosphodiesterase, as well as ADP- and collagen-induced platelet aggregation.
CSN10308 Anagrelide HCl 58579-51-4 Anagrelide HCl is a drug used for the treatment of essential thrombocytosis (ET; essential thrombocythemia), or overproduction of blood platelets, and also has been used in the treatment of chronic myeloid leukemia. It inhibits cyclic AMP phosphodiesterase, as well as ADP- and collagen-induced platelet aggregation.
CSN13152 AN-2728 906673-24-3 AN-2728 is a topically administered, boron-containing, anti-inflammatory compound that inhibits PDE4 activity with an IC50 of 0.49 μM and thereby suppresses the release of TNFalpha, IL-12, IL-23 and other cytokines.
CSN10951 Amrinone 60719-84-8 Amrinone is a type 3 pyridine phosphodiesterase inhibitor used in the treatment of congestive heart failure.
CSN17008 (S)-(+)-Rolipram 85416-73-5 (S)-(+)-Rolipram is a PDE4-inhibitor and an anti-inflammatory agent, less potent than its R-enantiomer.
CSN13179 (R)-(-)-Rolipram 85416-75-7 (R)-(-)-rolipram, R-enantiomer of rolipram, is a potent and cAMP-specific PDE4 inhibitor with IC50 of 0.22 μM and 2.5-fold more potent than(+)-rolipram (IC50= 2.58 μM) in inhibiting membrane-bound PDE 4.
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