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PDE

PDE

货号 产品名 CAS号 信息
CSN12231 Zardaverine 101975-10-4 Zardaverine is a dual-selective PDE3/4 inhibitor with IC50 values of 0.5 μM and 0.8 μM respectively.
CSN23206 YM 976 191219-80-4 YM976 is an orally active PDE4 inhibitor (IC50 = 2.2 nM). YM976 has low emetogenic activity, suggested to be due to poor brain penetration.
CSN12204 Vinpocetine 42971-09-5 Vinpocetine is a selective inhibitor for PDE1 with IC50 of 21 μM, it also blocks voltage-gated Na+ channels. It's a natural product isolated and purified from the herbs of Catharanthus roseus (L.) G. Don.
CSN12196 Vesnarinone 81840-15-5 Vesnarinone is a PDE3 inhibitor with IC50 value of 1.1μM for inhibiton of HERG current.
CSN13690 Vardenafil 224785-90-4 Vardenafil is a PDE5 inhibitor used for treating erectile dysfunction.
CSN12189 Vardenafil HCl 3H2O 330808-88-3 Vardenafil HCl is a type PDE inhibitor with IC50 of 0.7 and 180 nM for PDE5 and PDE1, respectively.
CSN12994 Udenafil 268203-93-6 Udenafil is a PDE5 inhibitor used in urology to treat erectile dysfunction.
CSN23151 TC-E 5005 959705-64-7 TC-E 5005 is a selective PDE10A inhibitor.
CSN16723 Tadalafil 171596-29-5 Tadalafil is a PDE5 inhibitor with an IC50 value of 1.8 nM.
CSN23137 T 0156 HCl 324572-93-2 T 0156 hydrochloride is a potent and selective inhibitor of phosphodiesterase type 5 (PDE5). It is more selective than sildenafil (IC50 values are 0.23, 56 and > 63000 nM for T 0156 and 3.6, 29 and > 270 nM for sildenafil at PDE5, PDE6 and PDEs 1 - 4 respectively). T 0156 hydrochloride is selective over 30 other enzymes and receptors (IC50 > 10 mM) and potentiates electrical field stimulation-induced relaxation of isolated rabbit corpus cavernosum.
CSN11923 Sildenafil 139755-83-2 Sildenafil, one of the selective phosphodiesterase-5 (PDE5) inhibitors (IC50= 5.22 nM), is considered the best treatment for erectile dysfunction.
CSN11924 Sildenafil Citrate 171599-83-0 Sildenafil citrate, one of the selective phosphodiesterase-5 (PDE5) inhibitors (IC50= 5.22 nM), is considered the best treatment for erectile dysfunction.
CSN23118 Siguazodan 115344-47-3 Siguazodan is a selective phosphodiesterase inhibitor with anti-platelet action properties.
CSN23068 Ro 20-1724 29925-17-5 Ro20-1724 is a widely used inhibitor of cyclic nucleotide phosphodiesterase, selective for PDE4 (IC50 = 2.0 μM)
CSN23075 RS 25344 HCl 152815-28-6 Potent PDE4 inhibitor
CSN11723 Pimobendan 74150-27-9 Pimobendan is a selective inhibitor of PDE3 with IC50 of 0.32 μM.
CSN13560 PF-8380 1144035-53-9 PF-8380 is a potent and specific autotaxin inhibitor with IC50 of 2.8 nM.
CSN12802 PF-2545920 898562-94-2 PF-2545920 is a potent and selective PDE10A inhibitor with IC50 of 0.37 nM, with > 1000-fold selectivity over the other PDEs.
CSN13921 PF-04447943 1082744-20-4 PF-04447943 is a potent, selective brain penetrant PDE9 inhibitor (Ki of 2.8, 4.5 and 18 nM) for human, rhesus and rat recombinant PDE9 respectively and high selectivity for PDE9 versus PDEs1-8 and 10-11.
CSN10102 Pentoxifylline 6493-05-6 Pentoxifylline is a competitive nonselective phosphodiesterase inhibitor.
CSN13932 PDE10-IN-1 1516896-09-5 PDE10-IN-1 is a potent PDE10 inhibitor for treating CNS and metabolic disorders.
CSN17450 PDE-9 Inhibitor 1082743-70-1 PDE-9 inhibitor is useful for neurodegenerative diseases.
CSN10027 Olprinone 106730-54-5 Olprinone is a selective phosphodiesterase 3 (PDE3) inhibitor.
CSN11605 Olprinone HCl 119615-63-3 Olprinone HCl is a selective phosphodiesterase 3 (PDE3) inhibitor.
CSN13420 Oglemilast 778576-62-8 Oglemilast is a potent PDE4 inhibitor, under clinical studies in the treatment of allergen-induced asthma.
CSN15931 Nortadalafil 171596-36-4 Nortadalafil is demethyl tadalafil, which is a PDE5 inhibitor, currently marketed in pill form for treating erectile dysfunction (ED) and pulmonary arterial hypertension.
CSN14435 Moracin M 56317-21-6 Moracin M is a phytoalexin and inhibits PDE4D2, PDE4B2, PDE5A1, and PDE9A2 with the IC(50) values of 2.9, 4.5, > 40, and > 100 μM, respectively.
CSN12406 Mirodenafil 862189-95-5 Mirodenafil is a phosphodiesterase type 5 (PDE-5) inhibitor developed for the treatment of erectile dysfunction.
CSN12286 Milrinone Lactate 100286-97-3 Milrinone lactate is a phosphodiesterase 3 (PDE3) inhibitor and a medication used in patients who have heart failure.
CSN11549 Milrinone 78415-72-2 Milrinone is a phosphodiesterase 3 (PDE3) inhibitor with IC50 of 56 nM, it increases intracellular cyclic adenosine monophosphate resulting in improved ventricular function and vasodilation.
CSN24782 Lotamilast   947620-48-6 Lotamilast (RVT-501; E6005) is a selective phosphodiesterase 4 (PDE4) inhibitor with an IC50 of 2.8 nM.
CSN16764 Irsogladine 57381-26-7 Irsogladine is a PDE4 inhibitor and muscarinic acetylcholine receptor binder.
CSN13001 Irsogladine Maleate 84504-69-8 Irsogladine is a PDE4 inhibitor and muscarinic acetylcholine receptor binder.
CSN16383 Hesperetin 520-33-2 Hesperetin is a flavanone extracted from the peel of citrus that exhibits inhibition of PDE4 and UGT. Hesperetin has antioxidative and anti-inflammatory effects as well. Hesperetin dose-dependently inhibited cleavage activity of the 3CLpro with IC50 value of 8.3μM in the cell-based assay.
CSN16998 HA130 1229652-21-4 HA130 is a selective ATX (autotaxin) inhibitor with IC50 of 28 nM.
CSN10162 Diphylline 479-18-5 Dyphylline, a xanthine derivative, acts as an adenosine receptor antagonist and phosphodiesterase inhibitor, which is used in the treatment of respiratory disorders.
CSN10863 Doxofylline 69975-86-6 Doxofylline is a methylxanthine bronchodilator used to treat asthma, COPD and bronchospasm, whiel the anti-asthmatic effects are mediated primarily through inhibiting the activities of the phosphodiesterase (PDE) enzyme.
CSN23886 D 159687 1155877-97-6 D 159687 is selective inhibitor of PDE4B and PDE4D with brain permeability.
CSN14045 Citreorosein 481-73-2 Citreorosein, a cAMP phosphodiesterase inhibitor isolated and purified from the root and rhizome of Rheum palmatum L., has anti-inflammatory effect, inhibits proinflammatory cytokines production through the inhibition of both MAPKs and AKT-mediated IκB kinase (IKK) phosphorylation and subsequent inhibition of transcription factor NF-κB activation.
CSN12923 Cilostazol 73963-72-1 Cilostazol is a potent cyclic nucleotide phosphodiesterase type 3 (PDE3) inhibitor with IC50 of 0.2 μM and inhibitor of adenosine uptake.
CSN10640 Cilomilast 153259-65-5 Cilomilast is a potent PDE4 inhibitor with IC50 of about 110 nM, has anti-inflammatory activity and low central nervous system activity.
CSN25348 BIO-32546 1548743-66-3 BIO-32546 is a novel modulator of the activity of the autotaxin (ATX) enzyme.
CSN25573 BI-409306 1189767-28-9 BI-409306 is a potent and selective PDE9A inhibitor, with an IC50 of 52 nM, and shows weak activity against other PDEs, such as PDE1A (IC50, 1.4 µM), PDE1C (IC50, 1.0 µM), PDE2A, PDE3A, PDE4B, PDE5A, PDE6AB, PDE7A, and PDE10A (IC50 all > 10 μM). BI-409306 can be used in the research of memory enhancement in CNS disorders. It is currently being investigated in clinical trials.
CSN24065 BAY 73-6691 794568-92-6 BAY 73-6691 is a potent, selective brain penetrant PDE9A inhibitor.
CSN10307 Anagrelide 68475-42-3 Anagrelide is a drug used for the treatment of essential thrombocytosis (ET; essential thrombocythemia), or overproduction of blood platelets, and also has been used in the treatment of chronic myeloid leukemia. It inhibits cyclic AMP phosphodiesterase, as well as ADP- and collagen-induced platelet aggregation.
CSN10308 Anagrelide HCl 58579-51-4 Anagrelide HCl is a drug used for the treatment of essential thrombocytosis (ET; essential thrombocythemia), or overproduction of blood platelets, and also has been used in the treatment of chronic myeloid leukemia. It inhibits cyclic AMP phosphodiesterase, as well as ADP- and collagen-induced platelet aggregation.
CSN13152 AN-2728 906673-24-3 AN-2728 is a topically administered, boron-containing, anti-inflammatory compound that inhibits PDE4 activity with an IC50 of 0.49 μM and thereby suppresses the release of TNFalpha, IL-12, IL-23 and other cytokines.
CSN10951 Amrinone 60719-84-8 Amrinone is a type 3 pyridine phosphodiesterase inhibitor used in the treatment of congestive heart failure.
CSN17008 (S)-(+)-Rolipram 85416-73-5 (S)-(+)-Rolipram is a PDE4-inhibitor and an anti-inflammatory agent, less potent than its R-enantiomer.
CSN13179 (R)-(-)-Rolipram 85416-75-7 (R)-(-)-rolipram, R-enantiomer of rolipram, is a potent and cAMP-specific PDE4 inhibitor with IC50 of 0.22 μM and 2.5-fold more potent than(+)-rolipram (IC50= 2.58 μM) in inhibiting membrane-bound PDE 4.
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