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PDE

PDE

货号 产品名 CAS号 信息
CSN12231 Zardaverine 101975-10-4 Zardaverine is a dual-selective PDE3/4 inhibitor with IC50 values of 0.5 μM and 0.8 μM respectively.
CSN12204 Vinpocetine 42971-09-5 Vinpocetine is a selective inhibitor for PDE1 with IC50 of 21 μM, it also blocks voltage-gated Na+ channels. It's a natural product isolated and purified from the herbs of Catharanthus roseus (L.) G. Don.
CSN12196 Vesnarinone 81840-15-5 Vesnarinone is a quinolinone derivative, and its pharmacodynamic effects include inhibition of phosphodiesterase III (PDE3) activity, increases in calcium flux and decreases in potassium flux.
CSN13690 Vardenafil 224785-90-4 Vardenafil is a PDE5 inhibitor used for treating erectile dysfunction.
CSN12190 Vardenafil HCl 224785-91-5 Vardenafil hydrochloride is a PDE5 inhibitor used for treating erectile dysfunction.
CSN12189 Vardenafil HCl 3H2O 330808-88-3 Vardenafil HCl is a type PDE inhibitor with IC50 of 0.7 and 180 nM for PDE5 and PDE1, respectively.
CSN12994 Udenafil 268203-93-6 Udenafil is a PDE5 inhibitor used in urology to treat erectile dysfunction.
CSN16723 Tadalafil 171596-29-5 Tadalafil is a PDE5 inhibitor with an IC50 value of 1.8 nM.
CSN11923 Sildenafil 139755-83-2 Sildenafil, one of the selective phosphodiesterase-5 (PDE5) inhibitors (IC50= 5.22 nM), is considered the best treatment for erectile dysfunction.
CSN11924 Sildenafil Citrate 171599-83-0 Sildenafil citrate, one of the selective phosphodiesterase-5 (PDE5) inhibitors (IC50= 5.22 nM), is considered the best treatment for erectile dysfunction.
CSN11859 Rolipram 61413-54-5 Rolipram is a selective inhibitor of phosphodiesterases PDE 4, especially the PDE 4B with IC50 of 130 nM while IC50 for PDE4D is 240 nM, it's an anti-inflammatory agent.
CSN11857 Roflumilast 162401-32-3 Roflumilast is a selective and long-acting inhibitor of PDE-4 with IC50 of 0.8 nM.
CSN11838 Revizinone 133718-29-3 Revizinone is a selective phosphodiesterase (PDE) inhibitor with IC50 values on this enzyme to 0.036 mM.
CSN11723 Pimobendan 74150-27-9 Pimobendan is a selective inhibitor of PDE3 with IC50 of 0.32 μM.
CSN13560 PF-8380 1144035-53-9 PF-8380 is a potent and specific autotaxin inhibitor with IC50 of 2.8 nM.
CSN12802 PF-2545920 898562-94-2 PF-2545920 is a potent and selective PDE10A inhibitor with IC50 of 0.37 nM, with > 1000-fold selectivity over the other PDEs.
CSN13921 PF-04447943 1082744-20-4 PF-04447943 is a potent, selective brain penetrant PDE9 inhibitor (Ki of 2.8, 4.5 and 18 nM) for human, rhesus and rat recombinant PDE9 respectively and high selectivity for PDE9 versus PDEs1-8 and 10-11.
CSN10102 Pentoxifylline 6493-05-6 Pentoxifylline is a competitive nonselective phosphodiesterase inhibitor.
CSN13932 PDE10-IN-1 1516896-09-5 PDE10-IN-1 is a potent PDE10 inhibitor for treating CNS and metabolic disorders.
CSN17450 PDE-9 Inhibitor 1082743-70-1 PDE-9 inhibitor is useful for neurodegenerative diseases.
CSN10027 Olprinone 106730-54-5 Olprinone is a selective phosphodiesterase 3 (PDE3) inhibitor.
CSN11605 Olprinone HCl 119615-63-3 Olprinone hydrochloride is a selective phosphodiesterase 3 (PDE3) inhibitor.
CSN13420 Oglemilast 778576-62-8 Oglemilast is a potent PDE4 inhibitor, under clinical studies in the treatment of allergen-induced asthma.
CSN15931 Nortadalafil 171596-36-4 Nortadalafil is demethyl tadalafil, which is a PDE5 inhibitor, currently marketed in pill form for treating erectile dysfunction (ED) and pulmonary arterial hypertension.
CSN14435 Moracin M 56317-21-6 Moracin M is a phytoalexin and inhibits PDE4D2, PDE4B2, PDE5A1, and PDE9A2 with the IC(50) values of 2.9, 4.5, > 40, and > 100 μM, respectively.
CSN12406 Mirodenafil 862189-95-5 Mirodenafil is a phosphodiesterase type 5 (PDE-5) inhibitor developed for the treatment of erectile dysfunction.
CSN12286 Milrinone Lactate 100286-97-3 Milrinone lactate is a phosphodiesterase 3 (PDE3) inhibitor and a medication used in patients who have heart failure.
CSN11549 Milrinone 78415-72-2 Milrinone is a phosphodiesterase 3 (PDE3) inhibitor with IC50 of 56 nM, it increases intracellular cyclic adenosine monophosphate resulting in improved ventricular function and vasodilation.
CSN17506 ITI214 Free Base 1160521-50-5 ITI-214 free base is a picomolar PDE1 inhibitor with excellent selectivity against other PDE family members and against a panel of enzymes, receptors, transporters, and ion channels, exhibits potent PDE1 inhibitory activity (Ki = 58 pM).
CSN16764 Irsogladine 57381-26-7 Irsogladine is a PDE4 inhibitor and muscarinic acetylcholine receptor binder.
CSN13001 Irsogladine Maleate 84504-69-8 Irsogladine is a PDE4 inhibitor and muscarinic acetylcholine receptor binder.
CSN17075 Ibudilast 50847-11-5 Ibudilast is a nonselective phosphodiesterase inhibitor with IC50s of 53, 35, 48, 12 and 10 μM for PDE Ia, II, III, IV and V respectively, which has been marketed for treating asthma.
CSN16998 HA130 1229652-21-4 HA130 is a selective ATX (autotaxin) inhibitor with IC50 of 28 nM.
CSN16026 GSK256066 801312-28-7 GSK256066 is a selective PDE4B (equal affinity to isoforms A-D) inhibitor with IC50 of 3.2 pM, showing > 380,000-fold selectivity versus PDE1/2/3/5/6 and > 2500-fold selectivity against PDE4B versus PDE7.
CSN10162 Diphylline 479-18-5 Dyphylline, a xanthine derivative, acts as an adenosine receptor antagonist and phosphodiesterase inhibitor, which is used in the treatment of respiratory disorders.
CSN17233 DprE1-IN-1 1494675-86-3 DprE1-IN-1, a potent DprE1 inhibitor, with ic50 of 10 nM, also inhibits PDE6, with IC50 of 6 μM.
CSN10863 Doxofylline 69975-86-6 Doxofylline is a methylxanthine bronchodilator used to treat asthma, COPD and bronchospasm, whiel the anti-asthmatic effects are mediated primarily through inhibiting the activities of the phosphodiesterase (PDE) enzyme.
CSN16408 Dipyridamole 58-32-2 Dipyridamole is a phosphodiesterase inhibitor that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells.
CSN23886 D 159687 1155877-97-6 D 159687 is selective inhibitor of PDE4B and PDE4D with brain permeability.
CSN12923 Cilostazol 73963-72-1 Cilostazol is a potent cyclic nucleotide phosphodiesterase type 3 (PDE3) inhibitor with IC50 of 0.2 μM and inhibitor of adenosine uptake.
CSN10640 Cilomilast 153259-65-5 Cilomilast is a potent PDE4 inhibitor with IC50 of about 110 nM, has anti-inflammatory activity and low central nervous system activity.
CSN13776 BAY 60-7550 439083-90-6 BAY 60-7550 is a potent PDE2 inhibitor with IC50 values of 2.0 nM (bovine) and 4.7 nM (human), being 50-fold selective for PDE2 compared to PDE1 and greater than 100-fold selective compared to PDE5, PDE3B, PDE4B, PDE7B, PDE8A, PDE9A, PDE10A, and PDE11A.
CSN13812 Avanafil 330784-47-9 Avanafil is a potent and highly selective phosphodiesterase-5 (PDE-5) inhibitor with IC50 of 5.2 nM for erectile dysfunction, exhibiting lower selectivity against PDE1, PDE6, and PDE11.
CSN10307 Anagrelide 68475-42-3 Anagrelide is a drug used for the treatment of essential thrombocytosis (ET; essential thrombocythemia), or overproduction of blood platelets, and also has been used in the treatment of chronic myeloid leukemia. It inhibits cyclic AMP phosphodiesterase, as well as ADP- and collagen-induced platelet aggregation.
CSN10308 Anagrelide HCl 58579-51-4 Anagrelide hydrochloride is a drug used for the treatment of essential thrombocytosis (ET; essential thrombocythemia), or overproduction of blood platelets, and also has been used in the treatment of chronic myeloid leukemia. It inhibits cyclic AMP phosphodiesterase, as well as ADP- and collagen-induced platelet aggregation.
CSN13152 AN-2728 906673-24-3 AN-2728 is a topically administered, boron-containing, anti-inflammatory compound that inhibits PDE4 activity with an IC50 of 0.49 μM and thereby suppresses the release of TNFalpha, IL-12, IL-23 and other cytokines.
CSN10951 Amrinone 60719-84-8 Amrinone is a type 3 pyridine phosphodiesterase inhibitor used in the treatment of congestive heart failure.
CSN10285 Aminophylline 317-34-0 Aminophylline is a competitive nonselective phosphodiesterase inhibitor that is used to treat airway obstruction from asthma or COPD.
CSN17008 (S)-(+)-Rolipram 85416-73-5 (S)-(+)-Rolipram is a PDE4-inhibitor and an anti-inflammatory agent, less potent than its R-enantiomer.
CSN13179 (R)-(-)-Rolipram 85416-75-7 (R)-(-)-rolipram, R-enantiomer of rolipram, is a potent and cAMP-specific PDE4 inhibitor with IC50 of 0.22 μM and 2.5-fold more potent than(+)-rolipram (IC50= 2.58 μM) in inhibiting membrane-bound PDE 4.
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