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Alkaloids

Alkaloids

货号 产品名 CAS号 信息
CSN14756 Zanthobungeanine 64190-94-9 Zanthobungeanine, a natural product isolated and purified from the roots of Zanthoxylum nitidum with anti-inflammatory activity, shows the inhibitory action on the development of A549 cell only in high concentration and has no antipersonnel effect on A549 cell, moderate NO production inhibitory activity with an IC50 value of 37.26 mg /L, and obviously inhibitoryactivity to platelet aggregation caused by platelet-activating factor (PAF).
CSN14159 Strictosamide 23141-25-5 Strictosamide, a natural product isolated and purified from the herbs of Nauclea latifolia, may have important effects on inflammation and inflammatory pain, shows slightly toxicity to Charles River mouse (LD(50)=723.17 mg/kg), producing CNS depression and kidney toxicity, and has nonsignificant in vitro and in vivo effect on kidney Na(+),K(+)-ATPase activity but produced an in vivo increase of Na(+),K(+)-ATPase activity of brain.
CSN17136 Sophocarpine Hydrate 145572-44-7 Sophocarpine, a natural product isolated and purified from the herb of Sophora alopecuroidos L., with anti-viral, anti-cachectic and anti-inflammatory effects, can alleviate liver fibrosis mainly by inhibiting the TLR4 pathway, it may be a potential chemotherapeutic agent for chronic liver diseases, ameliorate the ischemic injury induced by transient focal cerebral ischemia in rats and that this neuroprotective effect may be related to the anti-ASIC1 channel and anti-apoptotic action of sophocarpine, and also alleviate hepatocyte steatosis and the potential mechanism may be the activated signaling pathway of AMPK.
CSN17136 Sophocarpine Hydrate 145572-44-7 Sophocarpine, a natural product isolated and purified from the herb of Sophora alopecuroidos L., with anti-viral, anti-cachectic and anti-inflammatory effects, can alleviate liver fibrosis mainly by inhibiting the TLR4 pathway, it may be a potential chemotherapeutic agent for chronic liver diseases, ameliorate the ischemic injury induced by transient focal cerebral ischemia in rats and that this neuroprotective effect may be related to the anti-ASIC1 channel and anti-apoptotic action of sophocarpine, and also alleviate hepatocyte steatosis and the potential mechanism may be the activated signaling pathway of AMPK.
CSN15659 Skimmianin 83-95-4 Skimmianin, a natural product isolated and purified from the herbs of Skimmia japonica, is an inhibitor against the Leishmania APRT enzyme and a strong acetylcholinesterase (AChE) inhibitor, and has a selective inhibitory effect on the 5-hydroxytryptamine-induced vasopressor responses of rats.
CSN15659 Skimmianin 83-95-4 Skimmianin, a natural product isolated and purified from the herbs of Skimmia japonica, is an inhibitor against the Leishmania APRT enzyme and a strong acetylcholinesterase (AChE) inhibitor, and has a selective inhibitory effect on the 5-hydroxytryptamine-induced vasopressor responses of rats.
CSN11929 Sinomenine HCl 6080-33-7 Sinomenine Hydrocloride is a an alkaloid found in the root of the climbing plant Sinomenium acutum which has anti-inflammatory effects in several animal models of inflammation and inhibits mast cell degranulation and histamine release. It is used to treat inflammatory diseases like rheumatoid arthritis.
CSN11916 Serpentine 18786-24-8 Serpentine is a natural product isolated and purified from the herbs of Rauvolfia yunnanensis.
CSN11913 Seneciphylline 480-81-9 Seneciphylline, a natural product isolated and purified from the herbs of Senecio scandens, can significantly increased the activities of epoxide hydrase and glutathione-S-transferase but cause reduction of cytochrome P-450 and related monooxygenase activities.
CSN11911 Securinine 5610-40-2 Securinine, a natural product isolated and purified from the leaves and twigs of Securinega suffruticosa with antifungal activity, induces apoptosis in human leukemia HL-60 cells, is a promising monocytic differentiation inducing agent for Acute Myeloid Leukemia (AML).
CSN11905 Scoulerine 6451-73-6 Scoulerine, a natural product isolated and purified from the herbs of Corydalis dubia., shows significant cytotoxic effects against both two cancer cell lines (Caco-2 and Hep-G2 cancer cells), with IC50 values 6.44 ± 0.87 and 4.57 ± 0.42, respectively.
CSN11892 Sanguinarine Chloride 5578-73-4 Sanguinarine chloride is a naturally occuring benzophenanthridine alkaloid which can inhibit sodium/potassium-ATPase protein (Na+/K+ ATPase) and cause Epidemic dropsy.
CSN15000 Sambutoxin 160047-56-3 Sambutoxin, a natural product isolated and purified from the rotted potato tubers, can cause toxic effects in rats, including body weight loss, feed refusal, hemorrhage in the stomach and intestines, and, finally, death when rats were fed diets supplemented with 0.05 and 0.1% sambutoxin.
CSN12999 Rocaglamide 84573-16-0 Rocaglamide, a naturally occurring product isolated from the herbs of Aglaia odorata Lour, induces apoptosis through the intrinsic death pathway in various human leukemia cell lines and in acute lymphoblastic leukemia, chronic myeloid leukemia and acute myeloid leukemia cells freshly isolated from patients.
CSN11841 Rhynchophylline 76-66-4 Rhyncholphylline, an alkaloid isolated and purified from the herbs of Uncaria rhynchophylla., can protect against ischemic damage and glutamate-induced neuronal death, and also inhibit MA impairment in cultured neurons in vitro.
CSN11840 Rhodamine B 81-88-9 Rhodamine B is used in biology as a staining fluorescent dye, applied in fluorescence microscopy, flow cytometry, fluorescence correlation spectroscopy and ELISA.
CSN20358 Pseudouridimycin 1566586-52-4 Pseudouridimycin is a natural product that potently and selectively inhibits bacterial RNAP in vitro, inhibits bacterial growth in culture, and clears infection in a mouse model of Streptococcus pyogenes peritonitis.
CSN11760 Pramipexole 2HCl 104632-25-9 Pramipexole 2HCl is an dopamine agonist and can inhibit multiple dopamine receptors including dopamine D2S receptor, dopamine D2L receptor, dopamine D3 receptor, and dopamine D4 receptor with respectively Ki values of 3.9, 2.2, 0.5 and 5.1 nM.
CSN14002 Pellitorine 18836-52-7 Pellitorine, a natural product isolated and purified from the herbs of Anacyclus pyrethrum, shows cytotoxic, antiprotozoal and potent antiplatelet aggregation activities against HL60 and MCF-7 cell lines.
CSN11639 Oxysophoridine 54809-74-4 Oxysophoridine is a natural product isolated and purified from the herb of Sophora alopecuroidos L.
CSN14542 Neoechinulin A 51551-29-2 Neoechinulin A, a natural product isolated and purified from Aspergillus chevalieri with anti-inflammatory effect against LPS-stimulated RAW264.7 macrophages through inhibition of the NF-κB and p38 MAPK pathways, may block the phosphorylation of mitogen-activated protein kinase (MAPK) molecule p38, apoptosis signal-regulating kinase 1 (ASK-1) and nuclear translocation of nuclear factor-κB (NF-κB) p65 and p50 subunits, and ameliorate rotenone toxicity by activating a cytoprotective machinery that requires ATP and antioxidant/anti-nitration activities.
CSN11710 Melatonin 73-31-4 Melatonin is a hormone which plays a role in natural sleep-wake cycle and also a ATF6 blocker.
CSN11275 Laurolitsine 5890-18-6 Laurolitsine is a natural product isolated and purified from the roots of Lindera aggregata (Sims) Kosterm.
CSN11233 Isotetrandrine 477-57-6 Isotetrandrine, a natural product isolated and purified from the roots of Stephania tetrandra S.Moore, dose-dependently suppresses the severity of LPS-induced ALI by inactivation of MAPK and NF-κB, which may involve the inhibition of tissue oxidative injury and pulmonary inflammatory process.
CSN11196 Imperialine 61825-98-7 Imperialine is a natural product isolated and purified from the bulbus of Fritillaria thunbergii Miq. with antiasthmatic effect,on tracheal M receptor antagonist.
CSN11120 Glutathione 70-18-8 Glutathione acts as an antioxidant, a free radical scavenger and a detoxifying agent. It is a tripeptide comprised of three amino acids (cysteine, glutamic acid, and glycine) present in most mammalian tissue.
CSN14540 Gelsevirine 38990-03-3 Gelsevirine, a natural product isolated and purified from the herbs of Gelsemium elegans with anxiolytic activity, may be via the agonist action of glycine receptor in the brain, and can significantly inhibit the proliferation of human carcinoma cell line SW480 and MGC80-3 in a dose-dependent manner, the 50% inhibiting concentration(IC50)of gelsevirine on SW480 cells and MGC80-3 cells are 1.41±0.06 mM and 1.22±0.11 mM respectively.
CSN10207 Flaconitine 77181-26-1 Flaconitine is an alkaloid isolated from Aconitum flavum.
CSN10986 Febrifugine 24159-07-7 Febrifugine, a natural product isolated and purified from the roots of Dichroa febrifuga, is an effective coccidiostat, possesses schizonticide property, shows high degree of antimalarial activity but use limited by toxicity .
CSN14581 Eriocalyxin B 84745-95-9 Eriocalyxin B, a natural product isolated and purified from the herbs of Isodon eriocalyx, is a potent NF-kappaB inhibitor, can inhibit the NF-kappaB transcriptional activity but not that of cAMP response element-binding protein.
CSN10819 Dihydrosanguinarine 3606-45-9 Dihydrosanguinarine is a natural compound isolated from the leaves of Macleaya microcarpa with antifungal and anticancer activity.
CSN10796 Dictamnine 484-29-7 Dictamnine, a natural product isolated and purified from the root barks of Dictamnus dasycarpus Turcz., has the ability to exert cytotoxicity in human cervix, colon, and oral carcinoma cells, and has antimicrobial activity against bacteria and fungi.
CSN19952 Dendrobine 2115-91-5 Dendrobine, a natural product isolated and purified from the herb of Dendrobium nobile Lindl., is an antagonist of β-alanine, taurine and of presynaptic inhibition in the frog spinal cord, has antitumor activity,can inhibit the growth of A549 cells through inducing apoptosis, which is partially dependent on mitochondrial-mediated pathway, and possesses antiviral activity against influenza A viruses, including A/FM-1/1/47 (H1N1), A/Puerto Rico/8/34 H274Y (H1N1), and A/Aichi/2/68 (H3N2) with IC50 values of 3.39 ± 0.32, 2.16 ± 0.91, 5.32 ± 1.68 ug/mL, respectively.
CSN15643 Demethoxyfumitremorgin C 111768-16-2 Demethoxyfumitremorgin C, a natural metabolite isolated and purified from marine fungus Aspergillus fumigatus, inhibits the proliferation of PC3 human prostate cancer cells via the intrinsic (mitochondrial) and extrinsic pathway, followed by downstream events leading to apoptotic cell death, and could therefore serve as a useful agent to treat human advanced prostate cancer.
CSN10762 Dehydrocorydaline 30045-16-0 Dehydrocorydaline, a natural product isolated and purified from the tubers of Corydalis ambigua, inhibits MCF-7 cell proliferation by inducing apoptosis mediated by regulating Bax/Bcl-2, activating caspases as well as cleaving PARP.
CSN15660 Daurisoline 70553-76-3 Daurisoline, a natural product isolated and purified from the roots of Menispermum dauricu with antiarrhythmic effects, exerts a blocking effect on hERG at concentrations below 30 uM, but does not affect the expression and function of the hERG channel.
CSN15660 Daurisoline 70553-76-3 Daurisoline, a natural product isolated and purified from the roots of Menispermum dauricu with antiarrhythmic effects, exerts a blocking effect on hERG at concentrations below 30 uM, but does not affect the expression and function of the hERG channel.
CSN14149 Crebanine 25127-29-1 Crebanine, a natural product isolated and purified from the herbs of Stephania yunnanensis, can eonvert BaCl_2-induced arrhythmia into sinus rhythm in rats, decrease the incidence of VF and CA by CaCl_2 in rats and by chloroform in mice, but has no proteetive effects on ouahain-indueed arrhythmias in guinea pigs.
CSN10155 Coixol 532-91-2 Coixol is a natural product isolated and purifed from the seeds of Coix lacryma-jobi L.
CSN10608 Chelidonine 476-32-4 Chelidonine, a natural product isolated and purified from the herbs of Chelidonium majus L., efficiently induced apoptosis in HeLa cells through possible alteration of p38-p53 and AKT/PI3 kinase signalling pathways.
CSN10506 Bulleyaconitine A 107668-79-1 Bulleyaconitine A is an alkaloid with analgesic and anti-inflammatory activities. It is found in Aconitum bulleyanum and used for the treatment of chronic pain and rheumatoid arthritis.
CSN10461 Bis(methylthio)gliotoxin 74149-38-5 Bis(methylthio)gliotoxin is an analog of gliotoxin known to inhibit PAF-induced platelet aggregation and collagen-aggregation, but has no activity with arachidonic or ADP induced aggregation.
CSN10418 Berbamine HCl 6078-17-7 Berbamine 2HCl, a natural product isolated and purified from the roots of Cocculus orbiculatus (L.) DC., has high binding affinity toward the (GGA)8 G-quadruplex, and is a promising agent to suppress liver cancer growth by targeting CAMKII.
CSN14746 Akuammigine 642-17-1 Akuammidine, a natural product isolated and purified from the herbs of Picralima nitida with in vitro antimalarial activity, shows a preference for mu-opioid binding sites with Ki values of 0.6, 2.4 and 8.6 mM at mu-, delta- and kappa-opioid binding sites, respectively and the agonist actions of akuammidine in the mouse-isolated vas deferens were antagonised by naloxone and the mu-opioid receptor selective antagonist D-Phe-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr-NH2 (CTOP) confirming an action at mu-opioid receptors, and competitively antagonizes the effect of noradrenaline on postsynaptic alpha-adrenoceptors, yielding pA2 values of 4.68.
CSN10208 Acetylcholine Chloride 60-31-1 Acetylcholine chloride is a neurotransmitter that can induce the opening of calcium channels.
CSN14545 5-Hydroxy-4-Methoxycanthin-6-One 18110-86-6 5-Hydroxy-4-methoxycanthin-6-one, a natural product isolated and purified from the barks of Picrasma quassioides (D.Don) Benn with anti-inflammatory effect and protective effect on dextran sulfate sodium -induced rat colitis, exhibits significant cytotoxic activity against CNE2 cell line, reduces the development of carrageenan-induced paw edema and complete Freund's adjuvant (CFA)-induced chronic arthritis in rats.
CSN15644 14-Norpseurotin A 1031727-34-0 14-Norpseurotin A is a natural product isolated and purified from the cultures of Aspergillus fumigatus, shows good antileishmanial and moderate anticancer activities, significantly induces neurite outgrowth of rat pheochromocytoma cells (PC12) at a 10.0 microM concentration, and displays significant antimicrobial activities against Escherichia coli, Bacillus subtilis, and Micrococcus lysoleikticus with MICs of 3.74, 14.97, and 7.49 mM , respectively.
CSN14152 1-Hydroxyrutaecarpine 53600-24-1 1-Hydroxyrutaecarpine, a natural product isolated and purified from the fruits of Evodia rutaecarpa (Juss.) Benth., exhibits cytotoxicities (ED50 values < 4 mg/mL) against P-388 or HT-29 cell lines in vitro and antiplatelet activity induced by AA and shows an IC50 value of ca.1-2 mg/mL.
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