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Chloride Channel

Chloride Channel

货号 产品名 CAS号 信息
CSN20208 TMinh-23 2098490-06-1 TMEM16A inhibitors C10bm contains an unusual bromodifluoroacetamide at the thiophene 2-position, had IC50 of ∼30 nM, ∼3.6-fold more potent than the most potent previously reported TMEM16A inhibitor 4 (Ani9), and > 10-fold improved metabolic stability.
CSN27627 T16Ainh-A01 552309-42-9 T16Ainh-A01, an aminophenylthiazole, is a potent transmembrane protein 16A (TMEM16A) inhibitor, inhibiting TMEM16A-mediated chloride currents with an IC50 value of ~1 µM. TMEM16A (ANO1) functions as a calcium-activated chloride channel (CaCC).
CSN12365 (R)-5,8-Dihydroxy-2-(1-hydroxy-4-methylpent-3-en-1-yl)naphthalene-1,4-dione 517-89-5 Shikonin is an inhibitor of TMEM16A chloride channel with IC50 of 6.5 μM, it's a natural product isolated and purified from the roots of Lithosperraum erythrorhizon Sieb. et Zucc..
CSN15941 Selamectin 220119-17-5 Selamectin is an avermectin derivative prepared by hydrolysis and oximation of doramectin. Selamectin is a potent nematocide used for the treatment of parasites, which selectively binds to parasite glutamate-gated chloride ion channels and disrupts neurotransmission.
CSN11822 (R)-2-((6,7-Dichloro-2-cyclopentyl-2-methyl-1-oxo-2,3-dihydro-1H-inden-5-yl)oxy)acetic acid 54197-31-8 R(+)-IAA-94 is a potent indanyloxyacetic acid blocker of epithelial chloride channels.
CSN22216 NS1652 1566-81-0 NS1652 is a reversible anion conductance inhibitor, blocks chloride channel, with an IC50 of 1.6 μM in human and mouse red blood cells.
CSN21767 NPPB 107254-86-4 NPPB can act as a blocker of the chloride channel with IC50 of 100 nM-100 µM and inhibitor of cyclooxygenase (IC50 = 8 µM).
CSN12665 2-((3-(Trifluoromethyl)phenyl)amino)nicotinic acid 4394-00-7 Niflumic acid, a Ca2+-activated Cl- channel blocker, is an analgesic and anti-inflammatory agent used in the treatment of rheumatoid arthritis.
CSN25684 MONNA 1572936-83-4 MONNA is a blocker of TMEM16A (Anoctamin-1) with IC50 of 80 nM.
CSN19806 (Rac)-Methylindazone 53108-00-2 IAA-94 is an indanyloxyacetic acid (IAA) inhibitor of chloride channels that binds channels in bovine kidney cortex microsomes with a Ki value of 1 µM.
CSN22401 Fluxametamide 928783-29-3 Fluxametamide is an insecticide with wide spectrum, acts as an antagonist of GABA- and glutamate-gated chloride channels, with IC50 of 1.95  nM and 225  nM for M. domestica GABACls and GluCls.
CSN23818 Fluralaner 864731-61-3 Fluralaner (INN) is a systemic insecticide and acaricide Fluralaner through potent blockage of GABA and L-glutamate gated chloride channels.
CSN33111 Emidurdar 265646-85-3 Endovion is a blocker of both VRAC and CaCC with IC50 value around 400nM for blocking swelling-activated anion currents in HEK293 cells.
CSN25671 Eact 461000-66-8 Eact is an activator of TMEM16A calcium-activated chloride channel (CaCC) with EC50 of 3 μM. It is also transient receptor potential vanilloid 1 (TRPV1) channel activator (EC50 = 11.6 μM).
CSN27709 Chlorotoxin 163515-35-3 Chlorotoxin is a small 36 amino-acid peptide identified from the venom of the scorpion Leiurus quinquestriatus. It works as a selective blocker of small conductance chloride channels.
CSN25670 Ani9 356102-14-2 Ani 9 is selective TMEM16A blocker with IC50 of 77 nM.
CSN84924 T16A(inh)-C01 171506-87-9
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